Gene table of GLUL : glutamate-ammonia ligase

Gene-disease associations table

Disease ID	Disease name	Source of annotation with GLUL	OMIM link	Number of associated genes	genes
610015	GLUTAMINE DEFICIENCY, CONGENITAL	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	GLUL

Download the gene annotation in CSV format

Annotation of the gene GLUL

Associated genes in ENSEMBL

ENSG00000135821

Associated proteins - SwissProt Accession ID

P15104

Associated PDB IDs

Cytogenetic Band

1q25.3

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
GABAergic synapse	hsa04727	6.24
Arginine and proline metabolism	hsa00330	6.84
Metabolic pathways	hsa01100	2.49
Glyoxylate and dicarboxylate metabolism	hsa00630	8.07
Alanine, aspartate and glutamate metabolism	hsa00250	7.64
Glutamatergic synapse	hsa04724	5.84
Nitrogen metabolism	hsa00910	8.6
Biosynthesis of amino acids	hsa01230	6.58

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Metabolism of amino acids and derivatives	R-HSA-71291	5.4
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	10.98
Metabolism	R-HSA-1430728	2.34
Neuronal System	R-HSA-112316	4.82
Transmission across Chemical Synapses	R-HSA-112315	5.28
Neurotransmitter uptake and Metabolism In Glial Cells	R-HSA-112313	10.98
Amino acid synthesis and interconversion (transamination)	R-HSA-70614	8.89

Associated GO terms for Molecular function

GO term	GO ID	GO IC
magnesium ion binding	GO:0000287	4.41
purine ribonucleoside triphosphate binding	GO:0035639	2.22
carbon-carbon lyase activity	GO:0016830	5.81
ammonia ligase activity	GO:0016211	9.05
acid-ammonia (or amide) ligase activity	GO:0016880	9.05
binding	GO:0005488	0.18
purine nucleoside binding	GO:0001883	2.22
ion binding	GO:0043167	1.36
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
anion binding	GO:0043168	4.17
cation binding	GO:0043169	1.4
transition metal ion binding	GO:0046914	2.48
lyase activity	GO:0016829	4.53
dynein light chain binding	GO:0045503	9.74
nucleotide binding	GO:0000166	1.96
glutamate binding	GO:0016595	7.54
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
dynein binding	GO:0045502	6.44
manganese ion binding	GO:0030145	5.89
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
ligase activity	GO:0016874	3.72
ligase activity, forming carbon-nitrogen bonds	GO:0016879	5.7
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
adenyl nucleotide binding	GO:0030554	2.4
carboxylic acid binding	GO:0031406	4.64
carboxy-lyase activity	GO:0016831	6.15
glutamate decarboxylase activity	GO:0004351	8.64
glutamate-ammonia ligase activity	GO:0004356	9.05
adenyl ribonucleotide binding	GO:0032559	2.41
identical protein binding	GO:0042802	2.63
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19