| Disease ID | Disease name | Source of annotation with SPARC | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS166200 | OSTEOGENESIS IMPERFECTA | OMIM, HUMSAVAR | link to OMIM | 14 | FKBP10, SPARC, IFITM5, PPIB, BMP1, TMEM38B, P3H1, COL1A1, COL1A2, CRTAP, WNT1, SERPINF1, SP7, SERPINH1 |
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| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Platelet degranulation | R-HSA-114608 | 6.68 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 6.59 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 5.38 |
| ECM proteoglycans | R-HSA-3000178 | 6.75 |
| Extracellular matrix organization | R-HSA-1474244 | 4.91 |
| Scavenging by Class H Receptors | R-HSA-3000497 | 10.98 |
| Hemostasis | R-HSA-109582 | 3.98 |
| Vesicle-mediated transport | R-HSA-5653656 | 4.33 |
| GO term | GO ID | GO IC |
|---|---|---|
| cation binding | GO:0043169 | 1.4 |
| collagen binding | GO:0005518 | 5.58 |
| extracellular matrix binding | GO:0050840 | 5.79 |
| ion binding | GO:0043167 | 1.36 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| protein complex binding | GO:0032403 | 3.09 |
| metal ion binding | GO:0046872 | 1.41 |
| calcium ion binding | GO:0005509 | 3.17 |