| Disease ID | Disease name | Source of annotation with TPO | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 274500 | THYROID DYSHORMONOGENESIS 2A | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | TPO |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Autoimmune thyroid disease | hsa05320 | 6.62 |
| Metabolic pathways | hsa01100 | 2.49 |
| Tyrosine metabolism | hsa00350 | 7.64 |
| Thyroid hormone synthesis | hsa04918 | 6.56 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Metabolism of amino acids and derivatives | R-HSA-71291 | 5.4 |
| Amine-derived hormones | R-HSA-209776 | 8.98 |
| Thyroxine biosynthesis | R-HSA-209968 | 9.98 |
| Metabolism | R-HSA-1430728 | 2.34 |
| GO term | GO ID | GO IC |
|---|---|---|
| oxidoreductase activity | GO:0016491 | 3.12 |
| cation binding | GO:0043169 | 1.4 |
| metal ion binding | GO:0046872 | 1.41 |
| iodide peroxidase activity | GO:0004447 | 9.05 |
| heme binding | GO:0020037 | 4.86 |
| tetrapyrrole binding | GO:0046906 | 4.8 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| antioxidant activity | GO:0016209 | 5.49 |
| catalytic activity | GO:0003824 | 1.05 |
| peroxidase activity | GO:0004601 | 6.05 |
| ion binding | GO:0043167 | 1.36 |
| calcium ion binding | GO:0005509 | 3.17 |
| oxidoreductase activity, acting on peroxide as acceptor | GO:0016684 | 6.0 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| binding | GO:0005488 | 0.18 |