Gene table of AKT3 : AKT serine/threonine kinase 3

Gene-disease associations table

Disease ID	Disease name	Source of annotation with AKT3	OMIM link	Number of associated genes	genes
PS603387	MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	3	CCND2, PIK3R2, AKT3

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Annotation of the gene AKT3

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Q9Y243

Associated PDB IDs

2x18

Cytogenetic Band

1q44

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Melanoma	hsa05218	6.56
Platelet activation	hsa04611	5.66
Progesterone-mediated oocyte maturation	hsa04914	6.18
Small cell lung cancer	hsa05222	6.17
Pancreatic cancer	hsa05212	6.56
Endometrial cancer	hsa05213	6.81
Colorectal cancer	hsa05210	6.52
MAPK signaling pathway	hsa04010	4.63
Jak-STAT signaling pathway	hsa04630	5.44
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6
Glioma	hsa05214	6.66
Prostate cancer	hsa05215	6.11
Tight junction	hsa04530	5.53
Neurotrophin signaling pathway	hsa04722	5.78
Cholinergic synapse	hsa04725	5.88
Choline metabolism in cancer	hsa05231	6.09
FoxO signaling pathway	hsa04068	5.63
Osteoclast differentiation	hsa04380	5.64
HIF-1 signaling pathway	hsa04066	5.9
Dopaminergic synapse	hsa04728	5.69
Chemokine signaling pathway	hsa04062	5.19
Adipocytokine signaling pathway	hsa04920	6.6
Focal adhesion	hsa04510	4.92
ErbB signaling pathway	hsa04012	6.15
Chagas disease (American trypanosomiasis)	hsa05142	5.99
cGMP-PKG signaling pathway	hsa04022	5.32
Epstein-Barr virus infection	hsa05169	4.97
Toxoplasmosis	hsa05145	5.71
Influenza A	hsa05164	5.21
Apoptosis	hsa04210	6.23
HTLV-I infection	hsa05166	4.59
Hepatitis C	hsa05160	5.68
Hepatitis B	hsa05161	5.52
Measles	hsa05162	5.6
B cell receptor signaling pathway	hsa04662	6.52
Renal cell carcinoma	hsa05211	6.6
VEGF signaling pathway	hsa04370	6.77
Proteoglycans in cancer	hsa05205	5.02
Estrogen signaling pathway	hsa04915	6.11
Toll-like receptor signaling pathway	hsa04620	6.0
Pathways in cancer	hsa05200	3.98
T cell receptor signaling pathway	hsa04660	6.01
Fc gamma R-mediated phagocytosis	hsa04666	6.21
Rap1 signaling pathway	hsa04015	4.97
Ras signaling pathway	hsa04014	4.9
Fc epsilon RI signaling pathway	hsa04664	6.6
cAMP signaling pathway	hsa04024	5.05
Acute myeloid leukemia	hsa05221	6.74
Chronic myeloid leukemia	hsa05220	6.48
TNF signaling pathway	hsa04668	5.96
Thyroid hormone signaling pathway	hsa04919	5.82
AMPK signaling pathway	hsa04152	5.8
mTOR signaling pathway	hsa04150	6.72
PI3K-Akt signaling pathway	hsa04151	4.21
Carbohydrate digestion and absorption	hsa04973	7.28
Non-small cell lung cancer	hsa05223	6.88
Insulin signaling pathway	hsa04910	5.55
Tuberculosis	hsa05152	5.17
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51
Central carbon metabolism in cancer	hsa05230	6.7
Adrenergic signaling in cardiomyocytes	hsa04261	5.44
Prolactin signaling pathway	hsa04917	6.6

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Transcriptional Regulation by TP53	R-HSA-3700989	6.73
Signalling by NGF	R-HSA-166520	4.23
Regulation of gene expression in beta cells	R-HSA-210745	8.66
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.59
PI3K/AKT activation	R-HSA-198203	6.32
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62
GPVI-mediated activation cascade	R-HSA-114604	7.18
Immune System	R-HSA-168256	2.37
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37
Programmed Cell Death	R-HSA-5357801	5.65
Downstream signal transduction	R-HSA-186763	4.65
AKT phosphorylates targets in the nucleus	R-HSA-198693	9.81
Signaling by ERBB4	R-HSA-1236394	4.7
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.28
Adaptive Immune System	R-HSA-1280218	3.19
Disease	R-HSA-1643685	3.33
Platelet activation, signaling and aggregation	R-HSA-76002	5.15
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.98
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71
PIP3 activates AKT signaling	R-HSA-1257604	6.37
Generic Transcription Pathway	R-HSA-212436	3.86
Signaling by VEGF	R-HSA-194138	4.66
Gene Expression	R-HSA-74160	2.72
PI-3K cascade:FGFR1	R-HSA-5654689	6.37
CTLA4 inhibitory signaling	R-HSA-389513	8.52
Activation of BAD and translocation to mitochondria	R-HSA-111447	9.08
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.4
Developmental Biology	R-HSA-1266738	3.48
CD28 co-stimulation	R-HSA-389356	7.98
AKT-mediated inactivation of FOXO1A	R-HSA-211163	10.98
Costimulation by the CD28 family	R-HSA-388841	6.56
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95
Signaling by FGFR4	R-HSA-5654743	4.69
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71
Signaling by FGFR3	R-HSA-5654741	4.69
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
Signaling by FGFR	R-HSA-190236	4.67
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56
Diseases of signal transduction	R-HSA-5663202	4.89
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03
GPCR downstream signaling	R-HSA-388396	3.07
Signaling by ERBB2	R-HSA-1227986	4.66
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59
Innate Immune System	R-HSA-168249	3.17
Signaling by SCF-KIT	R-HSA-1433557	4.73
Activation of BH3-only proteins	R-HSA-114452	8.34
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.4
DAP12 signaling	R-HSA-2424491	4.64
AKT phosphorylates targets in the cytosol	R-HSA-198323	9.28
PI-3K cascade:FGFR2	R-HSA-5654695	6.37
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71
Signaling by EGFR	R-HSA-177929	4.59
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	9.28
Regulation of beta-cell development	R-HSA-186712	7.98
Signaling by GPCR	R-HSA-372790	2.68
Signaling by FGFR2	R-HSA-5654738	4.68
Signaling by FGFR1	R-HSA-5654736	4.69
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37
G-protein beta:gamma signalling	R-HSA-397795	7.31
PI-3K cascade:FGFR3	R-HSA-5654710	6.37
PI-3K cascade:FGFR4	R-HSA-5654720	6.37
DAP12 interactions	R-HSA-2172127	4.56
Apoptosis	R-HSA-109581	5.68
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71
Signaling by PDGF	R-HSA-186797	4.53
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.73
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.73
GAB1 signalosome	R-HSA-180292	6.31
Hemostasis	R-HSA-109582	3.98
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
binding	GO:0005488	0.18
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
ribonucleoside binding	GO:0032549	2.22
nucleotide binding	GO:0000166	1.96
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
purine nucleoside binding	GO:0001883	2.22
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
ATP binding	GO:0005524	2.43
kinase activity	GO:0016301	2.93
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19