Gene table of VCP : valosin containing protein

Gene-disease associations table

Disease ID	Disease name	Source of annotation with VCP	OMIM link	Number of associated genes	genes
PS118220	CHARCOT-MARIE-TOOTH DISEASE	ClinVar, OMIM	link to OMIM	48	KARS, FIG4, PRPS1, FGD4, MPZ, KIF1B, NEFL, GJB1, VCP, GDAP1, AIFM1, IGHMBP2, SH3TC2, TRIM2, JPH1, PLEKHG5, NEFH, NAGLU, TRPV4, HARS, HSPB8, HSPB1, PMP22, MED25, SPG11, SBF1, DYNC1H1, SURF1, DNM2, NDRG1, MARS, SBF2, RAB7A, MORC2, AARS, COX6A1, PDK3, DHTKD1, HK1, LMNA, LRSAM1, EGR2, PRX, MTMR2, LITAF, MFN2, YARS, GARS
PS167320	INCLUSION BODY MYOPATHY/PAGET DISEASE/FRONTOTEMPORAL DEMENTIA	ClinVar, OMIM, HUMSAVAR	link to OMIM	3	HNRNPA2B1, HNRNPA1, VCP
PS105400	AMYOTROPHIC LATERAL SCLEROSIS	ClinVar, OMIM, HUMSAVAR	link to OMIM	27	CHCHD10, FIG4, ERBB4, SQSTM1, ATXN2, UBQLN2, DCTN1, FUS, NEFH, PFN1, VAPB, MATR3, ALS2, TBK1, SPG11, TARDBP, TUBA4A, SIGMAR1, SOD1, CHMP2B, PRPH, ANG, VCP, OPTN, C9orf72, HNRNPA1, SETX

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Annotation of the gene VCP

Associated genes in ENSEMBL

ENSG00000165280

Associated proteins - SwissProt Accession ID

P55072

Associated PDB IDs

Cytogenetic Band

9p13.3

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Protein processing in endoplasmic reticulum	hsa04141	5.35
Legionellosis	hsa05134	6.88

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
HSF1 activation	R-HSA-3371511	9.4
Translesion Synthesis by POLH	R-HSA-110320	8.73
Diseases of signal transduction	R-HSA-5663202	4.89
Cellular responses to stress	R-HSA-2262752	4.56
Hh mutants abrogate ligand secretion	R-HSA-5387390	7.2
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	7.77
Cellular response to heat stress	R-HSA-3371556	6.59
Hedgehog ligand biogenesis	R-HSA-5358346	6.98
Signal Transduction	R-HSA-162582	1.78
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	R-HSA-5362768	7.2
Signaling by Hedgehog	R-HSA-5358351	5.79
DNA Repair	R-HSA-73894	5.8
Disease	R-HSA-1643685	3.33
DNA Damage Bypass	R-HSA-73893	7.46

Associated GO terms for Molecular function

GO term	GO ID	GO IC
ubiquitin-like protein ligase binding	GO:0044389	4.15
nucleic acid binding	GO:0003676	1.44
purine ribonucleoside triphosphate binding	GO:0035639	2.22
enzyme binding	GO:0019899	2.27
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
ATPase activity	GO:0016887	3.65
polyubiquitin binding	GO:0031593	5.98
molecular function regulator	GO:0098772	2.51
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
ATP binding	GO:0005524	2.43
ubiquitin-specific protease binding	GO:1990381	7.25
nucleotide binding	GO:0000166	1.96
purine ribonucleotide binding	GO:0032555	2.2
nucleoside phosphate binding	GO:1901265	1.96
protease binding	GO:0002020	5.08
ribonucleoside binding	GO:0032549	2.22
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
poly(A) RNA binding	GO:0044822	2.69
identical protein binding	GO:0042802	2.63
hydrolase activity	GO:0016787	1.9
K48-linked polyubiquitin binding	GO:0036435	8.13
MHC class I protein binding	GO:0042288	6.85
MHC protein binding	GO:0042287	6.18
enzyme regulator activity	GO:0030234	2.85
peptidase regulator activity	GO:0061134	4.37
nucleoside-triphosphatase activity	GO:0017111	3.09
lipid binding	GO:0008289	3.26
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
protein phosphatase binding	GO:0019903	4.93
phosphatase binding	GO:0019902	4.63
protein domain specific binding	GO:0019904	3.32
ADP binding	GO:0043531	6.24
deubiquitinase activator activity	GO:0035800	9.74
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	3.03
ubiquitin protein ligase binding	GO:0031625	4.17
BAT3 complex binding	GO:1904288	8.35
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
ubiquitin-like protein binding	GO:0032182	4.93
hydrolase activity, acting on acid anhydrides	GO:0016817	3.03
pyrophosphatase activity	GO:0016462	3.04
ubiquitin binding	GO:0043130	5.09
adenyl ribonucleotide binding	GO:0032559	2.41
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
peptidase activator activity	GO:0016504	6.13
receptor binding	GO:0005102	2.43
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
enzyme activator activity	GO:0008047	3.56