Disease table of CRYPTORCHIDISM, UNILATERAL OR BILATERAL OMIM ID: 219050

Gene-disease associations table

GeneAssociated with CRYPTORCHIDISM, UNILATERAL OR BILATERAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
RXFP2ClinVar, HUMSAVARHGNC link13q13.11219050
INSL3ClinVar, OMIM, HUMSAVARHGNC link19p13.111219050

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
RXFP2YES1SOX90
INSL3YES1NR5A10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
RXFP2INSL3Yes0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
RXFP2INSL3Yesbinding1RXFP1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
INSL3RXFP2yes, they interactRXFP2 may be a receptor for Leydig insulin-like peptide (INSL3). [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signaling by GPCRR-HSA-3727902.682INSL3, RXFP2
Relaxin receptorsR-HSA-4448219.982INSL3, RXFP2
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.692INSL3, RXFP2
Peptide ligand-binding receptorsR-HSA-3752765.412INSL3, RXFP2
GPCR downstream signalingR-HSA-3883963.072INSL3, RXFP2
GPCR ligand bindingR-HSA-5007924.192INSL3, RXFP2
G alpha (s) signalling eventsR-HSA-4185555.992INSL3, RXFP2
Signal TransductionR-HSA-1625821.782INSL3, RXFP2

NET-GE enrichment

Term New enriched termICP valueGenes
Relaxin receptors (R-HSA-444821) -9.980.0INSL3, RXFP2
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076) -4.690.014INSL3, RXFP2
GPCR ligand binding (R-HSA-500792) -4.190.027INSL3, RXFP2
G alpha (s) signalling events (R-HSA-418555) -5.990.002INSL3, RXFP2
Peptide ligand-binding receptors (R-HSA-375276) -5.410.005INSL3, RXFP2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.182INSL3, RXFP2

NET-GE enrichment

Term New enriched termICP valueGenes
peptide hormone binding (GO:0017046) NEW6.130.0INSL3, RXFP2
hormone activity (GO:0005179) NEW4.950.003INSL3, RXFP2
peptide binding (GO:0042277) NEW4.220.023INSL3, RXFP2
amide binding (GO:0033218) NEW4.140.023INSL3, RXFP2
G-protein coupled receptor binding (GO:0001664) NEW4.180.024INSL3, RXFP2
hormone binding (GO:0042562) NEW5.530.002INSL3, RXFP2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.362INSL3, RXFP2
regulation of phosphate metabolic process (GO:0019220) 2.352INSL3, RXFP2
regulation of primary metabolic process (GO:0080090) 1.082INSL3, RXFP2
regulation of metabolic process (GO:0019222) 1.022INSL3, RXFP2
positive regulation of biosynthetic process (GO:0009891) 2.292INSL3, RXFP2
regulation of cellular biosynthetic process (GO:0031326) 1.382INSL3, RXFP2
positive regulation of cellular metabolic process (GO:0031325) 1.812INSL3, RXFP2
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292INSL3, RXFP2
regulation of cellular metabolic process (GO:0031323) 1.072INSL3, RXFP2
cell maturation (GO:0048469) 4.982INSL3, RXFP2
male gonad development (GO:0008584) 5.082INSL3, RXFP2
signal transduction (GO:0007165) 1.282INSL3, RXFP2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352INSL3, RXFP2
regulation of cyclic nucleotide biosynthetic process (GO:0030802) 4.852INSL3, RXFP2
regulation of apoptotic process (GO:0042981) 2.52INSL3, RXFP2
regulation of biological process (GO:0050789) 0.452INSL3, RXFP2
single-organism process (GO:0044699) 0.482INSL3, RXFP2
positive regulation of metabolic process (GO:0009893) 1.742INSL3, RXFP2
regulation of cell death (GO:0010941) 2.432INSL3, RXFP2
positive regulation of cAMP biosynthetic process (GO:0030819) 5.352INSL3, RXFP2
positive regulation of cAMP metabolic process (GO:0030816) 5.252INSL3, RXFP2
cellular developmental process (GO:0048869) 1.822INSL3, RXFP2
regulation of cAMP metabolic process (GO:0030814) 4.882INSL3, RXFP2
positive regulation of cellular biosynthetic process (GO:0031328) 2.32INSL3, RXFP2
gonad development (GO:0008406) 4.922INSL3, RXFP2
regulation of programmed cell death (GO:0043067) 2.492INSL3, RXFP2
positive regulation of nucleotide biosynthetic process (GO:0030810) 5.092INSL3, RXFP2
positive regulation of nucleotide metabolic process (GO:0045981) 4.852INSL3, RXFP2
adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188) 4.782INSL3, RXFP2
animal organ development (GO:0048513) 2.532INSL3, RXFP2
biological regulation (GO:0065007) 0.392INSL3, RXFP2
positive regulation of biological process (GO:0048518) 1.22INSL3, RXFP2
negative regulation of biological process (GO:0048519) 1.332INSL3, RXFP2
G-protein coupled receptor signaling pathway (GO:0007186) 2.642INSL3, RXFP2
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) 4.62INSL3, RXFP2
regulation of cell proliferation (GO:0042127) 2.412INSL3, RXFP2
negative regulation of cell proliferation (GO:0008285) 3.262INSL3, RXFP2
reproductive structure development (GO:0048608) 4.082INSL3, RXFP2
positive regulation of phosphate metabolic process (GO:0045937) 2.782INSL3, RXFP2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432INSL3, RXFP2
negative regulation of cell death (GO:0060548) 2.952INSL3, RXFP2
cellular process (GO:0009987) 0.262INSL3, RXFP2
regulation of biosynthetic process (GO:0009889) 1.372INSL3, RXFP2
negative regulation of apoptotic process (GO:0043066) 3.042INSL3, RXFP2
regulation of cellular process (GO:0050794) 0.52INSL3, RXFP2
single-organism developmental process (GO:0044767) 1.492INSL3, RXFP2
developmental process involved in reproduction (GO:0003006) 3.362INSL3, RXFP2
regulation of purine nucleotide metabolic process (GO:1900542) 4.412INSL3, RXFP2
single-organism cellular process (GO:0044763) 0.652INSL3, RXFP2
regulation of nitrogen compound metabolic process (GO:0051171) 1.362INSL3, RXFP2
cellular process involved in reproduction in multicellular organism (GO:0022412) 4.32INSL3, RXFP2
regulation of cyclic nucleotide metabolic process (GO:0030799) 4.692INSL3, RXFP2
negative regulation of programmed cell death (GO:0043069) 3.022INSL3, RXFP2
oocyte maturation (GO:0001556) 6.842INSL3, RXFP2
positive regulation of purine nucleotide metabolic process (GO:1900544) 4.852INSL3, RXFP2
regulation of phosphorus metabolic process (GO:0051174) 2.352INSL3, RXFP2
single organism reproductive process (GO:0044702) 2.732INSL3, RXFP2
regulation of nucleotide biosynthetic process (GO:0030808) 4.792INSL3, RXFP2
reproductive process (GO:0022414) 2.552INSL3, RXFP2
positive regulation of cyclic nucleotide biosynthetic process (GO:0030804) 5.142INSL3, RXFP2
anatomical structure development (GO:0048856) 1.582INSL3, RXFP2
positive regulation of cyclic nucleotide metabolic process (GO:0030801) 5.052INSL3, RXFP2
positive regulation of purine nucleotide biosynthetic process (GO:1900373) 5.092INSL3, RXFP2
regulation of purine nucleotide biosynthetic process (GO:1900371) 4.82INSL3, RXFP2
developmental maturation (GO:0021700) 4.72INSL3, RXFP2
regulation of cAMP biosynthetic process (GO:0030817) 5.012INSL3, RXFP2
regulation of nucleotide metabolic process (GO:0006140) 4.382INSL3, RXFP2
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193) 5.482INSL3, RXFP2
positive regulation of phosphorus metabolic process (GO:0010562) 2.782INSL3, RXFP2
negative regulation of cellular process (GO:0048523) 1.412INSL3, RXFP2
positive regulation of cellular process (GO:0048522) 1.32INSL3, RXFP2

NET-GE enrichment

Term New enriched termICP valueGenes
cell maturation (GO:0048469) -4.980.003INSL3, RXFP2
male gonad development (GO:0008584) -5.080.002INSL3, RXFP2
regulation of purine nucleotide biosynthetic process (GO:1900371) -4.80.004INSL3, RXFP2
developmental maturation (GO:0021700) -4.70.006INSL3, RXFP2
positive regulation of nucleotide metabolic process (GO:0045981) -4.850.013INSL3, RXFP2
positive regulation of cAMP biosynthetic process (GO:0030819) -5.350.001INSL3, RXFP2
positive regulation of cAMP metabolic process (GO:0030816) -5.250.004INSL3, RXFP2
regulation of cAMP biosynthetic process (GO:0030817) -5.010.002INSL3, RXFP2
regulation of cAMP metabolic process (GO:0030814) -4.880.003INSL3, RXFP2
gonad development (GO:0008406) -4.920.023INSL3, RXFP2
positive regulation of nucleotide biosynthetic process (GO:0030810) -5.090.005INSL3, RXFP2
adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188) -4.780.004INSL3, RXFP2
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) -4.60.01INSL3, RXFP2
reproductive structure development (GO:0048608) -4.080.018INSL3, RXFP2
cellular process involved in reproduction in multicellular organism (GO:0022412) -4.30.013INSL3, RXFP2
regulation of cyclic nucleotide metabolic process (GO:0030799) -4.690.005INSL3, RXFP2
oocyte maturation (GO:0001556) -6.840.0INSL3, RXFP2
regulation of nucleotide biosynthetic process (GO:0030808) -4.790.004INSL3, RXFP2
positive regulation of purine nucleotide metabolic process (GO:1900544) -4.850.013INSL3, RXFP2
positive regulation of cyclic nucleotide biosynthetic process (GO:0030804) -5.140.004INSL3, RXFP2
positive regulation of cyclic nucleotide metabolic process (GO:0030801) -5.050.006INSL3, RXFP2
positive regulation of purine nucleotide biosynthetic process (GO:1900373) -5.090.005INSL3, RXFP2
regulation of cyclic nucleotide biosynthetic process (GO:0030802) -4.850.003INSL3, RXFP2
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193) -5.480.001INSL3, RXFP2
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.112INSL3, RXFP2