| Disease ID | Disease name | Source of annotation with PROZ | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 614024 | PROTEIN Z DEFICIENCY | OMIM | link to OMIM | 1 | PROZ |
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| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Gamma-carboxylation of protein precursors | R-HSA-159740 | 9.81 |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | R-HSA-163841 | 7.81 |
| Metabolism of proteins | R-HSA-392499 | 3.41 |
| Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | R-HSA-159854 | 9.52 |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | R-HSA-159782 | 9.81 |
| Post-translational protein modification | R-HSA-597592 | 4.54 |
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | R-HSA-159763 | 9.98 |
| GO term | GO ID | GO IC |
|---|---|---|
| hydrolase activity | GO:0016787 | 1.9 |
| endopeptidase activity | GO:0004175 | 3.63 |
| serine-type endopeptidase activity | GO:0004252 | 4.4 |
| serine hydrolase activity | GO:0017171 | 4.26 |
| metal ion binding | GO:0046872 | 1.41 |
| cation binding | GO:0043169 | 1.4 |
| ion binding | GO:0043167 | 1.36 |
| catalytic activity | GO:0003824 | 1.05 |
| peptidase activity, acting on L-amino acid peptides | GO:0070011 | 3.26 |
| binding | GO:0005488 | 0.18 |
| peptidase activity | GO:0008233 | 3.23 |
| serine-type peptidase activity | GO:0008236 | 4.27 |
| calcium ion binding | GO:0005509 | 3.17 |