Gene table of STAT3 : signal transducer and activator of transcription 3

Gene-disease associations table

Disease ID	Disease name	Source of annotation with STAT3	OMIM link	Number of associated genes	genes
147060	HYPER-IGE RECURRENT INFECTION SYNDROME, AUTOSOMAL DOMINANT	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	STAT3
PS615952	AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	STAT3

Download the gene annotation in CSV format

Annotation of the gene STAT3

Associated genes in ENSEMBL

ENSG00000168610

Associated proteins - SwissProt Accession ID

P40763

Associated PDB IDs

5ax3

Cytogenetic Band

17q21.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6
Inflammatory bowel disease (IBD)	hsa05321	6.43
Acute myeloid leukemia	hsa05221	6.74
Pancreatic cancer	hsa05212	6.56
Hepatitis C	hsa05160	5.68
MicroRNAs in cancer	hsa05206	5.38
Pathways in cancer	hsa05200	3.98
Viral carcinogenesis	hsa05203	5.08
Jak-STAT signaling pathway	hsa04630	5.44
Proteoglycans in cancer	hsa05205	5.02
Epstein-Barr virus infection	hsa05169	4.97
Prolactin signaling pathway	hsa04917	6.6
FoxO signaling pathway	hsa04068	5.63
Toxoplasmosis	hsa05145	5.71
HIF-1 signaling pathway	hsa04066	5.9
Chemokine signaling pathway	hsa04062	5.19
Hepatitis B	hsa05161	5.52
Measles	hsa05162	5.6
Adipocytokine signaling pathway	hsa04920	6.6

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Cellular Senescence	R-HSA-2559583	5.7
Signaling by Interleukins	R-HSA-449147	4.71
Immune System	R-HSA-168256	2.37
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Downstream signal transduction	R-HSA-186763	4.65
Developmental Biology	R-HSA-1266738	3.48
Signalling by NGF	R-HSA-166520	4.23
Growth hormone receptor signaling	R-HSA-982772	8.4
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.77
Cellular responses to stress	R-HSA-2262752	4.56
Disease	R-HSA-1643685	3.33
FGFR1 mutant receptor activation	R-HSA-1839124	8.12
Signaling by FGFR in disease	R-HSA-1226099	7.49
Signalling to STAT3	R-HSA-198745	11.4
Diseases of signal transduction	R-HSA-5663202	4.89
Signaling by Leptin	R-HSA-2586552	5.1
Signaling by SCF-KIT	R-HSA-1433557	4.73
Signaling by FGFR1 in disease	R-HSA-5655302	7.81
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	7.94
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	8.52
Interleukin-6 signaling	R-HSA-1059683	9.52
Signaling by FGFR1 fusion mutants	R-HSA-1839117	8.81
Signaling by PDGF	R-HSA-186797	4.53
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cytokine receptor binding	GO:0005126	4.14
nucleic acid binding	GO:0003676	1.44
sequence-specific double-stranded DNA binding	GO:1990837	3.2
RNA polymerase II regulatory region DNA binding	GO:0001012	3.36
enzyme binding	GO:0019899	2.27
chromatin DNA binding	GO:0031490	5.37
transcription factor activity, direct ligand regulated sequence-specific DNA binding	GO:0098531	5.87
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0001077	4.31
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
DNA binding	GO:0003677	1.92
G-protein coupled receptor binding	GO:0001664	4.18
CCR chemokine receptor binding	GO:0048020	6.21
heterocyclic compound binding	GO:1901363	1.06
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	GO:0004879	5.87
repressing transcription factor binding	GO:0070491	5.71
sequence-specific DNA binding	GO:0043565	2.79
structure-specific DNA binding	GO:0043566	4.98
chemokine receptor binding	GO:0042379	5.7
identical protein binding	GO:0042802	2.63
core promoter proximal region sequence-specific DNA binding	GO:0000987	3.83
double-stranded DNA binding	GO:0003690	3.09
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0000982	3.94
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
glucocorticoid receptor binding	GO:0035259	6.97
steroid hormone receptor binding	GO:0035258	5.32
RNA polymerase II core promoter proximal region sequence-specific DNA binding	GO:0000978	3.88
regulatory region nucleic acid binding	GO:0001067	3.03
transcription factor binding	GO:0008134	3.46
nuclear hormone receptor binding	GO:0035257	4.7
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
protein phosphatase binding	GO:0019903	4.93
phosphatase binding	GO:0019902	4.63
core promoter proximal region DNA binding	GO:0001159	3.82
RNA polymerase II repressing transcription factor binding	GO:0001103	6.44
hormone receptor binding	GO:0051427	4.57
receptor binding	GO:0005102	2.43
RNA polymerase II transcription factor binding	GO:0001085	5.08
transcription regulatory region DNA binding	GO:0044212	3.03
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	GO:0001228	3.98
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977	3.37
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
CCR5 chemokine receptor binding	GO:0031730	7.95
protein dimerization activity	GO:0046983	2.72
chromatin binding	GO:0003682	3.64
nucleic acid binding transcription factor activity	GO:0001071	2.65