Gene table of SPRY2 : sprouty RTK signaling antagonist 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with SPRY2	OMIM link	Number of associated genes	genes
PS161950	IGA NEPHROPATHY	ClinVar, OMIM	link to OMIM	2	SPRY2, PIGR

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
MicroRNAs in cancer	hsa05206	5.38
Jak-STAT signaling pathway	hsa04630	5.44

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signaling by FGFR	R-HSA-190236	4.67
EGFR downregulation	R-HSA-182971	8.28
Signaling by FGFR2	R-HSA-5654738	4.68
Spry regulation of FGF signaling	R-HSA-1295596	9.18
Signaling by FGFR1	R-HSA-5654736	4.69
Signaling by EGFR	R-HSA-177929	4.59
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.03
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.12
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.98
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.89
Signaling by FGFR4	R-HSA-5654743	4.69
Signal Transduction	R-HSA-162582	1.78
Signaling by FGFR3	R-HSA-5654741	4.69

Associated GO terms for Molecular function

GO term	GO ID	GO IC
protein kinase inhibitor activity	GO:0004860	5.28
kinase regulator activity	GO:0019207	4.5
protein kinase regulator activity	GO:0019887	4.6
enzyme regulator activity	GO:0030234	2.85
kinase activator activity	GO:0019209	5.58
enzyme binding	GO:0019899	2.27
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
kinase inhibitor activity	GO:0019210	5.25
binding	GO:0005488	0.18
protein binding	GO:0005515	0.46
protein serine/threonine kinase inhibitor activity	GO:0030291	6.34
enzyme inhibitor activity	GO:0004857	3.78
molecular function regulator	GO:0098772	2.51
protein kinase activator activity	GO:0030295	5.68
protein serine/threonine kinase activator activity	GO:0043539	6.91
enzyme activator activity	GO:0008047	3.56