Disease table of SPASTIC PARAPLEGIA OMIM ID: PS303350

Gene-disease associations table

Gene	Associated with SPASTIC PARAPLEGIA in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
B4GALNT1	ClinVar, OMIM, HUMSAVAR	HGNC link	12q13.3	1	PS303350
SPAST	ClinVar, OMIM, HUMSAVAR	HGNC link	2p22.3	1	PS303350
SPG7	ClinVar, OMIM, HUMSAVAR	HGNC link	16q24.3	1	PS303350
AMPD2	OMIM	HGNC link	1p13.3	2	PS607596, PS303350
NIPA1	ClinVar, OMIM, HUMSAVAR	HGNC link	15q11.2	1	PS303350
SLC33A1	ClinVar, OMIM, HUMSAVAR	HGNC link	3q25.31	2	PS303350, 614482
L1CAM	ClinVar, OMIM, HUMSAVAR	HGNC link	Xq28	3	307000, 304100, PS303350
PLP1	ClinVar, OMIM, HUMSAVAR	HGNC link	Xq22.2	2	PS312080, PS303350
AP4B1	ClinVar, OMIM	HGNC link	1p13.2	1	PS303350
CYP2U1	ClinVar, OMIM, HUMSAVAR	HGNC link	4q25	1	PS303350
ENTPD1	ClinVar, OMIM, HUMSAVAR	HGNC link	10q24.1	1	PS303350
SPG21	ClinVar, OMIM	HGNC link	15q22.31	1	PS303350
SPG20	ClinVar, OMIM	HGNC link	13q13.3	1	PS303350
DDHD1	ClinVar, OMIM	HGNC link	14q22.1	1	PS303350
DDHD2	ClinVar, OMIM, HUMSAVAR	HGNC link	8p11.23	1	PS303350
VPS37A	ClinVar, OMIM, HUMSAVAR	HGNC link	8p22	1	PS303350
C19orf12	ClinVar, OMIM, HUMSAVAR	HGNC link	19q12	2	PS234200, PS303350
HSPD1	ClinVar, OMIM, HUMSAVAR	HGNC link	2q33.1	2	PS312080, PS303350
PNPLA6	ClinVar, OMIM, HUMSAVAR	HGNC link	19p13.2	4	215470, PS303350, 275400, 245800
REEP1	ClinVar, OMIM, HUMSAVAR	HGNC link	2p11.2	2	614751, PS303350
ALDH18A1	ClinVar, OMIM	HGNC link	10q24.1	3	616603, 219150, PS303350
BSCL2	OMIM, HUMSAVAR	HGNC link	11q12.3	4	PS608594, PS303350, 600794, 615924
NT5C2	ClinVar, OMIM	HGNC link	10q24.33	1	PS303350
CPT1C	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.33	1	PS303350
C12orf65	ClinVar, OMIM	HGNC link	12q24.31	2	PS609060, PS303350
KIAA0196	ClinVar, OMIM, HUMSAVAR	HGNC link	8q24.13	2	PS220210, PS303350
TECPR2	ClinVar, OMIM	HGNC link	14q32.31	1	PS303350
AP5Z1	ClinVar, OMIM	HGNC link	7p22.1	1	PS303350
AP4E1	OMIM	HGNC link	15q21.2	2	PS184450, PS303350
ARL6IP1	OMIM	HGNC link	16p12.3	1	PS303350
GBA2	ClinVar, OMIM, HUMSAVAR	HGNC link	9p13.3	1	PS303350
KIF1A	ClinVar, OMIM	HGNC link	2q37.3	3	PS156200, PS303350, PS162400
CYP7B1	ClinVar, OMIM, HUMSAVAR	HGNC link	8q12.3	2	PS607765, PS303350
ZFYVE27	ClinVar, OMIM, HUMSAVAR	HGNC link	10q24.2	1	PS303350
ZFYVE26	ClinVar, OMIM	HGNC link	14q24.1	1	PS303350
ERLIN2	ClinVar, OMIM	HGNC link	8p11.23	1	PS303350
KIF5A	ClinVar, OMIM, HUMSAVAR	HGNC link	12q13.3	1	PS303350
TFG	ClinVar, OMIM, HUMSAVAR	HGNC link	3q12.2	2	604484, PS303350
GJC2	ClinVar, OMIM, HUMSAVAR	HGNC link	1q42.13	3	PS153100, PS312080, PS303350
FA2H	ClinVar, OMIM, HUMSAVAR	HGNC link	16q23.1	1	PS303350
ATL1	ClinVar, OMIM, HUMSAVAR	HGNC link	14q22.1	2	PS162400, PS303350
AP4M1	ClinVar, OMIM	HGNC link	7q22.1	1	PS303350
AP4S1	ClinVar, OMIM	HGNC link	14q12	1	PS303350
IBA57	ClinVar, OMIM	HGNC link	1q42.13	2	PS605711, PS303350
MAG	ClinVar, OMIM	HGNC link	19q13.12	1	PS303350
RTN2	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.32	1	PS303350
SPG11	ClinVar, OMIM, HUMSAVAR	HGNC link	15q21.1	3	PS118220, PS303350, PS105400

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
14q22.1	2	DDHD1, ATL1
1q42.13	2	GJC2, IBA57
8p11.23	2	DDHD2, ERLIN2
10q24.1	2	ALDH18A1, ENTPD1
12q13.3	2	B4GALNT1, KIF5A

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
14q22	2	DDHD1, ATL1
1q42	2	GJC2, IBA57
15q21	2	SPG11, AP4E1
8p11	2	DDHD2, ERLIN2
10q24	4	ALDH18A1, ZFYVE27, ENTPD1, NT5C2
19q13	3	MAG, RTN2, CPT1C
12q13	2	B4GALNT1, KIF5A
1p13	2	AP4B1, AMPD2

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
12q1	2	B4GALNT1, KIF5A
19q1	4	C19orf12, MAG, CPT1C, RTN2
Xq2	2	L1CAM, PLP1
1p1	2	AP4B1, AMPD2
8p1	2	DDHD2, ERLIN2
15q2	3	SPG21, SPG11, AP4E1
2q3	2	KIF1A, HSPD1
1q4	2	GJC2, IBA57
14q2	3	DDHD1, ATL1, ZFYVE26
16q2	2	FA2H, SPG7
10q2	4	ALDH18A1, ZFYVE27, ENTPD1, NT5C2

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
14q	5	DDHD1, ATL1, AP4S1, TECPR2, ZFYVE26
12q	3	B4GALNT1, KIF5A, C12orf65
10q	4	ALDH18A1, ZFYVE27, ENTPD1, NT5C2
16q	2	FA2H, SPG7
1q	2	GJC2, IBA57
1p	2	AP4B1, AMPD2
3q	2	TFG, SLC33A1
15q	4	SPG21, AP4E1, SPG11, NIPA1
19q	4	C19orf12, MAG, CPT1C, RTN2
8p	3	ERLIN2, DDHD2, VPS37A
8q	2	CYP7B1, KIAA0196
2p	2	SPAST, REEP1
2q	2	KIF1A, HSPD1
Xq	2	L1CAM, PLP1

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
10	4	ALDH18A1, ZFYVE27, ENTPD1, NT5C2
12	3	B4GALNT1, KIF5A, C12orf65
15	4	SPG21, AP4E1, SPG11, NIPA1
14	5	DDHD1, ATL1, AP4S1, TECPR2, ZFYVE26
16	3	ARL6IP1, SPG7, FA2H
19	5	C19orf12, PNPLA6, RTN2, CPT1C, MAG
1	4	GJC2, AP4B1, IBA57, AMPD2
3	2	TFG, SLC33A1
2	4	SPAST, KIF1A, REEP1, HSPD1
7	2	AP5Z1, AP4M1
8	5	KIAA0196, DDHD2, VPS37A, ERLIN2, CYP7B1
X	2	L1CAM, PLP1

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs
SPAST	YES	2	NRF1, SOX11
L1CAM	YES	3	SNAI2, PAX2, TFAP2A
HSPD1	YES	1	RUNX3
CYP7B1	YES	1	SP1
GJC2	YES	1	SOX10

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
SPAST	HSPD1	No	1	VCP
SPAST	REEP1	No	1	ELAVL1
SPAST	ALDH18A1	No	1	VCP
SPAST	AP4E1	No	2	ALB, ELAVL1
SPAST	ARL6IP1	No	1	ELAVL1
SPAST	ERLIN2	No	1	ELAVL1
SPAST	TFG	No	3	CHMP4B, CHMP1B, IST1
SPAST	GJC2	No	1	ALB
SPG7	AMPD2	No	1	CCNDBP1
SPG7	HSPD1	No	6	MAPK6, KRTAP10-3, NOTCH2NL, KRT40, LZTS2, KRTAP5-9
SPG7	PNPLA6	No	1	FAF2
SPG7	ALDH18A1	No	1	CERK
SPG7	AP5Z1	No	1	MDFI
SPG7	ARL6IP1	No	1	FAF2
SPG7	KIF1A	No	5	RBPMS, MTUS2, PLSCR1, NOTCH2NL, MDFI
SPG7	ZFYVE26	No	6	KRTAP10-9, KRTAP10-7, PNMA1, MDFI, KRTAP10-3, KRT40
SPG7	ERLIN2	No	2	FAF2, TRIM28
SPG7	TFG	No	3	RBPMS, MTUS2, PLSCR1
AMPD2	L1CAM	No	1	NTRK1
AMPD2	HSPD1	No	1	NTRK1
AMPD2	PNPLA6	No	1	NTRK1
AMPD2	ALDH18A1	No	1	NTRK1
AMPD2	NT5C2	No	1	NTRK1
AMPD2	KIAA0196	No	1	NTRK1
AMPD2	KIF1A	No	1	NTRK1
AMPD2	ERLIN2	No	1	NTRK1
AMPD2	TFG	No	1	NTRK1
AMPD2	ATL1	No	1	NTRK1
SLC33A1	L1CAM	No	2	CANX, HAX1
SLC33A1	AP4B1	No	1	TMEM17
SLC33A1	HSPD1	No	1	HSP90AB1
SLC33A1	BSCL2	No	1	CANX
SLC33A1	NT5C2	No	2	NUDT18, ATP5O
SLC33A1	KIAA0196	No	1	ZW10
SLC33A1	AP4E1	No	1	TMEM17
SLC33A1	GBA2	No	1	TMEM216
SLC33A1	ERLIN2	No	5	NF2, CANX, ATP2A2, HSP90B1, HAX1
SLC33A1	TFG	No	1	TMEM17
SLC33A1	FA2H	No	1	TCTN3
L1CAM	PLP1	No	1	ITGAV
L1CAM	ENTPD1	No	1	RANBP9
L1CAM	HSPD1	No	2	NTRK1, FBXO6
L1CAM	PNPLA6	No	1	NTRK1
L1CAM	ALDH18A1	No	1	NTRK1
L1CAM	BSCL2	No	1	CANX
L1CAM	NT5C2	No	1	NTRK1
L1CAM	KIAA0196	No	1	NTRK1
L1CAM	KIF1A	No	1	NTRK1
L1CAM	ERLIN2	No	4	NTRK1, CANX, FBXO6, HAX1
L1CAM	TFG	No	1	NTRK1
L1CAM	ATL1	No	1	NTRK1
AP4B1	VPS37A	No	1	XPO1
AP4B1	KIAA0196	No	1	XPO1
AP4B1	AP4E1	Yes	4	AP4S1, TMEM17, AP4M1, XPO1
AP4B1	TFG	No	1	TMEM17
AP4B1	AP4M1	Yes	3	AP4S1, AP4E1, XPO1
AP4B1	AP4S1	Yes	2	AP4E1, AP4M1
SPG21	HSPD1	No	2	CD4, MOV10
SPG21	PNPLA6	No	1	MOV10
SPG21	ALDH18A1	No	3	CMTM5, MOV10, AGTRAP
SPG21	ARL6IP1	Yes	2	ARL6IP1, RTN4
SPG21	KIF1A	No	2	TRAF1, MID2
SPG21	ZFYVE26	No	2	KRT15, TRAF1
SPG21	TFG	Yes	1	TFG
SPG21	RTN2	No	1	RTN4
SPG20	DDHD2	No	1	APP
SPG20	VPS37A	No	1	APP
SPG20	C19orf12	No	1	APP
SPG20	HSPD1	Yes	5	UBC, SMURF1, HSPA5, HSPA9, APP
SPG20	C12orf65	No	1	APP
SPG20	GBA2	No	1	APP
SPG20	KIF1A	No	1	KIF5B
SPG20	ZFYVE27	No	1	APP
SPG20	ERLIN2	No	3	UBC, TUBA1A, HSPA5
SPG20	KIF5A	No	1	KLC2
SPG20	TFG	No	1	HSPA5
SPG20	AP4S1	No	1	APP
SPG20	MAG	No	1	APP
SPG20	RTN2	No	1	UBC
DDHD2	VPS37A	No	1	APP
DDHD2	C19orf12	No	1	APP
DDHD2	HSPD1	No	1	APP
DDHD2	C12orf65	No	1	APP
DDHD2	GBA2	No	1	APP
DDHD2	ZFYVE27	No	1	APP
DDHD2	AP4S1	No	1	APP
DDHD2	MAG	No	1	APP
VPS37A	C19orf12	No	1	APP
VPS37A	HSPD1	No	1	APP
VPS37A	C12orf65	No	1	APP
VPS37A	KIAA0196	No	1	XPO1
VPS37A	AP4E1	No	1	XPO1
VPS37A	GBA2	No	1	APP
VPS37A	ZFYVE27	No	1	APP
VPS37A	KIF5A	No	1	TSG101
VPS37A	TFG	No	1	TSG101
VPS37A	AP4M1	No	1	XPO1
VPS37A	AP4S1	No	1	APP
VPS37A	MAG	No	1	APP
C19orf12	HSPD1	No	1	APP
C19orf12	C12orf65	No	1	APP
C19orf12	GBA2	No	1	APP
C19orf12	ZFYVE27	No	1	APP
C19orf12	AP4S1	No	1	APP
C19orf12	MAG	No	1	APP
HSPD1	PNPLA6	No	4	NTRK1, NXF1, BAX, MOV10
HSPD1	ALDH18A1	No	11	STAU1, MYC, ADRB2, ICT1, VCP, CDK2, CUL3, NTRK1, NXF1, HDAC5, MOV10
HSPD1	NT5C2	No	1	NTRK1
HSPD1	C12orf65	No	2	APP, CDK2
HSPD1	KIAA0196	No	1	NTRK1
HSPD1	ARL6IP1	No	2	UNK, C12ORF10
HSPD1	GBA2	No	1	APP
HSPD1	KIF1A	No	5	NTRK1, RGS20, PSMA3, ESR1, NOTCH2NL
HSPD1	ZFYVE27	No	1	APP
HSPD1	ZFYVE26	No	2	KRTAP10-3, KRT40
HSPD1	ERLIN2	No	12	FN1, ICT1, HSPA4, ADRB2, UBC, AMFR, EEF2, FBXO6, NTRK1, HSPA5, UBL4A, CFTR
HSPD1	KIF5A	No	1	STAU1
HSPD1	TFG	No	15	UNK, NEDD8, AURKB, MCM2, CUL3, CAND1, CUL1, CFTR, COPS5, CUL4A, CUL2, NTRK1, HSPA5, GRB2, CUL7
HSPD1	ATL1	No	1	NTRK1
HSPD1	AP4S1	No	2	GRB2, APP
HSPD1	MAG	No	1	APP
HSPD1	RTN2	No	1	UBC
PNPLA6	ALDH18A1	No	3	NTRK1, NXF1, MOV10
PNPLA6	BSCL2	No	1	TSPAN17
PNPLA6	NT5C2	No	1	NTRK1
PNPLA6	KIAA0196	No	1	NTRK1
PNPLA6	ARL6IP1	No	1	FAF2
PNPLA6	KIF1A	No	1	NTRK1
PNPLA6	ERLIN2	No	4	NTRK1, FAF2, KTN1, RAB5C
PNPLA6	TFG	No	1	NTRK1
PNPLA6	ATL1	No	1	NTRK1
REEP1	AP4E1	No	1	ELAVL1
REEP1	ARL6IP1	No	1	ELAVL1
REEP1	ERLIN2	No	1	ELAVL1
ALDH18A1	NT5C2	No	1	NTRK1
ALDH18A1	C12orf65	No	1	CDK2
ALDH18A1	KIAA0196	No	1	NTRK1
ALDH18A1	ARL6IP1	No	1	SHMT2
ALDH18A1	KIF1A	No	2	NTRK1, SIRT7
ALDH18A1	ERLIN2	No	6	GOLT1B, ICT1, ADRB2, TCF3, NTRK1, C1QBP
ALDH18A1	KIF5A	No	1	STAU1
ALDH18A1	TFG	No	2	NTRK1, CUL3
ALDH18A1	ATL1	No	1	NTRK1
ALDH18A1	IBA57	No	1	NONO
BSCL2	ERLIN2	No	1	CANX
BSCL2	RTN2	No	1	ICAM2
NT5C2	KIAA0196	No	1	NTRK1
NT5C2	ARL6IP1	No	1	FXR2
NT5C2	KIF1A	No	2	NTRK1, FXR2
NT5C2	ERLIN2	No	1	NTRK1
NT5C2	TFG	No	1	NTRK1
NT5C2	ATL1	No	1	NTRK1
C12orf65	GBA2	No	1	APP
C12orf65	ZFYVE27	No	1	APP
C12orf65	AP4S1	No	1	APP
C12orf65	MAG	No	1	APP
KIAA0196	AP4E1	No	1	XPO1
KIAA0196	KIF1A	No	1	NTRK1
KIAA0196	ERLIN2	No	2	NTRK1, CEP128
KIAA0196	KIF5A	No	1	VPS26B
KIAA0196	TFG	No	1	NTRK1
KIAA0196	ATL1	No	1	NTRK1
KIAA0196	AP4M1	No	1	XPO1
AP5Z1	KIF1A	No	1	MDFI
AP5Z1	ZFYVE26	No	1	MDFI
AP4E1	ARL6IP1	No	1	ELAVL1
AP4E1	ERLIN2	No	1	ELAVL1
AP4E1	TFG	No	1	TMEM17
AP4E1	GJC2	No	1	ALB
AP4E1	AP4M1	Yes	5	ENTHD2, AP4S1, AP4B1, ARF1, XPO1
AP4E1	AP4S1	Yes	5	CEP104, GOLIM4, AP4B1, ENTHD2, AP4M1
ARL6IP1	KIF1A	No	1	FXR2
ARL6IP1	ERLIN2	No	2	FAF2, ELAVL1
ARL6IP1	TFG	No	3	UNK, SPG21, SNX3
ARL6IP1	RTN2	No	1	RTN4
GBA2	ZFYVE27	No	1	APP
GBA2	AP4S1	No	1	APP
GBA2	MAG	No	1	APP
KIF1A	ZFYVE26	No	2	TRAF1, MDFI
KIF1A	ERLIN2	No	1	NTRK1
KIF1A	KIF5A	No	1	TRIP6
KIF1A	TFG	No	4	RBPMS, NTRK1, MTUS2, PLSCR1
KIF1A	ATL1	No	1	NTRK1
ZFYVE27	AP4S1	No	1	APP
ZFYVE27	MAG	No	1	APP
ERLIN2	TFG	No	5	EWSR1, NTRK1, HSPA5, CFTR, FLOT2
ERLIN2	FA2H	No	1	ERLIN1
ERLIN2	ATL1	No	1	NTRK1
ERLIN2	RTN2	No	1	UBC
KIF5A	TFG	No	3	PIN1, ITSN1, TSG101
TFG	ATL1	No	1	NTRK1
TFG	AP4S1	No	1	GRB2
AP4M1	AP4S1	Yes	5	ENTHD2, GALNT2, AP4B1, AP4E1, C19ORF52
AP4S1	MAG	No	1	APP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
SPAST	HSPD1	No	1	KRAS
SPAST	RTN2	No	1	KRAS
HSPD1	RTN2	No	1	KRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
SPAST	REEP1	No	-	1	ATL1
SPAST	ZFYVE27	Yes	binding	0
SPAST	ATL1	Yes	binding	0
SPAST	RTN2	Yes	binding	0
SPG7	HSPD1	No	-	1	TLR2
AMPD2	SLC33A1	No	-	1	UBC
AMPD2	SPG21	No	-	1	UBC
AMPD2	SPG20	No	-	1	UBC
AMPD2	VPS37A	No	-	1	UBC
AMPD2	HSPD1	No	-	1	UBC
AMPD2	PNPLA6	No	-	1	UBC
AMPD2	ALDH18A1	No	-	1	UBC
AMPD2	BSCL2	No	-	1	UBC
AMPD2	NT5C2	No	-	1	UBC
AMPD2	KIAA0196	No	-	1	UBC
AMPD2	AP5Z1	No	-	1	UBC
AMPD2	ARL6IP1	No	-	1	UBC
AMPD2	KIF1A	No	-	1	UBC
AMPD2	ERLIN2	No	-	1	UBC
AMPD2	TFG	No	-	1	UBC
AMPD2	AP4M1	No	-	1	UBC
AMPD2	SPG11	No	-	1	UBC
SLC33A1	SPG21	No	-	1	UBC
SLC33A1	SPG20	No	-	1	UBC
SLC33A1	VPS37A	No	-	1	UBC
SLC33A1	HSPD1	No	-	1	UBC
SLC33A1	PNPLA6	No	-	1	UBC
SLC33A1	ALDH18A1	No	-	1	UBC
SLC33A1	BSCL2	No	-	1	UBC
SLC33A1	NT5C2	No	-	1	UBC
SLC33A1	KIAA0196	No	-	1	UBC
SLC33A1	AP5Z1	No	-	1	UBC
SLC33A1	ARL6IP1	No	-	1	UBC
SLC33A1	KIF1A	No	-	1	UBC
SLC33A1	ERLIN2	No	-	1	UBC
SLC33A1	TFG	No	-	1	UBC
SLC33A1	AP4M1	No	-	1	UBC
SLC33A1	SPG11	No	-	1	UBC
PLP1	ARL6IP1	No	-	1	SHH
AP4B1	AP5Z1	No	-	8	AP2S1, AP1S1, AP1G2, AP4M1, AP1S2, AP5M1, AP1G1, AP2A1
AP4B1	AP4E1	Yes	binding	11	CLHC1, AP1M2, AP1S1, AP1M1, AP4S1, AP4M1, AP1S2, AP5M1, AP2M1, CLTC, CLTCL1
AP4B1	AP4M1	Yes	binding	10	AP2S1, AP2A2, AP1S1, AP1G2, AP4S1, AP4E1, AP1S2, AP5M1, AP1G1, AP2A1
AP4B1	AP4S1	Yes	binding	9	AP2A2, AP3D1, AP1G2, AP1M1, AP4E1, AP4M1, AP2M1, AP1G1, AP2A1
SPG21	SPG20	No	-	1	UBC
SPG21	VPS37A	No	-	1	UBC
SPG21	HSPD1	No	-	1	UBC
SPG21	PNPLA6	No	-	1	UBC
SPG21	ALDH18A1	No	-	1	UBC
SPG21	BSCL2	No	-	1	UBC
SPG21	NT5C2	No	-	1	UBC
SPG21	KIAA0196	No	-	1	UBC
SPG21	AP5Z1	No	-	1	UBC
SPG21	ARL6IP1	No	-	1	UBC
SPG21	KIF1A	No	-	1	UBC
SPG21	ERLIN2	No	-	1	UBC
SPG21	TFG	No	-	1	UBC
SPG21	AP4M1	No	-	1	UBC
SPG21	SPG11	No	-	1	UBC
SPG20	VPS37A	No	-	1	UBC
SPG20	HSPD1	No	-	2	UBC, HSPA9
SPG20	PNPLA6	No	-	1	UBC
SPG20	ALDH18A1	No	-	1	UBC
SPG20	BSCL2	No	-	1	UBC
SPG20	NT5C2	No	-	1	UBC
SPG20	KIAA0196	No	-	1	UBC
SPG20	AP5Z1	No	-	1	UBC
SPG20	ARL6IP1	No	-	1	UBC
SPG20	KIF1A	No	-	1	UBC
SPG20	ERLIN2	No	-	1	UBC
SPG20	TFG	No	-	1	UBC
SPG20	AP4M1	No	-	1	UBC
SPG20	SPG11	No	-	1	UBC
VPS37A	HSPD1	No	-	1	UBC
VPS37A	PNPLA6	No	-	1	UBC
VPS37A	ALDH18A1	No	-	1	UBC
VPS37A	BSCL2	No	-	1	UBC
VPS37A	NT5C2	No	-	1	UBC
VPS37A	KIAA0196	No	-	1	UBC
VPS37A	AP5Z1	No	-	1	UBC
VPS37A	ARL6IP1	No	-	1	UBC
VPS37A	KIF1A	No	-	1	UBC
VPS37A	ERLIN2	No	-	1	UBC
VPS37A	TFG	No	-	1	UBC
VPS37A	AP4M1	No	-	1	UBC
VPS37A	SPG11	No	-	1	UBC
HSPD1	PNPLA6	No	-	1	UBC
HSPD1	ALDH18A1	No	-	1	UBC
HSPD1	BSCL2	No	-	1	UBC
HSPD1	NT5C2	No	-	1	UBC
HSPD1	KIAA0196	No	-	1	UBC
HSPD1	AP5Z1	No	-	1	UBC
HSPD1	ARL6IP1	No	-	1	UBC
HSPD1	KIF1A	No	-	1	UBC
HSPD1	ERLIN2	No	-	1	UBC
HSPD1	TFG	No	-	1	UBC
HSPD1	AP4M1	No	-	1	UBC
HSPD1	SPG11	No	-	1	UBC
PNPLA6	ALDH18A1	No	-	1	UBC
PNPLA6	BSCL2	No	-	1	UBC
PNPLA6	NT5C2	No	-	1	UBC
PNPLA6	KIAA0196	No	-	1	UBC
PNPLA6	AP5Z1	No	-	1	UBC
PNPLA6	ARL6IP1	No	-	1	UBC
PNPLA6	KIF1A	No	-	1	UBC
PNPLA6	ERLIN2	No	-	1	UBC
PNPLA6	TFG	No	-	1	UBC
PNPLA6	AP4M1	No	-	1	UBC
PNPLA6	SPG11	No	-	1	UBC
REEP1	ATL1	Yes	binding	0
ALDH18A1	BSCL2	No	-	1	UBC
ALDH18A1	NT5C2	No	-	1	UBC
ALDH18A1	KIAA0196	No	-	1	UBC
ALDH18A1	AP5Z1	No	-	1	UBC
ALDH18A1	ARL6IP1	No	-	1	UBC
ALDH18A1	KIF1A	No	-	1	UBC
ALDH18A1	ERLIN2	No	-	1	UBC
ALDH18A1	TFG	No	-	1	UBC
ALDH18A1	AP4M1	No	-	1	UBC
ALDH18A1	SPG11	No	-	1	UBC
BSCL2	NT5C2	No	-	1	UBC
BSCL2	KIAA0196	No	-	1	UBC
BSCL2	AP5Z1	No	-	1	UBC
BSCL2	ARL6IP1	No	-	1	UBC
BSCL2	KIF1A	No	-	1	UBC
BSCL2	ERLIN2	No	-	1	UBC
BSCL2	TFG	No	-	1	UBC
BSCL2	AP4M1	No	-	1	UBC
BSCL2	SPG11	No	-	1	UBC
NT5C2	KIAA0196	No	-	1	UBC
NT5C2	AP5Z1	No	-	1	UBC
NT5C2	ARL6IP1	No	-	1	UBC
NT5C2	KIF1A	No	-	1	UBC
NT5C2	ERLIN2	No	-	1	UBC
NT5C2	TFG	No	-	1	UBC
NT5C2	AP4M1	No	-	1	UBC
NT5C2	SPG11	No	-	1	UBC
KIAA0196	AP5Z1	No	-	1	UBC
KIAA0196	ARL6IP1	No	-	1	UBC
KIAA0196	KIF1A	No	-	1	UBC
KIAA0196	ERLIN2	No	-	1	UBC
KIAA0196	TFG	No	-	1	UBC
KIAA0196	AP4M1	No	-	1	UBC
KIAA0196	SPG11	No	-	1	UBC
AP5Z1	AP4E1	No	-	4	AP1S1, AP1S2, AP5M1, AP4M1
AP5Z1	ARL6IP1	No	-	1	UBC
AP5Z1	KIF1A	No	-	1	UBC
AP5Z1	ZFYVE26	Yes	binding	0
AP5Z1	ERLIN2	No	-	1	UBC
AP5Z1	TFG	No	-	1	UBC
AP5Z1	AP4M1	Yes	binding	17	AP2S1, AP3S2, AP3S1, UBC, AP1S1, AP1G2, SGIP1, SYNRG, AP5S1, AP5B1, AP5M1, AP3M2, AP1G1, AFTPH, AP2B1, AP1S2, AP2A1
AP5Z1	AP4S1	No	-	5	AP1G1, AP1G2, AP2B1, AP2A1, AP4M1
AP5Z1	SPG11	Yes	binding	1	UBC
AP4E1	AP4M1	Yes	binding	8	AP4S1, AP3B2, AP1S1, ARF1, AP1S2, AP5M1, AP4B1, AP3B1
AP4E1	AP4S1	Yes	binding	6	AP3B2, AP1M1, AP4M1, AP2M1, AP4B1, AP3B1
ARL6IP1	KIF1A	No	-	1	UBC
ARL6IP1	ERLIN2	No	-	1	UBC
ARL6IP1	TFG	No	-	1	UBC
ARL6IP1	ATL1	No	-	1	RTN4
ARL6IP1	AP4M1	No	-	1	UBC
ARL6IP1	MAG	No	-	1	RTN4
ARL6IP1	SPG11	No	-	1	UBC
KIF1A	ERLIN2	No	-	1	UBC
KIF1A	KIF5A	No	-	1	GRIA2
KIF1A	TFG	No	-	1	UBC
KIF1A	AP4M1	No	-	1	UBC
KIF1A	SPG11	No	-	1	UBC
ZFYVE27	ATL1	No	-	1	SPAST
ZFYVE27	RTN2	No	-	1	SPAST
ZFYVE26	AP4M1	No	-	1	AP5Z1
ZFYVE26	SPG11	No	-	1	AP5Z1
ERLIN2	TFG	No	-	1	UBC
ERLIN2	AP4M1	No	-	1	UBC
ERLIN2	SPG11	No	-	1	UBC
TFG	AP4M1	No	-	1	UBC
TFG	SPG11	No	-	1	UBC
ATL1	MAG	No	-	1	RTN4
ATL1	RTN2	No	-	1	SPAST
AP4M1	AP4S1	Yes	binding	10	AP1B1, AP3B2, AP2B1, AP1G2, AP4E1, AP2A1, AP1G1, AP2A2, AP4B1, AP3B1
AP4M1	SPG11	No	-	2	UBC, AP5Z1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
AP4B1	AP4E1	Yes	AP4 adaptor complex	2	AP4S1, AP4M1
AP4B1	AP4M1	Yes	AP4 adaptor complex	2	AP4S1, AP4E1
AP4B1	AP4S1	Yes	AP4 adaptor complex	2	AP4M1, AP4E1
AP4E1	AP4M1	Yes	AP4 adaptor complex	2	AP4S1, AP4B1
AP4E1	AP4S1	Yes	AP4 adaptor complex	2	AP4B1, AP4M1
AP4M1	AP4S1	Yes	AP4 adaptor complex	2	AP4B1, AP4E1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
HSPD1	ERLIN2	No	1	EEF2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
AMPD2	PLP1	No	2	B2M, HLA-A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Metabolic pathways	hsa01100	2.49	7	CYP2U1, SLC33A1, GBA2, AMPD2, ALDH18A1, B4GALNT1, NT5C2
Lysosome	hsa04142	5.78	4	AP4S1, AP4B1, AP4M1, AP4E1
Purine metabolism	hsa00230	5.28	3	AMPD2, NT5C2, ENTPD1
Cell adhesion molecules (CAMs)	hsa04514	5.36	2	MAG, L1CAM
Glycosphingolipid biosynthesis - ganglio series	hsa00604	8.77	2	SLC33A1, B4GALNT1
Pyrimidine metabolism	hsa00240	6.01	2	NT5C2, ENTPD1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Lysosome (hsa04142)	-	5.78	0.027	AP4S1, AP4B1, AP4M1, AP4E1

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Membrane Trafficking	R-HSA-199991	5.26	6	AP4S1, GJC2, AP4E1, VPS37A, AP4M1, AP4B1
Metabolism	R-HSA-1430728	2.34	6	CYP2U1, CYP7B1, GBA2, AMPD2, ALDH18A1, NT5C2
Vesicle-mediated transport	R-HSA-5653656	4.33	6	AP4S1, GJC2, AP4E1, VPS37A, AP4M1, AP4B1
trans-Golgi Network Vesicle Budding	R-HSA-199992	6.85	4	AP4S1, AP4B1, AP4M1, AP4E1
Clathrin derived vesicle budding	R-HSA-421837	6.85	4	AP4S1, AP4B1, AP4M1, AP4E1
Lysosome Vesicle Biogenesis	R-HSA-432720	7.85	4	AP4S1, AP4B1, AP4M1, AP4E1
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	3	CYP7B1, CYP2U1, GBA2
Hemostasis	R-HSA-109582	3.98	3	L1CAM, MAG, KIF5A
Disease	R-HSA-1643685	3.33	3	CYP7B1, CYP2U1, VPS37A
Signal Transduction	R-HSA-162582	1.78	2	MAG, KIF5A
Cytochrome P450 - arranged by substrate type	R-HSA-211897	7.08	2	CYP7B1, CYP2U1
Biological oxidations	R-HSA-211859	5.55	2	CYP7B1, CYP2U1
Transmembrane transport of small molecules	R-HSA-382551	3.79	2	SLC33A1, NIPA1
Cell surface interactions at the vascular wall	R-HSA-202733	6.32	2	MAG, L1CAM
Diseases of metabolism	R-HSA-5668914	6.57	2	CYP7B1, CYP2U1
Phase 1 - Functionalization of compounds	R-HSA-211945	6.7	2	CYP7B1, CYP2U1
Metabolism of nucleotides	R-HSA-15869	6.7	2	AMPD2, NT5C2
Metabolism of proteins	R-HSA-392499	3.41	2	HSPD1, KIF5A
Basigin interactions	R-HSA-210991	8.34	2	MAG, L1CAM
Golgi Associated Vesicle Biogenesis	R-HSA-432722	7.23	2	AP4B1, AP4E1
Purine metabolism	R-HSA-73847	7.94	2	AMPD2, NT5C2
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	7.85	2	CYP7B1, CYP2U1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Membrane Trafficking (R-HSA-199991)	-	5.26	0.0	AP4S1, GJC2, AP4B1, AP4E1, VPS37A, AP4M1, KIF5A
trans-Golgi Network Vesicle Budding (R-HSA-199992)	-	6.85	0.001	AP4S1, AP4B1, AP4M1, AP4E1
Clathrin derived vesicle budding (R-HSA-421837)	-	6.85	0.001	AP4S1, AP4B1, AP4M1, AP4E1
Lysosome Vesicle Biogenesis (R-HSA-432720)	-	7.85	0.001	AP4S1, AP4B1, AP4E1, AP4M1
Vesicle-mediated transport (R-HSA-5653656)	-	4.33	0.013	AP4S1, GJC2, AP4E1, VPS37A, AP4M1, AP4B1

GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	37	KIF1A, DDHD2, HSPD1, IBA57, ATL1, ENTPD1, CPT1C, KIAA0196, FA2H, SPAST, RTN2, MAG, AP5Z1, AP4B1, CYP2U1, PLP1, ARL6IP1, BSCL2, C12orf65, SPG20, TFG, ALDH18A1, REEP1, NT5C2, ERLIN2, SPG11, ZFYVE26, TECPR2, DDHD1, VPS37A, AP4M1, AMPD2, SPG21, ZFYVE27, SPG7, KIF5A, CYP7B1
protein binding (GO:0005515)	0.46	30	KIF1A, BSCL2, HSPD1, ATL1, ENTPD1, CPT1C, SPAST, KIAA0196, PLP1, RTN2, MAG, AP5Z1, AP4B1, ARL6IP1, SPG20, TFG, ALDH18A1, REEP1, NT5C2, ERLIN2, SPG11, ZFYVE26, TECPR2, VPS37A, AP4M1, AMPD2, SPG21, ZFYVE27, SPG7, KIF5A
catalytic activity (GO:0003824)	1.05	22	KIF1A, DDHD2, HSPD1, IBA57, B4GALNT1, ATL1, FA2H, CPT1C, SPAST, CYP2U1, C12orf65, ENTPD1, PNPLA6, ALDH18A1, NT5C2, ERLIN2, DDHD1, GBA2, AMPD2, SPG7, KIF5A, CYP7B1
organic cyclic compound binding (GO:0097159)	1.05	15	ENTPD1, KIF1A, C12orf65, CYP7B1, FA2H, ALDH18A1, NT5C2, SPAST, IBA57, CYP2U1, HSPD1, ATL1, SPG7, KIF5A, ERLIN2
hydrolase activity (GO:0016787)	1.9	14	ENTPD1, KIF1A, C12orf65, DDHD2, PNPLA6, AMPD2, NT5C2, SPAST, GBA2, HSPD1, ATL1, SPG7, KIF5A, DDHD1
heterocyclic compound binding (GO:1901363)	1.06	14	ENTPD1, KIF1A, SPAST, ALDH18A1, CYP7B1, FA2H, NT5C2, ATL1, IBA57, HSPD1, CYP2U1, SPG7, KIF5A, C12orf65
cation binding (GO:0043169)	1.4	11	ZFYVE26, FA2H, DDHD1, DDHD2, CYP2U1, AMPD2, ATL1, ZFYVE27, NT5C2, SPG7, CYP7B1
metal ion binding (GO:0046872)	1.41	11	ZFYVE26, FA2H, DDHD1, DDHD2, CYP2U1, AMPD2, ATL1, ZFYVE27, NT5C2, SPG7, CYP7B1
ion binding (GO:0043167)	1.36	11	ZFYVE26, FA2H, DDHD1, DDHD2, CYP2U1, AMPD2, ATL1, ZFYVE27, NT5C2, SPG7, CYP7B1
small molecule binding (GO:0036094)	1.89	10	ENTPD1, KIF1A, ALDH18A1, NT5C2, SPAST, HSPD1, ATL1, SPG7, KIF5A, ERLIN2
nucleoside phosphate binding (GO:1901265)	1.96	9	ENTPD1, KIF1A, ALDH18A1, NT5C2, SPAST, HSPD1, SPG7, KIF5A, ATL1
nucleotide binding (GO:0000166)	1.96	9	ENTPD1, KIF1A, ALDH18A1, NT5C2, SPAST, HSPD1, ATL1, KIF5A, SPG7
carbohydrate derivative binding (GO:0097367)	2.03	8	ENTPD1, KIF1A, ALDH18A1, SPAST, HSPD1, SPG7, KIF5A, ATL1
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	8	ENTPD1, KIF1A, ALDH18A1, SPAST, HSPD1, SPG7, KIF5A, ATL1
purine nucleoside binding (GO:0001883)	2.22	8	ENTPD1, KIF1A, ALDH18A1, SPAST, HSPD1, ATL1, KIF5A, SPG7
ribonucleoside binding (GO:0032549)	2.22	8	ENTPD1, KIF1A, ALDH18A1, SPAST, HSPD1, ATL1, KIF5A, SPG7
purine ribonucleotide binding (GO:0032555)	2.2	8	ENTPD1, KIF1A, ALDH18A1, SPAST, HSPD1, ATL1, KIF5A, SPG7
purine nucleotide binding (GO:0017076)	2.19	8	ENTPD1, KIF1A, ALDH18A1, SPAST, HSPD1, ATL1, KIF5A, SPG7
purine ribonucleoside binding (GO:0032550)	2.22	8	ENTPD1, KIF1A, ALDH18A1, SPAST, HSPD1, SPG7, KIF5A, ATL1
ribonucleotide binding (GO:0032553)	2.19	8	ENTPD1, KIF1A, ALDH18A1, SPAST, HSPD1, ATL1, KIF5A, SPG7
nucleoside binding (GO:0001882)	2.21	8	ENTPD1, KIF1A, ALDH18A1, SPAST, HSPD1, ATL1, KIF5A, SPG7
adenyl ribonucleotide binding (GO:0032559)	2.41	7	ENTPD1, KIF1A, ALDH18A1, SPAST, HSPD1, SPG7, KIF5A
ATP binding (GO:0005524)	2.43	7	ENTPD1, KIF1A, ALDH18A1, SPAST, HSPD1, SPG7, KIF5A
adenyl nucleotide binding (GO:0030554)	2.4	7	ENTPD1, KIF1A, ALDH18A1, SPAST, HSPD1, SPG7, KIF5A
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	6	KIF1A, SPAST, HSPD1, ATL1, KIF5A, SPG7
transporter activity (GO:0005215)	2.57	6	AP4S1, NIPA1, GJC2, SLC33A1, AP4M1, AP4B1
nucleoside-triphosphatase activity (GO:0017111)	3.09	6	KIF1A, SPAST, HSPD1, ATL1, KIF5A, SPG7
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	6	KIF1A, SPAST, HSPD1, ATL1, KIF5A, SPG7
pyrophosphatase activity (GO:0016462)	3.04	6	KIF1A, SPAST, HSPD1, ATL1, KIF5A, SPG7
transferase activity (GO:0016740)	1.95	6	CPT1C, B4GALNT1, ALDH18A1, IBA57, NT5C2, ERLIN2
ATPase activity (GO:0016887)	3.65	5	HSPD1, KIF5A, SPG7, KIF1A, SPAST
nucleic acid binding (GO:0003676)	1.44	5	HSPD1, ALDH18A1, IBA57, ATL1, C12orf65
tubulin binding (GO:0015631)	4.1	4	KIF1A, SPAST, KIF5A, REEP1
substrate-specific transporter activity (GO:0022892)	2.72	4	SLC33A1, AP4S1, AP4B1, NIPA1
transition metal ion binding (GO:0046914)	2.48	4	SPG7, CYP7B1, CYP2U1, FA2H
cytoskeletal protein binding (GO:0008092)	3.02	4	KIF1A, SPAST, KIF5A, REEP1
microtubule binding (GO:0008017)	4.42	4	KIF1A, SPAST, KIF5A, REEP1
enzyme binding (GO:0019899)	2.27	4	HSPD1, ERLIN2, SPG20, MAG
RNA binding (GO:0003723)	2.36	4	HSPD1, ALDH18A1, IBA57, C12orf65
oxidoreductase activity (GO:0016491)	3.12	4	CYP7B1, FA2H, CYP2U1, ALDH18A1
ubiquitin protein ligase binding (GO:0031625)	4.17	3	HSPD1, ERLIN2, SPG20
ubiquitin-like protein ligase binding (GO:0044389)	4.15	3	HSPD1, ERLIN2, SPG20
heme binding (GO:0020037)	4.86	3	CYP7B1, CYP2U1, FA2H
tetrapyrrole binding (GO:0046906)	4.8	3	CYP7B1, CYP2U1, FA2H
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	3	NT5C2, ALDH18A1, ERLIN2
poly(A) RNA binding (GO:0044822)	2.69	3	HSPD1, ALDH18A1, IBA57
kinase activity (GO:0016301)	2.93	3	NT5C2, ALDH18A1, ERLIN2
lipid binding (GO:0008289)	3.26	3	HSPD1, ZFYVE26, ERLIN2
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	3	NT5C2, C12orf65, PNPLA6
transmembrane transporter activity (GO:0022857)	2.82	3	SLC33A1, GJC2, NIPA1
iron ion binding (GO:0005506)	4.65	3	CYP7B1, CYP2U1, FA2H
receptor binding (GO:0005102)	2.43	3	MAG, SPG21, REEP1
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	2	SLC33A1, NIPA1
protein transporter activity (GO:0008565)	5.17	2	AP4S1, AP4B1
monooxygenase activity (GO:0004497)	5.1	2	CYP7B1, CYP2U1
cation transmembrane transporter activity (GO:0008324)	3.32	2	SLC33A1, NIPA1
carboxylic ester hydrolase activity (GO:0052689)	4.81	2	C12orf65, PNPLA6
ATPase activity, coupled (GO:0042623)	3.97	2	SPAST, SPG7
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	2	NT5C2, ERLIN2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705)	4.65	2	CYP7B1, CYP2U1
unfolded protein binding (GO:0051082)	5.13	2	HSPD1, SPG7
ion transmembrane transporter activity (GO:0015075)	3.04	2	SLC33A1, NIPA1
identical protein binding (GO:0042802)	2.63	2	ALDH18A1, ATL1
steroid hydroxylase activity (GO:0008395)	6.3	2	CYP7B1, CYP2U1
motor activity (GO:0003774)	4.81	2	KIF1A, KIF5A
microtubule motor activity (GO:0003777)	5.34	2	KIF1A, KIF5A

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	37	L1CAM, GJC2, DDHD2, HSPD1, IBA57, B4GALNT1, KIF1A, ATL1, FA2H, CPT1C, SPAST, KIAA0196, AP5Z1, MAG, PLP1, CYP2U1, ARL6IP1, BSCL2, C12orf65, SPG20, TFG, PNPLA6, VPS37A, REEP1, NT5C2, ERLIN2, SPG11, ZFYVE26, TECPR2, DDHD1, ALDH18A1, GBA2, AMPD2, ZFYVE27, SPG7, KIF5A, CYP7B1
single-organism process (GO:0044699)	0.48	34	L1CAM, GJC2, DDHD2, HSPD1, IBA57, B4GALNT1, KIF1A, ATL1, ENTPD1, CPT1C, SLC33A1, KIAA0196, PLP1, SPAST, CYP2U1, ARL6IP1, BSCL2, C12orf65, SPG20, FA2H, PNPLA6, ALDH18A1, NT5C2, ERLIN2, SPG11, ZFYVE26, MAG, DDHD1, GBA2, AMPD2, ZFYVE27, SPG7, KIF5A, CYP7B1
single-organism cellular process (GO:0044763)	0.65	29	L1CAM, GJC2, BSCL2, HSPD1, IBA57, GBA2, KIF1A, ATL1, FA2H, CPT1C, KIAA0196, PLP1, SPAST, CYP2U1, ARL6IP1, C12orf65, SPG20, PNPLA6, ALDH18A1, NT5C2, SPG11, ZFYVE26, MAG, CYP7B1, B4GALNT1, AMPD2, ZFYVE27, SPG7, KIF5A
biological regulation (GO:0065007)	0.39	23	L1CAM, DDHD2, ENTPD1, SLC33A1, SPAST, RTN2, MAG, PLP1, ARL6IP1, BSCL2, C12orf65, SPG20, FA2H, REEP1, HSPD1, ERLIN2, TFG, DDHD1, B4GALNT1, AMPD2, SPG21, ZFYVE27, CYP7B1
metabolic process (GO:0008152)	0.58	23	BSCL2, HSPD1, IBA57, B4GALNT1, FA2H, CPT1C, SPAST, AP5Z1, CYP2U1, PLP1, DDHD2, C12orf65, PNPLA6, ALDH18A1, NT5C2, ERLIN2, ZFYVE26, DDHD1, VPS37A, GBA2, AMPD2, SPG7, CYP7B1
organic substance metabolic process (GO:0071704)	0.63	22	BSCL2, HSPD1, IBA57, B4GALNT1, FA2H, CPT1C, PLP1, AP5Z1, CYP2U1, DDHD2, C12orf65, PNPLA6, ALDH18A1, NT5C2, ERLIN2, ZFYVE26, DDHD1, VPS37A, GBA2, AMPD2, SPG7, CYP7B1
primary metabolic process (GO:0044238)	0.69	21	ZFYVE26, FA2H, PLP1, NT5C2, GBA2, CPT1C, ALDH18A1, DDHD1, C12orf65, DDHD2, AP5Z1, PNPLA6, AMPD2, CYP7B1, VPS37A, BSCL2, B4GALNT1, HSPD1, SPG7, CYP2U1, ERLIN2
localization (GO:0051179)	1.4	21	AP4S1, KIF1A, ARL6IP1, NIPA1, SPAST, SLC33A1, KIF5A, KIAA0196, RTN2, REEP1, VPS37A, AP4M1, B4GALNT1, AP5Z1, AP4B1, AP4E1, ZFYVE27, GJC2, SPG7, SPG11, BSCL2
regulation of biological process (GO:0050789)	0.45	20	TFG, PLP1, DDHD2, REEP1, ARL6IP1, SPG21, SLC33A1, DDHD1, C12orf65, SPG20, FA2H, RTN2, MAG, SPAST, ZFYVE27, HSPD1, L1CAM, ERLIN2, BSCL2, CYP7B1
cellular metabolic process (GO:0044237)	0.69	20	ZFYVE26, FA2H, PLP1, PNPLA6, CPT1C, C12orf65, DDHD1, DDHD2, VPS37A, B4GALNT1, AMPD2, NT5C2, AP5Z1, ALDH18A1, IBA57, GBA2, HSPD1, ERLIN2, CYP2U1, CYP7B1
establishment of localization (GO:0051234)	1.48	18	AP4S1, KIF1A, NIPA1, ARL6IP1, SPAST, SLC33A1, KIF5A, KIAA0196, RTN2, AP5Z1, AP4E1, VPS37A, AP4B1, AP4M1, REEP1, GJC2, SPG7, SPG11
single-organism metabolic process (GO:0044710)	1.63	17	FA2H, GBA2, CPT1C, BSCL2, DDHD1, DDHD2, PLP1, B4GALNT1, AMPD2, NT5C2, ALDH18A1, IBA57, PNPLA6, HSPD1, ERLIN2, CYP2U1, CYP7B1
transport (GO:0006810)	1.51	17	AP4S1, KIF1A, ARL6IP1, GJC2, SLC33A1, KIF5A, KIAA0196, RTN2, AP5Z1, AP4M1, SPAST, AP4B1, AP4E1, NIPA1, SPG7, VPS37A, SPG11
regulation of cellular process (GO:0050794)	0.5	17	TFG, L1CAM, ARL6IP1, SPAST, SLC33A1, DDHD2, C12orf65, SPG20, FA2H, MAG, CYP7B1, PLP1, ZFYVE27, SPG21, HSPD1, ERLIN2, DDHD1
cellular component organization (GO:0016043)	1.24	16	TFG, PLP1, REEP1, ARL6IP1, SPAST, BSCL2, KIAA0196, SPG20, FA2H, VPS37A, IBA57, ZFYVE27, HSPD1, ATL1, SPG7, C12orf65
cellular component organization or biogenesis (GO:0071840)	1.22	16	TFG, PLP1, REEP1, ARL6IP1, BSCL2, C12orf65, SPG20, FA2H, SPAST, IBA57, ZFYVE27, HSPD1, ATL1, SPG7, VPS37A, KIAA0196
nitrogen compound metabolic process (GO:0006807)	1.13	13	ZFYVE26, FA2H, GBA2, CPT1C, C12orf65, AP5Z1, B4GALNT1, AMPD2, NT5C2, ALDH18A1, IBA57, PNPLA6, HSPD1
positive regulation of biological process (GO:0048518)	1.2	12	TFG, PLP1, L1CAM, ARL6IP1, DDHD1, DDHD2, SPG21, MAG, SPAST, HSPD1, ERLIN2, CYP7B1
developmental process (GO:0032502)	1.36	12	MAG, L1CAM, CYP7B1, SPG20, PLP1, PNPLA6, KIAA0196, SPAST, GBA2, SPG7, SPG11, ATL1
lipid metabolic process (GO:0006629)	2.68	12	FA2H, GBA2, CPT1C, BSCL2, DDHD1, DDHD2, CYP2U1, B4GALNT1, PLP1, PNPLA6, ERLIN2, CYP7B1
cellular localization (GO:0051641)	2.32	12	KIF1A, ARL6IP1, SPG11, RTN2, VPS37A, AP4M1, SPAST, AP4B1, AP4E1, ZFYVE27, SPG7, KIF5A
macromolecule localization (GO:0033036)	2.34	11	AP4S1, AP4M1, ARL6IP1, AP4B1, KIAA0196, AP5Z1, AP4E1, VPS37A, RTN2, ZFYVE27, KIF5A
protein localization (GO:0008104)	2.36	11	AP4S1, ARL6IP1, AP4B1, KIAA0196, RTN2, AP5Z1, AP4M1, VPS37A, AP4E1, ZFYVE27, KIF5A
intracellular transport (GO:0046907)	2.67	11	KIF1A, ARL6IP1, SPG11, AP4B1, RTN2, VPS37A, AP4M1, SPAST, AP4E1, SPG7, KIF5A
establishment of localization in cell (GO:0051649)	2.47	11	KIF1A, ARL6IP1, SPG11, AP4B1, RTN2, VPS37A, AP4M1, SPAST, AP4E1, SPG7, KIF5A
organelle organization (GO:0006996)	2.02	10	TFG, ARL6IP1, BSCL2, KIAA0196, SPG20, VPS37A, SPAST, REEP1, SPG7, ATL1
establishment of protein localization (GO:0045184)	2.53	10	AP4S1, ARL6IP1, KIAA0196, AP4E1, AP5Z1, RTN2, VPS37A, AP4M1, REEP1, AP4B1
organic substance biosynthetic process (GO:1901576)	1.34	10	FA2H, C12orf65, DDHD1, DDHD2, ALDH18A1, B4GALNT1, AMPD2, PLP1, IBA57, CYP7B1
cellular nitrogen compound metabolic process (GO:0034641)	1.22	10	ZFYVE26, CPT1C, C12orf65, B4GALNT1, AMPD2, NT5C2, AP5Z1, IBA57, GBA2, HSPD1
single-organism developmental process (GO:0044767)	1.49	10	MAG, L1CAM, CYP7B1, PLP1, PNPLA6, SPAST, GBA2, ATL1, SPG11, KIAA0196
biosynthetic process (GO:0009058)	1.32	10	FA2H, C12orf65, DDHD1, DDHD2, ALDH18A1, B4GALNT1, AMPD2, PLP1, IBA57, CYP7B1
small molecule metabolic process (GO:0044281)	2.38	10	FA2H, CPT1C, CYP7B1, ALDH18A1, GBA2, AMPD2, PLP1, NT5C2, ERLIN2, CYP2U1
organic substance transport (GO:0071702)	2.15	10	AP4S1, ARL6IP1, SLC33A1, KIAA0196, AP4E1, VPS37A, RTN2, AP5Z1, AP4M1, AP4B1
organic substance catabolic process (GO:1901575)	2.45	9	CPT1C, BSCL2, DDHD1, DDHD2, PNPLA6, VPS37A, GBA2, NT5C2, ERLIN2
organonitrogen compound metabolic process (GO:1901564)	2.32	9	FA2H, CPT1C, C12orf65, B4GALNT1, AMPD2, ALDH18A1, IBA57, GBA2, NT5C2
protein transport (GO:0015031)	2.62	9	AP4S1, ARL6IP1, KIAA0196, RTN2, VPS37A, AP4E1, AP5Z1, AP4M1, AP4B1
catabolic process (GO:0009056)	2.38	9	CPT1C, BSCL2, DDHD1, DDHD2, PNPLA6, VPS37A, GBA2, NT5C2, ERLIN2
organic cyclic compound metabolic process (GO:1901360)	1.26	9	ZFYVE26, CYP7B1, GBA2, AMPD2, NT5C2, AP5Z1, IBA57, HSPD1, ERLIN2
positive regulation of cellular process (GO:0048522)	1.3	9	TFG, L1CAM, DDHD1, DDHD2, MAG, SPAST, HSPD1, ERLIN2, CYP7B1
macromolecule metabolic process (GO:0043170)	0.83	8	ZFYVE26, C12orf65, AP5Z1, B4GALNT1, VPS37A, HSPD1, SPG7, ERLIN2
cellular biosynthetic process (GO:0044249)	1.37	8	FA2H, CYP7B1, ALDH18A1, B4GALNT1, AMPD2, PLP1, IBA57, C12orf65
cellular component assembly (GO:0022607)	2.14	8	TFG, ARL6IP1, KIAA0196, VPS37A, SPAST, IBA57, HSPD1, ATL1
regulation of metabolic process (GO:0019222)	1.02	8	ARL6IP1, SLC33A1, BSCL2, C12orf65, SPG20, PLP1, HSPD1, ERLIN2
cellular developmental process (GO:0048869)	1.82	8	FA2H, L1CAM, KIAA0196, BSCL2, PLP1, GBA2, SPAST, ATL1
single-organism catabolic process (GO:0044712)	3.21	7	CPT1C, BSCL2, DDHD1, DDHD2, PNPLA6, GBA2, NT5C2
single-organism biosynthetic process (GO:0044711)	2.8	7	FA2H, CYP7B1, ALDH18A1, B4GALNT1, AMPD2, PLP1, IBA57
regulation of primary metabolic process (GO:0080090)	1.08	7	ARL6IP1, SLC33A1, BSCL2, C12orf65, SPG20, HSPD1, ERLIN2
organic acid metabolic process (GO:0006082)	3.01	7	FA2H, CPT1C, CYP7B1, PLP1, GBA2, ALDH18A1, CYP2U1
regulation of macromolecule metabolic process (GO:0060255)	1.08	7	ARL6IP1, SLC33A1, C12orf65, SPG20, PLP1, HSPD1, ERLIN2
response to stimulus (GO:0050896)	1.22	7	ZFYVE26, MAG, GJC2, PLP1, AP5Z1, HSPD1, ERLIN2
anatomical structure development (GO:0048856)	1.58	7	MAG, L1CAM, SPG20, PLP1, GBA2, SPAST, SPG7
carboxylic acid metabolic process (GO:0019752)	3.12	7	FA2H, CPT1C, CYP7B1, PLP1, GBA2, ALDH18A1, CYP2U1
movement of cell or subcellular component (GO:0006928)	2.61	7	MAG, L1CAM, SPG11, SPAST, KIF1A, SPG7, KIF5A
cellular macromolecule metabolic process (GO:0044260)	0.93	7	ZFYVE26, C12orf65, VPS37A, B4GALNT1, AP5Z1, HSPD1, ERLIN2
signal transduction (GO:0007165)	1.28	7	TFG, SLC33A1, PLP1, SPG21, ZFYVE27, HSPD1, ERLIN2
phosphorus metabolic process (GO:0006793)	2.15	7	DDHD1, DDHD2, PNPLA6, AMPD2, ALDH18A1, NT5C2, ERLIN2
oxoacid metabolic process (GO:0043436)	3.12	7	FA2H, CPT1C, CYP7B1, PLP1, GBA2, ALDH18A1, CYP2U1
negative regulation of biological process (GO:0048519)	1.33	7	MAG, ARL6IP1, BSCL2, CYP7B1, SPG20, HSPD1, ERLIN2
cellular lipid metabolic process (GO:0044255)	2.92	7	FA2H, GBA2, CPT1C, CYP2U1, PNPLA6, PLP1, B4GALNT1
single-organism localization (GO:1902578)	2.09	7	KIF1A, ARL6IP1, SLC33A1, SPAST, ZFYVE27, SPG7, SPG11
multicellular organismal process (GO:0032501)	1.45	6	ENTPD1, L1CAM, SPG20, AMPD2, SPAST, HSPD1
vesicle-mediated transport (GO:0016192)	2.72	6	KIF5A, AP4E1, SPAST, AP4B1, AP4M1, SPG11
organonitrogen compound biosynthetic process (GO:1901566)	2.85	6	FA2H, C12orf65, B4GALNT1, AMPD2, ALDH18A1, IBA57
protein metabolic process (GO:0019538)	1.45	6	C12orf65, B4GALNT1, VPS37A, HSPD1, ERLIN2, SPG7
cellular aromatic compound metabolic process (GO:0006725)	1.3	6	ZFYVE26, AMPD2, NT5C2, AP5Z1, IBA57, HSPD1
regulation of cellular metabolic process (GO:0031323)	1.07	6	ARL6IP1, SLC33A1, C12orf65, SPG20, HSPD1, ERLIN2
regulation of cellular component organization (GO:0051128)	2.01	6	MAG, L1CAM, SPG20, DDHD1, DDHD2, SPAST
cellular catabolic process (GO:0044248)	2.62	6	CPT1C, PNPLA6, VPS37A, GBA2, NT5C2, ERLIN2
single-organism transport (GO:0044765)	2.18	6	KIF1A, ARL6IP1, SLC33A1, SPAST, SPG7, SPG11
microtubule-based process (GO:0007017)	3.54	6	KIF1A, KIF5A, KIAA0196, SPAST, SPG7, SPG11
regulation of biological quality (GO:0065008)	1.68	6	ENTPD1, SPG20, BSCL2, B4GALNT1, AMPD2, HSPD1
monocarboxylic acid metabolic process (GO:0032787)	3.57	6	CYP2U1, CPT1C, CYP7B1, FA2H, GBA2, PLP1
single-organism cellular localization (GO:1902580)	3.16	6	KIF1A, ARL6IP1, SPAST, ZFYVE27, SPG7, SPG11
lipid catabolic process (GO:0016042)	4.21	6	CPT1C, DDHD2, DDHD1, BSCL2, PNPLA6, GBA2
negative regulation of cellular process (GO:0048523)	1.41	6	MAG, ARL6IP1, CYP7B1, SPG20, HSPD1, ERLIN2
heterocycle metabolic process (GO:0046483)	1.31	6	ZFYVE26, AMPD2, NT5C2, AP5Z1, IBA57, HSPD1
nucleobase-containing compound metabolic process (GO:0006139)	1.35	5	AMPD2, NT5C2, AP5Z1, HSPD1, ZFYVE26
cell differentiation (GO:0030154)	2.14	5	L1CAM, PLP1, BSCL2, FA2H, SPAST
protein complex subunit organization (GO:0071822)	2.6	5	C12orf65, ATL1, SPAST, HSPD1, TFG
single-multicellular organism process (GO:0044707)	1.78	5	AMPD2, HSPD1, SPAST, L1CAM, ENTPD1
membrane organization (GO:0061024)	3.04	5	VPS37A, FA2H, ARL6IP1, SPAST, ZFYVE27
regulation of developmental process (GO:0050793)	2.1	5	DDHD2, DDHD1, L1CAM, SPG20, MAG
microtubule-based movement (GO:0007018)	4.39	5	SPG11, SPAST, KIF5A, SPG7, KIF1A
intracellular protein transport (GO:0006886)	3.2	5	ARL6IP1, RTN2, AP4B1, AP4E1, AP4M1
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	5	SPG20, DDHD2, DDHD1, L1CAM, MAG
regulation of response to stimulus (GO:0048583)	1.54	5	HSPD1, TFG, SPG20, CYP7B1, SPG21
response to stress (GO:0006950)	1.8	5	HSPD1, ZFYVE26, AP5Z1, PLP1, ERLIN2
cytoskeleton-dependent intracellular transport (GO:0030705)	4.96	5	SPG11, SPAST, KIF5A, SPG7, KIF1A
immune system process (GO:0002376)	2.29	5	HSPD1, KIF5A, MAG, L1CAM, SPG21
macromolecular complex subunit organization (GO:0043933)	2.14	5	HSPD1, ATL1, TFG, SPAST, C12orf65
phosphate-containing compound metabolic process (GO:0006796)	2.16	5	AMPD2, NT5C2, ALDH18A1, ERLIN2, PNPLA6
regulation of multicellular organismal process (GO:0051239)	1.87	5	HSPD1, SPG20, FA2H, L1CAM, MAG
cell adhesion (GO:0007155)	2.82	5	HSPD1, MAG, SPG7, L1CAM, ENTPD1
single-organism intracellular transport (GO:1902582)	3.59	5	KIF1A, SPG7, SPG11, SPAST, ARL6IP1
biological adhesion (GO:0022610)	2.81	5	HSPD1, SPG7, MAG, L1CAM, ENTPD1
regulation of gene expression (GO:0010468)	1.37	5	ERLIN2, SLC33A1, PLP1, SPG20, C12orf65
oxidation-reduction process (GO:0055114)	2.91	5	CYP7B1, FA2H, CYP2U1, ALDH18A1, CPT1C
fatty acid metabolic process (GO:0006631)	4.03	4	PLP1, CYP2U1, FA2H, CPT1C
cell projection organization (GO:0030030)	3.14	4	PLP1, ATL1, ZFYVE27, SPAST
regulation of cellular biosynthetic process (GO:0031326)	1.38	4	SLC33A1, ERLIN2, SPG20, C12orf65
signaling (GO:0023052)	3.25	4	KIF5A, PLP1, SPG11, GJC2
cell surface receptor signaling pathway (GO:0007166)	2.09	4	SLC33A1, PLP1, SPG21, ZFYVE27
small molecule biosynthetic process (GO:0044283)	3.79	4	CYP7B1, PLP1, FA2H, ALDH18A1
anatomical structure morphogenesis (GO:0009653)	2.53	4	ATL1, SPAST, CYP7B1, PNPLA6
cellular response to stimulus (GO:0051716)	1.97	4	ZFYVE26, ERLIN2, AP5Z1, MAG
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	4	SLC33A1, C12orf65, SPG20, ERLIN2
axo-dendritic transport (GO:0008088)	6.12	4	KIF1A, SPAST, SPG11, SPG7
macromolecular complex assembly (GO:0065003)	2.55	4	HSPD1, ATL1, TFG, SPAST
positive regulation of cellular component organization (GO:0051130)	2.68	4	L1CAM, DDHD1, DDHD2, SPAST
protein complex assembly (GO:0006461)	2.78	4	HSPD1, ATL1, TFG, SPAST
regulation of biosynthetic process (GO:0009889)	1.37	4	SLC33A1, ERLIN2, SPG20, C12orf65
establishment of localization by movement along microtubule (GO:0010970)	5.14	4	KIF1A, SPAST, SPG11, SPG7
single-organism membrane organization (GO:0044802)	3.19	4	SPAST, FA2H, ARL6IP1, ZFYVE27
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	4	SLC33A1, ERLIN2, SPG20, C12orf65
cell-cell signaling (GO:0007267)	3.35	4	SPG11, PLP1, KIF5A, GJC2
cell communication (GO:0007154)	3.04	4	SPG11, PLP1, KIF5A, GJC2
transmembrane transport (GO:0055085)	2.72	4	SLC33A1, RTN2, GJC2, NIPA1
lipid biosynthetic process (GO:0008610)	3.49	4	PLP1, FA2H, CYP7B1, B4GALNT1
endosomal transport (GO:0016197)	4.28	4	KIAA0196, AP5Z1, VPS37A, AP4M1
single organism signaling (GO:0044700)	3.25	4	KIF5A, PLP1, SPG11, GJC2
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	4	AMPD2, C12orf65, IBA57, B4GALNT1
nervous system development (GO:0007399)	3.53	4	SPG7, MAG, L1CAM, SPAST
vacuolar transport (GO:0007034)	4.18	4	KIAA0196, VPS37A, AP5Z1, AP4M1
positive regulation of developmental process (GO:0051094)	2.77	4	L1CAM, DDHD1, DDHD2, MAG
carboxylic acid biosynthetic process (GO:0046394)	4.32	4	ALDH18A1, PLP1, FA2H, CYP7B1
carbohydrate derivative metabolic process (GO:1901135)	3.07	4	AMPD2, NT5C2, B4GALNT1, GBA2
organic acid biosynthetic process (GO:0016053)	4.26	4	ALDH18A1, PLP1, FA2H, CYP7B1
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	4	SLC33A1, C12orf65, SPG20, ERLIN2
system development (GO:0048731)	2.92	4	SPG7, MAG, L1CAM, SPAST
regulation of cell morphogenesis (GO:0022604)	3.4	3	L1CAM, MAG, SPG20
negative regulation of metabolic process (GO:0009892)	1.93	3	ERLIN2, BSCL2, ARL6IP1
positive regulation of metabolic process (GO:0009893)	1.74	3	HSPD1, ERLIN2, PLP1
regulation of organelle organization (GO:0033043)	2.72	3	DDHD1, DDHD2, SPAST
regulation of transport (GO:0051049)	2.24	3	RTN2, ARL6IP1, REEP1
chemical synaptic transmission (GO:0007268)	3.98	3	KIF5A, PLP1, SPG11
nucleic acid metabolic process (GO:0090304)	1.46	3	HSPD1, ZFYVE26, AP5Z1
cell cycle process (GO:0022402)	2.75	3	ZFYVE26, SPAST, KIAA0196
regulation of signaling (GO:0023051)	1.72	3	CYP7B1, SPG20, TFG
cellular lipid catabolic process (GO:0044242)	4.73	3	PNPLA6, GBA2, CPT1C
glycosyl compound metabolic process (GO:1901657)	4.04	3	AMPD2, NT5C2, GBA2
organic cyclic compound biosynthetic process (GO:1901362)	1.66	3	AMPD2, CYP7B1, IBA57
regulation of cell projection organization (GO:0031344)	3.38	3	SPG20, MAG, L1CAM
cell division (GO:0051301)	3.68	3	ZFYVE26, SPAST, SPG20
cellular protein metabolic process (GO:0044267)	1.63	3	ERLIN2, C12orf65, B4GALNT1
endoplasmic reticulum organization (GO:0007029)	6.26	3	ATL1, ARL6IP1, REEP1
regulation of cell communication (GO:0010646)	1.73	3	TFG, SPG20, CYP7B1
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	3	HSPD1, PLP1, ERLIN2
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	3	SLC33A1, ERLIN2, SPG20
regulation of signal transduction (GO:0009966)	1.84	3	TFG, SPG20, CYP7B1
positive regulation of multicellular organismal process (GO:0051240)	2.49	3	HSPD1, MAG, L1CAM
Golgi vesicle transport (GO:0048193)	4.07	3	SPAST, KIF5A, AP4M1
regulation of protein metabolic process (GO:0051246)	1.93	3	HSPD1, C12orf65, ARL6IP1
regulation of cell development (GO:0060284)	3.01	3	SPG20, MAG, L1CAM
anterograde axonal transport (GO:0008089)	6.47	3	SPAST, KIF1A, SPG7
regulation of neuron differentiation (GO:0045664)	3.39	3	SPG20, MAG, L1CAM
regulation of cell morphogenesis involved in differentiation (GO:0010769)	3.91	3	L1CAM, MAG, SPG20
phosphorylation (GO:0016310)	2.63	3	NT5C2, ALDH18A1, ERLIN2
organophosphate metabolic process (GO:0019637)	3.04	3	AMPD2, NT5C2, PNPLA6
sphingolipid metabolic process (GO:0006665)	4.79	3	FA2H, B4GALNT1, GBA2
DNA recombination (GO:0006310)	4.39	3	HSPD1, ZFYVE26, AP5Z1
positive regulation of response to stimulus (GO:0048584)	2.18	3	HSPD1, TFG, SPG21
membrane lipid metabolic process (GO:0006643)	4.51	3	FA2H, B4GALNT1, GBA2
regulation of neurogenesis (GO:0050767)	3.21	3	SPG20, MAG, L1CAM
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	3	SLC33A1, ERLIN2, SPG20
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	3	SLC33A1, ERLIN2, SPG20
reproductive process (GO:0022414)	2.55	3	CYP7B1, KIAA0196, B4GALNT1
regulation of cell differentiation (GO:0045595)	2.42	3	L1CAM, MAG, SPG20
regulation of cellular protein metabolic process (GO:0032268)	1.99	3	HSPD1, C12orf65, ARL6IP1
regulation of neuron projection development (GO:0010975)	3.69	3	L1CAM, MAG, SPG20
regulation of RNA biosynthetic process (GO:2001141)	1.55	3	SLC33A1, ERLIN2, SPG20
regulation of localization (GO:0032879)	1.94	3	ARL6IP1, RTN2, REEP1
lipid modification (GO:0030258)	4.37	3	FA2H, B4GALNT1, CPT1C
proteolysis (GO:0006508)	2.73	3	SPG7, VPS37A, ERLIN2
steroid metabolic process (GO:0008202)	4.32	3	CYP7B1, ERLIN2, GBA2
anterograde trans-synaptic signaling (GO:0098916)	3.98	3	SPG11, PLP1, KIF5A
single organism reproductive process (GO:0044702)	2.73	3	CYP7B1, KIAA0196, B4GALNT1
regulation of axonogenesis (GO:0050770)	4.59	3	L1CAM, MAG, SPG20
cellular amide metabolic process (GO:0043603)	3.23	3	C12orf65, B4GALNT1, GBA2
regulation of RNA metabolic process (GO:0051252)	1.52	3	SLC33A1, ERLIN2, SPG20
positive regulation of organelle organization (GO:0010638)	3.38	3	DDHD1, DDHD2, SPAST
(GO:0098930)	6.26	3	SPAST, KIF1A, SPG7
monocarboxylic acid biosynthetic process (GO:0072330)	4.74	3	PLP1, FA2H, CYP7B1
regulation of transcription, DNA-templated (GO:0006355)	1.56	3	SLC33A1, ERLIN2, SPG20
single-organism organelle organization (GO:1902589)	2.68	3	SPAST, KIAA0196, ARL6IP1
regulation of nervous system development (GO:0051960)	3.1	3	L1CAM, MAG, SPG20
regulation of multicellular organismal development (GO:2000026)	2.31	3	SPG20, MAG, L1CAM
cellular response to stress (GO:0033554)	2.51	3	ZFYVE26, AP5Z1, ERLIN2
DNA metabolic process (GO:0006259)	3.09	3	HSPD1, ZFYVE26, AP5Z1
cytokinesis (GO:0000910)	5.22	3	ZFYVE26, KIAA0196, SPAST
synaptic signaling (GO:0099536)	3.98	3	SPG11, PLP1, KIF5A
trans-synaptic signaling (GO:0099537)	3.98	3	SPG11, PLP1, KIF5A
organophosphate catabolic process (GO:0046434)	5.03	2	NT5C2, PNPLA6
negative regulation of response to stimulus (GO:0048585)	2.52	2	CYP7B1, SPG20
cell development (GO:0048468)	3.28	2	PLP1, GBA2
cell maturation (GO:0048469)	4.98	2	PLP1, KIAA0196
purine ribonucleoside monophosphate metabolic process (GO:0009167)	4.7	2	AMPD2, NT5C2
plasma membrane organization (GO:0007009)	4.8	2	FA2H, ZFYVE27
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	2	SLC33A1, ZFYVE27
establishment of organelle localization (GO:0051656)	4.15	2	SPAST, SPG11
negative regulation of cell projection organization (GO:0031345)	4.72	2	MAG, SPG20
purine ribonucleoside metabolic process (GO:0046128)	4.33	2	AMPD2, NT5C2
double-strand break repair (GO:0006302)	4.73	2	ZFYVE26, AP5Z1
negative regulation of signal transduction (GO:0009968)	2.75	2	CYP7B1, SPG20
cellular macromolecule localization (GO:0070727)	3.1	2	ARL6IP1, ZFYVE27
negative regulation of neuron differentiation (GO:0045665)	4.45	2	MAG, SPG20
negative regulation of lipid metabolic process (GO:0045833)	5.33	2	ERLIN2, BSCL2
positive regulation of cell development (GO:0010720)	3.57	2	MAG, L1CAM
negative regulation of cell development (GO:0010721)	4.02	2	MAG, SPG20
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)	4.43	2	HSPD1, ARL6IP1
glycolipid metabolic process (GO:0006664)	5.01	2	B4GALNT1, GBA2
regulation of cell proliferation (GO:0042127)	2.41	2	CYP7B1, FA2H
negative regulation of developmental process (GO:0051093)	3.17	2	MAG, SPG20
DNA repair (GO:0006281)	3.59	2	ZFYVE26, AP5Z1
negative regulation of cell death (GO:0060548)	2.95	2	HSPD1, ARL6IP1
secondary alcohol metabolic process (GO:1902652)	5.0	2	CYP7B1, ERLIN2
regulation of proteolysis (GO:0030162)	3.2	2	HSPD1, ARL6IP1
protein localization to membrane (GO:0072657)	3.95	2	ARL6IP1, ZFYVE27
neuron projection guidance (GO:0097485)	4.43	2	L1CAM, KIF5A
multi-organism process (GO:0051704)	2.65	2	HSPD1, VPS37A
organonitrogen compound catabolic process (GO:1901565)	3.91	2	NT5C2, GBA2
cell motility (GO:0048870)	3.02	2	MAG, L1CAM
vesicle organization (GO:0016050)	4.13	2	TFG, VPS37A
purine nucleotide metabolic process (GO:0006163)	4.09	2	AMPD2, NT5C2
aromatic compound biosynthetic process (GO:0019438)	1.7	2	AMPD2, IBA57
ceramide metabolic process (GO:0006672)	5.41	2	B4GALNT1, GBA2
cell part morphogenesis (GO:0032990)	3.99	2	SPAST, ATL1
ribonucleoside monophosphate metabolic process (GO:0009161)	4.62	2	AMPD2, NT5C2
positive regulation of gene expression (GO:0010628)	2.35	2	PLP1, ERLIN2
microtubule cytoskeleton organization (GO:0000226)	4.13	2	KIAA0196, SPAST
cytoskeleton-dependent cytokinesis (GO:0061640)	6.2	2	KIAA0196, SPAST
neuron projection development (GO:0031175)	4.58	2	PLP1, ZFYVE27
regulation of apoptotic process (GO:0042981)	2.5	2	HSPD1, ARL6IP1
cellular macromolecule catabolic process (GO:0044265)	3.19	2	ERLIN2, VPS37A
immune response-regulating signaling pathway (GO:0002764)	3.72	2	HSPD1, SPG21
regulation of peptidase activity (GO:0052547)	3.75	2	HSPD1, ARL6IP1
positive regulation of immune system process (GO:0002684)	2.96	2	HSPD1, SPG21
regulation of immune system process (GO:0002682)	2.5	2	HSPD1, SPG21
glycosphingolipid metabolic process (GO:0006687)	5.49	2	B4GALNT1, GBA2
regulation of molecular function (GO:0065009)	1.78	2	HSPD1, ARL6IP1
cell migration (GO:0016477)	3.12	2	MAG, L1CAM
heterocycle biosynthetic process (GO:0018130)	1.7	2	AMPD2, IBA57
sphingolipid biosynthetic process (GO:0030148)	5.38	2	FA2H, B4GALNT1
cation transport (GO:0006812)	3.11	2	SLC33A1, NIPA1
ion transport (GO:0006811)	2.66	2	SLC33A1, NIPA1
regulation of catalytic activity (GO:0050790)	1.97	2	HSPD1, ARL6IP1
purine ribonucleotide metabolic process (GO:0009150)	4.16	2	AMPD2, NT5C2
spindle organization (GO:0007051)	5.33	2	SPAST, KIAA0196
macromolecule modification (GO:0043412)	1.73	2	ERLIN2, B4GALNT1
protein modification process (GO:0036211)	1.79	2	ERLIN2, B4GALNT1
long-chain fatty acid metabolic process (GO:0001676)	5.27	2	PLP1, CYP2U1
maintenance of location (GO:0051235)	4.77	2	BSCL2, B4GALNT1
regulation of hydrolase activity (GO:0051336)	2.53	2	HSPD1, ARL6IP1
proteolysis involved in cellular protein catabolic process (GO:0051603)	3.59	2	VPS37A, ERLIN2
lipid particle organization (GO:0034389)	7.09	2	BSCL2, SPG20
nucleoside monophosphate metabolic process (GO:0009123)	4.54	2	AMPD2, NT5C2
positive regulation of nervous system development (GO:0051962)	3.64	2	MAG, L1CAM
negative regulation of nervous system development (GO:0051961)	4.15	2	MAG, SPG20
ubiquitin-dependent protein catabolic process (GO:0006511)	3.72	2	ERLIN2, VPS37A
nucleotide metabolic process (GO:0009117)	3.73	2	AMPD2, NT5C2
nucleoside phosphate metabolic process (GO:0006753)	3.71	2	AMPD2, NT5C2
organic hydroxy compound metabolic process (GO:1901615)	3.84	2	CYP7B1, ERLIN2
fatty acid biosynthetic process (GO:0006633)	5.01	2	PLP1, FA2H
regulation of developmental growth (GO:0048638)	4.04	2	L1CAM, SPG20
purine nucleoside metabolic process (GO:0042278)	4.32	2	AMPD2, NT5C2
negative regulation of cellular component organization (GO:0051129)	3.35	2	MAG, SPG20
negative regulation of signaling (GO:0023057)	2.65	2	CYP7B1, SPG20
substantia nigra development (GO:0021762)	5.9	2	PLP1, MAG
negative regulation of cell communication (GO:0010648)	2.66	2	CYP7B1, SPG20
axon guidance (GO:0007411)	4.44	2	L1CAM, KIF5A
purine nucleoside monophosphate metabolic process (GO:0009126)	4.69	2	AMPD2, NT5C2
ribonucleotide metabolic process (GO:0009259)	4.11	2	AMPD2, NT5C2
cell cycle (GO:0007049)	3.14	2	ZFYVE26, SPAST
regulation of extent of cell growth (GO:0061387)	5.09	2	L1CAM, SPG20
interspecies interaction between organisms (GO:0044419)	3.08	2	HSPD1, VPS37A
recombinational repair (GO:0000725)	5.37	2	ZFYVE26, AP5Z1
double-strand break repair via homologous recombination (GO:0000724)	5.38	2	ZFYVE26, AP5Z1
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	MAG, SPG20
negative regulation of neurogenesis (GO:0050768)	4.22	2	MAG, SPG20
positive regulation of neurogenesis (GO:0050769)	3.77	2	MAG, L1CAM
membrane lipid biosynthetic process (GO:0046467)	4.99	2	FA2H, B4GALNT1
liposaccharide metabolic process (GO:1903509)	4.98	2	B4GALNT1, GBA2
sterol metabolic process (GO:0016125)	4.92	2	CYP7B1, ERLIN2
lipid storage (GO:0019915)	6.4	2	BSCL2, B4GALNT1
modification-dependent protein catabolic process (GO:0019941)	3.71	2	VPS37A, ERLIN2
cellular response to DNA damage stimulus (GO:0006974)	3.17	2	ZFYVE26, AP5Z1
negative regulation of cell differentiation (GO:0045596)	3.33	2	MAG, SPG20
immune response-activating signal transduction (GO:0002757)	3.8	2	HSPD1, SPG21
axonogenesis (GO:0007409)	4.74	2	SPAST, ATL1
bile acid metabolic process (GO:0008206)	6.15	2	CYP7B1, GBA2
nucleobase-containing small molecule metabolic process (GO:0055086)	3.59	2	AMPD2, NT5C2
cholesterol metabolic process (GO:0008203)	5.03	2	CYP7B1, ERLIN2
protein oligomerization (GO:0051259)	3.71	2	ATL1, SPAST
amide biosynthetic process (GO:0043604)	3.6	2	C12orf65, B4GALNT1
regulation of immune response (GO:0050776)	2.98	2	HSPD1, SPG21
negative regulation of axonogenesis (GO:0050771)	5.52	2	MAG, SPG20
carbohydrate derivative biosynthetic process (GO:1901137)	3.73	2	AMPD2, B4GALNT1
positive regulation of cell differentiation (GO:0045597)	3.01	2	MAG, L1CAM
positive regulation of immune response (GO:0050778)	3.4	2	HSPD1, SPG21
negative regulation of cell morphogenesis involved in differentiation (GO:0010771)	4.96	2	MAG, SPG20
regulation of mitochondrion organization (GO:0010821)	4.34	2	DDHD1, DDHD2
phosphatidic acid metabolic process (GO:0046473)	6.2	2	DDHD1, DDHD2
phosphatidic acid biosynthetic process (GO:0006654)	6.23	2	DDHD1, DDHD2
neuron projection morphogenesis (GO:0048812)	4.34	2	ATL1, SPAST
positive regulation of cellular metabolic process (GO:0031325)	1.81	2	HSPD1, ERLIN2
negative regulation of cellular metabolic process (GO:0031324)	2.01	2	ERLIN2, ARL6IP1
leukocyte migration (GO:0050900)	4.19	2	MAG, L1CAM
IMP metabolic process (GO:0046040)	7.09	2	AMPD2, NT5C2
positive regulation of mitochondrion organization (GO:0010822)	4.61	2	DDHD1, DDHD2
purine-containing compound metabolic process (GO:0072521)	4.0	2	AMPD2, NT5C2
modification-dependent macromolecule catabolic process (GO:0043632)	3.69	2	ERLIN2, VPS37A
regulation of cell death (GO:0010941)	2.43	2	HSPD1, ARL6IP1
multicellular organism development (GO:0007275)	2.54	2	SPAST, L1CAM
endoplasmic reticulum tubular network organization (GO:0071786)	7.53	2	ARL6IP1, REEP1
regulation of cysteine-type endopeptidase activity (GO:2000116)	4.37	2	HSPD1, ARL6IP1
developmental maturation (GO:0021700)	4.7	2	PLP1, KIAA0196
regulation of mitochondrial fission (GO:0090140)	6.84	2	DDHD1, DDHD2
positive regulation of mitochondrial fission (GO:0090141)	7.09	2	DDHD1, DDHD2
protein homooligomerization (GO:0051260)	4.21	2	ATL1, SPAST
cellular component morphogenesis (GO:0032989)	3.5	2	SPAST, ATL1
regulation of programmed cell death (GO:0043067)	2.49	2	HSPD1, ARL6IP1
negative regulation of apoptotic process (GO:0043066)	3.04	2	HSPD1, ARL6IP1
negative regulation of programmed cell death (GO:0043069)	3.02	2	HSPD1, ARL6IP1
activation of immune response (GO:0002253)	3.67	2	HSPD1, SPG21
regulation of lipid metabolic process (GO:0019216)	4.08	2	ERLIN2, BSCL2
regulation of endopeptidase activity (GO:0052548)	3.8	2	HSPD1, ARL6IP1
autophagy (GO:0006914)	3.82	2	TECPR2, VPS37A
cellular protein localization (GO:0034613)	3.11	2	ARL6IP1, ZFYVE27
cellular protein modification process (GO:0006464)	1.79	2	ERLIN2, B4GALNT1
negative regulation of neuron projection development (GO:0010977)	4.88	2	MAG, SPG20
multi-organism cellular process (GO:0044764)	3.14	2	HSPD1, VPS37A
cellular component disassembly (GO:0022411)	3.52	2	SPAST, C12orf65
nucleoside metabolic process (GO:0009116)	4.12	2	AMPD2, NT5C2
response to chemical (GO:0042221)	1.98	2	HSPD1, GJC2
ribonucleoside metabolic process (GO:0009119)	4.21	2	AMPD2, NT5C2
organelle assembly (GO:0070925)	3.75	2	KIAA0196, VPS37A
macromolecule catabolic process (GO:0009057)	3.0	2	ERLIN2, VPS37A
organelle localization (GO:0051640)	3.94	2	SPAST, SPG11
locomotion (GO:0040011)	2.91	2	MAG, L1CAM
response to abiotic stimulus (GO:0009628)	2.8	2	HSPD1, MAG
cytoskeleton organization (GO:0007010)	3.22	2	KIAA0196, SPAST
cell projection morphogenesis (GO:0048858)	4.05	2	ATL1, SPAST
developmental process involved in reproduction (GO:0003006)	3.36	2	CYP7B1, KIAA0196
establishment of protein localization to membrane (GO:0090150)	4.14	2	ARL6IP1, REEP1
neural nucleus development (GO:0048857)	5.57	2	PLP1, MAG
ribose phosphate metabolic process (GO:0019693)	4.06	2	AMPD2, NT5C2
alcohol metabolic process (GO:0006066)	4.2	2	CYP7B1, ERLIN2
regulation of cell growth (GO:0001558)	3.75	2	SPG20, L1CAM
viral process (GO:0016032)	3.15	2	HSPD1, VPS37A
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	2	HSPD1, VPS37A
regulation of growth (GO:0040008)	3.26	2	L1CAM, SPG20

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
single-organism catabolic process (GO:0044712)	-	3.21	0.003	ENTPD1, KIF1A, CPT1C, BSCL2, DDHD1, DDHD2, PNPLA6, NT5C2, SPAST, IBA57, GBA2, HSPD1, ATL1, KIF5A
organic substance catabolic process (GO:1901575)	-	2.45	0.013	ENTPD1, KIF1A, CPT1C, BSCL2, DDHD1, DDHD2, SPAST, PNPLA6, NT5C2, VPS37A, IBA57, GBA2, HSPD1, ERLIN2, KIF5A, ATL1
intracellular transport (GO:0046907)	-	2.67	0.027	KIF1A, ARL6IP1, SPAST, AP4B1, KIAA0196, AP4E1, VPS37A, AP4M1, AP5Z1, RTN2, SPG7, KIF5A
lipid catabolic process (GO:0016042)	-	4.21	0.022	CPT1C, DDHD2, DDHD1, BSCL2, PNPLA6, GBA2
single-organism cellular process (GO:0044763)	-	0.65	0.0	L1CAM, GJC2, DDHD2, HSPD1, IBA57, B4GALNT1, KIF1A, ATL1, ENTPD1, NIPA1, SLC33A1, KIAA0196, FA2H, SPAST, RTN2, MAG, AP5Z1, C19orf12, PLP, CYP2U1, BSCL2, C12orf65, SPG20, TFG, PNPLA6, VPS37A, REEP1, NT5C2, ERLIN2, SPG11, ZFYVE26, TECPR2, CPT1C, DDHD1, ALDH18A1, GBA2, AMPD2, SPG21, ZFYVE27, SPG7, KIF5A, CYP7B1
cell death (GO:0008219)	NEW	3.05	0.0	L1CAM, GJC2, BSCL2, HSPD1, B4GALNT1, KIF1A, ATL1, ENTPD1, NIPA1, SLC33A1, KIAA0196, FA2H, AP5Z1, RTN2, SPAST, C19orf12, PLP, CYP2U1, DDHD2, C12orf65, SPG20, TFG, PNPLA6, VPS37A, REEP1, NT5C2, ERLIN2, SPG11, ZFYVE26, TECPR2, DDHD1, GBA2, SPG21, ZFYVE27, SPG7, KIF5A, CYP7B1
catabolic process (GO:0009056)	-	2.38	0.01	TECPR2, KIF1A, CPT1C, BSCL2, DDHD1, DDHD2, ENTPD1, PNPLA6, NT5C2, SPAST, IBA57, GBA2, VPS37A, HSPD1, ERLIN2, KIF5A, ATL1
single-organism process (GO:0044699)	-	0.48	0.001	L1CAM, GJC2, DDHD2, NT5C2, IBA57, GBA2, KIF1A, ATL1, ENTPD1, AP4M1, CPT1C, SLC33A1, KIAA0196, FA2H, AP5Z1, RTN2, MAG, SPAST, C19orf12, PLP, CYP2U1, ARL6IP1, BSCL2, C12orf65, SPG20, TFG, PNPLA6, ALDH18A1, REEP1, HSPD1, ERLIN2, SPG11, ZFYVE26, TECPR2, NIPA1, DDHD1, VPS37A, B4GALNT1, AMPD2, SPG21, ZFYVE27, SPG7, KIF5A, CYP7B1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	46	L1CAM, GJC2, DDHD2, HSPD1, IBA57, GBA2, KIF1A, ATL1, AP4S1, AP4M1, NIPA1, SPAST, SLC33A1, KIAA0196, FA2H, AP5Z1, RTN2, MAG, PLP1, C19orf12, AP4B1, CYP2U1, ARL6IP1, BSCL2, C12orf65, SPG20, ENTPD1, PNPLA6, ALDH18A1, AP4E1, REEP1, NT5C2, ERLIN2, SPG11, ZFYVE26, TFG, CPT1C, CYP7B1, VPS37A, B4GALNT1, AMPD2, SPG21, ZFYVE27, SPG7, KIF5A, DDHD1
intracellular part (GO:0044424)	0.28	42	KIF1A, DDHD2, HSPD1, IBA57, GBA2, ATL1, FA2H, AP4M1, CPT1C, SLC33A1, KIAA0196, SPAST, C19orf12, MAG, AP5Z1, AP4B1, CYP2U1, ARL6IP1, BSCL2, C12orf65, SPG20, AP4S1, PNPLA6, VPS37A, AP4E1, REEP1, NT5C2, ERLIN2, SPG11, ZFYVE26, TFG, NIPA1, DDHD1, RTN2, ALDH18A1, B4GALNT1, AMPD2, SPG21, ZFYVE27, SPG7, KIF5A, CYP7B1
cytoplasmic part (GO:0044444)	0.82	41	KIF1A, DDHD2, HSPD1, IBA57, GBA2, ATL1, AP4S1, AP4M1, CPT1C, SLC33A1, KIAA0196, SPAST, C19orf12, AP5Z1, AP4B1, CYP2U1, ARL6IP1, BSCL2, C12orf65, SPG20, FA2H, PNPLA6, VPS37A, AP4E1, REEP1, NT5C2, ERLIN2, SPG11, ZFYVE26, TFG, NIPA1, CYP7B1, RTN2, ALDH18A1, B4GALNT1, AMPD2, SPG21, ZFYVE27, SPG7, KIF5A, DDHD1
organelle (GO:0043226)	0.4	39	KIF1A, DDHD2, IBA57, GBA2, ATL1, AP4S1, AP4M1, CPT1C, SLC33A1, KIAA0196, FA2H, SPAST, C19orf12, AP5Z1, AP4B1, CYP2U1, ARL6IP1, BSCL2, C12orf65, SPG20, ENTPD1, PNPLA6, VPS37A, AP4E1, REEP1, HSPD1, ERLIN2, SPG11, ZFYVE26, TFG, NIPA1, CYP7B1, RTN2, ALDH18A1, B4GALNT1, SPG21, ZFYVE27, SPG7, KIF5A
intracellular organelle (GO:0043229)	0.51	37	KIF1A, DDHD2, IBA57, GBA2, ATL1, AP4S1, AP4M1, CPT1C, SLC33A1, KIAA0196, SPAST, C19orf12, AP5Z1, AP4B1, CYP2U1, ARL6IP1, BSCL2, C12orf65, SPG20, FA2H, PNPLA6, VPS37A, AP4E1, REEP1, HSPD1, ERLIN2, SPG11, ZFYVE26, NIPA1, CYP7B1, RTN2, ALDH18A1, B4GALNT1, SPG21, ZFYVE27, SPG7, KIF5A
membrane (GO:0016020)	0.68	37	L1CAM, GJC2, BSCL2, B4GALNT1, ATL1, AP4S1, GBA2, CPT1C, SLC33A1, FA2H, SPAST, C19orf12, MAG, PLP1, AP4B1, CYP2U1, ARL6IP1, SPG20, ENTPD1, PNPLA6, VPS37A, AP4E1, REEP1, HSPD1, ERLIN2, SPG11, ZFYVE26, TFG, NIPA1, CYP7B1, RTN2, ALDH18A1, AP4M1, SPG21, ZFYVE27, SPG7, KIF5A
intracellular organelle part (GO:0044446)	0.81	36	KIF1A, DDHD2, B4GALNT1, IBA57, AP4M1, ATL1, AP4S1, CPT1C, SLC33A1, SPAST, C19orf12, AP5Z1, AP4B1, CYP2U1, ARL6IP1, BSCL2, C12orf65, SPG20, FA2H, AP4E1, ALDH18A1, PNPLA6, REEP1, HSPD1, ERLIN2, SPG11, ZFYVE26, TFG, CYP7B1, RTN2, VPS37A, GBA2, SPG21, ZFYVE27, SPG7, KIF5A
organelle part (GO:0044422)	0.79	36	KIF1A, DDHD2, IBA57, B4GALNT1, ATL1, AP4S1, GBA2, CPT1C, SLC33A1, AP5Z1, RTN2, SPAST, C19orf12, AP4B1, CYP2U1, ARL6IP1, BSCL2, C12orf65, SPG20, FA2H, PNPLA6, VPS37A, AP4E1, REEP1, HSPD1, ERLIN2, SPG11, ZFYVE26, TFG, CYP7B1, ALDH18A1, AP4M1, SPG21, ZFYVE27, SPG7, KIF5A
membrane-bounded organelle (GO:0043227)	0.47	35	DDHD2, IBA57, B4GALNT1, ATL1, ENTPD1, GBA2, CPT1C, SLC33A1, KIAA0196, FA2H, SPAST, C19orf12, AP5Z1, AP4B1, CYP2U1, ARL6IP1, BSCL2, C12orf65, AP4S1, PNPLA6, VPS37A, AP4E1, REEP1, HSPD1, ERLIN2, SPG11, TFG, NIPA1, CYP7B1, RTN2, ALDH18A1, AP4M1, SPG21, ZFYVE27, SPG7
intracellular membrane-bounded organelle (GO:0043231)	0.6	33	DDHD2, B4GALNT1, IBA57, AP4M1, ATL1, AP4S1, NIPA1, SLC33A1, KIAA0196, SPAST, C19orf12, AP5Z1, AP4B1, CYP2U1, ARL6IP1, BSCL2, C12orf65, FA2H, AP4E1, ALDH18A1, PNPLA6, REEP1, HSPD1, ERLIN2, SPG11, CPT1C, CYP7B1, RTN2, VPS37A, GBA2, SPG21, ZFYVE27, SPG7
membrane part (GO:0044425)	0.95	32	L1CAM, GJC2, BSCL2, B4GALNT1, AP4M1, ATL1, ENTPD1, NIPA1, SPAST, SLC33A1, FA2H, PLP1, C19orf12, AP5Z1, AP4B1, CYP2U1, ARL6IP1, AP4S1, AP4E1, VPS37A, PNPLA6, REEP1, HSPD1, ERLIN2, SPG11, MAG, CPT1C, CYP7B1, RTN2, GBA2, ZFYVE27, SPG7
integral component of membrane (GO:0016021)	1.14	26	L1CAM, GJC2, BSCL2, B4GALNT1, ATL1, ENTPD1, NIPA1, SLC33A1, PLP1, RTN2, SPAST, C19orf12, CYP2U1, ARL6IP1, FA2H, AP4E1, PNPLA6, REEP1, ERLIN2, SPG11, MAG, CPT1C, CYP7B1, GBA2, ZFYVE27, SPG7
intrinsic component of membrane (GO:0031224)	1.13	26	L1CAM, GJC2, BSCL2, B4GALNT1, ATL1, ENTPD1, NIPA1, SLC33A1, PLP1, RTN2, SPAST, C19orf12, CYP2U1, ARL6IP1, FA2H, AP4E1, PNPLA6, REEP1, ERLIN2, SPG11, MAG, CPT1C, CYP7B1, GBA2, ZFYVE27, SPG7
organelle membrane (GO:0031090)	1.97	25	B4GALNT1, ATL1, AP4S1, GBA2, CPT1C, SLC33A1, C19orf12, SPAST, AP4B1, CYP2U1, SPG20, FA2H, AP4E1, ALDH18A1, REEP1, HSPD1, SPG11, ZFYVE26, TFG, CYP7B1, VPS37A, AP4M1, SPG21, ZFYVE27, SPG7
cytoplasm (GO:0005737)	1.01	23	KIF1A, DDHD2, HSPD1, ATL1, KIAA0196, SPAST, AP5Z1, ARL6IP1, SPG20, MAG, ALDH18A1, REEP1, NT5C2, ERLIN2, SPG11, ZFYVE26, TFG, DDHD1, VPS37A, SPG21, ZFYVE27, SPG7, KIF5A
endoplasmic reticulum (GO:0005783)	2.56	17	FA2H, CPT1C, ARL6IP1, ZFYVE27, SLC33A1, KIAA0196, BSCL2, CYP2U1, RTN2, GBA2, SPAST, PNPLA6, REEP1, C19orf12, ATL1, ERLIN2, CYP7B1
endoplasmic reticulum part (GO:0044432)	2.73	16	FA2H, ARL6IP1, CPT1C, SLC33A1, BSCL2, CYP7B1, RTN2, REEP1, CYP2U1, PNPLA6, SPAST, GBA2, ZFYVE27, C19orf12, ERLIN2, ATL1
bounding membrane of organelle (GO:0098588)	2.39	16	ZFYVE26, AP4S1, AP4M1, CPT1C, SLC33A1, AP4B1, SPG20, TFG, AP4E1, B4GALNT1, SPG21, GBA2, ZFYVE27, VPS37A, ATL1, SPG11
endoplasmic reticulum membrane (GO:0005789)	2.95	16	FA2H, CPT1C, ARL6IP1, SLC33A1, BSCL2, CYP7B1, RTN2, REEP1, CYP2U1, PNPLA6, SPAST, GBA2, ZFYVE27, C19orf12, ERLIN2, ATL1
macromolecular complex (GO:0032991)	1.35	14	KIF1A, CPT1C, ARL6IP1, AP4B1, KIAA0196, AP5Z1, AP4M1, VPS37A, AP4E1, HSPD1, GJC2, ERLIN2, KIF5A, C12orf65
protein complex (GO:0043234)	1.51	13	KIF1A, GJC2, CPT1C, AP4B1, KIAA0196, VPS37A, AP4M1, ARL6IP1, AP5Z1, AP4E1, HSPD1, ERLIN2, KIF5A
cytosol (GO:0005829)	1.68	12	TFG, ARL6IP1, SPG11, DDHD1, DDHD2, AP4M1, AMPD2, NT5C2, SPG21, HSPD1, KIF5A, KIAA0196
plasma membrane (GO:0005886)	1.39	12	ENTPD1, L1CAM, GJC2, NIPA1, SPG20, MAG, B4GALNT1, PLP1, GBA2, ZFYVE27, ERLIN2, SPG11
neuron part (GO:0097458)	2.64	10	MAG, KIF1A, CPT1C, SPG11, SPAST, ZFYVE27, L1CAM, SPG7, KIF5A, ATL1
Golgi apparatus part (GO:0044431)	3.0	10	TFG, GBA2, AP4M1, SLC33A1, AP4S1, B4GALNT1, SPG21, AP4E1, ATL1, AP4B1
Golgi apparatus (GO:0005794)	2.7	9	AP4S1, GBA2, DDHD2, B4GALNT1, AP4E1, SPG21, AP4M1, ATL1, AP4B1
membrane protein complex (GO:0098796)	2.84	9	CPT1C, GJC2, AP4B1, VPS37A, AP4M1, AP5Z1, AP4E1, HSPD1, ARL6IP1
vacuolar part (GO:0044437)	3.26	9	ZFYVE26, AP4S1, AP4B1, VPS37A, AP4M1, SPG21, AP4E1, ZFYVE27, SPG11
mitochondrial part (GO:0044429)	2.92	9	CPT1C, C12orf65, SPG20, C19orf12, ALDH18A1, IBA57, REEP1, HSPD1, SPG7
Golgi membrane (GO:0000139)	3.28	9	AP4S1, GBA2, SLC33A1, TFG, AP4E1, B4GALNT1, AP4M1, ATL1, AP4B1
vacuole (GO:0005773)	2.92	8	NIPA1, KIAA0196, SPAST, AP4M1, VPS37A, ZFYVE27, HSPD1, SPG21
endosome (GO:0005768)	3.25	8	NIPA1, SPAST, KIAA0196, SPG21, AP4M1, VPS37A, ZFYVE27, HSPD1
vesicle (GO:0031982)	1.64	8	ENTPD1, SPAST, AP4M1, SPG21, TFG, HSPD1, ERLIN2, SPG11
mitochondrion (GO:0005739)	2.42	8	CPT1C, C12orf65, C19orf12, ALDH18A1, IBA57, REEP1, HSPD1, SPG7
membrane-bounded vesicle (GO:0031988)	1.71	8	ENTPD1, SPG21, AP4M1, SPAST, TFG, HSPD1, ERLIN2, SPG11
extracellular organelle (GO:0043230)	1.89	7	ENTPD1, TFG, AP4M1, SPAST, HSPD1, ERLIN2, SPG11
extracellular exosome (GO:0070062)	1.89	7	TFG, ENTPD1, AP4M1, SPAST, HSPD1, ERLIN2, SPG11
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	7	ZFYVE26, KIF1A, KIF5A, SPG20, VPS37A, SPAST, SPG11
whole membrane (GO:0098805)	2.85	7	ZFYVE26, CPT1C, SPG20, VPS37A, SPG21, ZFYVE27, SPG11
cell projection part (GO:0044463)	2.97	7	MAG, KIF1A, SPAST, ZFYVE27, L1CAM, SPG7, KIF5A
mitochondrial membrane (GO:0031966)	3.31	7	CPT1C, SPG20, C19orf12, ALDH18A1, REEP1, HSPD1, SPG7
non-membrane-bounded organelle (GO:0043228)	1.76	7	ZFYVE26, KIF1A, KIF5A, SPG20, VPS37A, SPAST, SPG11
endosomal part (GO:0044440)	3.73	7	AP4S1, VPS37A, AP4E1, SPG21, AP4M1, ZFYVE27, AP4B1
extracellular vesicle (GO:1903561)	1.89	7	ENTPD1, TFG, AP4M1, SPAST, HSPD1, ERLIN2, SPG11
extracellular region part (GO:0044421)	1.57	7	ENTPD1, TFG, AP4M1, SPAST, HSPD1, ERLIN2, SPG11
organelle lumen (GO:0043233)	3.05	6	AP4S1, AP4E1, IBA57, AP4M1, HSPD1, AP4B1
membrane-enclosed lumen (GO:0031974)	3.05	6	AP4S1, AP4E1, IBA57, AP4M1, HSPD1, AP4B1
intracellular organelle lumen (GO:0070013)	3.05	6	AP4S1, AP4E1, IBA57, AP4M1, HSPD1, AP4B1
cytoskeletal part (GO:0044430)	2.49	6	ZFYVE26, KIF1A, DDHD2, VPS37A, SPAST, KIF5A
cell projection (GO:0042995)	2.47	6	L1CAM, CPT1C, KIF5A, ZFYVE27, ATL1, SPG11
plasma membrane part (GO:0044459)	1.95	6	ENTPD1, CPT1C, GJC2, SLC33A1, RTN2, ZFYVE27
organelle subcompartment (GO:0031984)	4.55	5	ATL1, RTN2, AP4B1, ZFYVE27, AP4M1
membrane region (GO:0098589)	3.95	5	HSPD1, AP4S1, AP4B1, ERLIN2, AP4E1
vacuolar membrane (GO:0005774)	3.45	5	ZFYVE26, SPG21, SPG11, VPS37A, ZFYVE27
nuclear part (GO:0044428)	1.55	5	HSPD1, AP5Z1, SPG11, SPAST, VPS37A
neuron projection (GO:0043005)	3.12	5	SPG11, ATL1, KIF5A, ZFYVE27, CPT1C
axon part (GO:0033267)	4.4	5	L1CAM, MAG, KIF1A, SPAST, SPG7
cytoskeleton (GO:0005856)	2.55	4	ZFYVE26, KIF1A, SPAST, KIF5A
cytoplasmic vesicle (GO:0031410)	2.87	4	HSPD1, SPG21, SPG11, SPAST
nucleus (GO:0005634)	1.07	4	SPAST, AP5Z1, SPG11, VPS37A
vacuolar lumen (GO:0005775)	5.06	4	AP4S1, AP4B1, AP4M1, AP4E1
microtubule organizing center (GO:0005815)	3.42	4	ZFYVE26, SPAST, DDHD2, VPS37A
trans-Golgi network membrane (GO:0032588)	5.4	4	AP4S1, AP4B1, AP4M1, AP4E1
intracellular vesicle (GO:0097708)	2.86	4	HSPD1, SPG21, SPG11, SPAST
axon (GO:0030424)	4.15	4	ATL1, SPG11, ZFYVE27, CPT1C
endosome lumen (GO:0031904)	6.54	4	AP4S1, AP4B1, AP4E1, AP4M1
clathrin-coated pit (GO:0005905)	5.64	4	HSPD1, AP4S1, AP4B1, AP4E1
cytoplasmic region (GO:0099568)	4.51	3	SPAST, KIF1A, SPG7
supramolecular fiber (GO:0099512)	3.31	3	KIF1A, SPAST, KIF5A
polymeric cytoskeletal fiber (GO:0099513)	3.31	3	KIF1A, SPAST, KIF5A
cell projection cytoplasm (GO:0032838)	5.89	3	SPAST, KIF1A, SPG7
myelin sheath (GO:0043209)	4.76	3	PLP1, MAG, GJC2
centrosome (GO:0005813)	3.75	3	ZFYVE26, SPAST, VPS37A
axon cytoplasm (GO:1904115)	6.28	3	SPAST, KIF1A, SPG7
midbody (GO:0030496)	4.95	3	ZFYVE26, SPAST, SPG20
dendrite (GO:0030425)	3.92	3	SPG11, ZFYVE27, CPT1C
early endosome (GO:0005769)	4.34	3	HSPD1, KIAA0196, NIPA1
integral component of endoplasmic reticulum membrane (GO:0030176)	5.01	3	BSCL2, RTN2, ARL6IP1
synapse (GO:0045202)	3.58	3	SPG20, SPG11, CPT1C
Golgi subcompartment (GO:0098791)	4.63	3	ATL1, AP4B1, AP4M1
AP-type membrane coat adaptor complex (GO:0030119)	6.06	3	AP5Z1, AP4B1, AP4M1
microtubule (GO:0005874)	3.81	3	KIF1A, SPAST, KIF5A
intrinsic component of endoplasmic reticulum membrane (GO:0031227)	4.97	3	BSCL2, ARL6IP1, RTN2
cell junction (GO:0030054)	2.75	3	L1CAM, GJC2, CPT1C
endosome membrane (GO:0010008)	3.83	3	VPS37A, SPG21, ZFYVE27
membrane coat (GO:0030117)	5.68	2	AP4B1, AP4E1
clathrin adaptor complex (GO:0030131)	6.51	2	AP4B1, AP4M1
kinesin complex (GO:0005871)	5.74	2	KIF1A, KIF5A
coated vesicle (GO:0030135)	4.94	2	HSPD1, SPG21
microtubule associated complex (GO:0005875)	4.79	2	KIF1A, KIF5A
Golgi cisterna (GO:0031985)	6.58	2	ATL1, AP4M1
lysosomal membrane (GO:0005765)	4.19	2	ZFYVE26, SPG11
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	2	HSPD1, SPG21
intrinsic component of plasma membrane (GO:0031226)	2.53	2	SLC33A1, ENTPD1
lipid particle (GO:0005811)	5.66	2	SPAST, SPG20
nucleoplasm (GO:0005654)	1.89	2	AP5Z1, VPS37A
endoplasmic reticulum subcompartment (GO:0098827)	7.03	2	RTN2, ZFYVE27
mitochondrial matrix (GO:0005759)	4.03	2	HSPD1, IBA57
perinuclear region of cytoplasm (GO:0048471)	3.35	2	SPAST, KIF5A
organelle outer membrane (GO:0031968)	4.63	2	SPG20, CPT1C
cell surface (GO:0009986)	3.44	2	HSPD1, L1CAM
integral component of plasma membrane (GO:0005887)	2.57	2	SLC33A1, ENTPD1
receptor complex (GO:0043235)	4.01	2	HSPD1, CPT1C
trans-Golgi network (GO:0005802)	4.92	2	AP4B1, AP4M1
organelle inner membrane (GO:0019866)	3.56	2	HSPD1, ALDH18A1
outer membrane (GO:0019867)	4.6	2	SPG20, CPT1C
plasma membrane protein complex (GO:0098797)	3.55	2	GJC2, CPT1C
mitochondrial inner membrane (GO:0005743)	3.65	2	HSPD1, ALDH18A1
mitochondrial outer membrane (GO:0005741)	4.76	2	SPG20, CPT1C
lytic vacuole membrane (GO:0098852)	4.19	2	ZFYVE26, SPG11

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
membrane region (GO:0098589)	-	3.95	0.008	FA2H, REEP1, CPT1C, SLC33A1, CYP7B1, CYP2U1, PNPLA6, GBA2, ZFYVE27, C19orf12, ATL1, ERLIN2
organelle membrane (GO:0031090)	-	1.97	0.0	L1CAM, HSPD1, GBA2, ATL1, FA2H, CPT1C, SLC33A1, SPAST, C19orf12, AP5Z1, AP4B1, CYP2U1, ARL6IP1, SPG20, PNPLA6, ALDH18A1, REEP1, NT5C2, ERLIN2, SPG11, ZFYVE26, CYP7B1, VPS37A, AP4M1, SPG21, ZFYVE27, SPG7, KIF5A
bounding membrane of organelle (GO:0098588)	-	2.39	0.0	ZFYVE26, FA2H, REEP1, CPT1C, SLC33A1, CYP7B1, SPG20, VPS37A, PNPLA6, SPG21, GBA2, ZFYVE27, C19orf12, CYP2U1, ERLIN2, SPG11, ATL1
membrane (GO:0016020)	-	0.68	0.041	AP4S1, L1CAM, HSPD1, IBA57, GBA2, KIF1A, ATL1, ENTPD1, AP4M1, CPT1C, SLC33A1, KIAA0196, SPAST, RTN2, MAG, AP5Z1, C19orf12, AP4B1, PLP, CYP2U1, ARL6IP1, SPG20, FA2H, PNPLA6, ALDH18A1, REEP1, NT5C2, ERLIN2, SPG11, ZFYVE26, TFG, NIPA1, CYP7B1, VPS37A, B4GALNT1, AMPD2, SPG21, ZFYVE27, SPG7, KIF5A
endoplasmic reticulum membrane (GO:0005789)	-	2.95	0.0	FA2H, L1CAM, REEP1, CPT1C, SLC33A1, CYP7B1, CYP2U1, PNPLA6, SPAST, GBA2, ZFYVE27, C19orf12, ATL1, ERLIN2
intracellular organelle part (GO:0044446)	-	0.81	0.008	KIF1A, DDHD2, B4GALNT1, ATL1, FA2H, GBA2, CPT1C, SLC33A1, RTN2, SPAST, C19orf12, AP4B1, CYP2U1, ARL6IP1, BSCL2, SPG20, PNPLA6, ALDH18A1, REEP1, HSPD1, ERLIN2, SPG11, ZFYVE26, CYP7B1, VPS37A, AP4M1, SPG21, ZFYVE27, SPG7, KIF5A
endoplasmic reticulum part (GO:0044432)	-	2.73	0.008	CYP2U1, L1CAM, ARL6IP1, CPT1C, SLC33A1, BSCL2, CYP7B1, RTN2, REEP1, FA2H, PNPLA6, MAG, SPAST, GBA2, ZFYVE27, C19orf12, ERLIN2, ATL1
cytoplasmic part (GO:0044444)	-	0.82	0.0	DDHD2, HSPD1, IBA57, GBA2, ATL1, AP4S1, AP4M1, CPT1C, SLC33A1, KIAA0196, SPAST, RTN2, AP5Z1, C19orf12, AP4B1, CYP2U1, ARL6IP1, BSCL2, C12orf65, SPG20, FA2H, PNPLA6, VPS37A, AP4E1, REEP1, NT5C2, ERLIN2, SPG11, ZFYVE26, NIPA1, CYP7B1, ALDH18A1, B4GALNT1, AMPD2, SPG21, ZFYVE27, SPG7, KIF5A
organelle subcompartment (GO:0031984)	-	4.55	0.004	ATL1, RTN2, AP4M1
coated pit (GO:0005905)	-	5.64	0.0	HSPD1, AP4S1, AP4B1, AP4M1, AP4E1
membrane part (GO:0044425)	-	0.95	0.0	L1CAM, GJC2, BSCL2, B4GALNT1, AP4M1, ATL1, ENTPD1, NIPA1, SLC33A1, FA2H, SPAST, C19orf12, AP5Z1, AP4B1, CYP2U1, ARL6IP1, AP4S1, AP4E1, VPS37A, PNPLA6, REEP1, HSPD1, ERLIN2, SPG11, PLP, MAG, CPT1C, CYP7B1, RTN2, GBA2, ZFYVE27, SPG7
AP-type membrane coat adaptor complex (GO:0030119)	-	6.06	0.043	AP5Z1, AP4B1, AP4M1
mitochondrial membrane (GO:0031966)	-	3.31	0.022	CPT1C, SPG20, C19orf12, ALDH18A1, REEP1, HSPD1, SPG7
organelle part (GO:0044422)	-	0.79	0.016	KIF1A, DDHD2, B4GALNT1, AP4M1, ATL1, FA2H, CPT1C, SLC33A1, RTN2, SPAST, C19orf12, AP4B1, CYP2U1, ARL6IP1, BSCL2, SPG20, PNPLA6, ALDH18A1, REEP1, HSPD1, ERLIN2, SPG11, ZFYVE26, CYP7B1, VPS37A, GBA2, SPG21, ZFYVE27, SPG7, KIF5A