Gene table of DICER1 : dicer 1, ribonuclease III

Gene-disease associations table

Disease ID	Disease name	Source of annotation with DICER1	OMIM link	Number of associated genes	genes
601200	PLEUROPULMONARY BLASTOMA	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	DICER1
PS138800	GOITER, MULTINODULAR	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	DICER1
180295	RHABDOMYOSARCOMA, EMBRYONAL, 2	OMIM	link to OMIM	1	DICER1

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Annotation of the gene DICER1

Associated genes in ENSEMBL

ENSG00000100697

Associated proteins - SwissProt Accession ID

Q9UPY3

Associated PDB IDs

Cytogenetic Band

14q32.13

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
MicroRNAs in cancer	hsa05206	5.38

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Gene Expression	R-HSA-74160	2.72
Regulatory RNA pathways	R-HSA-211000	6.35
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	9.81
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.46

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
pre-miRNA binding	GO:0070883	8.35
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
endodeoxyribonuclease activity, producing 5'-phosphomonoesters	GO:0016888	7.25
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
pyrophosphatase activity	GO:0016462	3.04
ribonuclease III activity	GO:0004525	8.35
ribonuclease activity	GO:0004540	5.04
endoribonuclease activity	GO:0004521	5.58
endodeoxyribonuclease activity	GO:0004520	5.81
ion binding	GO:0043167	1.36
nucleoside phosphate binding	GO:1901265	1.96
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
deoxyribonuclease activity	GO:0004536	5.48
ATP binding	GO:0005524	2.43
double-stranded RNA-specific ribonuclease activity	GO:0032296	8.35
hydrolase activity	GO:0016787	1.9
nucleoside-triphosphatase activity	GO:0017111	3.09
hydrolase activity, acting on ester bonds	GO:0016788	3.1
helicase activity	GO:0004386	4.69
small molecule binding	GO:0036094	1.89
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	GO:0016893	5.83
endoribonuclease activity, producing 5'-phosphomonoesters	GO:0016891	6.02
protein domain specific binding	GO:0019904	3.32
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	3.03
adenyl nucleotide binding	GO:0030554	2.4
nuclease activity	GO:0004518	4.33
endonuclease activity	GO:0004519	4.78
catalytic activity	GO:0003824	1.05
siRNA binding	GO:0035197	7.66
hydrolase activity, acting on acid anhydrides	GO:0016817	3.03
deoxyribonuclease I activity	GO:0004530	9.05
carbohydrate derivative binding	GO:0097367	2.03
double-stranded RNA binding	GO:0003725	5.58
adenyl ribonucleotide binding	GO:0032559	2.41
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
organic cyclic compound binding	GO:0097159	1.05
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19