Gene table of HPSE2 : heparanase 2 (inactive)

Gene-disease associations table

Disease ID	Disease name	Source of annotation with HPSE2	OMIM link	Number of associated genes	genes
PS236730	UROFACIAL SYNDROME	ClinVar, OMIM	link to OMIM	2	HPSE2, LRIG2

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Proteoglycans in cancer	hsa05205	5.02
Metabolic pathways	hsa01100	2.49
Glycosaminoglycan degradation	hsa00531	8.45

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Glycosaminoglycan metabolism	R-HSA-1630316	6.04
HS-GAG degradation	R-HSA-2024096	8.52
Metabolism	R-HSA-1430728	2.34
Metabolism of carbohydrates	R-HSA-71387	4.93
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	7.2

Associated GO terms for Molecular function

GO term	GO ID	GO IC
sulfur compound binding	GO:1901681	4.32
hydrolase activity	GO:0016787	1.9
carbohydrate derivative binding	GO:0097367	2.03
heparanase activity	GO:0030305	9.05
hydrolase activity, acting on glycosyl bonds	GO:0016798	4.91
catalytic activity	GO:0003824	1.05
heparan sulfate proteoglycan binding	GO:0043395	6.85
proteoglycan binding	GO:0043394	6.34
binding	GO:0005488	0.18
hydrolase activity, hydrolyzing O-glycosyl compounds	GO:0004553	5.14
glycoprotein binding	GO:0001948	5.11