Gene table of UBB : ubiquitin B

Gene-disease associations table

Disease IDDisease nameSource of annotation with UBBOMIM linkNumber of associated genesgenes

Download the gene annotation in CSV format

Annotation of the gene UBB

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
Parkinson's diseasehsa050125.59
Associated REACTOME pathways
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.47
Glucose metabolismR-HSA-703266.77
Activation of NF-kappaB in B cellsR-HSA-11690916.94
Myoclonic epilepsy of LaforaR-HSA-37856539.52
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.11
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
Signaling by NOTCHR-HSA-1571186.2
ISG15 antiviral mechanismR-HSA-11694086.83
p75 NTR receptor-mediated signallingR-HSA-1937046.59
Cell CycleR-HSA-16401703.89
Association of licensing factors with the pre-replicative complexR-HSA-692989.08
Dectin-1 mediated noncanonical NF-kB signalingR-HSA-56077617.1
Developmental BiologyR-HSA-12667383.48
Translesion Synthesis by POLHR-HSA-1103208.73
Switching of origins to a post-replicative stateR-HSA-690526.85
TAK1 activates NFkB by phosphorylation and activation of IKKs complexR-HSA-4459898.08
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulationR-HSA-9751639.66
Generic Transcription PathwayR-HSA-2124363.86
degradation of DVLR-HSA-46412587.18
FCERI mediated MAPK activationR-HSA-28717964.32
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.47
Cellular responses to stressR-HSA-22627524.56
HIV InfectionR-HSA-1629065.22
IRS-mediated signallingR-HSA-1123994.87
Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-56378158.73
Regulation of ApoptosisR-HSA-1699117.34
Orc1 removal from chromatinR-HSA-689496.85
Late Phase of HIV Life CycleR-HSA-1625996.02
p53-Dependent G1/S DNA damage checkpointR-HSA-695807.15
Regulation of mRNA stability by proteins that bind AU-rich elementsR-HSA-4505316.56
Interferon SignalingR-HSA-9135314.95
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsR-HSA-28948627.15
TCR signalingR-HSA-2024036.64
Constitutive Signaling by NOTCH1 HD Domain MutantsR-HSA-26912329.08
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Assembly of the pre-replicative complexR-HSA-688676.92
Regulation of APC/C activators between G1/S and early anaphaseR-HSA-1764086.72
APC/C:Cdc20 mediated degradation of mitotic proteinsR-HSA-1764096.81
Spry regulation of FGF signalingR-HSA-12955969.18
Glycogen storage diseasesR-HSA-32291219.52
Recognition of DNA damage by PCNA-containing replication complexR-HSA-1103148.18
Interleukin-2 signalingR-HSA-4519275.05
beta-catenin independent WNT signalingR-HSA-38584945.83
Diseases of carbohydrate metabolismR-HSA-56630848.28
NIK--noncanonical NF-kB signalingR-HSA-56765907.12
MAP kinase activation in TLR cascadeR-HSA-4502947.28
Translesion synthesis by REV1R-HSA-1103128.98
Regulation of activated PAK-2p34 by proteasome mediated degradationR-HSA-2117337.37
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.47
Class I MHC mediated antigen processing & presentationR-HSA-9831694.65
Hedgehog ligand biogenesisR-HSA-53583466.98
NRIF signals cell death from the nucleusR-HSA-2050439.08
Regulation of necroptotic cell deathR-HSA-56754828.98
Downregulation of ERBB4 signalingR-HSA-12532889.98
Signaling by EGFRR-HSA-1779294.59
Vesicle-mediated transportR-HSA-56536564.33
Cellular response to hypoxiaR-HSA-22627498.4
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.51
Regulation of innate immune responses to cytosolic DNAR-HSA-31349759.08
G1/S TransitionR-HSA-692066.21
TCF dependent signaling in response to WNTR-HSA-2016815.36
Signaling by NOTCH1 in CancerR-HSA-26446037.15
Signaling by NOTCH1 PEST Domain Mutants in CancerR-HSA-26446027.15
Cyclin E associated events during G1/S transition R-HSA-692026.96
Toll Like Receptor 5 (TLR5) CascadeR-HSA-1681766.73
SCF-beta-TrCP mediated degradation of Emi1R-HSA-1741137.23
G1/S DNA Damage CheckpointsR-HSA-696157.08
FRS-mediated FGFR4 signalingR-HSA-56547125.14
p53-Independent DNA Damage ResponseR-HSA-696107.28
p53-Independent G1/S DNA damage checkpointR-HSA-696137.28
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
IGF1R signaling cascadeR-HSA-24289244.85
VEGFR2 mediated cell proliferationR-HSA-52189215.07
NOTCH2 Activation and Transmission of Signal to the NucleusR-HSA-29790968.59
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signalingR-HSA-9751109.08
GLI3 is processed to GLI3R by the proteasomeR-HSA-56107857.1
IRAK2 mediated activation of TAK1 complexR-HSA-9370429.66
IKK complex recruitment mediated by RIP1R-HSA-9370418.46
Immune SystemR-HSA-1682562.37
Frs2-mediated activationR-HSA-1709685.12
SHC1 events in ERBB4 signalingR-HSA-12503475.15
IRS-related events triggered by IGF1RR-HSA-24289284.85
Cdc20:Phospho-APC/C mediated degradation of Cyclin AR-HSA-1741846.87
Stimuli-sensing channelsR-HSA-26723516.28
Downstream signal transductionR-HSA-1867634.65
Hh mutants that don't undergo autocatalytic processing are degraded by ERADR-HSA-53627687.2
Signaling by HedgehogR-HSA-53583515.79
Constitutive Signaling by NOTCH1 PEST Domain MutantsR-HSA-26446067.15
Vpu mediated degradation of CD4R-HSA-1805347.31
SCF(Skp2)-mediated degradation of p27/p21R-HSA-1875777.18
Toll Like Receptor 10 (TLR10) CascadeR-HSA-1681426.73
Signaling by NOTCH1R-HSA-19801436.81
Mitotic Metaphase and AnaphaseR-HSA-25553965.45
CDT1 association with the CDC6:ORC:origin complexR-HSA-688277.12
Signalling to p38 via RIT and RINR-HSA-1877065.12
G2/M DNA damage checkpointR-HSA-694737.15
Ubiquitin Mediated Degradation of Phosphorylated Cdc25AR-HSA-696017.28
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysR-HSA-1686437.31
p53-Dependent G1 DNA Damage ResponseR-HSA-695637.15
Cytosolic sensors of pathogen-associated DNA R-HSA-18349496.94
Cell Cycle, MitoticR-HSA-692784.16
FRS-mediated FGFR3 signalingR-HSA-56547065.14
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointR-HSA-1794196.85
NF-kB is activated and signals survivalR-HSA-2095609.28
Downstream signaling of activated FGFR3R-HSA-56547084.71
Termination of translesion DNA synthesisR-HSA-56561698.08
G2/M TransitionR-HSA-692756.06
Interleukin-1 signalingR-HSA-4466527.52
Mitotic G1-G1/S phasesR-HSA-4532795.91
activated TAK1 mediates p38 MAPK activationR-HSA-4503028.59
Interleukin receptor SHC signalingR-HSA-9125265.09
TRAF6 mediated induction of TAK1 complexR-HSA-9370728.98
Host Interactions of HIV factorsR-HSA-1629095.99
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Ubiquitin-dependent degradation of Cyclin DR-HSA-758157.34
Innate Immune SystemR-HSA-1682493.17
Mitotic G2-G2/M phasesR-HSA-4532746.04
Vif-mediated degradation of APOBEC3GR-HSA-1805857.25
DNA RepairR-HSA-738945.8
Glycogen synthesisR-HSA-33220779.08
CLEC7A (Dectin-1) signalingR-HSA-56077646.38
Mitotic AnaphaseR-HSA-688825.46
Regulation of mitotic cell cycleR-HSA-4532766.61
Assembly Of The HIV VirionR-HSA-1754749.28
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
degradation of AXINR-HSA-46412577.23
Signaling by WntR-HSA-1957214.79
Downregulation of ERBB2:ERBB3 signalingR-HSA-13588039.28
Signaling by FGFR2R-HSA-56547384.68
Regulation of PLK1 Activity at G2/M TransitionR-HSA-25659426.66
Signaling by FGFR1R-HSA-56547364.69
APC/C:Cdc20 mediated degradation of Cyclin BR-HSA-1740488.59
Negative regulation of FGFR4 signalingR-HSA-56547338.03
MyD88 cascade initiated on plasma membraneR-HSA-9758716.73
APC-Cdc20 mediated degradation of Nek2AR-HSA-1794098.46
Signaling by VEGFR-HSA-1941384.66
DAP12 interactionsR-HSA-21721274.56
TGF-beta receptor signaling activates SMADsR-HSA-21737897.98
Removal of licensing factors from originsR-HSA-693006.81
Axon guidanceR-HSA-4224753.93
Toll Like Receptor 9 (TLR9) CascadeR-HSA-1681386.62
M/G1 TransitionR-HSA-688746.62
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonR-HSA-9369648.81
Oncogene Induced SenescenceR-HSA-25595858.03
Autodegradation of the E3 ubiquitin ligase COP1R-HSA-3494257.31
Oxidative Stress Induced SenescenceR-HSA-25595806.51
Cellular SenescenceR-HSA-25595835.7
Senescence-Associated Secretory Phenotype (SASP)R-HSA-25595826.77
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.51
Signaling by LeptinR-HSA-25865525.1
Synthesis And Processing Of GAG, GAGPOL PolyproteinsR-HSA-1744959.52
Programmed Cell DeathR-HSA-53578015.65
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1R-HSA-4503218.66
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysR-HSA-1689286.7
deactivation of the beta-catenin transactivating complexR-HSA-37694027.59
Signaling by EGFR in CancerR-HSA-16437138.73
CDK-mediated phosphorylation and removal of Cdc6R-HSA-690177.34
Endosomal Sorting Complex Required For Transport (ESCRT)R-HSA-9177298.18
M PhaseR-HSA-688864.87
Signaling by Insulin receptorR-HSA-747524.73
Insulin receptor signalling cascadeR-HSA-747514.85
Regulation of the Fanconi anemia pathwayR-HSA-4195529.66
Toll-Like Receptors CascadesR-HSA-1688985.91
IRAK1 recruits IKK complexR-HSA-9370399.18
Downstream signaling of activated FGFR1R-HSA-56546874.71
Metabolism of carbohydratesR-HSA-713874.93
Gene ExpressionR-HSA-741602.72
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Antigen processing-Cross presentationR-HSA-12369755.88
ER-Phagosome pathwayR-HSA-12369746.08
Negative regulation of FGFR1 signalingR-HSA-56547267.98
Negative regulation of FGFR2 signalingR-HSA-56547277.89
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulationR-HSA-9751449.18
Stabilization of p53R-HSA-695417.28
p75NTR recruits signalling complexesR-HSA-2095439.28
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)R-HSA-21737918.98
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerR-HSA-21737937.56
FCERI mediated NF-kB activationR-HSA-28718375.11
Downregulation of SMAD2/3:SMAD4 transcriptional activityR-HSA-21737958.46
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionR-HSA-21737968.03
Infectious diseaseR-HSA-56632054.47
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.56
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerR-HSA-28948587.15
Downstream TCR signalingR-HSA-2024247.01
AUF1 (hnRNP D0) destabilizes mRNAR-HSA-4504087.23
GRB2 events in ERBB2 signalingR-HSA-19636405.15
RIPK1-mediated regulated necrosisR-HSA-52134608.81
Signaling by TGF-beta Receptor ComplexR-HSA-1708346.81
NOD1/2 Signaling PathwayR-HSA-1686387.85
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaR-HSA-12341768.89
Regulation of Hypoxia-inducible Factor (HIF) by oxygenR-HSA-12341748.4
Signalling to RASR-HSA-1670445.08
NOTCH1 Intracellular Domain Regulates TranscriptionR-HSA-21229477.43
FRS-mediated FGFR2 signalingR-HSA-56547005.14
Downstream signaling of activated FGFR2R-HSA-56546964.71
Activated NOTCH1 Transmits Signal to the NucleusR-HSA-21229488.08
SHC1 events in EGFR signalingR-HSA-1803365.15
DNA Replication Pre-InitiationR-HSA-690026.62
FRS-mediated FGFR1 signalingR-HSA-56546935.14
Circadian ClockR-HSA-4002537.03
G2/M CheckpointsR-HSA-694816.46
Degradation of beta-catenin by the destruction complexR-HSA-1952536.64
APC/C:Cdc20 mediated degradation of SecurinR-HSA-1741546.98
EGFR downregulationR-HSA-1829718.28
Cyclin A:Cdk2-associated events at S phase entryR-HSA-696566.94
SHC1 events in ERBB2 signalingR-HSA-12501965.15
PCP/CE pathwayR-HSA-40864006.47
ARMS-mediated activationR-HSA-1709845.12
S PhaseR-HSA-692426.02
GRB2 events in EGFR signalingR-HSA-1798125.15
MyD88 dependent cascade initiated on endosomeR-HSA-9751556.68
Hedgehog 'on' stateR-HSA-56326846.62
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.56
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationR-HSA-9751386.72
Signaling by PDGFR-HSA-1867974.53
MAPK family signaling cascadesR-HSA-56830574.89
Activated TLR4 signallingR-HSA-1660546.27
DNA Damage BypassR-HSA-738937.46
Ion channel transportR-HSA-9837125.34
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Asymmetric localization of PCP proteinsR-HSA-46088707.01
Separation of Sister ChromatidsR-HSA-24678135.55
Signaling by InterleukinsR-HSA-4491474.71
Signaling by NOTCH1 HD Domain Mutants in CancerR-HSA-26912309.08
Transmembrane transport of small moleculesR-HSA-3825513.79
Negative regulation of FGFR3 signalingR-HSA-56547328.12
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
Degradation of GLI1 by the proteasomeR-HSA-56107807.1
regulation of FZD by ubiquitinationR-HSA-46412638.59
Signaling by ERBB4R-HSA-12363944.7
Translesion synthesis by POLKR-HSA-56558628.89
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
APC/C-mediated degradation of cell cycle proteinsR-HSA-1741436.61
Diseases of metabolismR-HSA-56689146.57
TNFR2 non-canonical NF-kB pathwayR-HSA-56685416.4
Hedgehog 'off' stateR-HSA-56107876.19
Antiviral mechanism by IFN-stimulated genesR-HSA-11694106.83
Membrane binding and targetting of GAG proteinsR-HSA-1744909.52
Translesion synthesis by POLIR-HSA-56561218.89
Diseases of signal transductionR-HSA-56632024.89
Hh mutants abrogate ligand secretionR-HSA-53873907.2
Cell death signalling via NRAGE, NRIF and NADER-HSA-2049987.05
G1 PhaseR-HSA-692367.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
Regulation of DNA replicationR-HSA-693046.75
Cyclin D associated events in G1R-HSA-692317.73
RAF/MAP kinase cascadeR-HSA-56730015.15
Cell Cycle CheckpointsR-HSA-696205.64
Signaling by FGFR4R-HSA-56547434.69
Synthesis of DNAR-HSA-692396.37
Signaling by FGFR3R-HSA-56547414.69
C-type lectin receptors (CLRs)R-HSA-56214816.06
Toll Like Receptor 7/8 (TLR7/8) CascadeR-HSA-1681816.68
Signaling by FGFRR-HSA-1902364.67
Degradation of GLI2 by the proteasomeR-HSA-56107837.1
MAPK6/MAPK4 signalingR-HSA-56871286.54
Downregulation of TGF-beta receptor signalingR-HSA-21737888.28
Signaling by SCF-KITR-HSA-14335574.73
p75NTR signals via NF-kBR-HSA-1936398.98
Membrane TraffickingR-HSA-1999915.26
Signaling by NOTCH2R-HSA-19801457.98
Negative regulators of RIG-I/MDA5 signalingR-HSA-9364407.98
DAP12 signalingR-HSA-24244914.64
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1R-HSA-1741786.87
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Regulation of signaling by CBLR-HSA-9126318.52
Regulated NecrosisR-HSA-52188598.81
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateR-HSA-1103137.77
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-12363828.73
Fanconi Anemia pathwayR-HSA-4195248.4
Negative regulation of MAPK pathwayR-HSA-56752217.66
Regulation of RAS by GAPsR-HSA-56584426.92
Signalling by NGFR-HSA-1665204.23
Signaling by GPCRR-HSA-3727902.68
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsR-HSA-1768146.79
Signalling to ERKsR-HSA-1876875.04
Autodegradation of Cdh1 by Cdh1:APC/CR-HSA-1740847.08
DNA ReplicationR-HSA-693066.25
Antigen processing: Ubiquitination & Proteasome degradationR-HSA-9831685.19
Budding and maturation of HIV virionR-HSA-1625888.34
Signal TransductionR-HSA-1625821.78
HIV Life CycleR-HSA-1625875.89
Ubiquitin-dependent degradation of Cyclin D1R-HSA-692297.34
Associated GO terms for Molecular function
protein bindingGO:00055150.46