| Disease ID | Disease name | Source of annotation with ADAM10 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 615590 | ALZHEIMER DISEASE 18 | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | ADAM10 |
| PS179850 | RETICULATE PIGMENT DISORDERS | OMIM, HUMSAVAR | link to OMIM | 5 | ADAM10, POFUT1, POGLUT1, ADAR, KRT5 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Epithelial cell signaling in Helicobacter pylori infection | hsa05120 | 6.58 |
| Alzheimer's disease | hsa05010 | 5.34 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Signaling by NOTCH | R-HSA-157118 | 6.2 |
| Extracellular matrix organization | R-HSA-1474244 | 4.91 |
| Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | R-HSA-2660826 | 10.18 |
| Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | R-HSA-2660825 | 10.18 |
| Collagen degradation | R-HSA-1442490 | 7.03 |
| Developmental Biology | R-HSA-1266738 | 3.48 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 8.08 |
| Signaling by NOTCH4 | R-HSA-1980150 | 9.52 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 6.11 |
| Disease | R-HSA-1643685 | 3.33 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 7.15 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | R-HSA-2691232 | 9.08 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | R-HSA-2691230 | 9.08 |
| Diseases of signal transduction | R-HSA-5663202 | 4.89 |
| EPH-Ephrin signaling | R-HSA-2682334 | 6.43 |
| Signaling by EGFR | R-HSA-177929 | 4.59 |
| Signaling by NOTCH1 | R-HSA-1980143 | 6.81 |
| Signaling by NOTCH2 | R-HSA-1980145 | 7.98 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 7.34 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 7.15 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 7.15 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 7.15 |
| Signaling by NOTCH3 | R-HSA-1980148 | 9.52 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 7.15 |
| Axon guidance | R-HSA-422475 | 3.93 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 8.59 |
| GO term | GO ID | GO IC |
|---|---|---|
| endopeptidase activity | GO:0004175 | 3.63 |
| integrin binding | GO:0005178 | 5.07 |
| SH3 domain binding | GO:0017124 | 4.98 |
| enzyme binding | GO:0019899 | 2.27 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| peptidase activity | GO:0008233 | 3.23 |
| metallopeptidase activity | GO:0008237 | 4.5 |
| cation binding | GO:0043169 | 1.4 |
| transition metal ion binding | GO:0046914 | 2.48 |
| ion binding | GO:0043167 | 1.36 |
| protein complex binding | GO:0032403 | 3.09 |
| metal ion binding | GO:0046872 | 1.41 |
| identical protein binding | GO:0042802 | 2.63 |
| protein homodimerization activity | GO:0042803 | 3.16 |
| hydrolase activity | GO:0016787 | 1.9 |
| metalloendopeptidase activity | GO:0004222 | 5.02 |
| protein kinase binding | GO:0019901 | 3.44 |
| catalytic activity | GO:0003824 | 1.05 |
| protein domain specific binding | GO:0019904 | 3.32 |
| cell adhesion molecule binding | GO:0050839 | 4.5 |
| receptor binding | GO:0005102 | 2.43 |
| kinase binding | GO:0019900 | 3.32 |
| peptidase activity, acting on L-amino acid peptides | GO:0070011 | 3.26 |
| protein binding | GO:0005515 | 0.46 |
| protein dimerization activity | GO:0046983 | 2.72 |
| zinc ion binding | GO:0008270 | 2.66 |