| Disease ID | Disease name | Source of annotation with GRIN2A | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 245570 | EPILEPSY, FOCAL, WITH SPEECH DISORDER AND WITH OR WITHOUT MENTAL RETARDATION | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | GRIN2A |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Ras signaling pathway | hsa04014 | 4.9 |
| Nicotine addiction | hsa05033 | 7.38 |
| Systemic lupus erythematosus | hsa05322 | 5.95 |
| Neuroactive ligand-receptor interaction | hsa04080 | 4.58 |
| Calcium signaling pathway | hsa04020 | 5.22 |
| Cocaine addiction | hsa05030 | 7.07 |
| cAMP signaling pathway | hsa04024 | 5.05 |
| Long-term potentiation | hsa04720 | 6.64 |
| Rap1 signaling pathway | hsa04015 | 4.97 |
| Amphetamine addiction | hsa05031 | 6.62 |
| Glutamatergic synapse | hsa04724 | 5.84 |
| Alcoholism | hsa05034 | 5.59 |
| Amyotrophic lateral sclerosis (ALS) | hsa05014 | 7.01 |
| Dopaminergic synapse | hsa04728 | 5.69 |
| Circadian entrainment | hsa04713 | 6.11 |
| Alzheimer's disease | hsa05010 | 5.34 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| CREB phosphorylation through the activation of CaMKII | R-HSA-442729 | 9.08 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 4.85 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.26 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 4.9 |
| Signaling by Interleukins | R-HSA-449147 | 4.71 |
| Post NMDA receptor activation events | R-HSA-438064 | 7.85 |
| Signaling by Leptin | R-HSA-2586552 | 5.1 |
| Frs2-mediated activation | R-HSA-170968 | 5.12 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
| IGF1R signaling cascade | R-HSA-2428924 | 4.85 |
| Unblocking of NMDA receptor, glutamate binding and activation | R-HSA-438066 | 8.89 |
| Ras activation uopn Ca2+ infux through NMDA receptor | R-HSA-442982 | 8.89 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 4.85 |
| Signaling by ERBB4 | R-HSA-1236394 | 4.7 |
| IRS-mediated signalling | R-HSA-112399 | 4.87 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 5.11 |
| CREB phosphorylation through the activation of Ras | R-HSA-442742 | 8.23 |
| Developmental Biology | R-HSA-1266738 | 3.48 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 5.15 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 4.71 |
| MAPK family signaling cascades | R-HSA-5683057 | 4.89 |
| Signalling by NGF | R-HSA-166520 | 4.23 |
| Signaling by VEGF | R-HSA-194138 | 4.66 |
| Signalling to p38 via RIT and RIN | R-HSA-187706 | 5.12 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 4.32 |
| Signaling by EGFR | R-HSA-177929 | 4.59 |
| FRS-mediated FGFR2 signaling | R-HSA-5654700 | 5.14 |
| SOS-mediated signalling | R-HSA-112412 | 5.15 |
| FRS-mediated FGFR3 signaling | R-HSA-5654706 | 5.14 |
| Signaling by Insulin receptor | R-HSA-74752 | 4.73 |
| Neuronal System | R-HSA-112316 | 4.82 |
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | R-HSA-112314 | 5.85 |
| Transmission across Chemical Synapses | R-HSA-112315 | 5.28 |
| Signaling by FGFR4 | R-HSA-5654743 | 4.69 |
| Signaling by FGFR3 | R-HSA-5654741 | 4.69 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 4.7 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 5.15 |
| Interleukin receptor SHC signaling | R-HSA-912526 | 5.09 |
| Signaling by FGFR | R-HSA-190236 | 4.67 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 4.71 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 4.03 |
| Immune System | R-HSA-168256 | 2.37 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 4.71 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Signaling by SCF-KIT | R-HSA-1433557 | 4.73 |
| Interleukin-2 signaling | R-HSA-451927 | 5.05 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 5.15 |
| Signaling by ERBB2 | R-HSA-1227986 | 4.66 |
| Signalling to RAS | R-HSA-167044 | 5.08 |
| DAP12 signaling | R-HSA-2424491 | 4.64 |
| Interleukin-3, 5 and GM-CSF signaling | R-HSA-512988 | 4.99 |
| Activation of NMDA receptor upon glutamate binding and postsynaptic events | R-HSA-442755 | 7.7 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 4.71 |
| Signaling by FGFR1 | R-HSA-5654736 | 4.69 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 5.15 |
| NGF signalling via TRKA from the plasma membrane | R-HSA-187037 | 4.51 |
| FRS-mediated FGFR1 signaling | R-HSA-5654693 | 5.14 |
| Prolonged ERK activation events | R-HSA-169893 | 5.11 |
| FRS-mediated FGFR4 signaling | R-HSA-5654712 | 5.14 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| Signaling by FGFR2 | R-HSA-5654738 | 4.68 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 5.15 |
| Signalling to ERKs | R-HSA-187687 | 5.04 |
| Insulin receptor signalling cascade | R-HSA-74751 | 4.85 |
| ARMS-mediated activation | R-HSA-170984 | 5.12 |
| DAP12 interactions | R-HSA-2172127 | 4.56 |
| SHC1 events in ERBB4 signaling | R-HSA-1250347 | 5.15 |
| Signaling by PDGF | R-HSA-186797 | 4.53 |
| Axon guidance | R-HSA-422475 | 3.93 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 5.07 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| Downstream signal transduction | R-HSA-186763 | 4.65 |
| GO term | GO ID | GO IC |
|---|---|---|
| Ras guanyl-nucleotide exchange factor activity | GO:0005088 | 4.31 |
| cation channel activity | GO:0005261 | 4.04 |
| calcium channel activity | GO:0005262 | 5.03 |
| guanyl-nucleotide exchange factor activity | GO:0005085 | 4.02 |
| molecular transducer activity | GO:0060089 | 2.32 |
| glutamate receptor activity | GO:0008066 | 6.44 |
| receptor activity | GO:0004872 | 2.32 |
| signal transducer activity | GO:0004871 | 2.28 |
| signaling receptor activity | GO:0038023 | 2.49 |
| divalent inorganic cation transmembrane transporter activity | GO:0072509 | 4.62 |
| NMDA glutamate receptor activity | GO:0004972 | 7.66 |
| ionotropic glutamate receptor activity | GO:0004970 | 6.79 |
| calcium ion transmembrane transporter activity | GO:0015085 | 4.89 |
| molecular function regulator | GO:0098772 | 2.51 |
| transition metal ion binding | GO:0046914 | 2.48 |
| zinc ion binding | GO:0008270 | 2.66 |
| ligand-gated ion channel activity | GO:0015276 | 4.8 |
| ion binding | GO:0043167 | 1.36 |
| transmembrane transporter activity | GO:0022857 | 2.82 |
| transmitter-gated ion channel activity | GO:0022824 | 6.41 |
| passive transmembrane transporter activity | GO:0022803 | 3.6 |
| metal ion transmembrane transporter activity | GO:0046873 | 3.71 |
| metal ion binding | GO:0046872 | 1.41 |
| extracellular ligand-gated ion channel activity | GO:0005230 | 5.42 |
| neurotransmitter receptor activity | GO:0030594 | 5.5 |
| transmitter-gated channel activity | GO:0022835 | 6.41 |
| cation binding | GO:0043169 | 1.4 |
| transporter activity | GO:0005215 | 2.57 |
| ion channel activity | GO:0005216 | 3.71 |
| excitatory extracellular ligand-gated ion channel activity | GO:0005231 | 5.73 |
| extracellular-glutamate-gated ion channel activity | GO:0005234 | 6.74 |
| cation transmembrane transporter activity | GO:0008324 | 3.32 |
| substrate-specific transmembrane transporter activity | GO:0022891 | 2.9 |
| inorganic cation transmembrane transporter activity | GO:0022890 | 3.49 |
| substrate-specific transporter activity | GO:0022892 | 2.72 |
| ion transmembrane transporter activity | GO:0015075 | 3.04 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| channel activity | GO:0015267 | 3.6 |
| gated channel activity | GO:0022836 | 3.96 |
| protein binding | GO:0005515 | 0.46 |
| ligand-gated channel activity | GO:0022834 | 4.8 |
| substrate-specific channel activity | GO:0022838 | 3.67 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| binding | GO:0005488 | 0.18 |