Gene table of PDE10A : phosphodiesterase 10A

Gene-disease associations table

Disease ID	Disease name	Source of annotation with PDE10A	OMIM link	Number of associated genes	genes
616921	DYSKINESIA, LIMB AND OROFACIAL, INFANTILE-ONSET	ClinVar	link to OMIM	1	PDE10A
616922	STRIATAL DEGENERATION, AUTOSOMAL DOMINANT 2	ClinVar	link to OMIM	1	PDE10A

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Morphine addiction	hsa05032	6.15
Purine metabolism	hsa00230	5.28

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signaling by GPCR	R-HSA-372790	2.68
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.34
GPCR downstream signaling	R-HSA-388396	3.07
cGMP effects	R-HSA-418457	8.81
Platelet homeostasis	R-HSA-418346	6.68
G alpha (s) signalling events	R-HSA-418555	5.99
Hemostasis	R-HSA-109582	3.98
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	GO:0004118	8.64
3',5'-cyclic-nucleotide phosphodiesterase activity	GO:0004114	6.52
3',5'-cyclic-AMP phosphodiesterase activity	GO:0004115	7.03
cyclic-nucleotide phosphodiesterase activity	GO:0004112	6.48
drug binding	GO:0008144	5.03
phosphoric ester hydrolase activity	GO:0042578	3.82
binding	GO:0005488	0.18
ion binding	GO:0043167	1.36
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
cation binding	GO:0043169	1.4
phosphoric diester hydrolase activity	GO:0008081	5.23
nucleotide binding	GO:0000166	1.96
guanyl ribonucleotide binding	GO:0032561	3.73
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
3',5'-cyclic-GMP phosphodiesterase activity	GO:0047555	7.1
hydrolase activity	GO:0016787	1.9
hydrolase activity, acting on ester bonds	GO:0016788	3.1
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
cGMP binding	GO:0030553	6.97
cAMP binding	GO:0030552	6.56
cyclic nucleotide binding	GO:0030551	6.13
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
guanyl nucleotide binding	GO:0019001	3.73
adenyl ribonucleotide binding	GO:0032559	2.41
purine ribonucleotide binding	GO:0032555	2.2
ribonucleotide binding	GO:0032553	2.19