Disease table of COLD-INDUCED SWEATING SYNDROME OMIM ID: PS272430

Gene-disease associations table

GeneAssociated with COLD-INDUCED SWEATING SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CLCF1ClinVar, OMIM, HUMSAVARHGNC link11q13.21PS272430
CRLF1ClinVar, OMIM, HUMSAVARHGNC link19p13.111PS272430

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CRLF1YES1PLAG10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CLCF1CRLF1Yes0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
CLCF1CRLF1Yesbinding0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
CLCF1CRLF1yes, they interactThey are in interaction. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytokine receptor binding (GO:0005126) 4.142CLCF1, CRLF1
ciliary neurotrophic factor receptor binding (GO:0005127) 8.132CLCF1, CRLF1
cytokine activity (GO:0005125) 4.342CLCF1, CRLF1
binding (GO:0005488) 0.182CLCF1, CRLF1
protein binding (GO:0005515) 0.462CLCF1, CRLF1
protein dimerization activity (GO:0046983) 2.722CLCF1, CRLF1
protein heterodimerization activity (GO:0046982) 3.642CLCF1, CRLF1
receptor binding (GO:0005102) 2.432CLCF1, CRLF1

NET-GE enrichment

Term New enriched termICP valueGenes
cytokine binding (GO:0019955) NEW5.210.001CLCF1, CRLF1
protein dimerization activity (GO:0046983) -2.720.041CLCF1, CRLF1
protein heterodimerization activity (GO:0046982) -3.640.006CLCF1, CRLF1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
positive regulation of cell proliferation (GO:0008284) 3.012CLCF1, CRLF1
regulation of phosphate metabolic process (GO:0019220) 2.352CLCF1, CRLF1
regulation of primary metabolic process (GO:0080090) 1.082CLCF1, CRLF1
regulation of metabolic process (GO:0019222) 1.022CLCF1, CRLF1
regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516) 5.942CLCF1, CRLF1
positive regulation of cellular metabolic process (GO:0031325) 1.812CLCF1, CRLF1
positive regulation of response to stimulus (GO:0048584) 2.182CLCF1, CRLF1
regulation of response to stimulus (GO:0048583) 1.542CLCF1, CRLF1
positive regulation of protein metabolic process (GO:0051247) 2.432CLCF1, CRLF1
positive regulation of signaling (GO:0023056) 2.412CLCF1, CRLF1
regulation of neuron apoptotic process (GO:0043523) 4.472CLCF1, CRLF1
negative regulation of neuron apoptotic process (GO:0043524) 4.822CLCF1, CRLF1
regulation of signaling (GO:0023051) 1.722CLCF1, CRLF1
positive regulation of phosphate metabolic process (GO:0045937) 2.782CLCF1, CRLF1
positive regulation of cell communication (GO:0010647) 2.412CLCF1, CRLF1
regulation of cell communication (GO:0010646) 1.732CLCF1, CRLF1
regulation of apoptotic process (GO:0042981) 2.52CLCF1, CRLF1
regulation of biological process (GO:0050789) 0.452CLCF1, CRLF1
positive regulation of metabolic process (GO:0009893) 1.742CLCF1, CRLF1
regulation of intracellular signal transduction (GO:1902531) 2.312CLCF1, CRLF1
positive regulation of macromolecule metabolic process (GO:0010604) 1.812CLCF1, CRLF1
positive regulation of cellular process (GO:0048522) 1.32CLCF1, CRLF1
regulation of signal transduction (GO:0009966) 1.842CLCF1, CRLF1
positive regulation of signal transduction (GO:0009967) 2.52CLCF1, CRLF1
positive regulation of phosphorus metabolic process (GO:0010562) 2.782CLCF1, CRLF1
regulation of protein metabolic process (GO:0051246) 1.932CLCF1, CRLF1
positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531) 5.632CLCF1, CRLF1
regulation of programmed cell death (GO:0043067) 2.492CLCF1, CRLF1
negative regulation of apoptotic process (GO:0043066) 3.042CLCF1, CRLF1
biological regulation (GO:0065007) 0.392CLCF1, CRLF1
regulation of protein modification process (GO:0031399) 2.322CLCF1, CRLF1
positive regulation of biological process (GO:0048518) 1.22CLCF1, CRLF1
positive regulation of cellular protein metabolic process (GO:0032270) 2.492CLCF1, CRLF1
negative regulation of programmed cell death (GO:0043069) 3.022CLCF1, CRLF1
regulation of cell proliferation (GO:0042127) 2.412CLCF1, CRLF1
regulation of tyrosine phosphorylation of STAT protein (GO:0042509) 5.492CLCF1, CRLF1
positive regulation of JAK-STAT cascade (GO:0046427) 5.442CLCF1, CRLF1
positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517) 6.122CLCF1, CRLF1
regulation of JAK-STAT cascade (GO:0046425) 4.782CLCF1, CRLF1
regulation of macromolecule metabolic process (GO:0060255) 1.082CLCF1, CRLF1
negative regulation of cell death (GO:0060548) 2.952CLCF1, CRLF1
regulation of cellular process (GO:0050794) 0.52CLCF1, CRLF1
regulation of cellular metabolic process (GO:0031323) 1.072CLCF1, CRLF1
negative regulation of biological process (GO:0048519) 1.332CLCF1, CRLF1
positive regulation of intracellular signal transduction (GO:1902533) 2.952CLCF1, CRLF1
regulation of neuron death (GO:1901214) 4.192CLCF1, CRLF1
negative regulation of neuron death (GO:1901215) 4.572CLCF1, CRLF1
regulation of phosphorylation (GO:0042325) 2.52CLCF1, CRLF1
regulation of phosphorus metabolic process (GO:0051174) 2.352CLCF1, CRLF1
positive regulation of phosphorylation (GO:0042327) 2.92CLCF1, CRLF1
regulation of cellular protein metabolic process (GO:0032268) 1.992CLCF1, CRLF1
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 4.622CLCF1, CRLF1
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.352CLCF1, CRLF1
positive regulation of protein modification process (GO:0031401) 2.72CLCF1, CRLF1
regulation of cell death (GO:0010941) 2.432CLCF1, CRLF1
regulation of STAT cascade (GO:1904892) 4.782CLCF1, CRLF1
regulation of protein phosphorylation (GO:0001932) 2.572CLCF1, CRLF1
positive regulation of protein phosphorylation (GO:0001934) 2.952CLCF1, CRLF1
negative regulation of cellular process (GO:0048523) 1.412CLCF1, CRLF1
positive regulation of STAT cascade (GO:1904894) 5.442CLCF1, CRLF1

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of tyrosine phosphorylation of STAT protein (GO:0042509) -5.490.001CLCF1, CRLF1
positive regulation of JAK-STAT cascade (GO:0046427) -5.440.001CLCF1, CRLF1
regulation of JAK-STAT cascade (GO:0046425) -4.780.003CLCF1, CRLF1
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) -4.620.009CLCF1, CRLF1
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) -4.350.016CLCF1, CRLF1
mesonephric epithelium development (GO:0072163) NEW5.80.005CLCF1, CRLF1
regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516) -5.940.0CLCF1, CRLF1
positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531) -5.630.001CLCF1, CRLF1
positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517) -6.120.0CLCF1, CRLF1
regulation of neuron apoptotic process (GO:0043523) -4.470.016CLCF1, CRLF1
negative regulation of neuron apoptotic process (GO:0043524) -4.820.008CLCF1, CRLF1
negative regulation of motor neuron apoptotic process (GO:2000672) NEW8.340.0CLCF1, CRLF1
regulation of motor neuron apoptotic process (GO:2000671) NEW8.120.0CLCF1, CRLF1
ureteric bud development (GO:0001657) NEW5.970.004CLCF1, CRLF1
mesonephric tubule development (GO:0072164) NEW5.820.005CLCF1, CRLF1
regulation of neuron death (GO:1901214) -4.190.021CLCF1, CRLF1
negative regulation of neuron death (GO:1901215) -4.570.01CLCF1, CRLF1
kidney epithelium development (GO:0072073) NEW5.540.011CLCF1, CRLF1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein complex (GO:0043234) 1.512CLCF1, CRLF1
macromolecular complex (GO:0032991) 1.352CLCF1, CRLF1
extracellular space (GO:0005615) 2.632CLCF1, CRLF1
extracellular region (GO:0005576) 2.182CLCF1, CRLF1
extracellular region part (GO:0044421) 1.572CLCF1, CRLF1
CRLF-CLCF1 complex (GO:0097058) 8.72CLCF1, CRLF1

NET-GE enrichment

Term New enriched termICP valueGenes
CRLF-CLCF1 complex (GO:0097058) -8.70.0CLCF1, CRLF1