Gene table of CYP2C19 : cytochrome P450 family 2 subfamily C member 19

Gene-disease associations table

Disease IDDisease nameSource of annotation with CYP2C19OMIM linkNumber of associated genesgenes
609535DRUG METABOLISM, POOR, CYP2C19-RELATEDOMIM link to OMIM 1CYP2C19

Download the gene annotation in CSV format

Annotation of the gene CYP2C19

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation

The gene is in the tandem Group 475, together with the genes:

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Drug metabolism - cytochrome P450hsa009826.6
Chemical carcinogenesishsa052046.36
Arachidonic acid metabolismhsa005906.79
Linoleic acid metabolismhsa005917.91
Serotonergic synapsehsa047265.84
Metabolic pathwayshsa011002.49
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
XenobioticsR-HSA-2119818.66
Biological oxidationsR-HSA-2118595.55
CYP2E1 reactionsR-HSA-2119999.52
Arachidonic acid metabolismR-HSA-21427537.34
Cytochrome P450 - arranged by substrate typeR-HSA-2118977.08
Phase 1 - Functionalization of compoundsR-HSA-2119456.7
MetabolismR-HSA-14307282.34
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)R-HSA-21426709.98
Metabolism of lipids and lipoproteinsR-HSA-5568333.79
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)R-HSA-21428169.81
Associated GO terms for Molecular function
GO termGO IDGO IC
monooxygenase activityGO:00044975.1
limonene monooxygenase activityGO:00191139.05
enzyme bindingGO:00198992.27
bindingGO:00054880.18
heterocyclic compound bindingGO:19013631.06
oxidoreductase activityGO:00164913.12
cation bindingGO:00431691.4
transition metal ion bindingGO:00469142.48
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenGO:00167096.07
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenGO:00167054.65
ion bindingGO:00431671.36
iron ion bindingGO:00055064.65
metal ion bindingGO:00468721.41
(S)-limonene 6-monooxygenase activityGO:00186759.05
(S)-limonene 7-monooxygenase activityGO:00186769.05
heme bindingGO:00200374.86
catalytic activityGO:00038241.05
oxygen bindingGO:00198255.89
tetrapyrrole bindingGO:00469064.8
organic cyclic compound bindingGO:00971591.05
(R)-limonene 6-monooxygenase activityGO:00527419.05
protein bindingGO:00055150.46
steroid hydroxylase activityGO:00083956.3
arachidonic acid epoxygenase activityGO:00083927.03
arachidonic acid monooxygenase activityGO:00083917.03