Gene table of UBB : ubiquitin B

Gene-disease associations table

Disease IDDisease nameSource of annotation with UBBOMIM linkNumber of associated genesgenes
119540CLEFT PALATE, ISOLATEDOMIM link to OMIM 2UBB, PDGFRA

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Annotation of the gene UBB

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Parkinson's diseasehsa050125.59
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.47
Glucose metabolismR-HSA-703266.77
Activation of NF-kappaB in B cellsR-HSA-11690916.94
Myoclonic epilepsy of LaforaR-HSA-37856539.52
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.11
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
Signaling by NOTCHR-HSA-1571186.2
ISG15 antiviral mechanismR-HSA-11694086.83
p75 NTR receptor-mediated signallingR-HSA-1937046.59
Cell CycleR-HSA-16401703.89
Association of licensing factors with the pre-replicative complexR-HSA-692989.08
Dectin-1 mediated noncanonical NF-kB signalingR-HSA-56077617.1
Developmental BiologyR-HSA-12667383.48
Translesion Synthesis by POLHR-HSA-1103208.73
Switching of origins to a post-replicative stateR-HSA-690526.85
TAK1 activates NFkB by phosphorylation and activation of IKKs complexR-HSA-4459898.08
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulationR-HSA-9751639.66
Generic Transcription PathwayR-HSA-2124363.86
degradation of DVLR-HSA-46412587.18
FCERI mediated MAPK activationR-HSA-28717964.32
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.47
Cellular responses to stressR-HSA-22627524.56
HIV InfectionR-HSA-1629065.22
IRS-mediated signallingR-HSA-1123994.87
Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-56378158.73
Regulation of ApoptosisR-HSA-1699117.34
Orc1 removal from chromatinR-HSA-689496.85
Late Phase of HIV Life CycleR-HSA-1625996.02
p53-Dependent G1/S DNA damage checkpointR-HSA-695807.15
Regulation of mRNA stability by proteins that bind AU-rich elementsR-HSA-4505316.56
Interferon SignalingR-HSA-9135314.95
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsR-HSA-28948627.15
TCR signalingR-HSA-2024036.64
Constitutive Signaling by NOTCH1 HD Domain MutantsR-HSA-26912329.08
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Assembly of the pre-replicative complexR-HSA-688676.92
Regulation of APC/C activators between G1/S and early anaphaseR-HSA-1764086.72
APC/C:Cdc20 mediated degradation of mitotic proteinsR-HSA-1764096.81
Spry regulation of FGF signalingR-HSA-12955969.18
Glycogen storage diseasesR-HSA-32291219.52
Recognition of DNA damage by PCNA-containing replication complexR-HSA-1103148.18
Interleukin-2 signalingR-HSA-4519275.05
beta-catenin independent WNT signalingR-HSA-38584945.83
Diseases of carbohydrate metabolismR-HSA-56630848.28
NIK--noncanonical NF-kB signalingR-HSA-56765907.12
MAP kinase activation in TLR cascadeR-HSA-4502947.28
Translesion synthesis by REV1R-HSA-1103128.98
Regulation of activated PAK-2p34 by proteasome mediated degradationR-HSA-2117337.37
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.47
Class I MHC mediated antigen processing & presentationR-HSA-9831694.65
Hedgehog ligand biogenesisR-HSA-53583466.98
NRIF signals cell death from the nucleusR-HSA-2050439.08
Regulation of necroptotic cell deathR-HSA-56754828.98
Downregulation of ERBB4 signalingR-HSA-12532889.98
Signaling by EGFRR-HSA-1779294.59
Vesicle-mediated transportR-HSA-56536564.33
Cellular response to hypoxiaR-HSA-22627498.4
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.51
Regulation of innate immune responses to cytosolic DNAR-HSA-31349759.08
G1/S TransitionR-HSA-692066.21
TCF dependent signaling in response to WNTR-HSA-2016815.36
Signaling by NOTCH1 in CancerR-HSA-26446037.15
Signaling by NOTCH1 PEST Domain Mutants in CancerR-HSA-26446027.15
Cyclin E associated events during G1/S transition R-HSA-692026.96
Toll Like Receptor 5 (TLR5) CascadeR-HSA-1681766.73
SCF-beta-TrCP mediated degradation of Emi1R-HSA-1741137.23
G1/S DNA Damage CheckpointsR-HSA-696157.08
FRS-mediated FGFR4 signalingR-HSA-56547125.14
p53-Independent DNA Damage ResponseR-HSA-696107.28
p53-Independent G1/S DNA damage checkpointR-HSA-696137.28
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
IGF1R signaling cascadeR-HSA-24289244.85
VEGFR2 mediated cell proliferationR-HSA-52189215.07
NOTCH2 Activation and Transmission of Signal to the NucleusR-HSA-29790968.59
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signalingR-HSA-9751109.08
GLI3 is processed to GLI3R by the proteasomeR-HSA-56107857.1
IRAK2 mediated activation of TAK1 complexR-HSA-9370429.66
IKK complex recruitment mediated by RIP1R-HSA-9370418.46
Immune SystemR-HSA-1682562.37
Frs2-mediated activationR-HSA-1709685.12
SHC1 events in ERBB4 signalingR-HSA-12503475.15
IRS-related events triggered by IGF1RR-HSA-24289284.85
Cdc20:Phospho-APC/C mediated degradation of Cyclin AR-HSA-1741846.87
Stimuli-sensing channelsR-HSA-26723516.28
Downstream signal transductionR-HSA-1867634.65
Hh mutants that don't undergo autocatalytic processing are degraded by ERADR-HSA-53627687.2
Signaling by HedgehogR-HSA-53583515.79
Constitutive Signaling by NOTCH1 PEST Domain MutantsR-HSA-26446067.15
Vpu mediated degradation of CD4R-HSA-1805347.31
SCF(Skp2)-mediated degradation of p27/p21R-HSA-1875777.18
Toll Like Receptor 10 (TLR10) CascadeR-HSA-1681426.73
Signaling by NOTCH1R-HSA-19801436.81
Mitotic Metaphase and AnaphaseR-HSA-25553965.45
CDT1 association with the CDC6:ORC:origin complexR-HSA-688277.12
Signalling to p38 via RIT and RINR-HSA-1877065.12
G2/M DNA damage checkpointR-HSA-694737.15
Ubiquitin Mediated Degradation of Phosphorylated Cdc25AR-HSA-696017.28
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysR-HSA-1686437.31
p53-Dependent G1 DNA Damage ResponseR-HSA-695637.15
Cytosolic sensors of pathogen-associated DNA R-HSA-18349496.94
Cell Cycle, MitoticR-HSA-692784.16
FRS-mediated FGFR3 signalingR-HSA-56547065.14
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointR-HSA-1794196.85
NF-kB is activated and signals survivalR-HSA-2095609.28
Downstream signaling of activated FGFR3R-HSA-56547084.71
Termination of translesion DNA synthesisR-HSA-56561698.08
G2/M TransitionR-HSA-692756.06
Interleukin-1 signalingR-HSA-4466527.52
Mitotic G1-G1/S phasesR-HSA-4532795.91
activated TAK1 mediates p38 MAPK activationR-HSA-4503028.59
Interleukin receptor SHC signalingR-HSA-9125265.09
TRAF6 mediated induction of TAK1 complexR-HSA-9370728.98
Host Interactions of HIV factorsR-HSA-1629095.99
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Ubiquitin-dependent degradation of Cyclin DR-HSA-758157.34
Innate Immune SystemR-HSA-1682493.17
Mitotic G2-G2/M phasesR-HSA-4532746.04
Vif-mediated degradation of APOBEC3GR-HSA-1805857.25
DNA RepairR-HSA-738945.8
Glycogen synthesisR-HSA-33220779.08
CLEC7A (Dectin-1) signalingR-HSA-56077646.38
Mitotic AnaphaseR-HSA-688825.46
Regulation of mitotic cell cycleR-HSA-4532766.61
Assembly Of The HIV VirionR-HSA-1754749.28
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
degradation of AXINR-HSA-46412577.23
Signaling by WntR-HSA-1957214.79
Downregulation of ERBB2:ERBB3 signalingR-HSA-13588039.28
Signaling by FGFR2R-HSA-56547384.68
Regulation of PLK1 Activity at G2/M TransitionR-HSA-25659426.66
Signaling by FGFR1R-HSA-56547364.69
APC/C:Cdc20 mediated degradation of Cyclin BR-HSA-1740488.59
Negative regulation of FGFR4 signalingR-HSA-56547338.03
MyD88 cascade initiated on plasma membraneR-HSA-9758716.73
APC-Cdc20 mediated degradation of Nek2AR-HSA-1794098.46
Signaling by VEGFR-HSA-1941384.66
DAP12 interactionsR-HSA-21721274.56
TGF-beta receptor signaling activates SMADsR-HSA-21737897.98
Removal of licensing factors from originsR-HSA-693006.81
Axon guidanceR-HSA-4224753.93
Toll Like Receptor 9 (TLR9) CascadeR-HSA-1681386.62
M/G1 TransitionR-HSA-688746.62
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonR-HSA-9369648.81
Oncogene Induced SenescenceR-HSA-25595858.03
Autodegradation of the E3 ubiquitin ligase COP1R-HSA-3494257.31
Oxidative Stress Induced SenescenceR-HSA-25595806.51
Cellular SenescenceR-HSA-25595835.7
Senescence-Associated Secretory Phenotype (SASP)R-HSA-25595826.77
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.51
Signaling by LeptinR-HSA-25865525.1
Synthesis And Processing Of GAG, GAGPOL PolyproteinsR-HSA-1744959.52
Programmed Cell DeathR-HSA-53578015.65
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1R-HSA-4503218.66
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysR-HSA-1689286.7
deactivation of the beta-catenin transactivating complexR-HSA-37694027.59
Signaling by EGFR in CancerR-HSA-16437138.73
CDK-mediated phosphorylation and removal of Cdc6R-HSA-690177.34
Endosomal Sorting Complex Required For Transport (ESCRT)R-HSA-9177298.18
M PhaseR-HSA-688864.87
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
Regulation of the Fanconi anemia pathwayR-HSA-4195529.66
Toll-Like Receptors CascadesR-HSA-1688985.91
IRAK1 recruits IKK complexR-HSA-9370399.18
Downstream signaling of activated FGFR1R-HSA-56546874.71
Metabolism of carbohydratesR-HSA-713874.93
Gene ExpressionR-HSA-741602.72
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Antigen processing-Cross presentationR-HSA-12369755.88
ER-Phagosome pathwayR-HSA-12369746.08
Negative regulation of FGFR1 signalingR-HSA-56547267.98
Negative regulation of FGFR2 signalingR-HSA-56547277.89
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulationR-HSA-9751449.18
Stabilization of p53R-HSA-695417.28
p75NTR recruits signalling complexesR-HSA-2095439.28
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)R-HSA-21737918.98
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerR-HSA-21737937.56
FCERI mediated NF-kB activationR-HSA-28718375.11
Downregulation of SMAD2/3:SMAD4 transcriptional activityR-HSA-21737958.46
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionR-HSA-21737968.03
Infectious diseaseR-HSA-56632054.47
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.56
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerR-HSA-28948587.15
Downstream TCR signalingR-HSA-2024247.01
AUF1 (hnRNP D0) destabilizes mRNAR-HSA-4504087.23
GRB2 events in ERBB2 signalingR-HSA-19636405.15
RIPK1-mediated regulated necrosisR-HSA-52134608.81
Signaling by TGF-beta Receptor ComplexR-HSA-1708346.81
NOD1/2 Signaling PathwayR-HSA-1686387.85
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaR-HSA-12341768.89
Regulation of Hypoxia-inducible Factor (HIF) by oxygenR-HSA-12341748.4
Signalling to RASR-HSA-1670445.08
NOTCH1 Intracellular Domain Regulates TranscriptionR-HSA-21229477.43
FRS-mediated FGFR2 signalingR-HSA-56547005.14
Downstream signaling of activated FGFR2R-HSA-56546964.71
Activated NOTCH1 Transmits Signal to the NucleusR-HSA-21229488.08
SHC1 events in EGFR signalingR-HSA-1803365.15
DNA Replication Pre-InitiationR-HSA-690026.62
FRS-mediated FGFR1 signalingR-HSA-56546935.14
Circadian ClockR-HSA-4002537.03
G2/M CheckpointsR-HSA-694816.46
Degradation of beta-catenin by the destruction complexR-HSA-1952536.64
APC/C:Cdc20 mediated degradation of SecurinR-HSA-1741546.98
EGFR downregulationR-HSA-1829718.28
Cyclin A:Cdk2-associated events at S phase entryR-HSA-696566.94
SHC1 events in ERBB2 signalingR-HSA-12501965.15
PCP/CE pathwayR-HSA-40864006.47
ARMS-mediated activationR-HSA-1709845.12
S PhaseR-HSA-692426.02
GRB2 events in EGFR signalingR-HSA-1798125.15
MyD88 dependent cascade initiated on endosomeR-HSA-9751556.68
Hedgehog 'on' stateR-HSA-56326846.62
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.56
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationR-HSA-9751386.72
Signaling by PDGFR-HSA-1867974.53
MAPK family signaling cascadesR-HSA-56830574.89
Activated TLR4 signallingR-HSA-1660546.27
DNA Damage BypassR-HSA-738937.46
Ion channel transportR-HSA-9837125.34
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Asymmetric localization of PCP proteinsR-HSA-46088707.01
Separation of Sister ChromatidsR-HSA-24678135.55
Signaling by InterleukinsR-HSA-4491474.71
Signaling by NOTCH1 HD Domain Mutants in CancerR-HSA-26912309.08
Transmembrane transport of small moleculesR-HSA-3825513.79
Negative regulation of FGFR3 signalingR-HSA-56547328.12
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
MetabolismR-HSA-14307282.34
Degradation of GLI1 by the proteasomeR-HSA-56107807.1
regulation of FZD by ubiquitinationR-HSA-46412638.59
Signaling by ERBB4R-HSA-12363944.7
Translesion synthesis by POLKR-HSA-56558628.89
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
APC/C-mediated degradation of cell cycle proteinsR-HSA-1741436.61
Diseases of metabolismR-HSA-56689146.57
TNFR2 non-canonical NF-kB pathwayR-HSA-56685416.4
Hedgehog 'off' stateR-HSA-56107876.19
Antiviral mechanism by IFN-stimulated genesR-HSA-11694106.83
Membrane binding and targetting of GAG proteinsR-HSA-1744909.52
Translesion synthesis by POLIR-HSA-56561218.89
Diseases of signal transductionR-HSA-56632024.89
Hh mutants abrogate ligand secretionR-HSA-53873907.2
Cell death signalling via NRAGE, NRIF and NADER-HSA-2049987.05
G1 PhaseR-HSA-692367.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
Regulation of DNA replicationR-HSA-693046.75
Cyclin D associated events in G1R-HSA-692317.73
RAF/MAP kinase cascadeR-HSA-56730015.15
Cell Cycle CheckpointsR-HSA-696205.64
Signaling by FGFR4R-HSA-56547434.69
Synthesis of DNAR-HSA-692396.37
Signaling by FGFR3R-HSA-56547414.69
C-type lectin receptors (CLRs)R-HSA-56214816.06
Toll Like Receptor 7/8 (TLR7/8) CascadeR-HSA-1681816.68
Signaling by FGFRR-HSA-1902364.67
Degradation of GLI2 by the proteasomeR-HSA-56107837.1
MAPK6/MAPK4 signalingR-HSA-56871286.54
Downregulation of TGF-beta receptor signalingR-HSA-21737888.28
Signaling by SCF-KITR-HSA-14335574.73
p75NTR signals via NF-kBR-HSA-1936398.98
Membrane TraffickingR-HSA-1999915.26
Signaling by NOTCH2R-HSA-19801457.98
Negative regulators of RIG-I/MDA5 signalingR-HSA-9364407.98
DAP12 signalingR-HSA-24244914.64
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1R-HSA-1741786.87
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Regulation of signaling by CBLR-HSA-9126318.52
Regulated NecrosisR-HSA-52188598.81
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateR-HSA-1103137.77
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-12363828.73
Fanconi Anemia pathwayR-HSA-4195248.4
Negative regulation of MAPK pathwayR-HSA-56752217.66
Regulation of RAS by GAPsR-HSA-56584426.92
Signalling by NGFR-HSA-1665204.23
Signaling by GPCRR-HSA-3727902.68
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsR-HSA-1768146.79
Signalling to ERKsR-HSA-1876875.04
Autodegradation of Cdh1 by Cdh1:APC/CR-HSA-1740847.08
DNA ReplicationR-HSA-693066.25
Antigen processing: Ubiquitination & Proteasome degradationR-HSA-9831685.19
Budding and maturation of HIV virionR-HSA-1625888.34
Signal TransductionR-HSA-1625821.78
HIV Life CycleR-HSA-1625875.89
Ubiquitin-dependent degradation of Cyclin D1R-HSA-692297.34
ApoptosisR-HSA-1095815.68
Associated GO terms for Molecular function
GO termGO IDGO IC
bindingGO:00054880.18
protein bindingGO:00055150.46