Gene table of SPAST : spastin

Gene-disease associations table

Disease IDDisease nameSource of annotation with SPASTOMIM linkNumber of associated genesgenes
PS303350SPASTIC PARAPLEGIAClinVar, OMIM, HUMSAVAR link to OMIM 47KIF5A, ATL1, C12orf65, IBA57, GJC2, GBA2, KIAA0196, ZFYVE26, ENTPD1, AP4E1, B4GALNT1, DDHD2, C19orf12, AP5Z1, SPG11, SLC33A1, MAG, CYP2U1, L1CAM, TFG, ARL6IP1, AP4M1, ERLIN2, KIF1A, AMPD2, SPAST, SPG20, AP4S1, HSPD1, RTN2, PLP1, CYP7B1, REEP1, SPG21, TECPR2, BSCL2, PNPLA6, SPG7, VPS37A, NT5C2, NIPA1, DDHD1, CPT1C, ALDH18A1, ZFYVE27, AP4B1, FA2H

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Annotation of the gene SPAST

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
Associated REACTOME pathways
Associated GO terms for Molecular function
GO termGO IDGO IC
purine ribonucleoside triphosphate bindingGO:00356392.22
beta-tubulin bindingGO:00484876.13
bindingGO:00054880.18
ATPase activityGO:00168873.65
heterocyclic compound bindingGO:19013631.06
nucleoside phosphate bindingGO:19012651.96
nucleoside bindingGO:00018822.21
ATPase activity, coupledGO:00426233.97
microtubule-severing ATPase activityGO:00085687.25
nucleotide bindingGO:00001661.96
purine nucleoside bindingGO:00018832.22
ribonucleoside bindingGO:00325492.22
purine nucleotide bindingGO:00170762.19
ATP bindingGO:00055242.43
hydrolase activityGO:00167871.9
tubulin bindingGO:00156314.1
microtubule bindingGO:00080174.42
nucleoside-triphosphatase activityGO:00171113.09
small molecule bindingGO:00360941.89
catalytic activityGO:00038241.05
purine ribonucleotide bindingGO:00325552.2
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesGO:00168183.03
cytoskeletal protein bindingGO:00080923.02
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
adenyl nucleotide bindingGO:00305542.4
hydrolase activity, acting on acid anhydridesGO:00168173.03
pyrophosphatase activityGO:00164623.04
adenyl ribonucleotide bindingGO:00325592.41
protein bindingGO:00055150.46
alpha-tubulin bindingGO:00430146.37
purine ribonucleoside bindingGO:00325502.22
ribonucleotide bindingGO:00325532.19