| Disease ID | Disease name | Source of annotation with CD3E | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 615615 | IMMUNODEFICIENCY 18 | ClinVar, OMIM | link to OMIM | 1 | CD3E |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Chagas disease (American trypanosomiasis) | hsa05142 | 5.99 |
| T cell receptor signaling pathway | hsa04660 | 6.01 |
| Hematopoietic cell lineage | hsa04640 | 6.18 |
| Primary immunodeficiency | hsa05340 | 7.52 |
| HTLV-I infection | hsa05166 | 4.59 |
| Measles | hsa05162 | 5.6 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Generation of second messenger molecules | R-HSA-202433 | 7.34 |
| PD-1 signaling | R-HSA-389948 | 7.62 |
| Translocation of ZAP-70 to Immunological synapse | R-HSA-202430 | 7.81 |
| Downstream TCR signaling | R-HSA-202424 | 7.01 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 7.73 |
| Immune System | R-HSA-168256 | 2.37 |
| TCR signaling | R-HSA-202403 | 6.64 |
| Costimulation by the CD28 family | R-HSA-388841 | 6.56 |
| Adaptive Immune System | R-HSA-1280218 | 3.19 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 4.7 |
| GO term | GO ID | GO IC |
|---|---|---|
| signaling receptor activity | GO:0038023 | 2.49 |
| receptor signaling complex scaffold activity | GO:0030159 | 6.6 |
| SH3 domain binding | GO:0017124 | 4.98 |
| enzyme binding | GO:0019899 | 2.27 |
| molecular transducer activity | GO:0060089 | 2.32 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| signal transducer activity | GO:0004871 | 2.28 |
| receptor signaling protein activity | GO:0005057 | 4.76 |
| T cell receptor binding | GO:0042608 | 7.95 |
| structural molecule activity | GO:0005198 | 3.1 |
| protein complex scaffold | GO:0032947 | 5.5 |
| protein complex binding | GO:0032403 | 3.09 |
| protein kinase binding | GO:0019901 | 3.44 |
| kinase binding | GO:0019900 | 3.32 |
| protein domain specific binding | GO:0019904 | 3.32 |
| receptor binding | GO:0005102 | 2.43 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| protein binding | GO:0005515 | 0.46 |
| protein dimerization activity | GO:0046983 | 2.72 |
| protein heterodimerization activity | GO:0046982 | 3.64 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| receptor activity | GO:0004872 | 2.32 |