Gene table of SLC1A3 : solute carrier family 1 member 3

Gene-disease associations table

Disease ID	Disease name	Source of annotation with SLC1A3	OMIM link	Number of associated genes	genes
PS160120	EPISODIC ATAXIA	ClinVar, OMIM, HUMSAVAR	link to OMIM	4	CACNA1A, KCNA1, CACNB4, SLC1A3

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Annotation of the gene SLC1A3

Associated genes in ENSEMBL

ENSG00000079215

Associated proteins - SwissProt Accession ID

P43003

Associated PDB IDs

Cytogenetic Band

5p13.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Glutamatergic synapse	hsa04724	5.84

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.4
Transport of inorganic cations/anions and amino acids/oligopeptides	R-HSA-425393	6.41
Transmembrane transport of small molecules	R-HSA-382551	3.79
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	10.98
SLC-mediated transmembrane transport	R-HSA-425407	4.95
Neuronal System	R-HSA-112316	4.82
Transmission across Chemical Synapses	R-HSA-112315	5.28
Neurotransmitter uptake and Metabolism In Glial Cells	R-HSA-112313	10.98
Neurotransmitter Release Cycle	R-HSA-112310	7.34

Associated GO terms for Molecular function

GO term	GO ID	GO IC
organic acid transmembrane transporter activity	GO:0005342	4.97
organic acid:sodium symporter activity	GO:0005343	6.48
binding	GO:0005488	0.18
amino acid binding	GO:0016597	5.71
glutamate binding	GO:0016595	7.54
anion binding	GO:0043168	4.17
sodium ion transmembrane transporter activity	GO:0015081	4.83
anion transmembrane transporter activity	GO:0008509	4.43
monovalent inorganic cation transmembrane transporter activity	GO:0015077	3.87
ion binding	GO:0043167	1.36
solute:sodium symporter activity	GO:0015370	5.83
transporter activity	GO:0005215	2.57
metal ion transmembrane transporter activity	GO:0046873	3.71
sodium:dicarboxylate symporter activity	GO:0017153	7.54
active transmembrane transporter activity	GO:0022804	3.85
solute:cation symporter activity	GO:0015294	5.15
anion:cation symporter activity	GO:0015296	6.15
secondary active transmembrane transporter activity	GO:0015291	4.29
symporter activity	GO:0015293	4.78
dicarboxylic acid transmembrane transporter activity	GO:0005310	7.03
L-glutamate transmembrane transporter activity	GO:0005313	7.17
cation transmembrane transporter activity	GO:0008324	3.32
high-affinity glutamate transmembrane transporter activity	GO:0005314	8.13
carboxylic acid transmembrane transporter activity	GO:0046943	4.99
substrate-specific transmembrane transporter activity	GO:0022891	2.9
inorganic cation transmembrane transporter activity	GO:0022890	3.49
substrate-specific transporter activity	GO:0022892	2.72
organic anion transmembrane transporter activity	GO:0008514	5.31
carboxylic acid binding	GO:0031406	4.64
ion transmembrane transporter activity	GO:0015075	3.04
transmembrane transporter activity	GO:0022857	2.82
active ion transmembrane transporter activity	GO:0022853	5.06
amino acid transmembrane transporter activity	GO:0015171	5.38
acidic amino acid transmembrane transporter activity	GO:0015172	7.1