Disease ID | Disease name | Source of annotation with LEP | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
614962 | LEPTIN DEFICIENCY OR DYSFUNCTION | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | LEP |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Neuroactive ligand-receptor interaction | hsa04080 | 4.58 |
Jak-STAT signaling pathway | hsa04630 | 5.44 |
Cytokine-cytokine receptor interaction | hsa04060 | 4.67 |
AMPK signaling pathway | hsa04152 | 5.8 |
Non-alcoholic fatty liver disease (NAFLD) | hsa04932 | 5.51 |
Adipocytokine signaling pathway | hsa04920 | 6.6 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | R-HSA-381771 | 8.66 |
Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 6.7 |
Signaling by Leptin | R-HSA-2586552 | 5.1 |
Peptide hormone metabolism | R-HSA-2980736 | 6.61 |
Metabolism of proteins | R-HSA-392499 | 3.41 |
Synthesis, secretion, and deacylation of Ghrelin | R-HSA-422085 | 8.89 |
Signal Transduction | R-HSA-162582 | 1.78 |
Incretin synthesis, secretion, and inactivation | R-HSA-400508 | 8.46 |
Developmental Biology | R-HSA-1266738 | 3.48 |
GO term | GO ID | GO IC |
---|---|---|
hormone activity | GO:0005179 | 4.95 |
growth factor activity | GO:0008083 | 4.66 |
protein binding | GO:0005515 | 0.46 |
binding | GO:0005488 | 0.18 |
peptide hormone receptor binding | GO:0051428 | 6.91 |
hormone receptor binding | GO:0051427 | 4.57 |
receptor binding | GO:0005102 | 2.43 |