Gene table of WRN : Werner syndrome RecQ like helicase

Gene-disease associations table

Disease ID	Disease name	Source of annotation with WRN	OMIM link	Number of associated genes	genes
277700	WERNER SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	WRN

Download the gene annotation in CSV format

Annotation of the gene WRN

Associated genes in ENSEMBL

ENSG00000165392

Associated proteins - SwissProt Accession ID

Q14191

Associated PDB IDs

Cytogenetic Band

8p12

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Post-translational protein modification	R-HSA-597592	4.54
SUMO E3 ligases SUMOylate target proteins	R-HSA-3108232	6.77
Metabolism of proteins	R-HSA-392499	3.41
SUMOylation	R-HSA-2990846	6.68
SUMOylation of DNA damage response and repair proteins	R-HSA-3108214	6.77

Associated GO terms for Molecular function

GO term	GO ID	GO IC
four-way junction helicase activity	GO:0009378	8.13
ATPase activity	GO:0016887	3.65
ATP-dependent helicase activity	GO:0008026	5.12
purine ribonucleoside triphosphate binding	GO:0035639	2.22
manganese ion binding	GO:0030145	5.89
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
DNA helicase activity	GO:0003678	5.73
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
3'-5' exonuclease activity	GO:0008408	5.83
transition metal ion binding	GO:0046914	2.48
pyrophosphatase activity	GO:0016462	3.04
carbohydrate derivative binding	GO:0097367	2.03
exonuclease activity	GO:0004527	5.33
magnesium ion binding	GO:0000287	4.41
ion binding	GO:0043167	1.36
purine nucleoside binding	GO:0001883	2.22
ATP-dependent 3'-5' DNA helicase activity	GO:0043140	7.95
ribonucleoside binding	GO:0032549	2.22
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
protein homodimerization activity	GO:0042803	3.16
hydrolase activity	GO:0016787	1.9
Y-form DNA binding	GO:0000403	8.35
ATP-dependent DNA helicase activity	GO:0004003	6.13
structure-specific DNA binding	GO:0043566	4.98
DNA secondary structure binding	GO:0000217	6.6
nucleoside-triphosphatase activity	GO:0017111	3.09
hydrolase activity, acting on ester bonds	GO:0016788	3.1
helicase activity	GO:0004386	4.69
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
bubble DNA binding	GO:0000405	7.79
DNA-dependent ATPase activity	GO:0008094	5.31
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	3.03
3'-5' DNA helicase activity	GO:0043138	7.25
G-quadruplex DNA binding	GO:0051880	7.95
adenyl nucleotide binding	GO:0030554	2.4
nuclease activity	GO:0004518	4.33
organic cyclic compound binding	GO:0097159	1.05
ATPase activity, coupled	GO:0042623	3.97
hydrolase activity, acting on acid anhydrides	GO:0016817	3.03
purine NTP-dependent helicase activity	GO:0070035	5.12
adenyl ribonucleotide binding	GO:0032559	2.41
identical protein binding	GO:0042802	2.63
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
protein dimerization activity	GO:0046983	2.72
chromatin binding	GO:0003682	3.64
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19