Gene table of ERBB3 : erb-b2 receptor tyrosine kinase 3

Gene-disease associations table

Disease ID	Disease name	Source of annotation with ERBB3	OMIM link	Number of associated genes	genes
PS253310	LETHAL CONGENITAL CONTRACTURE SYNDROME	ClinVar, OMIM	link to OMIM	9	MYBPC1, ZBTB42, ERBB3, GLE1, ADGRG6, CNTNAP1, DNM2, PIP5K1C, ADCY6

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Annotation of the gene ERBB3

Associated genes in ENSEMBL

ENSG00000065361

Associated proteins - SwissProt Accession ID

P21860

Associated PDB IDs

Cytogenetic Band

12q13.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Proteoglycans in cancer	hsa05205	5.02
Calcium signaling pathway	hsa04020	5.22
MicroRNAs in cancer	hsa05206	5.38
ErbB signaling pathway	hsa04012	6.15
Endocytosis	hsa04144	4.92

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85
Signalling by NGF	R-HSA-166520	4.23
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26
NCAM signaling for neurite out-growth	R-HSA-375165	4.9
PI3K/AKT activation	R-HSA-198203	6.32
Signaling by Interleukins	R-HSA-449147	4.71
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62
Signaling by Leptin	R-HSA-2586552	5.1
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.05
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
IGF1R signaling cascade	R-HSA-2428924	4.85
Downstream signal transduction	R-HSA-186763	4.65
GAB1 signalosome	R-HSA-180292	6.31
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85
Signaling by ERBB4	R-HSA-1236394	4.7
IRS-mediated signalling	R-HSA-112399	4.87
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11
Adaptive Immune System	R-HSA-1280218	3.19
Disease	R-HSA-1643685	3.33
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71
MAPK family signaling cascades	R-HSA-5683057	4.89
PIP3 activates AKT signaling	R-HSA-1257604	6.37
PI-3K cascade:FGFR3	R-HSA-5654710	6.37
Signaling by VEGF	R-HSA-194138	4.66
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12
PI-3K cascade:FGFR1	R-HSA-5654689	6.37
FCERI mediated MAPK activation	R-HSA-2871796	4.32
Signaling by EGFR	R-HSA-177929	4.59
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14
SOS-mediated signalling	R-HSA-112412	5.15
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14
Developmental Biology	R-HSA-1266738	3.48
Signaling by Insulin receptor	R-HSA-74752	4.73
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71
RAF/MAP kinase cascade	R-HSA-5673001	5.15
Signaling by FGFR4	R-HSA-5654743	4.69
Signaling by FGFR3	R-HSA-5654741	4.69
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15
Interleukin receptor SHC signaling	R-HSA-912526	5.09
Signaling by FGFR	R-HSA-190236	4.67
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56
Diseases of signal transduction	R-HSA-5663202	4.89
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03
Immune System	R-HSA-168256	2.37
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71
Innate Immune System	R-HSA-168249	3.17
Signaling by SCF-KIT	R-HSA-1433557	4.73
Interleukin-2 signaling	R-HSA-451927	5.05
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15
Signaling by ERBB2	R-HSA-1227986	4.66
Signalling to RAS	R-HSA-167044	5.08
DAP12 signaling	R-HSA-2424491	4.64
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99
GRB7 events in ERBB2 signaling	R-HSA-1306955	10.66
PI-3K cascade:FGFR2	R-HSA-5654695	6.37
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71
Signaling by FGFR1	R-HSA-5654736	4.69
SHC1 events in EGFR signaling	R-HSA-180336	5.15
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14
Prolonged ERK activation events	R-HSA-169893	5.11
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	9.28
Signaling by GPCR	R-HSA-372790	2.68
Signaling by FGFR2	R-HSA-5654738	4.68
GRB2 events in EGFR signaling	R-HSA-179812	5.15
Signalling to ERKs	R-HSA-187687	5.04
Insulin receptor signalling cascade	R-HSA-74751	4.85
ARMS-mediated activation	R-HSA-170984	5.12
Frs2-mediated activation	R-HSA-170968	5.12
PI-3K cascade:FGFR4	R-HSA-5654720	6.37
DAP12 interactions	R-HSA-2172127	4.56
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15
Signaling by PDGF	R-HSA-186797	4.53
Axon guidance	R-HSA-422475	3.93
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
Ras guanyl-nucleotide exchange factor activity	GO:0005088	4.31
signaling receptor activity	GO:0038023	2.49
kinase regulator activity	GO:0019207	4.5
purine ribonucleoside triphosphate binding	GO:0035639	2.22
kinase activator activity	GO:0019209	5.58
guanyl-nucleotide exchange factor activity	GO:0005085	4.02
growth factor binding	GO:0019838	4.89
molecular transducer activity	GO:0060089	2.32
receptor activity	GO:0004872	2.32
phosphatidylinositol 3-kinase activity	GO:0035004	5.49
enzyme activator activity	GO:0008047	3.56
molecular function regulator	GO:0098772	2.51
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	5.61
receptor signaling protein activity	GO:0005057	4.76
transferase activity	GO:0016740	1.95
nucleotide binding	GO:0000166	1.96
receptor signaling protein tyrosine kinase activity	GO:0004716	7.44
phosphatidylinositol bisphosphate kinase activity	GO:0052813	5.56
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
identical protein binding	GO:0042802	2.63
protein tyrosine kinase activity	GO:0004713	4.54
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
protein kinase activity	GO:0004672	3.27
ATP binding	GO:0005524	2.43
protein homodimerization activity	GO:0042803	3.16
protein kinase regulator activity	GO:0019887	4.6
enzyme regulator activity	GO:0030234	2.85
kinase activity	GO:0016301	2.93
nucleoside phosphate binding	GO:1901265	1.96
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
neuregulin binding	GO:0038132	8.13
signal transducer activity	GO:0004871	2.28
protein kinase activator activity	GO:0030295	5.68
protein tyrosine kinase activator activity	GO:0030296	6.91
protein heterodimerization activity	GO:0046982	3.64
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
transmembrane signaling receptor activity	GO:0004888	2.57
adenyl ribonucleotide binding	GO:0032559	2.41
transmembrane receptor activity	GO:0099600	2.53
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
protein dimerization activity	GO:0046983	2.72
transmembrane receptor protein kinase activity	GO:0019199	5.32
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
binding	GO:0005488	0.18