| Disease ID | Disease name | Source of annotation with MAOA | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 300615 | BRUNNER SYNDROME | ClinVar, OMIM | link to OMIM | 1 | MAOA |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Drug metabolism - cytochrome P450 | hsa00982 | 6.6 |
| Arginine and proline metabolism | hsa00330 | 6.84 |
| Metabolic pathways | hsa01100 | 2.49 |
| Cocaine addiction | hsa05030 | 7.07 |
| Amphetamine addiction | hsa05031 | 6.62 |
| Phenylalanine metabolism | hsa00360 | 8.6 |
| Alcoholism | hsa05034 | 5.59 |
| Serotonergic synapse | hsa04726 | 5.84 |
| Glycine, serine and threonine metabolism | hsa00260 | 7.45 |
| Dopaminergic synapse | hsa04728 | 5.69 |
| Tryptophan metabolism | hsa00380 | 7.34 |
| Tyrosine metabolism | hsa00350 | 7.64 |
| Histidine metabolism | hsa00340 | 8.24 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Transmission across Chemical Synapses | R-HSA-112315 | 5.28 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 8.81 |
| Metabolism of serotonin | R-HSA-380612 | 11.98 |
| Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB | R-HSA-141333 | 11.98 |
| Biological oxidations | R-HSA-211859 | 5.55 |
| Enzymatic degradation of dopamine by COMT | R-HSA-379397 | 11.98 |
| Enzymatic degradation of Dopamine by monoamine oxidase | R-HSA-379398 | 11.98 |
| Dopamine clearance from the synaptic cleft | R-HSA-379401 | 11.4 |
| Diseases of metabolism | R-HSA-5668914 | 6.57 |
| Defective MAOA causes Brunner syndrome (BRUNS) | R-HSA-5579012 | 12.98 |
| Phase 1 - Functionalization of compounds | R-HSA-211945 | 6.7 |
| Serotonin clearance from the synaptic cleft | R-HSA-380615 | 11.98 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Disease | R-HSA-1643685 | 3.33 |
| Neuronal System | R-HSA-112316 | 4.82 |
| Amine Oxidase reactions | R-HSA-140179 | 10.98 |
| Neurotransmitter Release Cycle | R-HSA-112310 | 7.34 |
| Metabolic disorders of biological oxidation enzymes | R-HSA-5579029 | 7.85 |
| Neurotransmitter Clearance In The Synaptic Cleft | R-HSA-112311 | 9.98 |
| GO term | GO ID | GO IC |
|---|---|---|
| coenzyme binding | GO:0050662 | 4.53 |
| serotonin binding | GO:0051378 | 7.54 |
| flavin adenine dinucleotide binding | GO:0050660 | 5.41 |
| oxidoreductase activity, acting on the CH-NH2 group of donors | GO:0016638 | 6.74 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor | GO:0016641 | 7.03 |
| primary amine oxidase activity | GO:0008131 | 7.95 |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| cofactor binding | GO:0048037 | 4.16 |
| binding | GO:0005488 | 0.18 |
| amine binding | GO:0043176 | 7.34 |
| nucleotide binding | GO:0000166 | 1.96 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| oxidoreductase activity | GO:0016491 | 3.12 |