| Disease ID | Disease name | Source of annotation with SOD1 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS105400 | AMYOTROPHIC LATERAL SCLEROSIS | ClinVar, OMIM, HUMSAVAR | link to OMIM | 27 | CHCHD10, FIG4, ERBB4, SQSTM1, ATXN2, UBQLN2, DCTN1, FUS, NEFH, PFN1, VAPB, MATR3, ALS2, TBK1, SPG11, TARDBP, TUBA4A, SIGMAR1, SOD1, CHMP2B, PRPH, ANG, VCP, OPTN, C9orf72, HNRNPA1, SETX |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Amyotrophic lateral sclerosis (ALS) | hsa05014 | 7.01 |
| Huntington's disease | hsa05016 | 5.17 |
| Prion diseases | hsa05020 | 7.48 |
| Peroxisome | hsa04146 | 6.34 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Platelet degranulation | R-HSA-114608 | 6.68 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
| Cellular responses to stress | R-HSA-2262752 | 4.56 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 6.59 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 8.23 |
| Hemostasis | R-HSA-109582 | 3.98 |
| GO term | GO ID | GO IC |
|---|---|---|
| enzyme binding | GO:0019899 | 2.27 |
| small GTPase binding | GO:0031267 | 4.13 |
| GTPase binding | GO:0051020 | 4.05 |
| protein phosphatase 2B binding | GO:0030346 | 7.54 |
| binding | GO:0005488 | 0.18 |
| oxidoreductase activity | GO:0016491 | 3.12 |
| oxidoreductase activity, acting on superoxide radicals as acceptor | GO:0016721 | 8.13 |
| transition metal ion binding | GO:0046914 | 2.48 |
| chaperone binding | GO:0051087 | 5.34 |
| ion binding | GO:0043167 | 1.36 |
| metal ion binding | GO:0046872 | 1.41 |
| identical protein binding | GO:0042802 | 2.63 |
| protein homodimerization activity | GO:0042803 | 3.16 |
| cation binding | GO:0043169 | 1.4 |
| antioxidant activity | GO:0016209 | 5.49 |
| Ras GTPase binding | GO:0017016 | 4.2 |
| catalytic activity | GO:0003824 | 1.05 |
| protein phosphatase binding | GO:0019903 | 4.93 |
| phosphatase binding | GO:0019902 | 4.63 |
| Rho GTPase binding | GO:0017048 | 5.36 |
| superoxide dismutase activity | GO:0004784 | 8.13 |
| copper ion binding | GO:0005507 | 5.71 |
| Rac GTPase binding | GO:0048365 | 6.05 |
| protein binding | GO:0005515 | 0.46 |
| protein dimerization activity | GO:0046983 | 2.72 |
| zinc ion binding | GO:0008270 | 2.66 |