| Disease ID | Disease name | Source of annotation with PRKAR1A | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 610489 | PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 1 | ClinVar, OMIM | link to OMIM | 1 | PRKAR1A |
| 160980 | CARNEY COMPLEX, TYPE 1 | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | PRKAR1A |
| PS101800 | ACRODYSOSTOSIS | ClinVar, OMIM, HUMSAVAR | link to OMIM | 2 | PRKAR1A, PDE4D |
| 255960 | MYXOMA, INTRACARDIAC | OMIM | link to OMIM | 1 | PRKAR1A |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Apoptosis | hsa04210 | 6.23 |
| Insulin signaling pathway | hsa04910 | 5.55 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Phospholipase C-mediated cascade; FGFR2 | R-HSA-5654221 | 7.37 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 7.85 |
| DAG and IP3 signaling | R-HSA-1489509 | 7.98 |
| Phospholipase C-mediated cascade; FGFR3 | R-HSA-5654227 | 7.52 |
| Ca-dependent events | R-HSA-111996 | 8.18 |
| Phospholipase C-mediated cascade; FGFR4 | R-HSA-5654228 | 7.46 |
| Immune System | R-HSA-168256 | 2.37 |
| Transmembrane transport of small molecules | R-HSA-382551 | 3.79 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Downstream signal transduction | R-HSA-186763 | 4.65 |
| Signaling by Hedgehog | R-HSA-5358351 | 5.79 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 5.88 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 7.56 |
| Calmodulin induced events | R-HSA-111933 | 8.28 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 8.89 |
| DARPP-32 events | R-HSA-180024 | 8.4 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 4.71 |
| CaM pathway | R-HSA-111997 | 8.28 |
| Signalling by NGF | R-HSA-166520 | 4.23 |
| PKA activation in glucagon signalling | R-HSA-164378 | 8.89 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 7.43 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 4.71 |
| Signaling by FGFR4 | R-HSA-5654743 | 4.69 |
| Signaling by FGFR3 | R-HSA-5654741 | 4.69 |
| Signaling by FGFR | R-HSA-190236 | 4.67 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Integration of energy metabolism | R-HSA-163685 | 6.24 |
| Aquaporin-mediated transport | R-HSA-445717 | 7.31 |
| PKA activation | R-HSA-163615 | 8.98 |
| Signaling by PDGF | R-HSA-186797 | 4.53 |
| DAP12 signaling | R-HSA-2424491 | 4.64 |
| Hedgehog 'off' state | R-HSA-5610787 | 6.19 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 4.71 |
| PLC-gamma1 signalling | R-HSA-167021 | 7.89 |
| Signaling by EGFR | R-HSA-177929 | 4.59 |
| NGF signalling via TRKA from the plasma membrane | R-HSA-187037 | 4.51 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 7.94 |
| EGFR interacts with phospholipase C-gamma | R-HSA-212718 | 7.89 |
| Regulation of insulin secretion | R-HSA-422356 | 6.66 |
| PLC beta mediated events | R-HSA-112043 | 7.52 |
| G-protein mediated events | R-HSA-112040 | 7.49 |
| Signaling by FGFR2 | R-HSA-5654738 | 4.68 |
| Signaling by FGFR1 | R-HSA-5654736 | 4.69 |
| Opioid Signalling | R-HSA-111885 | 6.64 |
| DAP12 interactions | R-HSA-2172127 | 4.56 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 4.71 |
| Signaling by ERBB2 | R-HSA-1227986 | 4.66 |
| Hemostasis | R-HSA-109582 | 3.98 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 7.59 |
| GO term | GO ID | GO IC |
|---|---|---|
| ubiquitin-like protein ligase binding | GO:0044389 | 4.15 |
| kinase regulator activity | GO:0019207 | 4.5 |
| protein kinase binding | GO:0019901 | 3.44 |
| enzyme binding | GO:0019899 | 2.27 |
| cAMP binding | GO:0030552 | 6.56 |
| protein kinase A catalytic subunit binding | GO:0034236 | 7.03 |
| binding | GO:0005488 | 0.18 |
| enzyme inhibitor activity | GO:0004857 | 3.78 |
| cAMP-dependent protein kinase regulator activity | GO:0008603 | 7.79 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| molecular function regulator | GO:0098772 | 2.51 |
| nucleotide binding | GO:0000166 | 1.96 |
| transferase activity | GO:0016740 | 1.95 |
| purine nucleotide binding | GO:0017076 | 2.19 |
| kinase inhibitor activity | GO:0019210 | 5.25 |
| protein kinase A binding | GO:0051018 | 6.02 |
| protein kinase regulator activity | GO:0019887 | 4.6 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| kinase activity | GO:0016301 | 2.93 |
| protein kinase inhibitor activity | GO:0004860 | 5.28 |
| kinase binding | GO:0019900 | 3.32 |
| cAMP-dependent protein kinase inhibitor activity | GO:0004862 | 7.54 |
| protein serine/threonine kinase inhibitor activity | GO:0030291 | 6.34 |
| small molecule binding | GO:0036094 | 1.89 |
| cyclic nucleotide binding | GO:0030551 | 6.13 |
| ubiquitin protein ligase binding | GO:0031625 | 4.17 |
| adenyl nucleotide binding | GO:0030554 | 2.4 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| catalytic activity | GO:0003824 | 1.05 |
| adenyl ribonucleotide binding | GO:0032559 | 2.41 |
| protein binding | GO:0005515 | 0.46 |
| transferase activity, transferring phosphorus-containing groups | GO:0016772 | 2.77 |
| purine ribonucleotide binding | GO:0032555 | 2.2 |
| ribonucleotide binding | GO:0032553 | 2.19 |