Disease table of NEPHROLITHIASIS/OSTEOPOROSIS, HYPOPHOSPHATEMIC OMIM ID: PS612286

Gene-disease associations table

GeneAssociated with NEPHROLITHIASIS/OSTEOPOROSIS, HYPOPHOSPHATEMIC inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SLC34A1ClinVar, OMIM, HUMSAVARHGNC link5q35.32PS612286, PS134600
SLC9A3R1ClinVar, OMIM, HUMSAVARHGNC link17q25.11PS612286

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SLC34A1SLC9A3R1No1PDZK1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SLC34A1SLC9A3R1No-1SLC9A3R2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
SLC34A1SLC9A3R1yes, they interactThey are in interaction. [UniProt]
KEGG pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term New enriched termICP valueGenes
Phosphatidylinositol signaling system (hsa04070) NEW6.380.014SLC9A3R1, SLC34A1
Choline metabolism in cancer (hsa05231) NEW6.090.027SLC9A3R1, SLC34A1
REACTOME pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term New enriched termICP valueGenes
Transport of inorganic cations/anions and amino acids/oligopeptides (R-HSA-425393) NEW6.410.016SLC9A3R1, SLC34A1
G alpha (q) signalling events (R-HSA-416476) NEW5.420.046SLC9A3R1, SLC34A1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
PDZ domain binding (GO:0030165) 5.222SLC9A3R1, SLC34A1
macromolecular complex binding (GO:0044877) 2.612SLC9A3R1, SLC34A1
binding (GO:0005488) 0.182SLC9A3R1, SLC34A1
protein binding (GO:0005515) 0.462SLC9A3R1, SLC34A1
protein complex binding (GO:0032403) 3.092SLC9A3R1, SLC34A1
protein domain specific binding (GO:0019904) 3.322SLC9A3R1, SLC34A1

NET-GE enrichment

Term New enriched termICP valueGenes
symporter activity (GO:0015293) NEW4.780.023SLC9A3R1, SLC34A1
sodium-dependent phosphate transmembrane transporter activity (GO:0015321) NEW7.440.019SLC9A3R1, SLC34A1
phosphate ion transmembrane transporter activity (GO:0015114) NEW6.910.0SLC9A3R1, SLC34A1
PDZ domain binding (GO:0030165) -5.220.036SLC9A3R1, SLC34A1
protein domain specific binding (GO:0019904) -3.320.036SLC9A3R1, SLC34A1
inorganic anion transmembrane transporter activity (GO:0015103) NEW4.870.029SLC9A3R1, SLC34A1
channel regulator activity (GO:0016247) NEW4.880.037SLC9A3R1, SLC34A1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular homeostasis (GO:0019725) 3.232SLC9A3R1, SLC34A1
cellular component assembly (GO:0022607) 2.142SLC9A3R1, SLC34A1
macromolecular complex subunit organization (GO:0043933) 2.142SLC9A3R1, SLC34A1
regulation of transport (GO:0051049) 2.242SLC9A3R1, SLC34A1
ion homeostasis (GO:0050801) 3.422SLC9A3R1, SLC34A1
homeostatic process (GO:0042592) 2.612SLC9A3R1, SLC34A1
anion transport (GO:0006820) 3.712SLC9A3R1, SLC34A1
multicellular organismal process (GO:0032501) 1.452SLC9A3R1, SLC34A1
regulation of transmembrane transport (GO:0034762) 3.742SLC9A3R1, SLC34A1
inorganic ion homeostasis (GO:0098771) 3.432SLC9A3R1, SLC34A1
regulation of ion transmembrane transport (GO:0034765) 3.772SLC9A3R1, SLC34A1
anatomical structure morphogenesis (GO:0009653) 2.532SLC9A3R1, SLC34A1
cellular phosphate ion homeostasis (GO:0030643) 7.532SLC9A3R1, SLC34A1
regulation of biological process (GO:0050789) 0.452SLC9A3R1, SLC34A1
cellular component organization or biogenesis (GO:0071840) 1.222SLC9A3R1, SLC34A1
trivalent inorganic anion homeostasis (GO:0072506) 7.242SLC9A3R1, SLC34A1
regulation of localization (GO:0032879) 1.942SLC9A3R1, SLC34A1
cellular trivalent inorganic anion homeostasis (GO:0072502) 7.532SLC9A3R1, SLC34A1
protein complex subunit organization (GO:0071822) 2.62SLC9A3R1, SLC34A1
cellular component organization (GO:0016043) 1.242SLC9A3R1, SLC34A1
macromolecular complex assembly (GO:0065003) 2.552SLC9A3R1, SLC34A1
biological regulation (GO:0065007) 0.392SLC9A3R1, SLC34A1
single-organism process (GO:0044699) 0.482SLC9A3R1, SLC34A1
positive regulation of biological process (GO:0048518) 1.22SLC9A3R1, SLC34A1
regulation of biological quality (GO:0065008) 1.682SLC9A3R1, SLC34A1
monovalent inorganic cation transport (GO:0015672) 3.742SLC9A3R1, SLC34A1
developmental process (GO:0032502) 1.362SLC9A3R1, SLC34A1
organ morphogenesis (GO:0009887) 3.552SLC9A3R1, SLC34A1
transport (GO:0006810) 1.512SLC9A3R1, SLC34A1
cation transport (GO:0006812) 3.112SLC9A3R1, SLC34A1
ion transport (GO:0006811) 2.662SLC9A3R1, SLC34A1
protein complex assembly (GO:0006461) 2.782SLC9A3R1, SLC34A1
cellular ion homeostasis (GO:0006873) 3.572SLC9A3R1, SLC34A1
sodium ion transport (GO:0006814) 4.752SLC9A3R1, SLC34A1
single-organism developmental process (GO:0044767) 1.492SLC9A3R1, SLC34A1
single-organism cellular process (GO:0044763) 0.652SLC9A3R1, SLC34A1
cellular anion homeostasis (GO:0030002) 7.022SLC9A3R1, SLC34A1
anion homeostasis (GO:0055081) 6.682SLC9A3R1, SLC34A1
cellular chemical homeostasis (GO:0055082) 3.42SLC9A3R1, SLC34A1
establishment of localization (GO:0051234) 1.482SLC9A3R1, SLC34A1
localization (GO:0051179) 1.42SLC9A3R1, SLC34A1
phosphate ion homeostasis (GO:0055062) 7.242SLC9A3R1, SLC34A1
chemical homeostasis (GO:0048878) 2.972SLC9A3R1, SLC34A1
regulation of ion transport (GO:0043269) 3.42SLC9A3R1, SLC34A1
metal ion transport (GO:0030001) 3.362SLC9A3R1, SLC34A1
cellular process (GO:0009987) 0.262SLC9A3R1, SLC34A1

NET-GE enrichment

Term New enriched termICP valueGenes
fat-soluble vitamin metabolic process (GO:0006775) NEW6.260.016SLC9A3R1, SLC34A1
positive regulation of transmembrane transport (GO:0034764) NEW4.990.014SLC9A3R1, SLC34A1
positive regulation of ion transmembrane transport (GO:0034767) NEW5.050.012SLC9A3R1, SLC34A1
cellular phosphate ion homeostasis (GO:0030643) -7.530.0SLC9A3R1, SLC34A1
trivalent inorganic anion homeostasis (GO:0072506) -7.240.0SLC9A3R1, SLC34A1
cellular trivalent inorganic anion homeostasis (GO:0072502) -7.530.0SLC9A3R1, SLC34A1
sodium-dependent phosphate transport (GO:0044341) NEW7.430.0SLC9A3R1, SLC34A1
response to mercury ion (GO:0046689) NEW7.020.001SLC9A3R1, SLC34A1
positive regulation of membrane potential (GO:0045838) NEW7.430.008SLC9A3R1, SLC34A1
phosphate ion transport (GO:0006817) NEW6.840.001SLC9A3R1, SLC34A1
sodium ion transport (GO:0006814) -4.750.019SLC9A3R1, SLC34A1
phosphate ion homeostasis (GO:0055062) -7.240.0SLC9A3R1, SLC34A1
anion homeostasis (GO:0055081) -6.680.001SLC9A3R1, SLC34A1
indole-containing compound metabolic process (GO:0042430) NEW6.510.007SLC9A3R1, SLC34A1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
plasma membrane region (GO:0098590) 2.972SLC9A3R1, SLC34A1
membrane raft (GO:0045121) 4.182SLC9A3R1, SLC34A1
intracellular organelle (GO:0043229) 0.512SLC9A3R1, SLC34A1
membrane-bounded organelle (GO:0043227) 0.472SLC9A3R1, SLC34A1
organelle (GO:0043226) 0.42SLC9A3R1, SLC34A1
cytoplasm (GO:0005737) 1.012SLC9A3R1, SLC34A1
vesicle (GO:0031982) 1.642SLC9A3R1, SLC34A1
membrane (GO:0016020) 0.682SLC9A3R1, SLC34A1
perinuclear region of cytoplasm (GO:0048471) 3.352SLC9A3R1, SLC34A1
plasma membrane part (GO:0044459) 1.952SLC9A3R1, SLC34A1
apical plasma membrane (GO:0016324) 4.132SLC9A3R1, SLC34A1
membrane region (GO:0098589) 3.952SLC9A3R1, SLC34A1
cell projection membrane (GO:0031253) 4.112SLC9A3R1, SLC34A1
plasma membrane (GO:0005886) 1.392SLC9A3R1, SLC34A1
intracellular membrane-bounded organelle (GO:0043231) 0.62SLC9A3R1, SLC34A1
cell projection part (GO:0044463) 2.972SLC9A3R1, SLC34A1
cell part (GO:0044464) 0.112SLC9A3R1, SLC34A1
brush border membrane (GO:0031526) 5.782SLC9A3R1, SLC34A1
cytoplasmic part (GO:0044444) 0.822SLC9A3R1, SLC34A1
intracellular part (GO:0044424) 0.282SLC9A3R1, SLC34A1
membrane part (GO:0044425) 0.952SLC9A3R1, SLC34A1
membrane microdomain (GO:0098857) 4.172SLC9A3R1, SLC34A1

NET-GE enrichment

Term New enriched termICP valueGenes
plasma membrane region (GO:0098590) -2.970.025SLC9A3R1, SLC34A1
apical plasma membrane (GO:0016324) -4.130.008SLC9A3R1, SLC34A1
membrane raft (GO:0045121) -4.180.006SLC9A3R1, SLC34A1
cell projection membrane (GO:0031253) -4.110.009SLC9A3R1, SLC34A1
brush border membrane (GO:0031526) -5.780.004SLC9A3R1, SLC34A1
intrinsic component of membrane (GO:0031224) NEW1.130.008SLC9A3R1, SLC34A1