Gene table of TDP1 : tyrosyl-DNA phosphodiesterase 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with TDP1	OMIM link	Number of associated genes	genes
607250	SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE, WITH AXONAL NEUROPATHY	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	TDP1

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
DNA Repair	R-HSA-73894	5.8
Processing of DNA ends prior to end rejoining	R-HSA-75924	10.66
Double-Strand Break Repair	R-HSA-73890	8.46
Nonhomologous End-Joining (NHEJ)	R-HSA-73889	10.18

Associated GO terms for Molecular function

GO term	GO ID	GO IC
hydrolase activity	GO:0016787	1.9
nucleic acid binding	GO:0003676	1.44
catalytic activity	GO:0003824	1.05
nuclease activity	GO:0004518	4.33
organic cyclic compound binding	GO:0097159	1.05
exonuclease activity	GO:0004527	5.33
phosphoric diester hydrolase activity	GO:0008081	5.23
hydrolase activity, acting on ester bonds	GO:0016788	3.1
single-stranded DNA binding	GO:0003697	5.17
phosphoric ester hydrolase activity	GO:0042578	3.82
tyrosyl-DNA phosphodiesterase activity	GO:0070259	9.05
binding	GO:0005488	0.18
protein binding	GO:0005515	0.46
DNA binding	GO:0003677	1.92
double-stranded DNA binding	GO:0003690	3.09
3'-tyrosyl-DNA phosphodiesterase activity	GO:0017005	9.74
heterocyclic compound binding	GO:1901363	1.06