Gene table of LRP6 : LDL receptor related protein 6

Gene-disease associations table

Disease ID	Disease name	Source of annotation with LRP6	OMIM link	Number of associated genes	genes
PS106600	TOOTH AGENESIS, SELECTIVE	ClinVar, OMIM	link to OMIM	5	PAX9, MSX1, EDA, LRP6, WNT10A
610947	CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	LRP6

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Wnt signaling pathway	hsa04310	5.49

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signaling by Wnt	R-HSA-195721	4.79
RNF mutants show enhanced WNT signaling and proliferation	R-HSA-5340588	9.98
Diseases of signal transduction	R-HSA-5663202	4.89
Signaling by WNT in cancer	R-HSA-4791275	7.89
disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.03
Signal Transduction	R-HSA-162582	1.78
TCF dependent signaling in response to WNT	R-HSA-201681	5.36
regulation of FZD by ubiquitination	R-HSA-4641263	8.59
negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	9.08
Disease	R-HSA-1643685	3.33

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cargo receptor activity	GO:0038024	5.53
signaling receptor activity	GO:0038023	2.49
lipoprotein particle receptor activity	GO:0030228	6.97
molecular transducer activity	GO:0060089	2.32
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
G-protein coupled receptor binding	GO:0001664	4.18
enzyme inhibitor activity	GO:0004857	3.78
molecular function regulator	GO:0098772	2.51
kinase regulator activity	GO:0019207	4.5
apolipoprotein binding	GO:0034185	6.97
coreceptor activity	GO:0015026	6.1
identical protein binding	GO:0042802	2.63
protein homodimerization activity	GO:0042803	3.16
kinase inhibitor activity	GO:0019210	5.25
coreceptor activity involved in canonical Wnt signaling pathway	GO:1904928	9.05
transporter activity	GO:0005215	2.57
enzyme regulator activity	GO:0030234	2.85
toxin transporter activity	GO:0019534	7.95
receptor binding	GO:0005102	2.43
coreceptor activity involved in Wnt signaling pathway	GO:0071936	7.66
low-density lipoprotein receptor activity	GO:0005041	7.17
Wnt-activated receptor activity	GO:0042813	6.65
frizzled binding	GO:0005109	6.1
transmembrane signaling receptor activity	GO:0004888	2.57
protein binding	GO:0005515	0.46
Wnt-protein binding	GO:0017147	6.3
protein dimerization activity	GO:0046983	2.72
transmembrane receptor activity	GO:0099600	2.53
receptor activity	GO:0004872	2.32