Gene table of STAT1 : signal transducer and activator of transcription 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with STAT1	OMIM link	Number of associated genes	genes
614892	IMMUNODEFICIENCY 31A	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	STAT1
PS114580	FAMILIAL CANDIDIASIS	ClinVar, OMIM, HUMSAVAR	link to OMIM	7	TRAF3IP2, IL17RC, IL17RA, IL17F, CARD9, STAT1, CLEC7A
613796	IMMUNODEFICIENCY 31B	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	STAT1

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Annotation of the gene STAT1

Associated genes in ENSEMBL

ENSG00000115415

Associated proteins - SwissProt Accession ID

P42224

Associated PDB IDs

Cytogenetic Band

2q32.2

Tandem repeats annotation

The gene is in the tandem Group 143, together with the genes:

STAT4

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Pancreatic cancer	hsa05212	6.56
Hepatitis C	hsa05160	5.68
Inflammatory bowel disease (IBD)	hsa05321	6.43
Toll-like receptor signaling pathway	hsa04620	6.0
Pathways in cancer	hsa05200	3.98
Jak-STAT signaling pathway	hsa04630	5.44
Leishmaniasis	hsa05140	6.32
Tuberculosis	hsa05152	5.17
Herpes simplex infection	hsa05168	5.08
Prolactin signaling pathway	hsa04917	6.6
Osteoclast differentiation	hsa04380	5.64
Influenza A	hsa05164	5.21
Toxoplasmosis	hsa05145	5.71
Thyroid hormone signaling pathway	hsa04919	5.82
Chemokine signaling pathway	hsa04062	5.19
Hepatitis B	hsa05161	5.52
Measles	hsa05162	5.6

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signaling by Interleukins	R-HSA-449147	4.71
Immune System	R-HSA-168256	2.37
ISG15 antiviral mechanism	R-HSA-1169408	6.83
Regulation of IFNA signaling	R-HSA-912694	8.34
Downstream signal transduction	R-HSA-186763	4.65
Disease	R-HSA-1643685	3.33
Growth hormone receptor signaling	R-HSA-982772	8.4
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Interferon gamma signaling	R-HSA-877300	5.67
Interferon Signaling	R-HSA-913531	4.95
FGFR1 mutant receptor activation	R-HSA-1839124	8.12
Signaling by FGFR in disease	R-HSA-1226099	7.49
Diseases of signal transduction	R-HSA-5663202	4.89
Signaling by FGFR1 fusion mutants	R-HSA-1839117	8.81
Signaling by SCF-KIT	R-HSA-1433557	4.73
Signaling by FGFR1 in disease	R-HSA-5655302	7.81
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	6.83
Interleukin-6 signaling	R-HSA-1059683	9.52
Regulation of IFNG signaling	R-HSA-877312	9.18
Interferon alpha/beta signaling	R-HSA-909733	6.04
Signaling by PDGF	R-HSA-186797	4.53
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cytokine receptor binding	GO:0005126	4.14
enzyme binding	GO:0019899	2.27
nucleic acid binding	GO:0003676	1.44
RNA polymerase II regulatory region DNA binding	GO:0001012	3.36
core promoter proximal region DNA binding	GO:0001159	3.82
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
DNA binding	GO:0003677	1.92
RNA polymerase II core promoter proximal region sequence-specific DNA binding	GO:0000978	3.88
heterocyclic compound binding	GO:1901363	1.06
sequence-specific DNA binding	GO:0043565	2.79
sequence-specific double-stranded DNA binding	GO:1990837	3.2
identical protein binding	GO:0042802	2.63
core promoter proximal region sequence-specific DNA binding	GO:0000987	3.83
double-stranded DNA binding	GO:0003690	3.09
transcription factor activity, RNA polymerase II core promoter sequence-specific	GO:0000983	7.1
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
protein homodimerization activity	GO:0042803	3.16
tumor necrosis factor receptor superfamily binding	GO:0032813	5.89
regulatory region nucleic acid binding	GO:0001067	3.03
tumor necrosis factor receptor binding	GO:0005164	6.3
core promoter binding	GO:0001047	4.71
core promoter sequence-specific DNA binding	GO:0001046	5.12
protein dimerization activity	GO:0046983	2.72
transcription regulatory region DNA binding	GO:0044212	3.03
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977	3.37
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
receptor binding	GO:0005102	2.43
RNA polymerase II core promoter sequence-specific DNA binding	GO:0000979	5.77
nucleic acid binding transcription factor activity	GO:0001071	2.65