Gene table of TNF : tumor necrosis factor

Gene-disease associations table

Disease ID	Disease name	Source of annotation with TNF	OMIM link	Number of associated genes	genes
611162	MALARIA, SUSCEPTIBILITY TO	OMIM	link to OMIM	16	FCGR2A, TIRAP, ICAM1, ACKR1, G6PD, GYPC, TNF, SLC4A1, NOS2, HBB, CISH, GYPB, FCGR2B, CR1, CD36, GYPA
157300	MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1	OMIM	link to OMIM	3	EDNRA, ESR1, TNF
600807	ASTHMA, SUSCEPTIBILITY TO	ClinVar, OMIM	link to OMIM	13	HLA-G, SCGB1A1, PLA2G7, PHF11, MUC7, TNF, HNMT, IL13, SPINK5, SCGB3A2, CCL11, ALOX5, ADRB2

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Annotation of the gene TNF

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

P01375

Associated PDB IDs

Cytogenetic Band

6p21.33

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Pertussis	hsa05133	6.46
Legionellosis	hsa05134	6.88
Natural killer cell mediated cytotoxicity	hsa04650	5.53
Asthma	hsa05310	7.34
Allograft rejection	hsa05330	6.91
Graft-versus-host disease	hsa05332	6.84
Osteoclast differentiation	hsa04380	5.64
Hypertrophic cardiomyopathy (HCM)	hsa05410	6.21
Type I diabetes mellitus	hsa04940	6.79
NF-kappa B signaling pathway	hsa04064	6.21
Dilated cardiomyopathy	hsa05414	6.08
Cytokine-cytokine receptor interaction	hsa04060	4.67
Adipocytokine signaling pathway	hsa04920	6.6
African trypanosomiasis	hsa05143	7.68
Antigen processing and presentation	hsa04612	6.04
Chagas disease (American trypanosomiasis)	hsa05142	5.99
Systemic lupus erythematosus	hsa05322	5.95
Leishmaniasis	hsa05140	6.32
Amoebiasis	hsa05146	5.82
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51
Malaria	hsa05144	7.15
Toxoplasmosis	hsa05145	5.71
Influenza A	hsa05164	5.21
Herpes simplex infection	hsa05168	5.08
HTLV-I infection	hsa05166	4.59
Hepatitis C	hsa05160	5.68
Hepatitis B	hsa05161	5.52
TGF-beta signaling pathway	hsa04350	6.41
Apoptosis	hsa04210	6.23
Proteoglycans in cancer	hsa05205	5.02
Rheumatoid arthritis	hsa05323	6.05
Inflammatory bowel disease (IBD)	hsa05321	6.43
Toll-like receptor signaling pathway	hsa04620	6.0
NOD-like receptor signaling pathway	hsa04621	6.88
RIG-I-like receptor signaling pathway	hsa04622	6.62
T cell receptor signaling pathway	hsa04660	6.01
Fc epsilon RI signaling pathway	hsa04664	6.6
Hematopoietic cell lineage	hsa04640	6.18
MAPK signaling pathway	hsa04010	4.63
TNF signaling pathway	hsa04668	5.96
Type II diabetes mellitus	hsa04930	7.12
mTOR signaling pathway	hsa04150	6.72
Tuberculosis	hsa05152	5.17
Amyotrophic lateral sclerosis (ALS)	hsa05014	7.01
Alzheimer's disease	hsa05010	5.34

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	6.4
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.28
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.7
Immune System	R-HSA-168256	2.37
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Signal Transduction	R-HSA-162582	1.78
Death Receptor Signalling	R-HSA-73887	8.52
TNF signaling	R-HSA-75893	9.08
Developmental Biology	R-HSA-1266738	3.48

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cytokine receptor binding	GO:0005126	4.14
transcription regulatory region DNA binding	GO:0044212	3.03
enzyme binding	GO:0019899	2.27
tumor necrosis factor receptor superfamily binding	GO:0032813	5.89
nucleic acid binding	GO:0003676	1.44
protein binding	GO:0005515	0.46
organic cyclic compound binding	GO:0097159	1.05
regulatory region DNA binding	GO:0000975	3.03
regulatory region nucleic acid binding	GO:0001067	3.03
tumor necrosis factor receptor binding	GO:0005164	6.3
cytokine activity	GO:0005125	4.34
binding	GO:0005488	0.18
protease binding	GO:0002020	5.08
DNA binding	GO:0003677	1.92
receptor binding	GO:0005102	2.43
heterocyclic compound binding	GO:1901363	1.06
identical protein binding	GO:0042802	2.63