Disease table of FRASER SYNDROME OMIM ID: 219000

Gene-disease associations table

GeneAssociated with FRASER SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
GRIP1OMIMHGNC link12q14.31219000
FREM2OMIM, HUMSAVARHGNC link13q13.31219000
FRAS1OMIMHGNC link4q21.211219000

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
FREM2FRAS1No5CHST8, LIPH, NXPH2, KLK5, TAZ

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
GRIP1FRAS1Yesbinding0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
FRAS1GRIP1yes, they interactFRAS1 and GRIP2 interact. [UniProt] FREM2 gene encodes a membrane protein that belongs to the FRAS1 family.
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.183FREM2, FRAS1, GRIP1
cation binding (GO:0043169) 1.42FREM2, FRAS1
metal ion binding (GO:0046872) 1.412FREM2, FRAS1
ion binding (GO:0043167) 1.362FREM2, FRAS1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.363FREM2, FRAS1, GRIP1
anatomical structure development (GO:0048856) 1.583FREM2, FRAS1, GRIP1
cellular process (GO:0009987) 0.263FREM2, FRAS1, GRIP1
single-organism developmental process (GO:0044767) 1.493FREM2, FRAS1, GRIP1
single-organism cellular process (GO:0044763) 0.653FREM2, FRAS1, GRIP1
single-organism process (GO:0044699) 0.483FREM2, FRAS1, GRIP1
morphogenesis of an epithelium (GO:0002009) 4.082FREM2, FRAS1
macromolecule localization (GO:0033036) 2.342FRAS1, GRIP1
protein localization (GO:0008104) 2.362FRAS1, GRIP1
animal organ development (GO:0048513) 2.532FREM2, FRAS1
tissue morphogenesis (GO:0048729) 3.872FREM2, FRAS1
cell communication (GO:0007154) 3.042FREM2, FRAS1
anatomical structure morphogenesis (GO:0009653) 2.532FREM2, FRAS1
localization (GO:0051179) 1.42FRAS1, GRIP1

NET-GE enrichment

Term New enriched termICP valueGenes
cell communication (GO:0007154) -3.040.008FREM2, FRAS1, GRIP1
kidney morphogenesis (GO:0060993) NEW6.960.004FRAS1, GRIP1
morphogenesis of an epithelium (GO:0002009) -4.080.05FREM2, FRAS1, GRIP1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane part (GO:0044425) 0.953FREM2, FRAS1, GRIP1
membrane (GO:0016020) 0.683FREM2, FRAS1, GRIP1
cell part (GO:0044464) 0.113FREM2, FRAS1, GRIP1
plasma membrane (GO:0005886) 1.393FREM2, FRAS1, GRIP1
basement membrane (GO:0005604) 5.342FREM2, FRAS1
vesicle (GO:0031982) 1.642FREM2, GRIP1
extracellular region part (GO:0044421) 1.572FREM2, FRAS1
extracellular matrix component (GO:0044420) 4.972FREM2, FRAS1
integral component of membrane (GO:0016021) 1.142FREM2, FRAS1
membrane-bounded vesicle (GO:0031988) 1.712FREM2, GRIP1
membrane-bounded organelle (GO:0043227) 0.472FREM2, GRIP1
organelle (GO:0043226) 0.42FREM2, GRIP1
intrinsic component of membrane (GO:0031224) 1.132FREM2, FRAS1

NET-GE enrichment

Term New enriched termICP valueGenes
extracellular matrix part (GO:0044420) -4.970.001FREM2, FRAS1, GRIP1