Gene table of PDE3A : phosphodiesterase 3A

Gene-disease associations table

Disease ID	Disease name	Source of annotation with PDE3A	OMIM link	Number of associated genes	genes
112410	HYPERTENSION AND BRACHYDACTYLY SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	PDE3A

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
cGMP-PKG signaling pathway	hsa04022	5.32
cAMP signaling pathway	hsa04024	5.05
Morphine addiction	hsa05032	6.15
Insulin signaling pathway	hsa04910	5.55
Progesterone-mediated oocyte maturation	hsa04914	6.18
Purine metabolism	hsa00230	5.28

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signaling by GPCR	R-HSA-372790	2.68
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.34
GPCR downstream signaling	R-HSA-388396	3.07
cGMP effects	R-HSA-418457	8.81
Platelet homeostasis	R-HSA-418346	6.68
G alpha (s) signalling events	R-HSA-418555	5.99
Hemostasis	R-HSA-109582	3.98
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	GO:0004119	9.05
3',5'-cyclic-nucleotide phosphodiesterase activity	GO:0004114	6.52
3',5'-cyclic-AMP phosphodiesterase activity	GO:0004115	7.03
cyclic-nucleotide phosphodiesterase activity	GO:0004112	6.48
phosphoric ester hydrolase activity	GO:0042578	3.82
binding	GO:0005488	0.18
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
cation binding	GO:0043169	1.4
phosphoric diester hydrolase activity	GO:0008081	5.23
ion binding	GO:0043167	1.36
3',5'-cyclic-GMP phosphodiesterase activity	GO:0047555	7.1
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
hydrolase activity	GO:0016787	1.9
hydrolase activity, acting on ester bonds	GO:0016788	3.1
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
cAMP binding	GO:0030552	6.56
cyclic nucleotide binding	GO:0030551	6.13
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
adenyl ribonucleotide binding	GO:0032559	2.41
purine ribonucleotide binding	GO:0032555	2.2
ribonucleotide binding	GO:0032553	2.19