| Gene | Associated with GLYCINE ENCEPHALOPATHY in | Link to HGNC | Cytogenetic band | Number of associated diseases | Associated diseases |
|---|---|---|---|---|---|
| GLDC | ClinVar, OMIM, HUMSAVAR | HGNC link | 9p24.1 | 1 | 605899 |
| AMT | ClinVar, OMIM, HUMSAVAR | HGNC link | 3p21.31 | 1 | 605899 |
| GCSH | ClinVar, OMIM | HGNC link | 16q23.2 | 1 | 605899 |
Download the disease annotation in CSV format
| Gene1 | Gene2 | Direct Interaction | Interaction mode | Number of shared interactors | Shared genes in interaction |
|---|---|---|---|---|---|
| GLDC | AMT | Yes | binding | 2 | DLD, GCSH |
| GLDC | GCSH | Yes | binding | 1 | AMT |
| AMT | GCSH | Yes | binding | 1 | GLDC |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
| Gene1 | Gene2 | Direct interaction | More information |
|---|---|---|---|
| AMT | GCSH | yes, they interact but maybe not in complex | The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST or AMT), L (DLD) and H (GCSH). [UniProt] |
| AMT | GLDC | yes, they interact but maybe not in complex | The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST or AMT), L (DLD) and H (GCSH). [UniProt] |
| GCSH | GLDC | yes, they interact but maybe not in complex | The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST or AMT), L (DLD) and H (GCSH). [UniProt] |
| KEGG term | KEGG term ID | IC | Number of genes with the same term | Genes |
|---|---|---|---|---|
| Glycine, serine and threonine metabolism | hsa00260 | 7.45 | 3 | AMT, GLDC, GCSH |
| Carbon metabolism | hsa01200 | 6.03 | 2 | AMT, GLDC |
| Metabolic pathways | hsa01100 | 2.49 | 2 | AMT, GLDC |
| Term | New enriched term | IC | P value | Genes |
|---|---|---|---|---|
| Glycine, serine and threonine metabolism (hsa00260) | - | 7.45 | 0.0 | AMT, GLDC, GCSH |
| Carbon metabolism (hsa01200) | - | 6.03 | 0.008 | AMT, GLDC, GCSH |
| Amino acid metabolism | NEW | 4.63 | 0.001 | AMT, GLDC, GCSH |
| One carbon pool by folate (hsa00670) | NEW | 8.52 | 0.002 | AMT, GCSH |
| GO | IC | Number of genes with the same GO | Genes |
|---|---|---|---|
| catalytic activity (GO:0003824) | 1.05 | 3 | AMT, GLDC, GCSH |
| aminomethyltransferase activity (GO:0004047) | 9.05 | 2 | AMT, GCSH |
| transferase activity (GO:0016740) | 1.95 | 2 | AMT, GCSH |
| transferase activity, transferring one-carbon groups (GO:0016741) | 4.3 | 2 | AMT, GCSH |
| binding (GO:0005488) | 0.18 | 2 | GLDC, GCSH |
| methyltransferase activity (GO:0008168) | 4.35 | 2 | AMT, GCSH |
| Term | New enriched term | IC | P value | Genes |
|---|---|---|---|---|
| aminomethyltransferase activity (GO:0004047) | - | 9.05 | 0.0 | AMT, GCSH |
| transaminase activity (GO:0008483) | NEW | 6.74 | 0.001 | AMT, GCSH |
| transferase activity, transferring one-carbon groups (GO:0016741) | - | 4.3 | 0.012 | AMT, GCSH |
| methyltransferase activity (GO:0008168) | - | 4.35 | 0.01 | AMT, GCSH |
| transferase activity, transferring nitrogenous groups (GO:0016769) | NEW | 6.65 | 0.001 | AMT, GCSH |
| electron carrier activity (GO:0009055) | NEW | 4.97 | 0.018 | GLDC, GCSH |
| Term | New enriched term | IC | P value | Genes |
|---|---|---|---|---|
| mitochondrion (GO:0005739) | - | 2.42 | 0.004 | AMT, GLDC, GCSH |