| Disease ID | Disease name | Source of annotation with MRE11A | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS604391 | ATAXIA-TELANGIECTASIA-LIKE DISORDER | ClinVar, OMIM, HUMSAVAR | link to OMIM | 2 | PCNA, MRE11A |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Homologous recombination | hsa03440 | 7.91 |
| Non-homologous end-joining | hsa03450 | 8.96 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 9.28 |
| Immune System | R-HSA-168256 | 2.37 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 7.15 |
| Cellular Senescence | R-HSA-2559583 | 5.7 |
| G2/M Checkpoints | R-HSA-69481 | 6.46 |
| Homologous recombination repair of replication-independent double-strand breaks | R-HSA-73951 | 8.98 |
| MRN complex relocalizes to nuclear foci | R-HSA-83572 | 10.98 |
| Homologous Recombination Repair | R-HSA-73888 | 8.98 |
| Meiotic recombination | R-HSA-912446 | 7.25 |
| Cellular responses to stress | R-HSA-2262752 | 4.56 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 8.98 |
| Cell Cycle Checkpoints | R-HSA-69620 | 5.64 |
| Meiosis | R-HSA-1500620 | 6.59 |
| Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks | R-HSA-75177 | 10.98 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 6.94 |
| Cell Cycle | R-HSA-1640170 | 3.89 |
| Recruitment of repair and signaling proteins to double-strand breaks | R-HSA-75154 | 9.98 |
| DNA Repair | R-HSA-73894 | 5.8 |
| Double-Strand Break Repair | R-HSA-73890 | 8.46 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 7.15 |
| GO term | GO ID | GO IC |
|---|---|---|
| protein C-terminus binding | GO:0008022 | 4.5 |
| ATPase activity | GO:0016887 | 3.65 |
| ATP-dependent helicase activity | GO:0008026 | 5.12 |
| manganese ion binding | GO:0030145 | 5.89 |
| binding | GO:0005488 | 0.18 |
| nucleic acid binding | GO:0003676 | 1.44 |
| DNA binding | GO:0003677 | 1.92 |
| DNA helicase activity | GO:0003678 | 5.73 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| cation binding | GO:0043169 | 1.4 |
| 3'-5' exonuclease activity | GO:0008408 | 5.83 |
| transition metal ion binding | GO:0046914 | 2.48 |
| pyrophosphatase activity | GO:0016462 | 3.04 |
| exonuclease activity | GO:0004527 | 5.33 |
| endodeoxyribonuclease activity | GO:0004520 | 5.81 |
| ion binding | GO:0043167 | 1.36 |
| double-stranded DNA binding | GO:0003690 | 3.09 |
| metal ion binding | GO:0046872 | 1.41 |
| deoxyribonuclease activity | GO:0004536 | 5.48 |
| hydrolase activity | GO:0016787 | 1.9 |
| single-stranded DNA endodeoxyribonuclease activity | GO:0000014 | 7.79 |
| ATP-dependent DNA helicase activity | GO:0004003 | 6.13 |
| nucleoside-triphosphatase activity | GO:0017111 | 3.09 |
| hydrolase activity, acting on ester bonds | GO:0016788 | 3.1 |
| helicase activity | GO:0004386 | 4.69 |
| catalytic activity | GO:0003824 | 1.05 |
| DNA-dependent ATPase activity | GO:0008094 | 5.31 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | GO:0016818 | 3.03 |
| nuclease activity | GO:0004518 | 4.33 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| ATPase activity, coupled | GO:0042623 | 3.97 |
| hydrolase activity, acting on acid anhydrides | GO:0016817 | 3.03 |
| purine NTP-dependent helicase activity | GO:0070035 | 5.12 |
| protein binding | GO:0005515 | 0.46 |
| endonuclease activity | GO:0004519 | 4.78 |