Gene table of SNCA : synuclein alpha

Gene-disease associations table

Disease ID	Disease name	Source of annotation with SNCA	OMIM link	Number of associated genes	genes
PS168600	PARKINSON DISEASE	ClinVar, OMIM, HUMSAVAR	link to OMIM	30	ATP13A2, FGF20, VPS13C, DNAJC13, ATXN2, PINK1, CHCHD2, ADH1C, UCHL1, GIGYF2, SYNJ1, PODXL, HTRA2, LRRK2, TBP, PARK2, ATXN8OS, SNCAIP, GBA, SNCA, NR4A2, PLA2G6, GLUD2, PARK7, ATXN3, MAPT, DNAJC6, EIF4G1, FBXO7, VPS35
127750	DEMENTIA, LEWY BODY	ClinVar, OMIM, HUMSAVAR	link to OMIM	3	SNCB, GBA, SNCA

Download the gene annotation in CSV format

Annotation of the gene SNCA

Associated genes in ENSEMBL

ENSG00000145335

Associated proteins - SwissProt Accession ID

P37840

Associated PDB IDs

Cytogenetic Band

4q22.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

ZSCAN21

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Alzheimer's disease	hsa05010	5.34
Parkinson's disease	hsa05012	5.59

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Amyloids	R-HSA-977225	7.37
Disease	R-HSA-1643685	3.33

Associated GO terms for Molecular function

GO term	GO ID	GO IC
kinesin binding	GO:0019894	6.24
phospholipase D inhibitor activity	GO:0060961	9.74
phosphoprotein binding	GO:0051219	5.64
enzyme binding	GO:0019899	2.27
beta-tubulin binding	GO:0048487	6.13
histone binding	GO:0042393	4.72
phospholipase inhibitor activity	GO:0004859	7.17
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
magnesium ion binding	GO:0000287	4.41
enzyme inhibitor activity	GO:0004857	3.78
lipase inhibitor activity	GO:0055102	6.85
heterocyclic compound binding	GO:1901363	1.06
oxidoreductase activity	GO:0016491	3.12
anion binding	GO:0043168	4.17
cation binding	GO:0043169	1.4
molecular function regulator	GO:0098772	2.51
transition metal ion binding	GO:0046914	2.48
dynein binding	GO:0045502	6.44
phospholipid binding	GO:0005543	3.91
ion binding	GO:0043167	1.36
cysteine-type endopeptidase regulator activity involved in apoptotic process	GO:0043028	6.02
calcium ion binding	GO:0005509	3.17
fatty acid binding	GO:0005504	6.37
iron ion binding	GO:0005506	4.65
metal ion binding	GO:0046872	1.41
enzyme regulator activity	GO:0030234	2.85
endopeptidase regulator activity	GO:0061135	4.57
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	GO:0043027	6.6
tubulin binding	GO:0015631	4.1
microtubule binding	GO:0008017	4.42
peptidase regulator activity	GO:0061134	4.37
regulatory region nucleic acid binding	GO:0001067	3.03
lipid binding	GO:0008289	3.26
tau protein binding	GO:0048156	7.25
ferrous iron binding	GO:0008198	6.65
catalytic activity	GO:0003824	1.05
peptidase inhibitor activity	GO:0030414	4.55
protein domain specific binding	GO:0019904	3.32
endopeptidase inhibitor activity	GO:0004866	4.6
cysteine-type endopeptidase inhibitor activity	GO:0004869	5.71
monocarboxylic acid binding	GO:0033293	5.61
transcription regulatory region DNA binding	GO:0044212	3.03
copper ion binding	GO:0005507	5.71
protein N-terminus binding	GO:0047485	5.11
cytoskeletal protein binding	GO:0008092	3.02
organic cyclic compound binding	GO:0097159	1.05
carboxylic acid binding	GO:0031406	4.64
identical protein binding	GO:0042802	2.63
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
alpha-tubulin binding	GO:0043014	6.37
phospholipase binding	GO:0043274	6.91
zinc ion binding	GO:0008270	2.66