Disease table of GALLBLADDER DISEASE OMIM ID: PS600803

Gene-disease associations table

GeneAssociated with GALLBLADDER DISEASE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ABCG8ClinVar, OMIMHGNC link2p212PS600803, 210250
ABCB4ClinVar, OMIM, HUMSAVARHGNC link7q21.123PS600803, 602347, 614972

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
ABCG8YES3NR5A2, SREBF2, HNF4A0
ABCB4YES1NR1H40
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
ABC transportershsa020107.282ABCB4, ABCG8
Bile secretionhsa049766.562ABCB4, ABCG8

NET-GE enrichment

Term New enriched termICP valueGenes
Membrane transportNEW7.280.0ABCB4, ABCG8
ABC transporters (hsa02010) -7.280.0ABCB4, ABCG8
Digestive systemNEW4.120.026ABCB4, ABCG8
Bile secretion (hsa04976) -6.560.001ABCB4, ABCG8
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Metabolism of lipids and lipoproteinsR-HSA-5568333.792ABCB4, ABCG8
MetabolismR-HSA-14307282.342ABCB4, ABCG8
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
purine ribonucleoside triphosphate binding (GO:0035639) 2.222ABCB4, ABCG8
binding (GO:0005488) 0.182ABCB4, ABCG8
ATPase activity (GO:0016887) 3.652ABCB4, ABCG8
heterocyclic compound binding (GO:1901363) 1.062ABCB4, ABCG8
nucleoside phosphate binding (GO:1901265) 1.962ABCB4, ABCG8
nucleoside binding (GO:0001882) 2.212ABCB4, ABCG8
ATPase activity, coupled to transmembrane movement of substances (GO:0042626) 5.062ABCB4, ABCG8
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (GO:0016820) 5.032ABCB4, ABCG8
ATPase activity, coupled (GO:0042623) 3.972ABCB4, ABCG8
nucleotide binding (GO:0000166) 1.962ABCB4, ABCG8
primary active transmembrane transporter activity (GO:0015399) 4.982ABCB4, ABCG8
purine nucleoside binding (GO:0001883) 2.222ABCB4, ABCG8
ribonucleoside binding (GO:0032549) 2.222ABCB4, ABCG8
purine nucleotide binding (GO:0017076) 2.192ABCB4, ABCG8
ATP binding (GO:0005524) 2.432ABCB4, ABCG8
lipid transporter activity (GO:0005319) 5.032ABCB4, ABCG8
hydrolase activity (GO:0016787) 1.92ABCB4, ABCG8
transporter activity (GO:0005215) 2.572ABCB4, ABCG8
nucleoside-triphosphatase activity (GO:0017111) 3.092ABCB4, ABCG8
small molecule binding (GO:0036094) 1.892ABCB4, ABCG8
catalytic activity (GO:0003824) 1.052ABCB4, ABCG8
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032ABCB4, ABCG8
substrate-specific transporter activity (GO:0022892) 2.722ABCB4, ABCG8
adenyl nucleotide binding (GO:0030554) 2.42ABCB4, ABCG8
carbohydrate derivative binding (GO:0097367) 2.032ABCB4, ABCG8
organic cyclic compound binding (GO:0097159) 1.052ABCB4, ABCG8
ATPase activity, coupled to movement of substances (GO:0043492) 4.932ABCB4, ABCG8
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032ABCB4, ABCG8
purine ribonucleoside binding (GO:0032550) 2.222ABCB4, ABCG8
pyrophosphatase activity (GO:0016462) 3.042ABCB4, ABCG8
transmembrane transporter activity (GO:0022857) 2.822ABCB4, ABCG8
adenyl ribonucleotide binding (GO:0032559) 2.412ABCB4, ABCG8
active transmembrane transporter activity (GO:0022804) 3.852ABCB4, ABCG8
protein binding (GO:0005515) 0.462ABCB4, ABCG8
purine ribonucleotide binding (GO:0032555) 2.22ABCB4, ABCG8
P-P-bond-hydrolysis-driven transmembrane transporter activity (GO:0015405) 4.982ABCB4, ABCG8
ribonucleotide binding (GO:0032553) 2.192ABCB4, ABCG8
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
lipid transport (GO:0006869) 4.242ABCB4, ABCG8
regulation of transport (GO:0051049) 2.242ABCB4, ABCG8
phospholipid transport (GO:0015914) 5.672ABCB4, ABCG8
homeostatic process (GO:0042592) 2.612ABCB4, ABCG8
regulation of biological process (GO:0050789) 0.452ABCB4, ABCG8
single-organism process (GO:0044699) 0.482ABCB4, ABCG8
regulation of localization (GO:0032879) 1.942ABCB4, ABCG8
regulation of cholesterol transport (GO:0032374) 6.092ABCB4, ABCG8
regulation of sterol transport (GO:0032371) 6.092ABCB4, ABCG8
localization (GO:0051179) 1.42ABCB4, ABCG8
biological regulation (GO:0065007) 0.392ABCB4, ABCG8
organic substance transport (GO:0071702) 2.152ABCB4, ABCG8
regulation of biological quality (GO:0065008) 1.682ABCB4, ABCG8
transport (GO:0006810) 1.512ABCB4, ABCG8
lipid homeostasis (GO:0055088) 5.02ABCB4, ABCG8
single-organism transport (GO:0044765) 2.182ABCB4, ABCG8
response to chemical (GO:0042221) 1.982ABCB4, ABCG8
establishment of localization (GO:0051234) 1.482ABCB4, ABCG8
transmembrane transport (GO:0055085) 2.722ABCB4, ABCG8
single-organism localization (GO:1902578) 2.092ABCB4, ABCG8
regulation of lipid transport (GO:0032368) 5.212ABCB4, ABCG8
response to stimulus (GO:0050896) 1.222ABCB4, ABCG8
response to drug (GO:0042493) 3.712ABCB4, ABCG8
chemical homeostasis (GO:0048878) 2.972ABCB4, ABCG8
organophosphate ester transport (GO:0015748) 5.332ABCB4, ABCG8

NET-GE enrichment

Term New enriched termICP valueGenes
ribonucleoside monophosphate catabolic process (GO:0009158) NEW8.120.048ABCB4, ABCG8
response to drug (GO:0042493) -3.710.049ABCB4, ABCG8
purine nucleoside monophosphate catabolic process (GO:0009128) NEW7.940.048ABCB4, ABCG8
nucleoside monophosphate catabolic process (GO:0009125) NEW7.650.049ABCB4, ABCG8
purine ribonucleoside monophosphate catabolic process (GO:0009169) NEW8.120.048ABCB4, ABCG8
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
plasma membrane region (GO:0098590) 2.972ABCB4, ABCG8
apical plasma membrane (GO:0016324) 4.132ABCB4, ABCG8
integral component of membrane (GO:0016021) 1.142ABCB4, ABCG8
membrane (GO:0016020) 0.682ABCB4, ABCG8
cell part (GO:0044464) 0.112ABCB4, ABCG8
plasma membrane (GO:0005886) 1.392ABCB4, ABCG8
membrane part (GO:0044425) 0.952ABCB4, ABCG8
plasma membrane part (GO:0044459) 1.952ABCB4, ABCG8
intrinsic component of membrane (GO:0031224) 1.132ABCB4, ABCG8