Disease ID | Disease name | Source of annotation with CCT5 | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
256840 | NEUROPATHY, HEREDITARY SENSORY, WITH SPASTIC PARAPLEGIA, AUTOSOMAL RECESSIVE | OMIM, HUMSAVAR | link to OMIM | 1 | CCT5 |
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REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Protein folding | R-HSA-391251 | 7.23 |
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 8.23 |
Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 8.28 |
Organelle biogenesis and maintenance | R-HSA-1852241 | 4.63 |
Metabolism of proteins | R-HSA-392499 | 3.41 |
Folding of actin by CCT/TriC | R-HSA-390450 | 9.81 |
Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 8.66 |
Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 7.31 |
Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 8.12 |
BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 8.46 |
Assembly of the primary cilium | R-HSA-5617833 | 5.44 |
Chaperonin-mediated protein folding | R-HSA-390466 | 7.4 |
GO term | GO ID | GO IC |
---|---|---|
purine ribonucleoside triphosphate binding | GO:0035639 | 2.22 |
beta-tubulin binding | GO:0048487 | 6.13 |
binding | GO:0005488 | 0.18 |
heterocyclic compound binding | GO:1901363 | 1.06 |
purine nucleoside binding | GO:0001883 | 2.22 |
nucleoside binding | GO:0001882 | 2.21 |
unfolded protein binding | GO:0051082 | 5.13 |
nucleotide binding | GO:0000166 | 1.96 |
nucleoside phosphate binding | GO:1901265 | 1.96 |
ribonucleoside binding | GO:0032549 | 2.22 |
purine nucleotide binding | GO:0017076 | 2.19 |
ATP binding | GO:0005524 | 2.43 |
G-protein beta-subunit binding | GO:0031681 | 7.54 |
tubulin binding | GO:0015631 | 4.1 |
small molecule binding | GO:0036094 | 1.89 |
cytoskeletal protein binding | GO:0008092 | 3.02 |
carbohydrate derivative binding | GO:0097367 | 2.03 |
organic cyclic compound binding | GO:0097159 | 1.05 |
adenyl nucleotide binding | GO:0030554 | 2.4 |
adenyl ribonucleotide binding | GO:0032559 | 2.41 |
protein binding | GO:0005515 | 0.46 |
purine ribonucleotide binding | GO:0032555 | 2.2 |
purine ribonucleoside binding | GO:0032550 | 2.22 |
ribonucleotide binding | GO:0032553 | 2.19 |