| Disease ID | Disease name | Source of annotation with DHFR | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 613839 | MEGALOBLASTIC ANEMIA DUE TO DIHYDROFOLATE REDUCTASE DEFICIENCY | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | DHFR |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Metabolic pathways | hsa01100 | 2.49 |
| Folate biosynthesis | hsa00790 | 8.86 |
| One carbon pool by folate | hsa00670 | 8.52 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Mitotic G1-G1/S phases | R-HSA-453279 | 5.91 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 6.54 |
| Metabolism of folate and pterines | R-HSA-196757 | 9.81 |
| G1/S Transition | R-HSA-69206 | 6.21 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 6.54 |
| G1/S-Specific Transcription | R-HSA-69205 | 8.89 |
| eNOS activation and regulation | R-HSA-203765 | 8.81 |
| Metabolism of nitric oxide | R-HSA-202131 | 8.81 |
| Cell Cycle, Mitotic | R-HSA-69278 | 4.16 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Cell Cycle | R-HSA-1640170 | 3.89 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 9.66 |
| E2F mediated regulation of DNA replication | R-HSA-113510 | 7.94 |
| GO term | GO ID | GO IC |
|---|---|---|
| drug binding | GO:0008144 | 5.03 |
| binding | GO:0005488 | 0.18 |
| nucleic acid binding | GO:0003676 | 1.44 |
| nucleotide binding | GO:0000166 | 1.96 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| oxidoreductase activity | GO:0016491 | 3.12 |
| anion binding | GO:0043168 | 4.17 |
| coenzyme binding | GO:0050662 | 4.53 |
| NADP binding | GO:0050661 | 5.93 |
| folic acid binding | GO:0005542 | 7.17 |
| folate reductase activity | GO:0033560 | 9.74 |
| oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor | GO:0016646 | 6.79 |
| oxidoreductase activity, acting on the CH-NH group of donors | GO:0016645 | 6.41 |
| ion binding | GO:0043167 | 1.36 |
| methotrexate binding | GO:0051870 | 8.64 |
| dihydrofolate reductase activity | GO:0004146 | 9.05 |
| amide binding | GO:0033218 | 4.14 |
| poly(A) RNA binding | GO:0044822 | 2.69 |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| cofactor binding | GO:0048037 | 4.16 |
| modified amino acid binding | GO:0072341 | 5.56 |
| organic acid binding | GO:0043177 | 6.6 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| carboxylic acid binding | GO:0031406 | 4.64 |
| vitamin binding | GO:0019842 | 5.34 |
| RNA binding | GO:0003723 | 2.36 |
| NADPH binding | GO:0070402 | 7.1 |
| mRNA binding | GO:0003729 | 4.68 |