| Disease ID | Disease name | Source of annotation with C4A | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 614380 | COMPLEMENT COMPONENT 4A DEFICIENCY | OMIM | link to OMIM | 1 | C4A |
| 614374 | BLOOD GROUP, CHIDO/RODGERS SYSTEM | OMIM | link to OMIM | 1 | C4A |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Pertussis | hsa05133 | 6.46 |
| Systemic lupus erythematosus | hsa05322 | 5.95 |
| Complement and coagulation cascades | hsa04610 | 6.58 |
| Staphylococcus aureus infection | hsa05150 | 6.64 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Immune System | R-HSA-168256 | 2.37 |
| Regulation of Complement cascade | R-HSA-977606 | 8.4 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Complement cascade | R-HSA-166658 | 5.38 |
| Activation of C3 and C5 | R-HSA-174577 | 10.18 |
| Initial triggering of complement | R-HSA-166663 | 5.51 |
| GO term | GO ID | GO IC |
|---|---|---|
| hydrolase activity | GO:0016787 | 1.9 |
| endopeptidase activity | GO:0004175 | 3.63 |
| serine-type endopeptidase activity | GO:0004252 | 4.4 |
| peptidase inhibitor activity | GO:0030414 | 4.55 |
| protein binding | GO:0005515 | 0.46 |
| serine hydrolase activity | GO:0017171 | 4.26 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| peptidase regulator activity | GO:0061134 | 4.37 |
| molecular function regulator | GO:0098772 | 2.51 |
| complement component C1q binding | GO:0001849 | 7.79 |
| catalytic activity | GO:0003824 | 1.05 |
| peptidase activity, acting on L-amino acid peptides | GO:0070011 | 3.26 |
| binding | GO:0005488 | 0.18 |
| endopeptidase inhibitor activity | GO:0004866 | 4.6 |
| endopeptidase regulator activity | GO:0061135 | 4.57 |
| complement binding | GO:0001848 | 6.79 |
| enzyme inhibitor activity | GO:0004857 | 3.78 |
| serine-type peptidase activity | GO:0008236 | 4.27 |
| peptidase activity | GO:0008233 | 3.23 |
| opsonin binding | GO:0001846 | 7.34 |