Gene table of FMO3 : flavin containing monooxygenase 3

Gene-disease associations table

Disease ID	Disease name	Source of annotation with FMO3	OMIM link	Number of associated genes	genes
602079	TRIMETHYLAMINURIA	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	FMO3

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Drug metabolism - cytochrome P450	hsa00982	6.6

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Biological oxidations	R-HSA-211859	5.55
FMO oxidises nucleophiles	R-HSA-217271	11.4
Diseases of metabolism	R-HSA-5668914	6.57
Phase 1 - Functionalization of compounds	R-HSA-211945	6.7
Defective FMO3 causes Trimethylaminuria (TMAU)	R-HSA-5579019	12.98
Metabolism	R-HSA-1430728	2.34
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	7.85
Disease	R-HSA-1643685	3.33

Associated GO terms for Molecular function

GO term	GO ID	GO IC
anion binding	GO:0043168	4.17
coenzyme binding	GO:0050662	4.53
monooxygenase activity	GO:0004497	5.1
flavin adenine dinucleotide binding	GO:0050660	5.41
carboxylic acid binding	GO:0031406	4.64
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	GO:0016709	6.07
organic cyclic compound binding	GO:0097159	1.05
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	4.65
N,N-dimethylaniline monooxygenase activity	GO:0004499	7.95
NADP binding	GO:0050661	5.93
ion binding	GO:0043167	1.36
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
trimethylamine monooxygenase activity	GO:0034899	9.74
cofactor binding	GO:0048037	4.16
binding	GO:0005488	0.18
nucleotide binding	GO:0000166	1.96
amino acid binding	GO:0016597	5.71
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
oxidoreductase activity	GO:0016491	3.12