Gene table of GPX4 : glutathione peroxidase 4

Gene-disease associations table

Disease IDDisease nameSource of annotation with GPX4OMIM linkNumber of associated genesgenes
250220SPONDYLOMETAPHYSEAL DYSPLASIA, SEDAGHATIAN TYPEClinVar, OMIM link to OMIM 1GPX4

Download the gene annotation in CSV format

Annotation of the gene GPX4

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Glutathione metabolismhsa004806.96
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Synthesis of 12-eicosatetraenoic acid derivativesR-HSA-214271210.4
MetabolismR-HSA-14307282.34
Synthesis of 5-eicosatetraenoic acidsR-HSA-214268810.4
Arachidonic acid metabolismR-HSA-21427537.34
Metabolism of lipids and lipoproteinsR-HSA-5568333.79
Synthesis of 15-eicosatetraenoic acid derivativesR-HSA-214277010.4
Associated GO terms for Molecular function
GO termGO IDGO IC
phospholipid-hydroperoxide glutathione peroxidase activityGO:00470669.74
antioxidant activityGO:00162095.49
catalytic activityGO:00038241.05
oxidoreductase activity, acting on peroxide as acceptorGO:00166846.0
peroxidase activityGO:00046016.05
glutathione peroxidase activityGO:00046026.85
oxidoreductase activityGO:00164913.12