Disease table of ARTHROGRYPOSIS, RENAL DYSFUNCTION, AND CHOLESTASIS OMIM ID: PS208085

Gene-disease associations table

GeneAssociated with ARTHROGRYPOSIS, RENAL DYSFUNCTION, AND CHOLESTASIS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
VPS33BClinVar, OMIM, HUMSAVARHGNC link15q26.11PS208085
VIPAS39ClinVar, OMIMHGNC link14q24.31PS208085

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
VPS33BVIPAS39Yes5VPS16, VPS18, VPS41, VPS11, YWHAB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
VPS33BVIPAS39Yesbinding0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
VPS33BVIPAS39Yes0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.182VPS33B, VIPAS39
protein binding (GO:0005515) 0.462VPS33B, VIPAS39
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein localization (GO:0008104) 2.362VPS33B, VIPAS39
endosome to lysosome transport (GO:0008333) 5.992VPS33B, VIPAS39
lysosomal transport (GO:0007041) 5.512VPS33B, VIPAS39
regulation of biological process (GO:0050789) 0.452VPS33B, VIPAS39
single-organism process (GO:0044699) 0.482VPS33B, VIPAS39
cellular developmental process (GO:0048869) 1.822VPS33B, VIPAS39
cellular component organization (GO:0016043) 1.242VPS33B, VIPAS39
biological regulation (GO:0065007) 0.392VPS33B, VIPAS39
cellular component organization or biogenesis (GO:0071840) 1.222VPS33B, VIPAS39
organic substance transport (GO:0071702) 2.152VPS33B, VIPAS39
autophagosome maturation (GO:0097352) 6.642VPS33B, VIPAS39
macromolecule localization (GO:0033036) 2.342VPS33B, VIPAS39
vacuole fusion (GO:0097576) 6.512VPS33B, VIPAS39
organelle organization (GO:0006996) 2.022VPS33B, VIPAS39
cellular process (GO:0009987) 0.262VPS33B, VIPAS39
transport (GO:0006810) 1.512VPS33B, VIPAS39
regulation of cellular process (GO:0050794) 0.52VPS33B, VIPAS39
establishment of protein localization (GO:0045184) 2.532VPS33B, VIPAS39
single-organism cellular process (GO:0044763) 0.652VPS33B, VIPAS39
establishment of localization in cell (GO:0051649) 2.472VPS33B, VIPAS39
establishment of localization (GO:0051234) 1.482VPS33B, VIPAS39
localization (GO:0051179) 1.42VPS33B, VIPAS39
cellular localization (GO:0051641) 2.322VPS33B, VIPAS39
endosomal transport (GO:0016197) 4.282VPS33B, VIPAS39
vacuole organization (GO:0007033) 4.672VPS33B, VIPAS39
vacuolar transport (GO:0007034) 4.182VPS33B, VIPAS39
intracellular transport (GO:0046907) 2.672VPS33B, VIPAS39
single-organism organelle organization (GO:1902589) 2.682VPS33B, VIPAS39
organelle fusion (GO:0048284) 4.862VPS33B, VIPAS39
protein transport (GO:0015031) 2.622VPS33B, VIPAS39

NET-GE enrichment

Term New enriched termICP valueGenes
vacuolar transport (GO:0007034) -4.180.009VPS33B, VIPAS39
endosome to lysosome transport (GO:0008333) -5.990.003VPS33B, VIPAS39
lysosomal transport (GO:0007041) -5.510.009VPS33B, VIPAS39
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
recycling endosome (GO:0055037) 5.112VPS33B, VIPAS39
intracellular organelle (GO:0043229) 0.512VPS33B, VIPAS39
(GO:0099023) 5.722VPS33B, VIPAS39
membrane-bounded organelle (GO:0043227) 0.472VPS33B, VIPAS39
organelle (GO:0043226) 0.42VPS33B, VIPAS39
cytoplasm (GO:0005737) 1.012VPS33B, VIPAS39
vesicle (GO:0031982) 1.642VPS33B, VIPAS39
vacuole (GO:0005773) 2.922VPS33B, VIPAS39
cytoplasmic vesicle (GO:0031410) 2.872VPS33B, VIPAS39
late endosome (GO:0005770) 4.852VPS33B, VIPAS39
membrane-bounded vesicle (GO:0031988) 1.712VPS33B, VIPAS39
HOPS complex (GO:0030897) 7.162VPS33B, VIPAS39
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122VPS33B, VIPAS39
intracellular vesicle (GO:0097708) 2.862VPS33B, VIPAS39
protein complex (GO:0043234) 1.512VPS33B, VIPAS39
macromolecular complex (GO:0032991) 1.352VPS33B, VIPAS39
intracellular membrane-bounded organelle (GO:0043231) 0.62VPS33B, VIPAS39
cell part (GO:0044464) 0.112VPS33B, VIPAS39
membrane protein complex (GO:0098796) 2.842VPS33B, VIPAS39
cytoplasmic part (GO:0044444) 0.822VPS33B, VIPAS39
intracellular part (GO:0044424) 0.282VPS33B, VIPAS39
membrane part (GO:0044425) 0.952VPS33B, VIPAS39
endosome (GO:0005768) 3.252VPS33B, VIPAS39
early endosome (GO:0005769) 4.342VPS33B, VIPAS39

NET-GE enrichment

Term New enriched termICP valueGenes
cytoplasmic membrane-bounded vesicle (GO:0016023) -3.120.037VPS33B, VIPAS39
cytoplasmic vesicle (GO:0031410) -2.870.049VPS33B, VIPAS39
late endosome (GO:0005770) -4.850.001VPS33B, VIPAS39
endosome (GO:0005768) -3.250.016VPS33B, VIPAS39