| Disease ID | Disease name | Source of annotation with LEP | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 614962 | LEPTIN DEFICIENCY OR DYSFUNCTION | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | LEP |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Neuroactive ligand-receptor interaction | hsa04080 | 4.58 |
| Jak-STAT signaling pathway | hsa04630 | 5.44 |
| Cytokine-cytokine receptor interaction | hsa04060 | 4.67 |
| AMPK signaling pathway | hsa04152 | 5.8 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 | 5.51 |
| Adipocytokine signaling pathway | hsa04920 | 6.6 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | R-HSA-381771 | 8.66 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 6.7 |
| Signaling by Leptin | R-HSA-2586552 | 5.1 |
| Peptide hormone metabolism | R-HSA-2980736 | 6.61 |
| Metabolism of proteins | R-HSA-392499 | 3.41 |
| Synthesis, secretion, and deacylation of Ghrelin | R-HSA-422085 | 8.89 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| Incretin synthesis, secretion, and inactivation | R-HSA-400508 | 8.46 |
| Developmental Biology | R-HSA-1266738 | 3.48 |
| GO term | GO ID | GO IC |
|---|---|---|
| hormone activity | GO:0005179 | 4.95 |
| growth factor activity | GO:0008083 | 4.66 |
| protein binding | GO:0005515 | 0.46 |
| binding | GO:0005488 | 0.18 |
| peptide hormone receptor binding | GO:0051428 | 6.91 |
| hormone receptor binding | GO:0051427 | 4.57 |
| receptor binding | GO:0005102 | 2.43 |