| Disease ID | Disease name | Source of annotation with TGFB3 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS107970 | ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA | ClinVar, OMIM | link to OMIM | 9 | TGFB3, DSP, TMEM43, DSC2, PKP2, CTNNA3, RYR2, DSG2, JUP |
| PS609192 | LOEYS-DIETZ SYNDROME | ClinVar, OMIM, HUMSAVAR | link to OMIM | 5 | TGFB3, SMAD3, TGFBR2, TGFBR1, TGFB2 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Pancreatic cancer | hsa05212 | 6.56 |
| Colorectal cancer | hsa05210 | 6.52 |
| Renal cell carcinoma | hsa05211 | 6.6 |
| Endocytosis | hsa04144 | 4.92 |
| FoxO signaling pathway | hsa04068 | 5.63 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 | 6.21 |
| Dilated cardiomyopathy | hsa05414 | 6.08 |
| Cytokine-cytokine receptor interaction | hsa04060 | 4.67 |
| Chagas disease (American trypanosomiasis) | hsa05142 | 5.99 |
| Leishmaniasis | hsa05140 | 6.32 |
| Amoebiasis | hsa05146 | 5.82 |
| Malaria | hsa05144 | 7.15 |
| Toxoplasmosis | hsa05145 | 5.71 |
| HTLV-I infection | hsa05166 | 4.59 |
| Hepatitis B | hsa05161 | 5.52 |
| TGF-beta signaling pathway | hsa04350 | 6.41 |
| Chronic myeloid leukemia | hsa05220 | 6.48 |
| Rheumatoid arthritis | hsa05323 | 6.05 |
| Cell cycle | hsa04110 | 5.68 |
| Inflammatory bowel disease (IBD) | hsa05321 | 6.43 |
| Pathways in cancer | hsa05200 | 3.98 |
| Hippo signaling pathway | hsa04390 | 5.37 |
| MAPK signaling pathway | hsa04010 | 4.63 |
| Tuberculosis | hsa05152 | 5.17 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Molecules associated with elastic fibres | R-HSA-2129379 | 7.73 |
| Platelet degranulation | R-HSA-114608 | 6.68 |
| Elastic fibre formation | R-HSA-1566948 | 7.49 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 6.59 |
| ECM proteoglycans | R-HSA-3000178 | 6.75 |
| Extracellular matrix organization | R-HSA-1474244 | 4.91 |
| Hemostasis | R-HSA-109582 | 3.98 |
| GO term | GO ID | GO IC |
|---|---|---|
| cytokine receptor binding | GO:0005126 | 4.14 |
| protein heterodimerization activity | GO:0046982 | 3.64 |
| growth factor activity | GO:0008083 | 4.66 |
| protein binding | GO:0005515 | 0.46 |
| transforming growth factor beta receptor binding | GO:0005160 | 5.81 |
| cytokine binding | GO:0019955 | 5.21 |
| growth factor binding | GO:0019838 | 4.89 |
| type III transforming growth factor beta receptor binding | GO:0034714 | 8.35 |
| cytokine activity | GO:0005125 | 4.34 |
| binding | GO:0005488 | 0.18 |
| type I transforming growth factor beta receptor binding | GO:0034713 | 7.44 |
| protein dimerization activity | GO:0046983 | 2.72 |
| type II transforming growth factor beta receptor binding | GO:0005114 | 7.79 |
| receptor binding | GO:0005102 | 2.43 |
| identical protein binding | GO:0042802 | 2.63 |
| transforming growth factor beta binding | GO:0050431 | 6.97 |