| Disease ID | Disease name | Source of annotation with CD4 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 613949 | OKT4 EPITOPE DEFICIENCY | ClinVar, OMIM | link to OMIM | 1 | CD4 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| T cell receptor signaling pathway | hsa04660 | 6.01 |
| Primary immunodeficiency | hsa05340 | 7.52 |
| Cell adhesion molecules (CAMs) | hsa04514 | 5.36 |
| Hematopoietic cell lineage | hsa04640 | 6.18 |
| Antigen processing and presentation | hsa04612 | 6.04 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Generation of second messenger molecules | R-HSA-202433 | 7.34 |
| PD-1 signaling | R-HSA-389948 | 7.62 |
| Translocation of ZAP-70 to Immunological synapse | R-HSA-202430 | 7.81 |
| Immune System | R-HSA-168256 | 2.37 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 8.18 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | R-HSA-164938 | 8.59 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 7.31 |
| Disease | R-HSA-1643685 | 3.33 |
| Defensins | R-HSA-1461973 | 7.49 |
| Binding and entry of HIV virion | R-HSA-173107 | 10.98 |
| Nef Mediated CD4 Down-regulation | R-HSA-167590 | 9.81 |
| HIV Infection | R-HSA-162906 | 5.22 |
| Adaptive Immune System | R-HSA-1280218 | 3.19 |
| Costimulation by the CD28 family | R-HSA-388841 | 6.56 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 9.4 |
| TCR signaling | R-HSA-202403 | 6.64 |
| Infectious disease | R-HSA-5663205 | 4.47 |
| Downstream TCR signaling | R-HSA-202424 | 7.01 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 7.73 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Host Interactions of HIV factors | R-HSA-162909 | 5.99 |
| HIV Life Cycle | R-HSA-162587 | 5.89 |
| Alpha-defensins | R-HSA-1462054 | 9.81 |
| GO term | GO ID | GO IC |
|---|---|---|
| extracellular matrix structural constituent | GO:0005201 | 5.37 |
| signaling receptor activity | GO:0038023 | 2.49 |
| enzyme binding | GO:0019899 | 2.27 |
| molecular transducer activity | GO:0060089 | 2.32 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| signal transducer activity | GO:0004871 | 2.28 |
| structural molecule activity | GO:0005198 | 3.1 |
| protein complex binding | GO:0032403 | 3.09 |
| glycoprotein binding | GO:0001948 | 5.11 |
| cation binding | GO:0043169 | 1.4 |
| transition metal ion binding | GO:0046914 | 2.48 |
| ion binding | GO:0043167 | 1.36 |
| receptor activity | GO:0004872 | 2.32 |
| metal ion binding | GO:0046872 | 1.41 |
| coreceptor activity | GO:0015026 | 6.1 |
| identical protein binding | GO:0042802 | 2.63 |
| protein homodimerization activity | GO:0042803 | 3.16 |
| MHC class II protein binding | GO:0042289 | 8.13 |
| MHC protein binding | GO:0042287 | 6.18 |
| protein kinase binding | GO:0019901 | 3.44 |
| kinase binding | GO:0019900 | 3.32 |
| receptor binding | GO:0005102 | 2.43 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| protein tyrosine kinase binding | GO:1990782 | 5.7 |
| virus receptor activity | GO:0001618 | 5.49 |
| immunoglobulin binding | GO:0019865 | 6.6 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| protein binding | GO:0005515 | 0.46 |
| protein dimerization activity | GO:0046983 | 2.72 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| zinc ion binding | GO:0008270 | 2.66 |