Disease ID | Disease name | Source of annotation with DHFR | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
613839 | MEGALOBLASTIC ANEMIA DUE TO DIHYDROFOLATE REDUCTASE DEFICIENCY | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | DHFR |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Metabolic pathways | hsa01100 | 2.49 |
Folate biosynthesis | hsa00790 | 8.86 |
One carbon pool by folate | hsa00670 | 8.52 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Mitotic G1-G1/S phases | R-HSA-453279 | 5.91 |
Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 6.54 |
Metabolism of folate and pterines | R-HSA-196757 | 9.81 |
G1/S Transition | R-HSA-69206 | 6.21 |
Metabolism of vitamins and cofactors | R-HSA-196854 | 6.54 |
G1/S-Specific Transcription | R-HSA-69205 | 8.89 |
eNOS activation and regulation | R-HSA-203765 | 8.81 |
Metabolism of nitric oxide | R-HSA-202131 | 8.81 |
Cell Cycle, Mitotic | R-HSA-69278 | 4.16 |
Metabolism | R-HSA-1430728 | 2.34 |
Cell Cycle | R-HSA-1640170 | 3.89 |
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 9.66 |
E2F mediated regulation of DNA replication | R-HSA-113510 | 7.94 |
GO term | GO ID | GO IC |
---|---|---|
drug binding | GO:0008144 | 5.03 |
binding | GO:0005488 | 0.18 |
nucleic acid binding | GO:0003676 | 1.44 |
nucleotide binding | GO:0000166 | 1.96 |
heterocyclic compound binding | GO:1901363 | 1.06 |
nucleoside phosphate binding | GO:1901265 | 1.96 |
oxidoreductase activity | GO:0016491 | 3.12 |
anion binding | GO:0043168 | 4.17 |
coenzyme binding | GO:0050662 | 4.53 |
NADP binding | GO:0050661 | 5.93 |
folic acid binding | GO:0005542 | 7.17 |
folate reductase activity | GO:0033560 | 9.74 |
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor | GO:0016646 | 6.79 |
oxidoreductase activity, acting on the CH-NH group of donors | GO:0016645 | 6.41 |
ion binding | GO:0043167 | 1.36 |
methotrexate binding | GO:0051870 | 8.64 |
dihydrofolate reductase activity | GO:0004146 | 9.05 |
amide binding | GO:0033218 | 4.14 |
poly(A) RNA binding | GO:0044822 | 2.69 |
small molecule binding | GO:0036094 | 1.89 |
catalytic activity | GO:0003824 | 1.05 |
cofactor binding | GO:0048037 | 4.16 |
modified amino acid binding | GO:0072341 | 5.56 |
organic acid binding | GO:0043177 | 6.6 |
organic cyclic compound binding | GO:0097159 | 1.05 |
carboxylic acid binding | GO:0031406 | 4.64 |
vitamin binding | GO:0019842 | 5.34 |
RNA binding | GO:0003723 | 2.36 |
NADPH binding | GO:0070402 | 7.1 |
mRNA binding | GO:0003729 | 4.68 |