Disease table of MOLYBDENUM COFACTOR DEFICIENCY OMIM ID: PS252150

Gene-disease associations table

GeneAssociated with MOLYBDENUM COFACTOR DEFICIENCY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MOCS2ClinVar, OMIM, HUMSAVARHGNC link5q11.21PS252150
MOCS1ClinVar, OMIM, HUMSAVARHGNC link6p21.21PS252150
GPHNClinVar, OMIM, HUMSAVARHGNC link14q23.32PS252150, 149400

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
MOCS2MOCS1Yesbinding0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolic pathwayshsa011002.492MOCS2, MOCS1
Folate biosynthesishsa007908.862MOCS2, MOCS1
Sulfur relay systemhsa041229.312MOCS2, MOCS1

NET-GE enrichment

Term New enriched termICP valueGenes
Folate biosynthesis (hsa00790) -8.860.0MOCS2, MOCS1
Metabolism of cofactors and vitaminsNEW5.160.009MOCS2, MOCS1
Sulfur relay system (hsa04122) -9.310.0MOCS2, MOCS1
Folding, sorting and degradationNEW3.860.015MOCS2, MOCS1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Molybdenum cofactor biosynthesisR-HSA-94758110.183MOCS2, GPHN, MOCS1
Metabolism of vitamins and cofactorsR-HSA-1968546.543MOCS2, GPHN, MOCS1
Metabolism of water-soluble vitamins and cofactorsR-HSA-1968496.543MOCS2, GPHN, MOCS1
MetabolismR-HSA-14307282.343MOCS2, GPHN, MOCS1

NET-GE enrichment

Term New enriched termICP valueGenes
Molybdenum cofactor biosynthesis (R-HSA-947581) -10.180.0MOCS2, GPHN, MOCS1
Metabolism of vitamins and cofactors (R-HSA-196854) -6.540.0MOCS2, GPHN, MOCS1
Metabolism of water-soluble vitamins and cofactors (R-HSA-196849) -6.540.0MOCS2, GPHN, MOCS1
Metabolism (R-HSA-1430728) -2.340.008MOCS2, GPHN, MOCS1
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
organic cyclic compound binding (GO:0097159) 1.053MOCS2, GPHN, MOCS1
nucleotide binding (GO:0000166) 1.963MOCS2, GPHN, MOCS1
small molecule binding (GO:0036094) 1.893MOCS2, GPHN, MOCS1
catalytic activity (GO:0003824) 1.053MOCS2, GPHN, MOCS1
binding (GO:0005488) 0.183MOCS2, GPHN, MOCS1
heterocyclic compound binding (GO:1901363) 1.063MOCS2, GPHN, MOCS1
nucleoside phosphate binding (GO:1901265) 1.963MOCS2, GPHN, MOCS1
cation binding (GO:0043169) 1.42GPHN, MOCS1
purine ribonucleoside triphosphate binding (GO:0035639) 2.222GPHN, MOCS1
ion binding (GO:0043167) 1.362GPHN, MOCS1
carbohydrate derivative binding (GO:0097367) 2.032GPHN, MOCS1
transferase activity (GO:0016740) 1.952MOCS2, GPHN
ribonucleotide binding (GO:0032553) 2.192GPHN, MOCS1
ribonucleoside binding (GO:0032549) 2.222GPHN, MOCS1
purine ribonucleotide binding (GO:0032555) 2.22GPHN, MOCS1
purine nucleotide binding (GO:0017076) 2.192GPHN, MOCS1
metal ion binding (GO:0046872) 1.412GPHN, MOCS1
purine ribonucleoside binding (GO:0032550) 2.222GPHN, MOCS1
purine nucleoside binding (GO:0001883) 2.222GPHN, MOCS1
nucleoside binding (GO:0001882) 2.212GPHN, MOCS1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
Mo-molybdopterin cofactor biosynthetic process (GO:0006777) 7.943MOCS2, GPHN, MOCS1
coenzyme metabolic process (GO:0006732) 4.143MOCS2, GPHN, MOCS1
nucleoside triphosphate metabolic process (GO:0009141) 4.613MOCS2, GPHN, MOCS1
purine nucleoside triphosphate metabolic process (GO:0009144) 4.763MOCS2, GPHN, MOCS1
cellular biosynthetic process (GO:0044249) 1.373MOCS2, GPHN, MOCS1
cellular nitrogen compound metabolic process (GO:0034641) 1.223MOCS2, GPHN, MOCS1
nitrogen compound metabolic process (GO:0006807) 1.133MOCS2, GPHN, MOCS1
coenzyme biosynthetic process (GO:0009108) 4.893MOCS2, GPHN, MOCS1
cellular metabolic process (GO:0044237) 0.693MOCS2, GPHN, MOCS1
purine-containing compound metabolic process (GO:0072521) 4.03MOCS2, GPHN, MOCS1
organic cyclic compound biosynthetic process (GO:1901362) 1.663MOCS2, GPHN, MOCS1
ribonucleotide metabolic process (GO:0009259) 4.113MOCS2, GPHN, MOCS1
single-organism process (GO:0044699) 0.483MOCS2, GPHN, MOCS1
nucleobase-containing compound metabolic process (GO:0006139) 1.353MOCS2, GPHN, MOCS1
single-organism metabolic process (GO:0044710) 1.633MOCS2, GPHN, MOCS1
single-organism biosynthetic process (GO:0044711) 2.83MOCS2, GPHN, MOCS1
molybdopterin cofactor metabolic process (GO:0043545) 7.943MOCS2, GPHN, MOCS1
purine nucleoside metabolic process (GO:0042278) 4.323MOCS2, GPHN, MOCS1
prosthetic group metabolic process (GO:0051189) 7.943MOCS2, GPHN, MOCS1
cofactor biosynthetic process (GO:0051188) 4.623MOCS2, GPHN, MOCS1
organic substance metabolic process (GO:0071704) 0.633MOCS2, GPHN, MOCS1
ribonucleoside triphosphate metabolic process (GO:0009199) 4.773MOCS2, GPHN, MOCS1
organic cyclic compound metabolic process (GO:1901360) 1.263MOCS2, GPHN, MOCS1
heterocycle biosynthetic process (GO:0018130) 1.73MOCS2, GPHN, MOCS1
purine ribonucleoside triphosphate metabolic process (GO:0009205) 4.813MOCS2, GPHN, MOCS1
GTP metabolic process (GO:0046039) 6.593MOCS2, GPHN, MOCS1
Mo-molybdopterin cofactor metabolic process (GO:0019720) 7.943MOCS2, GPHN, MOCS1
organic substance biosynthetic process (GO:1901576) 1.343MOCS2, GPHN, MOCS1
cellular process (GO:0009987) 0.263MOCS2, GPHN, MOCS1
cellular aromatic compound metabolic process (GO:0006725) 1.33MOCS2, GPHN, MOCS1
purine ribonucleotide metabolic process (GO:0009150) 4.163MOCS2, GPHN, MOCS1
biosynthetic process (GO:0009058) 1.323MOCS2, GPHN, MOCS1
cofactor metabolic process (GO:0051186) 3.913MOCS2, GPHN, MOCS1
nucleotide metabolic process (GO:0009117) 3.733MOCS2, GPHN, MOCS1
nucleoside metabolic process (GO:0009116) 4.123MOCS2, GPHN, MOCS1
metabolic process (GO:0008152) 0.583MOCS2, GPHN, MOCS1
ribonucleoside metabolic process (GO:0009119) 4.213MOCS2, GPHN, MOCS1
purine ribonucleoside metabolic process (GO:0046128) 4.333MOCS2, GPHN, MOCS1
organophosphate biosynthetic process (GO:0090407) 3.673MOCS2, GPHN, MOCS1
nucleobase-containing small molecule metabolic process (GO:0055086) 3.593MOCS2, GPHN, MOCS1
heterocycle metabolic process (GO:0046483) 1.313MOCS2, GPHN, MOCS1
primary metabolic process (GO:0044238) 0.693MOCS2, GPHN, MOCS1
organonitrogen compound metabolic process (GO:1901564) 2.323MOCS2, GPHN, MOCS1
organonitrogen compound biosynthetic process (GO:1901566) 2.853MOCS2, GPHN, MOCS1
protein metabolic process (GO:0019538) 1.453MOCS2, GPHN, MOCS1
guanosine-containing compound metabolic process (GO:1901068) 5.93MOCS2, GPHN, MOCS1
carbohydrate derivative metabolic process (GO:1901135) 3.073MOCS2, GPHN, MOCS1
ribose phosphate metabolic process (GO:0019693) 4.063MOCS2, GPHN, MOCS1
macromolecule metabolic process (GO:0043170) 0.833MOCS2, GPHN, MOCS1
purine nucleotide metabolic process (GO:0006163) 4.093MOCS2, GPHN, MOCS1
glycosyl compound metabolic process (GO:1901657) 4.043MOCS2, GPHN, MOCS1
phosphate-containing compound metabolic process (GO:0006796) 2.163MOCS2, GPHN, MOCS1
molybdopterin cofactor biosynthetic process (GO:0032324) 7.943MOCS2, GPHN, MOCS1
phosphorus metabolic process (GO:0006793) 2.153MOCS2, GPHN, MOCS1
organophosphate metabolic process (GO:0019637) 3.043MOCS2, GPHN, MOCS1
single-organism cellular process (GO:0044763) 0.653MOCS2, GPHN, MOCS1
nucleoside phosphate metabolic process (GO:0006753) 3.713MOCS2, GPHN, MOCS1
small molecule metabolic process (GO:0044281) 2.383MOCS2, GPHN, MOCS1

NET-GE enrichment

Term New enriched termICP valueGenes
Mo-molybdopterin cofactor biosynthetic process (GO:0006777) -7.940.0MOCS2, GPHN, MOCS1
coenzyme metabolic process (GO:0006732) -4.140.0MOCS2, GPHN, MOCS1
coenzyme biosynthetic process (GO:0009108) -4.890.0MOCS2, GPHN, MOCS1
small molecule metabolic process (GO:0044281) -2.380.029MOCS2, GPHN, MOCS1
organic cyclic compound biosynthetic process (GO:1901362) -1.660.042MOCS2, GPHN, MOCS1
cofactor metabolic process (GO:0051186) -3.910.0MOCS2, GPHN, MOCS1
molybdopterin cofactor metabolic process (GO:0043545) -7.940.0MOCS2, GPHN, MOCS1
prosthetic group metabolic process (GO:0051189) -7.940.0MOCS2, GPHN, MOCS1
cofactor biosynthetic process (GO:0051188) -4.620.0MOCS2, GPHN, MOCS1
heterocycle biosynthetic process (GO:0018130) -1.70.036MOCS2, GPHN, MOCS1
water-soluble vitamin metabolic process (GO:0006767) NEW5.290.0MOCS2, GPHN, MOCS1
vitamin metabolic process (GO:0006766) NEW4.970.0MOCS2, GPHN, MOCS1
Mo-molybdopterin cofactor metabolic process (GO:0019720) -7.940.0MOCS2, GPHN, MOCS1
organophosphate biosynthetic process (GO:0090407) -3.670.002MOCS2, GPHN, MOCS1
organonitrogen compound metabolic process (GO:1901564) -2.320.006MOCS2, GPHN, MOCS1
organonitrogen compound biosynthetic process (GO:1901566) -2.850.0MOCS2, GPHN, MOCS1
phosphate-containing compound metabolic process (GO:0006796) -2.160.019MOCS2, GPHN, MOCS1
molybdopterin cofactor biosynthetic process (GO:0032324) -7.940.0MOCS2, GPHN, MOCS1
phosphorus metabolic process (GO:0006793) -2.150.02MOCS2, GPHN, MOCS1
organophosphate metabolic process (GO:0019637) -3.040.002MOCS2, GPHN, MOCS1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.283MOCS2, GPHN, MOCS1
intracellular organelle (GO:0043229) 0.513MOCS2, GPHN, MOCS1
cell part (GO:0044464) 0.113MOCS2, GPHN, MOCS1
organelle (GO:0043226) 0.43MOCS2, GPHN, MOCS1
cytoplasm (GO:0005737) 1.012MOCS2, GPHN
protein complex (GO:0043234) 1.512MOCS2, MOCS1
macromolecular complex (GO:0032991) 1.352MOCS2, MOCS1
intracellular membrane-bounded organelle (GO:0043231) 0.62MOCS2, MOCS1
nucleus (GO:0005634) 1.072MOCS2, MOCS1
cytoplasmic part (GO:0044444) 0.822MOCS2, MOCS1
molybdopterin synthase complex (GO:0019008) 9.112MOCS2, MOCS1
membrane-bounded organelle (GO:0043227) 0.472MOCS2, MOCS1
cytosol (GO:0005829) 1.682MOCS2, MOCS1

NET-GE enrichment

Term New enriched termICP valueGenes
molybdopterin synthase complex (GO:0019008) -9.110.0MOCS2, MOCS1