Disease table of GLYCOGEN STORAGE DISEASE IB OMIM ID: 232220

Gene-disease associations table

GeneAssociated with GLYCOGEN STORAGE DISEASE IB inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
G6PCClinVarHGNC link17q21.312232220, 232200
SLC37A4ClinVar, OMIM, HUMSAVARHGNC link11q23.32232220, 232240

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
G6PCYES1NR0B20
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
G6PCSLC37A4yes, complexThey form the complex responsible for glucose production through glycogenolysis and gluconeogenesis. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Carbohydrate digestion and absorptionhsa049737.282SLC37A4, G6PC

NET-GE enrichment

Term New enriched termICP valueGenes
Carbohydrate digestion and absorption (hsa04973) -7.280.002SLC37A4, G6PC
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Metabolism of carbohydratesR-HSA-713874.932SLC37A4, G6PC
Transmembrane transport of small moleculesR-HSA-3825513.792SLC37A4, G6PC
Hexose transportR-HSA-1892007.432SLC37A4, G6PC
MetabolismR-HSA-14307282.342SLC37A4, G6PC
SLC-mediated transmembrane transportR-HSA-4254074.952SLC37A4, G6PC
Glucose transportR-HSA-701537.622SLC37A4, G6PC

NET-GE enrichment

Term New enriched termICP valueGenes
SLC-mediated transmembrane transport (R-HSA-425407) -4.950.007SLC37A4, G6PC
Hexose transport (R-HSA-189200) -7.430.0SLC37A4, G6PC
Glucose transport (R-HSA-70153) -7.620.0SLC37A4, G6PC
Metabolism of carbohydrates (R-HSA-71387) -4.930.007SLC37A4, G6PC
Transmembrane transport of small molecules (R-HSA-382551) -3.790.037SLC37A4, G6PC
GO - molecular function annotation: shared terms / NET-GE enrichment (no shared terms)
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
response to extracellular stimulus (GO:0009991) 3.712SLC37A4, G6PC
primary metabolic process (GO:0044238) 0.692SLC37A4, G6PC
glucose-6-phosphate transport (GO:0015760) 7.782SLC37A4, G6PC
acylglycerol metabolic process (GO:0006639) 5.272SLC37A4, G6PC
neutral lipid metabolic process (GO:0006638) 5.262SLC37A4, G6PC
homeostatic process (GO:0042592) 2.612SLC37A4, G6PC
glucose homeostasis (GO:0042593) 4.62SLC37A4, G6PC
glycogen metabolic process (GO:0005977) 5.672SLC37A4, G6PC
small molecule metabolic process (GO:0044281) 2.382SLC37A4, G6PC
response to chemical (GO:0042221) 1.982SLC37A4, G6PC
generation of precursor metabolites and energy (GO:0006091) 4.072SLC37A4, G6PC
macromolecule metabolic process (GO:0043170) 0.832SLC37A4, G6PC
cellular lipid metabolic process (GO:0044255) 2.922SLC37A4, G6PC
regulation of biological process (GO:0050789) 0.452SLC37A4, G6PC
organic cyclic compound metabolic process (GO:1901360) 1.262SLC37A4, G6PC
carbohydrate derivative transport (GO:1901264) 5.842SLC37A4, G6PC
single-organism metabolic process (GO:0044710) 1.632SLC37A4, G6PC
localization (GO:0051179) 1.42SLC37A4, G6PC
cellular carbohydrate metabolic process (GO:0044262) 4.742SLC37A4, G6PC
cellular macromolecule metabolic process (GO:0044260) 0.932SLC37A4, G6PC
hexose transport (GO:0008645) 5.762SLC37A4, G6PC
carbohydrate homeostasis (GO:0033500) 4.62SLC37A4, G6PC
carbohydrate transport (GO:0008643) 5.162SLC37A4, G6PC
glucose transport (GO:0015758) 5.82SLC37A4, G6PC
organic substance metabolic process (GO:0071704) 0.632SLC37A4, G6PC
biological regulation (GO:0065007) 0.392SLC37A4, G6PC
steroid metabolic process (GO:0008202) 4.322SLC37A4, G6PC
cellular glucan metabolic process (GO:0006073) 5.652SLC37A4, G6PC
organic substance transport (GO:0071702) 2.152SLC37A4, G6PC
single-organism localization (GO:1902578) 2.092SLC37A4, G6PC
energy reserve metabolic process (GO:0006112) 5.442SLC37A4, G6PC
regulation of biological quality (GO:0065008) 1.682SLC37A4, G6PC
developmental process (GO:0032502) 1.362SLC37A4, G6PC
multicellular organismal process (GO:0032501) 1.452SLC37A4, G6PC
lipid metabolic process (GO:0006629) 2.682SLC37A4, G6PC
triglyceride metabolic process (GO:0006641) 5.412SLC37A4, G6PC
transport (GO:0006810) 1.512SLC37A4, G6PC
hexose metabolic process (GO:0019318) 4.642SLC37A4, G6PC
cellular polysaccharide metabolic process (GO:0044264) 5.412SLC37A4, G6PC
hexose phosphate transport (GO:0015712) 7.782SLC37A4, G6PC
lipid homeostasis (GO:0055088) 5.02SLC37A4, G6PC
single-organism transport (GO:0044765) 2.182SLC37A4, G6PC
single-organism cellular process (GO:0044763) 0.652SLC37A4, G6PC
metabolic process (GO:0008152) 0.582SLC37A4, G6PC
single-organism carbohydrate metabolic process (GO:0044723) 3.422SLC37A4, G6PC
cholesterol homeostasis (GO:0042632) 5.62SLC37A4, G6PC
glycerolipid metabolic process (GO:0046486) 3.912SLC37A4, G6PC
establishment of localization (GO:0051234) 1.482SLC37A4, G6PC
glucose metabolic process (GO:0006006) 4.942SLC37A4, G6PC
oxidation-reduction process (GO:0055114) 2.912SLC37A4, G6PC
energy derivation by oxidation of organic compounds (GO:0015980) 4.932SLC37A4, G6PC
glucan metabolic process (GO:0044042) 5.652SLC37A4, G6PC
organic acid metabolic process (GO:0006082) 3.012SLC37A4, G6PC
single-organism process (GO:0044699) 0.482SLC37A4, G6PC
carbohydrate metabolic process (GO:0005975) 3.262SLC37A4, G6PC
single-multicellular organism process (GO:0044707) 1.782SLC37A4, G6PC
response to external stimulus (GO:0009605) 2.552SLC37A4, G6PC
polysaccharide metabolic process (GO:0005976) 5.322SLC37A4, G6PC
monosaccharide metabolic process (GO:0005996) 4.572SLC37A4, G6PC
response to stimulus (GO:0050896) 1.222SLC37A4, G6PC
response to nutrient levels (GO:0031667) 3.772SLC37A4, G6PC
cellular metabolic process (GO:0044237) 0.692SLC37A4, G6PC
chemical homeostasis (GO:0048878) 2.972SLC37A4, G6PC
single-organism developmental process (GO:0044767) 1.492SLC37A4, G6PC
monosaccharide transport (GO:0015749) 5.762SLC37A4, G6PC
organophosphate ester transport (GO:0015748) 5.332SLC37A4, G6PC
sterol homeostasis (GO:0055092) 5.62SLC37A4, G6PC
cellular process (GO:0009987) 0.262SLC37A4, G6PC

NET-GE enrichment

Term New enriched termICP valueGenes
glucose-6-phosphate transport (GO:0015760) -7.780.0SLC37A4, G6PC
monosaccharide metabolic process (GO:0005996) -4.570.015SLC37A4, G6PC
organophosphate ester transport (GO:0015748) -5.330.004SLC37A4, G6PC
hexose metabolic process (GO:0019318) -4.640.05SLC37A4, G6PC
carbohydrate homeostasis (GO:0033500) -4.60.042SLC37A4, G6PC
hexose phosphate transport (GO:0015712) -7.780.0SLC37A4, G6PC
carbohydrate transport (GO:0008643) -5.160.003SLC37A4, G6PC
glucose transport (GO:0015758) -5.80.001SLC37A4, G6PC
glucose homeostasis (GO:0042593) -4.60.042SLC37A4, G6PC
monosaccharide transport (GO:0015749) -5.760.004SLC37A4, G6PC
hexose transport (GO:0008645) -5.760.004SLC37A4, G6PC
glucose metabolic process (GO:0006006) -4.940.028SLC37A4, G6PC
carbohydrate derivative transport (GO:1901264) -5.840.001SLC37A4, G6PC
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.62SLC37A4, G6PC
integral component of membrane (GO:0016021) 1.142SLC37A4, G6PC
membrane (GO:0016020) 0.682SLC37A4, G6PC
cell part (GO:0044464) 0.112SLC37A4, G6PC
intracellular organelle (GO:0043229) 0.512SLC37A4, G6PC
endoplasmic reticulum membrane (GO:0005789) 2.952SLC37A4, G6PC
intracellular organelle part (GO:0044446) 0.812SLC37A4, G6PC
endoplasmic reticulum part (GO:0044432) 2.732SLC37A4, G6PC
cytoplasmic part (GO:0044444) 0.822SLC37A4, G6PC
integral component of endoplasmic reticulum membrane (GO:0030176) 5.012SLC37A4, G6PC
organelle part (GO:0044422) 0.792SLC37A4, G6PC
organelle (GO:0043226) 0.42SLC37A4, G6PC
intracellular part (GO:0044424) 0.282SLC37A4, G6PC
membrane part (GO:0044425) 0.952SLC37A4, G6PC
membrane-bounded organelle (GO:0043227) 0.472SLC37A4, G6PC
intrinsic component of endoplasmic reticulum membrane (GO:0031227) 4.972SLC37A4, G6PC
intrinsic component of membrane (GO:0031224) 1.132SLC37A4, G6PC
endoplasmic reticulum (GO:0005783) 2.562SLC37A4, G6PC

NET-GE enrichment

Term New enriched termICP valueGenes
integral component of endoplasmic reticulum membrane (GO:0030176) -5.010.002SLC37A4, G6PC
integral component of organelle membrane (GO:0031301) NEW4.850.005SLC37A4, G6PC
endoplasmic reticulum membrane (GO:0005789) -2.950.034SLC37A4, G6PC