| Disease ID | Disease name | Source of annotation with LRPPRC | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 220111 | LEIGH SYNDROME, FRENCH CANADIAN TYPE | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | LRPPRC |
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| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 6.73 |
| Respiratory electron transport | R-HSA-611105 | 6.44 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | R-HSA-163200 | 6.12 |
| Generic Transcription Pathway | R-HSA-212436 | 3.86 |
| The citric acid (TCA) cycle and respiratory electron transport | R-HSA-1428517 | 5.71 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Gene Expression | R-HSA-74160 | 2.72 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 6.73 |
| GO term | GO ID | GO IC |
|---|---|---|
| enzyme binding | GO:0019899 | 2.27 |
| ubiquitin protein ligase binding | GO:0031625 | 4.17 |
| ubiquitin-like protein ligase binding | GO:0044389 | 4.15 |
| protein binding | GO:0005515 | 0.46 |
| cytoskeletal protein binding | GO:0008092 | 3.02 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| microtubule binding | GO:0008017 | 4.42 |
| poly(A) RNA binding | GO:0044822 | 2.69 |
| tubulin binding | GO:0015631 | 4.1 |
| actin filament binding | GO:0051015 | 4.93 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| actin binding | GO:0003779 | 3.74 |
| beta-tubulin binding | GO:0048487 | 6.13 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| nucleic acid binding | GO:0003676 | 1.44 |
| DNA binding | GO:0003677 | 1.92 |
| protein complex binding | GO:0032403 | 3.09 |
| single-stranded DNA binding | GO:0003697 | 5.17 |
| RNA binding | GO:0003723 | 2.36 |