Disease table of LOEYS-DIETZ SYNDROME OMIM ID: PS609192

Gene-disease associations table

GeneAssociated with LOEYS-DIETZ SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TGFBR2ClinVar, OMIM, HUMSAVARHGNC link3p24.14133239, PS120435, PS607086, PS609192
TGFB2ClinVar, OMIM, HUMSAVARHGNC link1q411PS609192
TGFB3ClinVar, OMIM, HUMSAVARHGNC link14q24.32PS609192, PS107970
TGFBR1ClinVar, OMIM, HUMSAVARHGNC link9q22.333PS609192, 132800, PS607086
SMAD3ClinVar, OMIM, HUMSAVARHGNC link15q22.331PS609192

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SMAD3YES24SERPINE1, FSHB, EPO, MXD1, BGLAP, POR, BAMBI, CYP17A1, SMAD7, GLI2, TGFB1, CDKN1A, VDR, JUN, VEGFA, MYC, TNC, FSTL3, MMP9, APOC3, TERT, FOXA2, AHR, ZFP360
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TGFBR2YES5SP1, ETV4, ETS1, FLI1, EGR10
TGFB2YES4ATF1, ATF2, USF1, USF20
TGFB3YES1HIF1A0
TGFBR1YES2SMAD7, WWP10
SMAD3YES7WT1, NR0B2, TP53, CEBPB, WWTR1, ARID1A, TRIB30
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TGFBR2TGFB2Yes1APP
TGFBR2TGFB3Yes1ENG
TGFBR2TGFBR1Yes29SH3KBP1, OXSR1, CDC42, FBXO34, TRAF4, PEG10, SNX6, SMAD7, PIK3R2, CLU, MAP3K7, TGFB1, DAB2, SMURF1, ARHGEF6, STRAP, TRAF6, HSP90AA1, SMURF2, PAK1, TGFBRAP1, PPP1R16B, NRP1, ENG, PIK3R1, TSC22D1, AP2B1, KCNK18, OCLN
TGFBR2SMAD3No12SMURF1, CTNNB1, STRAP, CBL, DAB2, SMAD7, MAP3K7, TGFBR1, RCVRN, SMURF2, ACVR1B, APP
TGFB2TGFB3No2VASN, TGFBR2
TGFB2TGFBR1No1TGFBR2
TGFB2SMAD3No2APP, CEBPA
TGFB3TGFBR1No3ENG, ELAVL1, TGFBR2
TGFBR1SMAD3Yes25RASD2, USP15, RAB38, SMAD4, MAP2K3, SPTBN1, OTUB1, SMAD7, SKI, MAP3K7, SMAD3, DAB2, SMURF1, ARHGEF6, STRAP, SMAD2, SMURF2, RANBP9, EP300, NOTCH1, HSPA4, WWP2, ITCH, FBXO3, SKIL

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TGFBR2TGFBR1Yes0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TGFBR2TGFB2Yesactivation, binding13SMAD2, PPP2R5D, NR2C2, SAR1A, TGFBR3, TGFB3, MAP3K7, SMAD4, SMAD5, TGFBR1, SMAD3, SMAD6, TGFB1
TGFBR2TGFB3Yesactivation, binding17SMAD2, PPP2R5D, NR2C2, FKBP1A, SAR1A, SMAD1, SMAD4, ENG, SMAD9, TGFBR1, SMAD3, SMAD6, ACVRL1, SMAD5, TGFB1, MAP3K7, TGFB2
TGFBR2TGFBR1Yesbinding67SAR1A, ZFYVE9, CTGF, WWP1, PRKCZ, UCHL5, GPC1, SMAD4, PARD6A, USP15, CAV1, NRP1, ARHGEF18, PPP2R2A, EIF2A, PARD3, BAMBI, ACVR1, HSP90AA1, SPTBN1, NR2C2, NEDD4L, UBC, PML, SMAD7, MAP3K7, SMAD6, PPP2R5D, AXIN1, TGFB1, SMAD3, CTNNB1, SMAD9, SHC1, TGFBR3, DAB2, SMURF1, TGFB2, PPP1R15A, DYNLRB1, UBA52, ZFYVE16, STRAP, RPS27A, SMAD2, SMAD5, RPS6KB1, CGN, PPP1CB, ACVRL1, PDPK1, YAP1, PPP1CC, TAB1, TGFBRAP1, UBB, ITGAV, FKBP1A, TGFB3, XIAP, PPP1CA, ENG, F11R, TAB2, SMAD1, RHOA, OCLN
TGFBR2SMAD3Yesactivation, binding31CTGF, WWP1, USP15, SMAD4, CAV1, YAP1, UBB, ACVR1, SPTBN1, NEDD4L, PML, SMAD7, AXIN1, ZFYVE9, CTNNB1, TGFB1, DAB2, SMURF1, TGFB2, UBA52, STRAP, RPS27A, SMAD2, UBC, ACVRL1, FKBP1A, TGFB3, TGFBR1, ENG, ACVR1C, SMAD1
TGFB2TGFB3Yesbinding59PF4, FN1, SERPINE1, FIGF, SMAD4, MMP2, TGFBR1, INHBE, PROS1, DCN, A2M, KNG1, INHBA, SRGN, NR2C2, LTBP1, FOS, FMOD, INHBC, ALDOA, SMAD6, CLU, INHBB, MAP3K7, SMAD3, APP, SMAD5, F5, PPBP, ACTN4, MMRN1, ACTN1, PLG, VWF, F13A1, SMAD2, TGFB1, JUN, PPP2R5D, SERPINA1, TIMP1, VEGFA, VEGFB, LEFTY2, ACTN2, VASN, GAS6, TMSB4X, SAR1A, ALB, IGF2, TGFBR2, HRG, IGF1, EGF, VEGFC, RELA, SPARC, SERPINF2
TGFB2TGFBR1Yesbinding15SMAD2, PPP2R5D, NR2C2, SERPINE1, LUM, SAR1A, TGFBR3, TGFB3, SMAD4, SMAD5, MAP3K7, SMAD3, SMAD6, TGFBR2, TGFB1
TGFB2SMAD3Yesactivation, binding14TGFBR2, SOX9, SERPINE1, CDK4, TGFB3, JUN, SMAD4, TGFBR1, ATF2, SMAD2, TIMP1, TGFB1, ACVR1B, FOS
TGFB3TGFBR1Yesbinding18NR2C2, SMAD2, TGFBR2, TGFB2, SERPINE1, FKBP1A, SAR1A, SMAD1, SMAD4, ENG, TGFB1, PPP2R5D, SMAD3, SMAD6, ACVRL1, SMAD5, SMAD9, MAP3K7
TGFB3SMAD3Yesactivation, binding17ENG, ACVRL1, CDH1, SERPINE1, FKBP1A, TGFB2, JUN, SMAD4, TGFBR2, SMAD1, TGFBR1, SMAD2, TIMP1, TGFB1, PAX6, FOS, HIF1A
TGFBR1SMAD3Yesactivation, binding37ACVRL1, WWP1, USP15, SMAD4, CAV1, SERPINE1, CTGF, YAP1, UBB, ACVR1, SPTBN1, BMP4, PML, SMAD7, ZFYVE9, AXIN1, CTNNB1, TGFB1, MAPK14, DAB2, SMURF1, TGFB2, UBA52, STRAP, RPS27A, SMAD2, UBC, TGFBR2, EP300, NOTCH1, FKBP1A, TGFB3, NEDD4L, ENG, BMP2, SMAD1, SKIL

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
TGFBR2TGFB3YesTGF-beta receptor II-TGF-beta receptor I-TGF-beta3 complex;TGF-beta receptor II-TGF-beta3 complex2TGFBR1, TGFBR2
TGFBR2TGFBR1YesTGF-beta receptor II-TGF-beta receptor I-TGF-beta3 complex;TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex;TGF-beta-receptor-PAR6 complex;TGF-beta receptor-SMAD3 complex5TGFB1, TGFB3, PARD6A, SMAD3, TGFBR2
TGFBR2SMAD3YesTGF-beta receptor-SMAD3 complex2TGFBR1, TGFBR2
TGFB3TGFBR1YesTGF-beta receptor II-TGF-beta receptor I-TGF-beta3 complex1TGFBR2
TGFB3SMAD3No-2TGFBR1, TGFBR2
TGFBR1SMAD3YesTGF-beta receptor-SMAD3 complex;TGF-beta receptor I-Axin-SMAD3 complex2AXIN1, TGFBR2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
TGFBR2TGFB3Yes3TGFBR1, TGFB3, TGFBR2
TGFBR2TGFBR1Yes4TGFB1, TGFBR1, TGFB3, TGFBR2
TGFB3TGFBR1Yes3TGFBR1, TGFB3, TGFBR2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
TGF-beta signaling pathwayhsa043506.415SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Pancreatic cancerhsa052126.565SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Colorectal cancerhsa052106.525SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Pathways in cancerhsa052003.985SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Chagas disease (American trypanosomiasis)hsa051425.995SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Hippo signaling pathwayhsa043905.375SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Endocytosishsa041444.925SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
FoxO signaling pathwayhsa040685.635SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Chronic myeloid leukemiahsa052206.485SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
HTLV-I infectionhsa051664.595SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Hepatitis Bhsa051615.524SMAD3, TGFBR1, TGFB3, TGFB2
Cytokine-cytokine receptor interactionhsa040604.674TGFBR1, TGFB3, TGFB2, TGFBR2
MAPK signaling pathwayhsa040104.634TGFBR1, TGFB3, TGFB2, TGFBR2
Cell cyclehsa041105.683SMAD3, TGFB3, TGFB2
Inflammatory bowel disease (IBD)hsa053216.433SMAD3, TGFB3, TGFB2
Adherens junctionhsa045206.263TGFBR1, SMAD3, TGFBR2
Osteoclast differentiationhsa043805.643TGFBR1, TGFB2, TGFBR2
Rheumatoid arthritishsa053236.052TGFB3, TGFB2
Renal cell carcinomahsa052116.62TGFB3, TGFB2
Tuberculosishsa051525.172TGFB3, TGFB2
Leishmaniasishsa051406.322TGFB3, TGFB2
Amoebiasishsa051465.822TGFB3, TGFB2
Malariahsa051447.152TGFB3, TGFB2
Toxoplasmosishsa051455.712TGFB3, TGFB2
Hypertrophic cardiomyopathy (HCM)hsa054106.212TGFB3, TGFB2
Dilated cardiomyopathyhsa054146.082TGFB3, TGFB2

NET-GE enrichment

Term New enriched termICP valueGenes
Immune diseasesNEW4.470.041SMAD3, TGFB3, TGFB2
Pancreatic cancer (hsa05212) -6.560.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Colorectal cancer (hsa05210) -6.520.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Chronic myeloid leukemia (hsa05220) -6.480.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Cancers: Specific typesNEW4.10.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Endocytosis (hsa04144) -4.920.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
FoxO signaling pathway (hsa04068) -5.630.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Osteoclast differentiation (hsa04380) -5.640.004TGFBR1, TGFB2, TGFBR2
Hypertrophic cardiomyopathy (HCM) (hsa05410) -6.210.007TGFBR1, TGFB3, TGFB2
Dilated cardiomyopathy (hsa05414) -6.080.009TGFBR1, TGFB3, TGFB2
Cytokine-cytokine receptor interaction (hsa04060) -4.670.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
DevelopmentNEW4.580.033TGFBR1, TGFB2, TGFBR2
Chagas disease (American trypanosomiasis) (hsa05142) -5.990.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Leishmaniasis (hsa05140) -6.320.01TGFBR1, TGFB3, TGFB2
Amoebiasis (hsa05146) -5.820.03TGFBR1, TGFB3, TGFB2
Malaria (hsa05144) -7.150.023TGFB3, TGFB2
Toxoplasmosis (hsa05145) -5.710.029TGFBR1, TGFB3, TGFB2
Influenza A (hsa05164) NEW5.210.003SMAD3, TGFBR1, TGFB3, TGFBR2
HTLV-I infection (hsa05166) -4.590.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Cell cycle (hsa04110) -5.680.003SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
TGF-beta signaling pathway (hsa04350) -6.410.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Cancers: OverviewNEW2.720.004SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Inflammatory bowel disease (IBD) (hsa05321) -6.430.001SMAD3, TGFB3, TGFB2
Infectious diseases: BacterialNEW3.760.007SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Cardiovascular diseasesNEW5.060.003SMAD3, TGFBR1, TGFB3, TGFB2
Rheumatoid arthritis (hsa05323) -6.050.017TGFBR1, TGFB3, TGFB2
Infectious diseases: ViralNEW3.290.039SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Infectious diseases: ParasiticNEW4.460.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Pathways in cancer (hsa05200) -3.980.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Signal transductionNEW2.060.039SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Signaling molecules and interactionNEW3.090.029SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Transport and catabolismNEW3.490.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Hippo signaling pathway (hsa04390) -5.370.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
MAPK signaling pathway (hsa04010) -4.630.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Cell growth and deathNEW4.410.047SMAD3, TGFB3, TGFB2, TGFBR2
PI3K-Akt signaling pathway (hsa04151) NEW4.210.045TGFBR1, SMAD3, TGFB2, TGFBR2
Cellular ProcessesNEW2.220.022SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
Renal cell carcinoma (hsa05211) -6.60.0SMAD3, TGFBR1, TGFB3, TGFB2
Hepatitis B (hsa05161) -5.520.0SMAD3, TGFBR1, TGFB3, TGFB2
Adherens junction (hsa04520) -6.260.001TGFBR1, SMAD3, TGFBR2
Tuberculosis (hsa05152) -5.170.004SMAD3, TGFBR1, TGFB3, TGFB2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.783TGFBR1, SMAD3, TGFBR2
SMAD2/3 Phosphorylation Motif Mutants in CancerR-HSA-330435610.43TGFBR1, SMAD3, TGFBR2
SMAD2/3 MH2 Domain Mutants in CancerR-HSA-331548710.183TGFBR1, SMAD3, TGFBR2
Diseases of signal transductionR-HSA-56632024.893TGFBR1, SMAD3, TGFBR2
Signaling by TGF-beta Receptor ComplexR-HSA-1708346.813TGFBR1, SMAD3, TGFBR2
Loss of Function of SMAD2/3 in CancerR-HSA-330434910.183TGFBR1, SMAD3, TGFBR2
TGFBR1 KD Mutants in CancerR-HSA-365653210.183TGFBR1, SMAD3, TGFBR2
Loss of Function of TGFBR1 in CancerR-HSA-365653410.183TGFBR1, SMAD3, TGFBR2
TGF-beta receptor signaling activates SMADsR-HSA-21737897.983TGFBR1, SMAD3, TGFBR2
Downregulation of TGF-beta receptor signalingR-HSA-21737888.283TGFBR1, SMAD3, TGFBR2
Signaling by TGF-beta Receptor Complex in CancerR-HSA-33043519.983TGFBR1, SMAD3, TGFBR2
DiseaseR-HSA-16436853.333TGFBR1, SMAD3, TGFBR2
Molecules associated with elastic fibresR-HSA-21293797.732TGFB3, TGFB2
TGFBR2 Kinase Domain Mutants in CancerR-HSA-364579010.982TGFBR1, TGFBR2
Platelet degranulation R-HSA-1146086.682TGFB3, TGFB2
Loss of Function of TGFBR2 in CancerR-HSA-364227810.982TGFBR1, TGFBR2
Elastic fibre formationR-HSA-15669487.492TGFB3, TGFB2
Platelet activation, signaling and aggregationR-HSA-760025.152TGFB3, TGFB2
Response to elevated platelet cytosolic Ca2+R-HSA-760056.592TGFB3, TGFB2
ECM proteoglycansR-HSA-30001786.752TGFB3, TGFB2
Extracellular matrix organizationR-HSA-14742444.912TGFB3, TGFB2
TGFBR1 LBD Mutants in CancerR-HSA-365653510.982TGFBR1, TGFBR2
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)R-HSA-21737918.982TGFBR1, TGFBR2
HemostasisR-HSA-1095823.982TGFB3, TGFB2

NET-GE enrichment

Term New enriched termICP valueGenes
Molecules associated with elastic fibres (R-HSA-2129379) -7.730.0TGFBR1, TGFB3, TGFB2, TGFBR2
Platelet degranulation (R-HSA-114608) -6.680.033TGFB3, TGFB2
Loss of Function of SMAD2/3 in Cancer (R-HSA-3304349) -10.180.0TGFBR1, SMAD3, TGFBR2
Extracellular matrix organization (R-HSA-1474244) -4.910.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
SMAD2/3 MH2 Domain Mutants in Cancer (R-HSA-3315487) -10.180.0TGFBR1, SMAD3, TGFBR2
TGFBR2 Kinase Domain Mutants in Cancer (R-HSA-3645790) -10.980.0TGFBR1, TGFBR2
Elastic fibre formation (R-HSA-1566948) -7.490.011TGFBR1, TGFB3, TGFB2, TGFBR2
Platelet activation, signaling and aggregation (R-HSA-76002) -5.150.005SMAD3, TGFBR1, TGFB3, TGFB2
Response to elevated platelet cytosolic Ca2+ (R-HSA-76005) -6.590.038TGFB3, TGFB2
ECM proteoglycans (R-HSA-3000178) -6.750.03TGFB3, TGFB2
TGFBR1 KD Mutants in Cancer (R-HSA-3656532) -10.180.0TGFBR1, SMAD3, TGFBR2
TGFBR1 LBD Mutants in Cancer (R-HSA-3656535) -10.980.0TGFBR1, TGFBR2
Loss of Function of TGFBR1 in Cancer (R-HSA-3656534) -10.180.0TGFBR1, SMAD3, TGFBR2
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (R-HSA-2173791) -8.980.001TGFBR1, TGFBR2
SMAD2/3 Phosphorylation Motif Mutants in Cancer (R-HSA-3304356) -10.40.0TGFBR1, SMAD3, TGFBR2
Signaling by TGF-beta Receptor Complex in Cancer (R-HSA-3304351) -9.980.0TGFBR1, SMAD3, TGFBR2
Diseases of signal transduction (R-HSA-5663202) -4.890.013TGFBR1, SMAD3, TGFBR2
Signaling by TGF-beta Receptor Complex (R-HSA-170834) -6.810.003TGFBR1, SMAD3, TGFBR2
Loss of Function of TGFBR2 in Cancer (R-HSA-3642278) -10.980.0TGFBR1, TGFBR2
TGF-beta receptor signaling activates SMADs (R-HSA-2173789) -7.980.0TGFBR1, SMAD3, TGFBR2
Downregulation of TGF-beta receptor signaling (R-HSA-2173788) -8.280.0TGFBR1, SMAD3, TGFBR2
Hemostasis (R-HSA-109582) -3.980.006SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytokine receptor binding (GO:0005126) 4.145SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
receptor binding (GO:0005102) 2.435SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
transforming growth factor beta receptor binding (GO:0005160) 5.815SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
binding (GO:0005488) 0.185SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
protein binding (GO:0005515) 0.465SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
receptor signaling protein activity (GO:0005057) 4.764TGFBR1, SMAD3, TGFB2, TGFBR2
signal transducer activity (GO:0004871) 2.284TGFBR1, SMAD3, TGFB2, TGFBR2
cytokine binding (GO:0019955) 5.213TGFBR1, TGFB3, TGFBR2
heterocyclic compound binding (GO:1901363) 1.063TGFBR1, SMAD3, TGFBR2
transforming growth factor beta binding (GO:0050431) 6.973TGFBR1, TGFB3, TGFBR2
cation binding (GO:0043169) 1.43TGFBR1, SMAD3, TGFBR2
growth factor binding (GO:0019838) 4.893TGFBR1, TGFB3, TGFBR2
ion binding (GO:0043167) 1.363TGFBR1, SMAD3, TGFBR2
protein serine/threonine kinase activity (GO:0004674) 3.643TGFBR1, TGFB2, TGFBR2
transferase activity (GO:0016740) 1.953TGFBR1, TGFB2, TGFBR2
protein kinase activity (GO:0004672) 3.273TGFBR1, TGFB2, TGFBR2
type II transforming growth factor beta receptor binding (GO:0005114) 7.793TGFBR1, TGFB3, TGFB2
identical protein binding (GO:0042802) 2.633SMAD3, TGFB3, TGFB2
kinase activity (GO:0016301) 2.933TGFBR1, TGFB2, TGFBR2
SMAD binding (GO:0046332) 5.453TGFBR1, SMAD3, TGFBR2
type III transforming growth factor beta receptor binding (GO:0034714) 8.353TGFB3, TGFB2, TGFBR2
metal ion binding (GO:0046872) 1.413TGFBR1, SMAD3, TGFBR2
catalytic activity (GO:0003824) 1.053TGFBR1, TGFB2, TGFBR2
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.083TGFBR1, TGFB2, TGFBR2
organic cyclic compound binding (GO:0097159) 1.053TGFBR1, SMAD3, TGFBR2
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.773TGFBR1, TGFB2, TGFBR2
protein dimerization activity (GO:0046983) 2.723SMAD3, TGFB3, TGFB2
protein heterodimerization activity (GO:0046982) 3.643SMAD3, TGFB3, TGFB2
receptor signaling protein serine/threonine kinase activity (GO:0004702) 5.233TGFBR1, TGFB2, TGFBR2
cytokine activity (GO:0005125) 4.342TGFB3, TGFB2
signaling receptor activity (GO:0038023) 2.492TGFBR1, TGFBR2
purine ribonucleoside triphosphate binding (GO:0035639) 2.222TGFBR1, TGFBR2
enzyme binding (GO:0019899) 2.272SMAD3, TGFBR2
molecular transducer activity (GO:0060089) 2.322TGFBR1, TGFBR2
receptor activity (GO:0004872) 2.322TGFBR1, TGFBR2
nucleoside phosphate binding (GO:1901265) 1.962TGFBR1, TGFBR2
nucleoside binding (GO:0001882) 2.212TGFBR1, TGFBR2
growth factor activity (GO:0008083) 4.662TGFB3, TGFB2
nucleotide binding (GO:0000166) 1.962TGFBR1, TGFBR2
transmembrane receptor protein serine/threonine kinase activity (GO:0004675) 6.912TGFBR1, TGFBR2
purine nucleoside binding (GO:0001883) 2.222TGFBR1, TGFBR2
ribonucleoside binding (GO:0032549) 2.222TGFBR1, TGFBR2
purine nucleotide binding (GO:0017076) 2.192TGFBR1, TGFBR2
ATP binding (GO:0005524) 2.432TGFBR1, TGFBR2
protein homodimerization activity (GO:0042803) 3.162SMAD3, TGFB2
protein kinase binding (GO:0019901) 3.442SMAD3, TGFBR2
kinase binding (GO:0019900) 3.322SMAD3, TGFBR2
type I transforming growth factor beta receptor binding (GO:0034713) 7.442TGFB3, TGFBR2
small molecule binding (GO:0036094) 1.892TGFBR1, TGFBR2
adenyl nucleotide binding (GO:0030554) 2.42TGFBR1, TGFBR2
carbohydrate derivative binding (GO:0097367) 2.032TGFBR1, TGFBR2
transforming growth factor beta-activated receptor activity (GO:0005024) 7.442TGFBR1, TGFBR2
transmembrane signaling receptor activity (GO:0004888) 2.572TGFBR1, TGFBR2
adenyl ribonucleotide binding (GO:0032559) 2.412TGFBR1, TGFBR2
transmembrane receptor activity (GO:0099600) 2.532TGFBR1, TGFBR2
purine ribonucleotide binding (GO:0032555) 2.22TGFBR1, TGFBR2
transmembrane receptor protein kinase activity (GO:0019199) 5.322TGFBR1, TGFBR2
purine ribonucleoside binding (GO:0032550) 2.222TGFBR1, TGFBR2
ribonucleotide binding (GO:0032553) 2.192TGFBR1, TGFBR2

NET-GE enrichment

Term New enriched termICP valueGenes
cytokine receptor binding (GO:0005126) -4.140.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cytokine activity (GO:0005125) -4.340.002TGFBR1, SMAD3, TGFB2, TGFBR2
transforming growth factor beta receptor binding (GO:0005160) -5.810.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cytokine binding (GO:0019955) -5.210.0TGFBR1, TGFB3, TGFB2, TGFBR2
growth factor binding (GO:0019838) -4.890.0TGFBR1, TGFB3, TGFB2, TGFBR2
molecular transducer activity (GO:0060089) -2.320.036TGFBR1, SMAD3, TGFB2, TGFBR2
signal transducer activity (GO:0004871) -2.280.036TGFBR1, SMAD3, TGFB2, TGFBR2
transforming growth factor beta binding (GO:0050431) -6.970.0TGFBR1, TGFB3, TGFB2, TGFBR2
beta-amyloid binding (GO:0001540) NEW6.210.0TGFBR1, TGFB2, TGFBR2
growth factor activity (GO:0008083) -4.660.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
receptor signaling protein activity (GO:0005057) -4.760.0TGFBR1, SMAD3, TGFB2, TGFBR2
1-phosphatidylinositol binding (GO:0005545) NEW6.740.0TGFBR1, SMAD3, TGFBR2
transmembrane receptor protein serine/threonine kinase activity (GO:0004675) -6.910.005TGFBR1, TGFBR2
protein serine/threonine kinase activity (GO:0004674) -3.640.019TGFBR1, SMAD3, TGFB2, TGFBR2
type II transforming growth factor beta receptor binding (GO:0005114) -7.790.0TGFBR1, TGFB3, TGFB2
hormone activity (GO:0005179) NEW4.950.007TGFBR1, SMAD3, TGFBR2
protein kinase binding (GO:0019901) -3.440.042SMAD3, TGFBR1, TGFB3, TGFBR2
phosphatase binding (GO:0019902) NEW4.630.026TGFBR1, SMAD3, TGFBR2
type I transforming growth factor beta receptor binding (GO:0034713) -7.440.0TGFBR1, TGFB3, TGFBR2
SMAD binding (GO:0046332) -5.450.001TGFBR1, SMAD3, TGFBR2
transforming growth factor beta-activated receptor activity (GO:0005024) -7.440.005TGFBR1, TGFBR2
receptor signaling protein serine/threonine kinase activity (GO:0004702) -5.230.0TGFBR1, TGFB2, TGFBR2
receptor binding (GO:0005102) -2.430.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
transmembrane receptor protein kinase activity (GO:0019199) -5.320.025TGFBR1, TGFBR2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of cell morphogenesis (GO:0022604) 3.45SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of cellular component organization (GO:0051130) 2.685SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of phosphate metabolic process (GO:0019220) 2.355SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of metabolic process (GO:0009893) 1.745SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of metabolic process (GO:0019222) 1.025SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of anatomical structure morphogenesis (GO:0022603) 2.795SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of response to stimulus (GO:0048585) 2.525SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of response to stimulus (GO:0048584) 2.185SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of response to stimulus (GO:0048583) 1.545SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
organ morphogenesis (GO:0009887) 3.555SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cellular component organization (GO:0051128) 2.015SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of signaling (GO:0023057) 2.655SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
biological regulation (GO:0065007) 0.395SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
signal transduction (GO:0007165) 1.285SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cell surface receptor signaling pathway (GO:0007166) 2.095SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
enzyme linked receptor protein signaling pathway (GO:0007167) 3.245SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
anatomical structure morphogenesis (GO:0009653) 2.535SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
multicellular organism development (GO:0007275) 2.545SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
single-organism process (GO:0044699) 0.485SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of primary metabolic process (GO:0080090) 1.085SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of cell communication (GO:0010648) 2.665SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cell communication (GO:0010646) 1.735SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of macromolecule metabolic process (GO:0010604) 1.815SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of signal transduction (GO:0009968) 2.755SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of signal transduction (GO:0009966) 1.845SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of phosphorus metabolic process (GO:0010562) 2.785SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of multicellular organismal process (GO:0051241) 2.845SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of protein metabolic process (GO:0051246) 1.935SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of protein metabolic process (GO:0051247) 2.435SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cell development (GO:0060284) 3.015SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of biological process (GO:0050789) 0.455SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of signaling (GO:0023051) 1.725SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of macromolecule metabolic process (GO:0060255) 1.085SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
animal organ development (GO:0048513) 2.535SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of cellular protein metabolic process (GO:0032270) 2.495SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of catalytic activity (GO:0043085) 2.45SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of molecular function (GO:0044093) 2.235SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of biological process (GO:0048518) 1.25SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of biological process (GO:0048519) 1.335SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of molecular function (GO:0065009) 1.785SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of gene expression (GO:0010468) 1.375SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cell proliferation (GO:0042127) 2.415SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of cell proliferation (GO:0008285) 3.265SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4.395SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
multicellular organismal process (GO:0032501) 1.455SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of phosphate metabolic process (GO:0045937) 2.785SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of developmental process (GO:0050793) 2.15SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cellular metabolic process (GO:0031323) 1.075SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of catalytic activity (GO:0050790) 1.975SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
wound healing (GO:0042060) 5.135SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cellular process (GO:0050794) 0.55SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
single-organism developmental process (GO:0044767) 1.495SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to stress (GO:0006950) 1.85SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
single-organism cellular process (GO:0044763) 0.655SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of multicellular organismal process (GO:0051239) 1.875SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.915SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of localization (GO:0032879) 1.945SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
transforming growth factor beta receptor signaling pathway (GO:0007179) 5.195SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) 4.65SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of phosphorus metabolic process (GO:0051174) 2.355SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cellular protein metabolic process (GO:0032268) 1.995SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
single-multicellular organism process (GO:0044707) 1.785SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
embryo development (GO:0009790) 4.25SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of epithelial to mesenchymal transition (GO:0010717) 5.555SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to stimulus (GO:0050896) 1.225SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
anatomical structure development (GO:0048856) 1.585SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cell differentiation (GO:0045595) 2.425SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of cellular metabolic process (GO:0031325) 1.815SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
developmental process (GO:0032502) 1.365SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of multicellular organismal development (GO:2000026) 2.315SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cellular process (GO:0009987) 0.265SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to wounding (GO:0009611) 4.395SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of cellular process (GO:0048523) 1.415SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of cellular process (GO:0048522) 1.35SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of transport (GO:0051049) 2.244SMAD3, TGFBR1, TGFB3, TGFB2
activation of protein kinase activity (GO:0032147) 4.084TGFBR1, TGFB3, TGFB2, TGFBR2
cellular component organization or biogenesis (GO:0071840) 1.224SMAD3, TGFBR1, TGFB3, TGFB2
cellular developmental process (GO:0048869) 1.824TGFBR1, SMAD3, TGFB2, TGFBR2
negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512) 5.544SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of cell development (GO:0010720) 3.574SMAD3, TGFB3, TGFB2, TGFBR2
positive regulation of transport (GO:0051050) 2.94SMAD3, TGFBR1, TGFB3, TGFB2
regulation of protein kinase activity (GO:0045859) 3.154TGFBR1, TGFB3, TGFB2, TGFBR2
response to organic substance (GO:0010033) 2.24TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of phosphorylation (GO:0042325) 2.54TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of signaling (GO:0023056) 2.414SMAD3, TGFBR1, TGFB3, TGFB2
positive regulation of phosphorylation (GO:0042327) 2.94TGFBR1, TGFB3, TGFB2, TGFBR2
single organism reproductive process (GO:0044702) 2.734TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of cellular component movement (GO:0051272) 3.714TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of biosynthetic process (GO:0009891) 2.294SMAD3, TGFBR1, TGFB3, TGFB2
positive regulation of gene expression (GO:0010628) 2.354SMAD3, TGFBR1, TGFB3, TGFB2
positive regulation of protein transport (GO:0051222) 3.614SMAD3, TGFBR1, TGFB3, TGFB2
regulation of protein transport (GO:0051223) 3.124SMAD3, TGFBR1, TGFB3, TGFB2
regulation of apoptotic process (GO:0042981) 2.54SMAD3, TGFBR1, TGFB3, TGFB2
positive regulation of transferase activity (GO:0051347) 3.314TGFBR1, TGFB3, TGFB2, TGFBR2
cellular macromolecule metabolic process (GO:0044260) 0.934TGFBR1, SMAD3, TGFB2, TGFBR2
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090101) 5.14SMAD3, TGFBR1, TGFB3, TGFBR2
regulation of kinase activity (GO:0043549) 3.074TGFBR1, TGFB3, TGFB2, TGFBR2
cellular component organization (GO:0016043) 1.244SMAD3, TGFBR1, TGFB3, TGFB2
regulation of immune system process (GO:0002682) 2.54SMAD3, TGFB3, TGFB2, TGFBR2
positive regulation of cellular protein localization (GO:1903829) 3.854SMAD3, TGFBR1, TGFB3, TGFB2
anatomical structure formation involved in morphogenesis (GO:0048646) 3.014TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of establishment of protein localization (GO:0070201) 3.024SMAD3, TGFBR1, TGFB3, TGFB2
regulation of biosynthetic process (GO:0009889) 1.374SMAD3, TGFBR1, TGFB3, TGFB2
transport (GO:0006810) 1.514SMAD3, TGFB3, TGFB2, TGFBR2
regulation of transforming growth factor beta receptor signaling pathway (GO:0017015) 5.134SMAD3, TGFBR1, TGFB3, TGFBR2
metabolic process (GO:0008152) 0.584TGFBR1, SMAD3, TGFB2, TGFBR2
establishment of localization (GO:0051234) 1.484SMAD3, TGFB3, TGFB2, TGFBR2
regulation of protein localization to nucleus (GO:1900180) 4.344SMAD3, TGFBR1, TGFB3, TGFB2
positive regulation of protein localization to nucleus (GO:1900182) 4.874SMAD3, TGFBR1, TGFB3, TGFB2
positive regulation of epithelial to mesenchymal transition (GO:0010718) 6.234SMAD3, TGFB3, TGFB2, TGFBR2
positive regulation of protein modification process (GO:0031401) 2.74TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of transferase activity (GO:0051338) 2.884TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.394SMAD3, TGFBR1, TGFB3, TGFB2
regulation of macromolecule biosynthetic process (GO:0010556) 1.434SMAD3, TGFBR1, TGFB3, TGFB2
regulation of cell motility (GO:2000145) 3.164TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of cell motility (GO:2000147) 3.744TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of signal transduction (GO:0009967) 2.54SMAD3, TGFBR1, TGFB3, TGFB2
cell differentiation (GO:0030154) 2.144TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of cellular protein localization (GO:1903827) 3.434SMAD3, TGFBR1, TGFB3, TGFB2
embryo development ending in birth or egg hatching (GO:0009792) 4.354SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of cell communication (GO:0010647) 2.414SMAD3, TGFBR1, TGFB3, TGFB2
positive regulation of establishment of protein localization (GO:1904951) 3.494SMAD3, TGFBR1, TGFB3, TGFB2
response to organic cyclic compound (GO:0014070) 3.074TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of protein localization (GO:0032880) 2.884SMAD3, TGFBR1, TGFB3, TGFB2
response to endogenous stimulus (GO:0009719) 2.794TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cellular response to growth factor stimulus (GO:0090287) 4.294SMAD3, TGFBR1, TGFB3, TGFBR2
in utero embryonic development (GO:0001701) 4.44SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of multicellular organismal process (GO:0051240) 2.494SMAD3, TGFB3, TGFB2, TGFBR2
positive regulation of kinase activity (GO:0033674) 3.544TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of cellular response to growth factor stimulus (GO:0090288) 4.924SMAD3, TGFBR1, TGFB3, TGFBR2
regulation of protein modification process (GO:0031399) 2.324TGFBR1, TGFB3, TGFB2, TGFBR2
chordate embryonic development (GO:0043009) 4.384SMAD3, TGFBR1, TGFB3, TGFBR2
response to abiotic stimulus (GO:0009628) 2.84SMAD3, TGFB3, TGFB2, TGFBR2
positive regulation of cell differentiation (GO:0045597) 3.014SMAD3, TGFB3, TGFB2, TGFBR2
regulation of cellular component movement (GO:0051270) 3.084TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of developmental process (GO:0051094) 2.774SMAD3, TGFB3, TGFB2, TGFBR2
macromolecule metabolic process (GO:0043170) 0.834TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of cell morphogenesis involved in differentiation (GO:0010770) 4.654SMAD3, TGFB3, TGFB2, TGFBR2
positive regulation of protein kinase activity (GO:0045860) 3.614TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cellular localization (GO:0060341) 3.034SMAD3, TGFBR1, TGFB3, TGFB2
positive regulation of cell death (GO:0010942) 3.324SMAD3, TGFBR1, TGFB3, TGFB2
regulation of cell death (GO:0010941) 2.434SMAD3, TGFBR1, TGFB3, TGFB2
negative regulation of cellular response to transforming growth factor beta stimulus (GO:1903845) 5.544SMAD3, TGFBR1, TGFB3, TGFBR2
regulation of cellular response to transforming growth factor beta stimulus (GO:1903844) 5.134SMAD3, TGFBR1, TGFB3, TGFBR2
response to lipid (GO:0033993) 3.114TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of growth (GO:0040008) 3.264TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of apoptotic process (GO:0043065) 3.384SMAD3, TGFBR1, TGFB3, TGFB2
organic substance metabolic process (GO:0071704) 0.634TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of programmed cell death (GO:0043067) 2.494SMAD3, TGFBR1, TGFB3, TGFB2
positive regulation of programmed cell death (GO:0043068) 3.384SMAD3, TGFBR1, TGFB3, TGFB2
embryonic morphogenesis (GO:0048598) 3.724SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of cell migration (GO:0030335) 3.774TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of cell migration (GO:0030334) 3.234TGFBR1, SMAD3, TGFB2, TGFBR2
reproductive process (GO:0022414) 2.554TGFBR1, TGFB3, TGFB2, TGFBR2
response to chemical (GO:0042221) 1.984TGFBR1, TGFB3, TGFB2, TGFBR2
tube development (GO:0035295) 4.414SMAD3, TGFB3, TGFB2, TGFBR2
localization (GO:0051179) 1.44SMAD3, TGFB3, TGFB2, TGFBR2
growth (GO:0040007) 3.84SMAD3, TGFB3, TGFB2, TGFBR2
response to oxygen-containing compound (GO:1901700) 2.574TGFBR1, TGFB3, TGFB2, TGFBR2
primary metabolic process (GO:0044238) 0.694TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of locomotion (GO:0040012) 3.124TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of locomotion (GO:0040017) 3.714TGFBR1, SMAD3, TGFB2, TGFBR2
cellular metabolic process (GO:0044237) 0.694TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of protein phosphorylation (GO:0001932) 2.574TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of protein phosphorylation (GO:0001934) 2.954TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of intracellular protein transport (GO:0033157) 3.83SMAD3, TGFBR1, TGFB3
positive regulation of intracellular transport (GO:0032388) 4.083SMAD3, TGFBR1, TGFB3
regulation of apoptotic signaling pathway (GO:2001233) 3.833TGFBR1, SMAD3, TGFB2
regulation of intracellular transport (GO:0032386) 3.583SMAD3, TGFBR1, TGFB3
skeletal system development (GO:0001501) 4.493TGFBR1, SMAD3, TGFB2
signal transduction by protein phosphorylation (GO:0023014) 3.793TGFBR1, TGFB2, TGFBR2
single-organism metabolic process (GO:0044710) 1.633TGFBR1, TGFB2, TGFBR2
negative regulation of cell cycle (GO:0045786) 3.673TGFBR1, SMAD3, TGFB2
positive regulation of cell adhesion (GO:0045785) 3.793SMAD3, TGFB2, TGFBR2
positive regulation of protein import (GO:1904591) 5.083SMAD3, TGFBR1, TGFB3
negative regulation of cell death (GO:0060548) 2.953SMAD3, TGFBR1, TGFB3
regulation of RNA biosynthetic process (GO:2001141) 1.553SMAD3, TGFBR1, TGFB3
vesicle-mediated transport (GO:0016192) 2.723TGFB3, TGFB2, TGFBR2
protein metabolic process (GO:0019538) 1.453TGFBR1, TGFB2, TGFBR2
SMAD protein signal transduction (GO:0060395) 5.653SMAD3, TGFB3, TGFB2
regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393) 5.633TGFBR1, TGFB3, TGFB2
immune system process (GO:0002376) 2.293SMAD3, TGFB2, TGFBR2
regulation of protein import (GO:1904589) 4.523SMAD3, TGFBR1, TGFB3
regulation of RNA metabolic process (GO:0051252) 1.523SMAD3, TGFBR1, TGFB3
embryonic organ morphogenesis (GO:0048562) 4.923TGFBR1, SMAD3, TGFBR2
digestive tract development (GO:0048565) 5.493TGFB3, TGFB2, TGFBR2
positive regulation of ossification (GO:0045778) 5.273SMAD3, TGFB3, TGFB2
positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862) 5.863TGFBR1, TGFB3, TGFB2
cellular protein metabolic process (GO:0044267) 1.633TGFBR1, TGFB2, TGFBR2
cell growth (GO:0016049) 4.833TGFB3, TGFB2, TGFBR2
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) 5.123TGFBR1, TGFB3, TGFB2
pathway-restricted SMAD protein phosphorylation (GO:0060389) 7.163TGFBR1, TGFB2, TGFBR2
skeletal system morphogenesis (GO:0048705) 4.983TGFBR1, SMAD3, TGFBR2
embryonic skeletal system morphogenesis (GO:0048704) 5.313TGFBR1, SMAD3, TGFBR2
embryonic cranial skeleton morphogenesis (GO:0048701) 6.23TGFBR1, SMAD3, TGFBR2
cell cycle arrest (GO:0007050) 4.693TGFBR1, SMAD3, TGFB2
macromolecule modification (GO:0043412) 1.733TGFBR1, TGFB2, TGFBR2
protein modification process (GO:0036211) 1.793TGFBR1, TGFB2, TGFBR2
positive regulation of protein import into nucleus (GO:0042307) 5.113SMAD3, TGFBR1, TGFB3
regulation of protein import into nucleus (GO:0042306) 4.543SMAD3, TGFBR1, TGFB3
regulation of ossification (GO:0030278) 4.533SMAD3, TGFB3, TGFB2
regulation of intracellular signal transduction (GO:1902531) 2.313TGFBR1, TGFB3, TGFB2
positive regulation of MAPK cascade (GO:0043410) 3.573TGFBR1, TGFB3, TGFB2
response to decreased oxygen levels (GO:0036293) 4.093SMAD3, TGFB3, TGFB2
regulation of response to stress (GO:0080134) 2.533SMAD3, TGFB2, TGFBR2
cell activation (GO:0001775) 3.473TGFBR1, SMAD3, TGFBR2
regulation of transcription, DNA-templated (GO:0006355) 1.563SMAD3, TGFBR1, TGFB3
positive regulation of nucleocytoplasmic transport (GO:0046824) 4.933SMAD3, TGFBR1, TGFB3
regulation of nucleocytoplasmic transport (GO:0046822) 4.333SMAD3, TGFBR1, TGFB3
phosphorylation (GO:0016310) 2.633TGFBR1, TGFB2, TGFBR2
regulation of cell adhesion (GO:0030155) 3.273SMAD3, TGFB2, TGFBR2
regulation of protein targeting (GO:1903533) 4.03SMAD3, TGFBR1, TGFB3
positive regulation of intracellular signal transduction (GO:1902533) 2.953TGFBR1, TGFB3, TGFB2
negative regulation of metabolic process (GO:0009892) 1.933SMAD3, TGFB3, TGFB2
response to hypoxia (GO:0001666) 4.133SMAD3, TGFB3, TGFB2
regulation of MAPK cascade (GO:0043408) 3.223TGFBR1, TGFB3, TGFB2
gland morphogenesis (GO:0022612) 6.363TGFB3, TGFB2, TGFBR2
positive regulation of cell proliferation (GO:0008284) 3.013TGFBR1, TGFB2, TGFBR2
negative regulation of cellular metabolic process (GO:0031324) 2.013SMAD3, TGFB3, TGFB2
positive regulation of apoptotic signaling pathway (GO:2001235) 4.583TGFBR1, SMAD3, TGFB2
regulation of nucleic acid-templated transcription (GO:1903506) 1.553SMAD3, TGFBR1, TGFB3
negative regulation of cell differentiation (GO:0045596) 3.333TGFBR1, SMAD3, TGFB2
regulation of cell growth (GO:0001558) 3.753TGFBR1, SMAD3, TGFB2
positive regulation of transcription, DNA-templated (GO:0045893) 2.563SMAD3, TGFBR1, TGFB3
cell-cell junction organization (GO:0045216) 4.663SMAD3, TGFB3, TGFB2
negative regulation of developmental process (GO:0051093) 3.173TGFBR1, TGFB2, TGFBR2
regulation of immune response (GO:0050776) 2.983SMAD3, TGFB3, TGFB2
regulation of epithelial cell proliferation (GO:0050678) 4.063TGFBR1, SMAD3, TGFB2
response to hormone (GO:0009725) 3.333TGFB3, TGFB2, TGFBR2
regulation of binding (GO:0051098) 4.083TGFBR1, SMAD3, TGFB2
positive regulation of RNA metabolic process (GO:0051254) 2.513SMAD3, TGFBR1, TGFB3
negative regulation of macromolecule metabolic process (GO:0010605) 2.013SMAD3, TGFB3, TGFB2
positive regulation of RNA biosynthetic process (GO:1902680) 2.543SMAD3, TGFBR1, TGFB3
regulation of cytokine production (GO:0001817) 3.43SMAD3, TGFB3, TGFB2
system development (GO:0048731) 2.923TGFBR1, SMAD3, TGFB2
gland development (GO:0048732) 4.153SMAD3, TGFBR1, TGFB3
response to steroid hormone (GO:0048545) 4.243TGFB3, TGFB2, TGFBR2
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563SMAD3, TGFBR1, TGFB3
negative regulation of growth (GO:0045926) 4.243SMAD3, TGFB2, TGFBR2
positive regulation of growth (GO:0045927) 4.253TGFBR1, TGFB2, TGFBR2
positive regulation of cellular biosynthetic process (GO:0031328) 2.33SMAD3, TGFBR1, TGFB3
macromolecular complex subunit organization (GO:0043933) 2.143TGFBR1, SMAD3, TGFB2
regulation of cellular biosynthetic process (GO:0031326) 1.383SMAD3, TGFBR1, TGFB3
cell junction organization (GO:0034330) 4.513SMAD3, TGFB3, TGFB2
palate development (GO:0060021) 5.383TGFBR1, TGFB3, TGFBR2
cell cycle process (GO:0022402) 2.753TGFBR1, SMAD3, TGFB2
cell death (GO:0008219) 3.053TGFBR1, TGFB2, TGFBR2
pattern specification process (GO:0007389) 3.793TGFBR1, SMAD3, TGFBR2
protein complex subunit organization (GO:0071822) 2.63TGFBR1, SMAD3, TGFB2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463SMAD3, TGFBR1, TGFB3
negative regulation of apoptotic process (GO:0043066) 3.043SMAD3, TGFBR1, TGFB3
tissue morphogenesis (GO:0048729) 3.873SMAD3, TGFB2, TGFBR2
hematopoietic or lymphoid organ development (GO:0048534) 4.493TGFBR1, TGFB2, TGFBR2
negative regulation of programmed cell death (GO:0043069) 3.023SMAD3, TGFBR1, TGFB3
protein phosphorylation (GO:0006468) 2.893TGFBR1, TGFB2, TGFBR2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353SMAD3, TGFBR1, TGFB3
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433SMAD3, TGFBR1, TGFB3
positive regulation of intracellular protein transport (GO:0090316) 4.193SMAD3, TGFBR1, TGFB3
cellular protein modification process (GO:0006464) 1.793TGFBR1, TGFB2, TGFBR2
regulation of cartilage development (GO:0061035) 5.63TGFBR1, SMAD3, TGFB2
regulation of nitrogen compound metabolic process (GO:0051171) 1.363SMAD3, TGFBR1, TGFB3
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293SMAD3, TGFBR1, TGFB3
response to oxygen levels (GO:0070482) 4.023SMAD3, TGFB3, TGFB2
heart development (GO:0007507) 4.243TGFBR1, TGFB2, TGFBR2
regulation of cell cycle (GO:0051726) 2.933TGFBR1, SMAD3, TGFB2
regulation of cellular component biogenesis (GO:0044087) 3.083SMAD3, TGFBR1, TGFB3
phosphate-containing compound metabolic process (GO:0006796) 2.163TGFBR1, TGFB2, TGFBR2
phosphorus metabolic process (GO:0006793) 2.153TGFBR1, TGFB2, TGFBR2
positive regulation of cellular component biogenesis (GO:0044089) 3.713SMAD3, TGFBR1, TGFB3
nuclear transport (GO:0051169) 4.22TGFB3, TGFB2
protein localization (GO:0008104) 2.362TGFB3, TGFB2
activin receptor signaling pathway (GO:0032924) 6.642TGFBR1, SMAD3
regulation of secretion (GO:0051046) 3.22TGFB3, TGFB2
positive regulation of secretion (GO:0051047) 3.852TGFB3, TGFB2
cell development (GO:0048468) 3.282SMAD3, TGFB2
regulation of extrinsic apoptotic signaling pathway (GO:2001236) 4.692TGFBR1, TGFB2
regulation of cell projection assembly (GO:0060491) 4.662TGFBR1, TGFB3
regulation of neuron apoptotic process (GO:0043523) 4.472TGFB3, TGFB2
face morphogenesis (GO:0060325) 6.292TGFB3, TGFB2
negative regulation of production of molecular mediator of immune response (GO:0002701) 6.362TGFB3, TGFB2
regulation of production of molecular mediator of immune response (GO:0002700) 5.12TGFB3, TGFB2
regulation of bone mineralization (GO:0030500) 5.492SMAD3, TGFB3
positive regulation of bone mineralization (GO:0030501) 6.152SMAD3, TGFB3
regulation of transforming growth factor beta production (GO:0071634) 6.512SMAD3, TGFB2
organic cyclic compound biosynthetic process (GO:1901362) 1.662SMAD3, TGFB2
regulation of cell projection organization (GO:0031344) 3.382TGFBR1, TGFB3
organic cyclic compound metabolic process (GO:1901360) 1.262SMAD3, TGFB2
positive regulation of cell projection organization (GO:0031346) 3.992TGFBR1, TGFB3
response to cholesterol (GO:0070723) 6.682TGFBR1, TGFBR2
developmental growth (GO:0048589) 4.052SMAD3, TGFBR2
cellular macromolecule localization (GO:0070727) 3.12TGFB3, TGFB2
regulation of organelle organization (GO:0033043) 2.722SMAD3, TGFB2
regulation of cytoskeleton organization (GO:0051493) 3.722SMAD3, TGFB2
positive regulation of filopodium assembly (GO:0051491) 6.432TGFBR1, TGFB3
rhythmic process (GO:0048511) 4.022TGFB3, TGFB2
positive regulation of cell growth (GO:0030307) 4.732TGFBR1, TGFB2
macromolecule localization (GO:0033036) 2.342TGFB3, TGFB2
regulation of striated muscle tissue development (GO:0016202) 5.092SMAD3, TGFBR2
organic substance transport (GO:0071702) 2.152TGFB3, TGFB2
protein import into nucleus (GO:0006606) 5.242TGFB3, TGFB2
negative regulation of epithelial cell proliferation (GO:0050680) 4.982TGFBR1, TGFB2
establishment of protein localization (GO:0045184) 2.532TGFB3, TGFB2
cardiac epithelial to mesenchymal transition (GO:0060317) 6.552TGFBR1, TGFB2
regionalization (GO:0003002) 4.242TGFBR1, SMAD3
peptidyl-amino acid modification (GO:0018193) 2.982TGFBR1, TGFBR2
multi-organism process (GO:0051704) 2.652SMAD3, TGFB3
positive regulation of epithelial cell migration (GO:0010634) 5.092TGFB2, TGFBR2
regulation of biological quality (GO:0065008) 1.682SMAD3, TGFB2
peptidyl-serine modification (GO:0018209) 4.722TGFBR1, TGFBR2
response to external stimulus (GO:0009605) 2.552SMAD3, TGFBR2
regulation of epithelial cell migration (GO:0010632) 4.622TGFB2, TGFBR2
cell motility (GO:0048870) 3.022TGFBR1, TGFB2
regulation of SMAD protein import into nucleus (GO:0060390) 6.962TGFBR1, TGFB3
positive regulation of SMAD protein import into nucleus (GO:0060391) 7.242TGFBR1, TGFB3
positive regulation of cell division (GO:0051781) 5.352TGFB3, TGFB2
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532SMAD3, TGFB3
aromatic compound biosynthetic process (GO:0019438) 1.72SMAD3, TGFB2
regulation of secretion by cell (GO:1903530) 3.282TGFB3, TGFB2
negative regulation of biosynthetic process (GO:0009890) 2.472SMAD3, TGFB3
embryonic organ development (GO:0048568) 4.862TGFB2, TGFBR2
movement of cell or subcellular component (GO:0006928) 2.612TGFBR1, TGFB2
leukocyte activation (GO:0045321) 3.762SMAD3, TGFBR2
negative regulation of gene expression (GO:0010629) 2.482SMAD3, TGFB2
nitrogen compound metabolic process (GO:0006807) 1.132SMAD3, TGFB2
mesenchyme morphogenesis (GO:0072132) 6.962SMAD3, TGFB2
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582TGFBR1, TGFB3
neuron fate commitment (GO:0048663) 6.122TGFBR1, TGFB2
organic substance biosynthetic process (GO:1901576) 1.342SMAD3, TGFB2
cell morphogenesis involved in differentiation (GO:0000904) 4.672TGFBR1, TGFB2
regulation of protein secretion (GO:0050708) 3.772TGFB3, TGFB2
cell morphogenesis (GO:0000902) 4.352TGFBR1, TGFB2
intracellular protein transport (GO:0006886) 3.22TGFB3, TGFB2
exocytosis (GO:0006887) 4.112TGFB3, TGFB2
collagen fibril organization (GO:0030199) 6.072TGFBR1, TGFB2
regulated exocytosis (GO:0045055) 4.442TGFB3, TGFB2
positive regulation of immune system process (GO:0002684) 2.962TGFB2, TGFBR2
extracellular matrix organization (GO:0030198) 4.012TGFBR1, TGFB2
negative regulation of immune system process (GO:0002683) 3.852TGFB3, TGFB2
cell migration (GO:0016477) 3.122TGFBR1, TGFB2
SMAD protein import into nucleus (GO:0007184) 7.532TGFB3, TGFB2
regulation of muscle tissue development (GO:1901861) 5.072SMAD3, TGFBR2
positive regulation of biomineral tissue development (GO:0070169) 6.072SMAD3, TGFB3
regulation of biomineral tissue development (GO:0070167) 5.412SMAD3, TGFB3
negative regulation of macrophage cytokine production (GO:0010936) 8.122TGFB3, TGFB2
tissue development (GO:0009888) 3.272SMAD3, TGFBR2
programmed cell death (GO:0012501) 3.12TGFBR1, TGFBR2
regulation of actin cytoskeleton organization (GO:0032956) 4.092SMAD3, TGFB2
regulation of dephosphorylation (GO:0035303) 4.672SMAD3, TGFB2
cellular protein localization (GO:0034613) 3.112TGFB3, TGFB2
regulation of hydrolase activity (GO:0051336) 2.532SMAD3, TGFB2
secretion (GO:0046903) 3.382TGFB3, TGFB2
cell fate commitment (GO:0045165) 4.722TGFBR1, TGFB2
anterior/posterior pattern specification (GO:0009952) 4.712TGFBR1, SMAD3
intracellular transport (GO:0046907) 2.672TGFB3, TGFB2
positive regulation of protein secretion (GO:0050714) 4.392TGFB3, TGFB2
regulation of extracellular matrix organization (GO:1903053) 6.432SMAD3, TGFB2
biosynthetic process (GO:0009058) 1.322SMAD3, TGFB2
regulation of immune effector process (GO:0002697) 3.712TGFB3, TGFB2
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242SMAD3, TGFB3
response to alcohol (GO:0097305) 4.582TGFBR1, TGFBR2
negative regulation of immune effector process (GO:0002698) 5.12TGFB3, TGFB2
gastrulation (GO:0007369) 5.92SMAD3, TGFBR2
negative regulation of cell growth (GO:0030308) 4.582SMAD3, TGFB2
regulation of response to external stimulus (GO:0032101) 3.062SMAD3, TGFBR2
regulation of phosphatase activity (GO:0010921) 4.882SMAD3, TGFB2
regulation of muscle organ development (GO:0048634) 5.072SMAD3, TGFBR2
regulation of cytokine production involved in immune response (GO:0002718) 5.692TGFB3, TGFB2
regulation of MAP kinase activity (GO:0043405) 3.952TGFBR1, TGFB3
peptidyl-threonine modification (GO:0018210) 5.922TGFBR1, TGFBR2
positive regulation of secretion by cell (GO:1903532) 3.932TGFB3, TGFB2
regulation of neuron death (GO:1901214) 4.192TGFB3, TGFB2
ovulation cycle process (GO:0022602) 5.252TGFB3, TGFB2
regulation of chondrocyte differentiation (GO:0032330) 5.922TGFBR1, SMAD3
regulation of response to wounding (GO:1903034) 4.742SMAD3, TGFBR2
tube morphogenesis (GO:0035239) 4.352SMAD3, TGFBR2
single-organism nuclear import (GO:1902593) 5.242TGFB3, TGFB2
establishment of protein localization to organelle (GO:0072594) 3.922TGFB3, TGFB2
regulation of macrophage cytokine production (GO:0010935) 7.242TGFB3, TGFB2
protein import (GO:0017038) 4.852TGFB3, TGFB2
cellular aromatic compound metabolic process (GO:0006725) 1.32SMAD3, TGFB2
positive regulation of extracellular matrix organization (GO:1903055) 7.022SMAD3, TGFB2
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation (GO:1905005) 8.632TGFB3, TGFB2
negative regulation of immune response (GO:0050777) 4.942TGFB3, TGFB2
aging (GO:0007568) 4.162TGFB3, TGFBR2
response to drug (GO:0042493) 3.712TGFB2, TGFBR2
secretion by cell (GO:0032940) 3.592TGFB3, TGFB2
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812SMAD3, TGFB3
response to progesterone (GO:0032570) 5.842TGFB3, TGFB2
protein localization to organelle (GO:0033365) 3.572TGFB3, TGFB2
hemopoiesis (GO:0030097) 5.072TGFB2, TGFBR2
negative regulation of cytokine production (GO:0001818) 4.42TGFB3, TGFB2
protein localization to nucleus (GO:0034504) 4.92TGFB3, TGFB2
peptidyl-threonine phosphorylation (GO:0018107) 6.022TGFBR1, TGFBR2
peptidyl-serine phosphorylation (GO:0018105) 4.822TGFBR1, TGFBR2
regulation of transforming growth factor beta2 production (GO:0032909) 7.652SMAD3, TGFB2
negative regulation of cellular biosynthetic process (GO:0031327) 2.492SMAD3, TGFB3
apoptotic signaling pathway (GO:0097190) 4.122SMAD3, TGFB2
extrinsic apoptotic signaling pathway (GO:0097191) 5.162SMAD3, TGFB2
regulation of wound healing (GO:0061041) 4.882SMAD3, TGFBR2
protein transport (GO:0015031) 2.622TGFB3, TGFB2
lens development in camera-type eye (GO:0002088) 6.092TGFBR1, TGFBR2
angiogenesis (GO:0001525) 4.152TGFBR1, TGFB2
regulation of cell division (GO:0051302) 4.882TGFB3, TGFB2
uterine wall breakdown (GO:0042704) 9.042TGFB3, TGFB2
morphogenesis of an epithelium (GO:0002009) 4.082SMAD3, TGFBR2
platelet degranulation (GO:0002576) 5.122TGFB3, TGFB2
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62SMAD3, TGFB3
cellular component morphogenesis (GO:0032989) 3.52TGFBR1, TGFB2
extracellular structure organization (GO:0043062) 4.02TGFBR1, TGFB2
regulation of actin filament-based process (GO:0032970) 3.972SMAD3, TGFB2
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552SMAD3, TGFB3
apoptotic process (GO:0006915) 3.142TGFBR1, TGFBR2
nucleocytoplasmic transport (GO:0006913) 4.232TGFB3, TGFB2
negative regulation of cartilage development (GO:0061037) 6.512TGFBR1, TGFB2
single-organism transport (GO:0044765) 2.182TGFB3, TGFB2
salivary gland morphogenesis (GO:0007435) 7.432TGFB3, TGFB2
nuclear import (GO:0051170) 5.062TGFB3, TGFB2
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472SMAD3, TGFB3
establishment of localization in cell (GO:0051649) 2.472TGFB3, TGFB2
response to estrogen (GO:0043627) 5.252TGFB3, TGFBR2
negative regulation of cytokine production involved in immune response (GO:0002719) 6.642TGFB3, TGFB2
response to sterol (GO:0036314) 6.552TGFBR1, TGFBR2
regulation of heart morphogenesis (GO:2000826) 6.42TGFB3, TGFB2
single-organism localization (GO:1902578) 2.092TGFB3, TGFB2
cellular localization (GO:0051641) 2.322TGFB3, TGFB2
locomotion (GO:0040011) 2.912TGFBR1, TGFB2
regulation of filopodium assembly (GO:0051489) 6.042TGFBR1, TGFB3
odontogenesis (GO:0042476) 5.192TGFB3, TGFB2
epithelial to mesenchymal transition (GO:0001837) 5.762TGFBR1, TGFB2
response to ketone (GO:1901654) 4.532TGFB3, TGFB2
regulation of organ morphogenesis (GO:2000027) 4.222TGFB3, TGFB2
regulation of alkaline phosphatase activity (GO:0010692) 7.532SMAD3, TGFB2
single-organism intracellular transport (GO:1902582) 3.592TGFB3, TGFB2
single-organism cellular localization (GO:1902580) 3.162TGFB3, TGFB2
cellular biosynthetic process (GO:0044249) 1.372SMAD3, TGFB2
blood vessel development (GO:0001568) 4.952TGFB2, TGFBR2

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of intracellular protein transport (GO:0033157) -3.80.031SMAD3, TGFBR1, TGFB3, TGFB2
nuclear transport (GO:0051169) -4.20.007SMAD3, TGFB3, TGFB2, TGFBR2
response to abiotic stimulus (GO:0009628) -2.80.03SMAD3, TGFB3, TGFB2, TGFBR2
regulation of stem cell differentiation (GO:2000736) NEW6.260.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of secretion (GO:0051046) -3.20.02SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of response to stimulus (GO:0048585) -2.520.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
blood coagulation (GO:0007596) NEW4.520.004SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239) NEW5.860.009TGFBR1, SMAD3, TGFB2
regulation of homeostatic process (GO:0032844) NEW3.650.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
BMP signaling pathway (GO:0030509) NEW5.330.011TGFBR1, SMAD3, TGFBR2
regulation of cell projection assembly (GO:0060491) -4.660.001SMAD3, TGFBR1, TGFB3, TGFB2
face morphogenesis (GO:0060325) -6.290.0TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of production of molecular mediator of immune response (GO:0002701) -6.360.027TGFB3, TGFB2
enzyme linked receptor protein signaling pathway (GO:0007167) -3.240.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of macrophage cytokine production (GO:0010936) -8.120.0TGFB3, TGFB2
hemostasis (GO:0007599) NEW4.50.005SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of transforming growth factor beta production (GO:0071634) -6.510.001SMAD3, TGFB2, TGFBR2
regulation of cell projection organization (GO:0031344) -3.380.005SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
signal transduction by phosphorylation (GO:0023014) -3.790.011TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of cell projection organization (GO:0031346) -3.990.027SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of apoptotic process (GO:0043065) -3.380.003SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to cholesterol (GO:0070723) -6.680.009TGFBR1, TGFBR2
negative regulation of cell cycle (GO:0045786) -3.670.024TGFBR1, SMAD3, TGFB2
positive regulation of macromolecule metabolic process (GO:0010604) -1.810.02SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of signal transduction (GO:0009968) -2.750.022SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of cell adhesion (GO:0045785) -3.790.008TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of signal transduction (GO:0009966) -1.840.02SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of signal transduction (GO:0009967) -2.50.043SMAD3, TGFBR1, TGFB3, TGFB2
response to wounding (GO:0009611) -4.390.008TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of filopodium assembly (GO:0051491) -6.430.013SMAD3, TGFBR1, TGFB3
regulation of cardiac muscle contraction (GO:0055117) NEW5.570.004TGFBR1, SMAD3, TGFBR2
regulation of chondrocyte differentiation (GO:0032330) -5.920.038TGFBR1, SMAD3
organ development (GO:0048513) -2.530.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
transforming growth factor beta receptor signaling pathway (GO:0007179) -5.190.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of cell development (GO:0010720) -3.570.012SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of catagen (GO:0051794) NEW8.340.004TGFB2, TGFBR2
regulation of hair follicle development (GO:0051797) NEW6.960.035TGFB2, TGFBR2
positive regulation of osteoblast differentiation (GO:0045669) NEW5.620.01TGFBR1, SMAD3, TGFBR2
negative regulation of immune system process (GO:0002683) -3.850.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cell proliferation (GO:0042127) -2.410.002SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of phosphorylation (GO:0042325) -2.50.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
pathway-restricted SMAD protein phosphorylation (GO:0060389) -7.160.0TGFBR1, TGFB2, TGFBR2
regulation of DNA metabolic process (GO:0051052) NEW3.870.034SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of transport (GO:0051050) -2.90.006SMAD3, TGFBR1, TGFB3, TGFB2
regulation of protein kinase activity (GO:0045859) -3.150.008SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
protein import into nucleus (GO:0006606) -5.240.0SMAD3, TGFB3, TGFB2, TGFBR2
activation of protein kinase activity (GO:0032147) -4.080.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of immune effector process (GO:0002698) -5.10.048TGFBR1, TGFB3, TGFB2
regulation of cellular protein metabolic process (GO:0032268) -1.990.004SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cellular response to growth factor stimulus (GO:0071363) NEW4.270.015SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of MAP kinase activity (GO:0043406) NEW4.390.01SMAD3, TGFBR1, TGFB3, TGFBR2
negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512) -5.540.0SMAD3, TGFBR1, TGFB3, TGFBR2
platelet activation (GO:0030168) NEW4.960.007SMAD3, TGFBR1, TGFB3, TGFB2
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) -4.60.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of epithelial cell migration (GO:0010634) -5.090.0TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of phosphorylation (GO:0042327) -2.90.012TGFBR1, TGFB3, TGFB2, TGFBR2
cartilage development (GO:0051216) NEW5.310.0TGFBR1, SMAD3, TGFB2, TGFBR2
peptidyl-serine modification (GO:0018209) -4.720.038TGFBR1, SMAD3, TGFBR2
regulation of epithelial cell migration (GO:0010632) -4.620.002TGFBR1, SMAD3, TGFB2, TGFBR2
embryo development (GO:0009790) -4.20.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of SMAD protein import into nucleus (GO:0060390) -6.960.004TGFBR1, TGFB3
positive regulation of SMAD protein import into nucleus (GO:0060391) -7.240.02TGFBR1, TGFB3
regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393) -5.630.002TGFBR1, TGFB3, TGFBR2
collagen fibril organization (GO:0030199) -6.070.042TGFBR1, TGFB2
extracellular matrix organization (GO:0030198) -4.010.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of protein transport (GO:0051223) -3.120.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
SMAD protein import into nucleus (GO:0007184) -7.530.0SMAD3, TGFB3, TGFB2, TGFBR2
regulation of cell morphogenesis (GO:0022604) -3.40.006SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
skeletal system morphogenesis (GO:0048705) -4.980.001TGFBR1, SMAD3, TGFB2, TGFBR2
embryonic organ morphogenesis (GO:0048562) -4.920.002TGFBR1, SMAD3, TGFB2, TGFBR2
digestive tract development (GO:0048565) -5.490.0SMAD3, TGFB3, TGFB2, TGFBR2
positive regulation of metabolic process (GO:0009893) -1.740.034SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of anatomical structure morphogenesis (GO:0022603) -2.790.01SMAD3, TGFB3, TGFB2, TGFBR2
regulation of establishment of protein localization (GO:0070201) -3.020.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
embryonic organ development (GO:0048568) -4.860.002TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of protein localization to nucleus (GO:1900180) -4.340.005SMAD3, TGFBR1, TGFB3
positive regulation of cell migration (GO:0030335) -3.770.027SMAD3, TGFB2, TGFBR2
regulation of cell-matrix adhesion (GO:0001952) NEW5.210.036TGFBR1, SMAD3, TGFBR2
regulation of bone mineralization (GO:0030500) -5.490.0SMAD3, TGFBR1, TGFB3, TGFB2
regulation of vasculature development (GO:1901342) NEW4.260.02TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of bone mineralization (GO:0030501) -6.150.0SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of protein serine/threonine kinase activity (GO:0071902) NEW4.060.035SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of protein transport (GO:0051222) -3.610.0SMAD3, TGFBR1, TGFB3, TGFB2
positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862) -5.860.0TGFBR1, TGFB3, TGFBR2
regulation of phosphate metabolic process (GO:0019220) -2.350.009SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of intracellular transport (GO:0032388) -4.080.008SMAD3, TGFBR1, TGFB3
mitotic cell cycle phase transition (GO:0044772) NEW4.270.008TGFBR1, SMAD3, TGFB2, TGFBR2
response to hypoxia (GO:0001666) -4.130.018SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of transferase activity (GO:0051347) -3.310.004SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cell morphogenesis (GO:0000902) -4.350.018TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) -5.120.0SMAD3, TGFBR1, TGFB3, TGFBR2
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090101) -5.10.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cell communication (GO:0010646) -1.730.038SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
intracellular protein transport (GO:0006886) -3.20.009SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of kinase activity (GO:0043549) -3.070.01TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of MAPK cascade (GO:0043410) -3.570.002SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cellular response to fibroblast growth factor stimulus (GO:0044344) NEW6.40.004TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of protein secretion (GO:0050708) -3.770.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of catalytic activity (GO:0043085) -2.40.002SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of production of molecular mediator of immune response (GO:0002700) -5.10.044TGFBR1, TGFB3, TGFB2
SMAD protein complex assembly (GO:0007183) NEW7.650.004TGFBR1, SMAD3
regulation of molecular function (GO:0065009) -1.780.043SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of MAPK cascade (GO:0043408) -3.220.01SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
anatomical structure formation involved in morphogenesis (GO:0048646) -3.010.009TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of cellular component organization (GO:0051130) -2.680.008SMAD3, TGFBR1, TGFB3, TGFB2
embryonic skeletal system morphogenesis (GO:0048704) -5.310.001TGFBR1, SMAD3, TGFB2, TGFBR2
organ morphogenesis (GO:0009887) -3.550.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of biomineral tissue development (GO:0070169) -6.070.034SMAD3, TGFBR1, TGFB3, TGFBR2
embryonic cranial skeleton morphogenesis (GO:0048701) -6.20.001TGFBR1, SMAD3, TGFBR2
regulation of developmental process (GO:0050793) -2.10.007SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of heart contraction (GO:0008016) NEW4.350.003TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of transforming growth factor beta receptor signaling pathway (GO:0017015) -5.130.0SMAD3, TGFBR1, TGFB3, TGFBR2
regulation of biomineral tissue development (GO:0070167) -5.410.0SMAD3, TGFBR1, TGFB3, TGFB2
wound healing (GO:0042060) -5.130.0TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of intracellular protein transport (GO:0090316) -4.190.003SMAD3, TGFBR1, TGFB3
cell cycle arrest (GO:0007050) -4.690.004TGFBR1, SMAD3, TGFB2
cell activation (GO:0001775) -3.470.02SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
coagulation (GO:0050817) NEW4.510.004SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of skeletal muscle tissue regeneration (GO:0043415) NEW7.940.002SMAD3, TGFBR2
regulation of multicellular organismal process (GO:0051239) -1.870.017SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of actin cytoskeleton organization (GO:0032956) -4.090.031SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of protein import into nucleus (GO:0042307) -5.110.041SMAD3, TGFBR1, TGFB3
positive regulation of intracellular signal transduction (GO:1902533) -2.950.042SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of ossification (GO:0030278) -4.530.007SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of cell differentiation (GO:0045597) -3.010.005SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
vasculogenesis (GO:0001570) NEW5.650.023TGFBR1, SMAD3, TGFBR2
secretion (GO:0046903) -3.380.012SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cell morphogenesis involved in differentiation (GO:0000904) -4.670.005TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of epithelial to mesenchymal transition (GO:0010718) -6.230.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of epithelial to mesenchymal transition (GO:0010717) -5.550.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to decreased oxygen levels (GO:0036293) -4.090.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
odontogenesis (GO:0042476) -5.190.001SMAD3, TGFBR1, TGFB3, TGFB2
positive regulation of B cell tolerance induction (GO:0002663) NEW9.040.001SMAD3, TGFBR2
regulation of transferase activity (GO:0051338) -2.880.018TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of nucleocytoplasmic transport (GO:0046824) -4.930.001SMAD3, TGFBR1, TGFB3
regulation of nucleocytoplasmic transport (GO:0046822) -4.330.007SMAD3, TGFBR1, TGFB3
negative regulation of cytokine production (GO:0001818) -4.40.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of cell motility (GO:2000147) -3.740.03SMAD3, TGFB2, TGFBR2
positive regulation of protein modification process (GO:0031401) -2.70.018TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of hair follicle maturation (GO:0048819) NEW8.120.005TGFB2, TGFBR2
menstrual cycle phase (GO:0022601) NEW9.040.0SMAD3, TGFB3, TGFB2
positive regulation of kinase activity (GO:0033674) -3.540.002SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
hair follicle development (GO:0001942) NEW6.020.0TGFBR1, SMAD3, TGFB2, TGFBR2
negative regulation of cell growth (GO:0030308) -4.580.007TGFBR1, SMAD3, TGFB2, TGFBR2
cellular response to organic substance (GO:0071310) NEW2.780.005SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to growth factor (GO:0070848) NEW4.140.018SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of signaling (GO:0023057) -2.650.027SMAD3, TGFBR1, TGFB3, TGFBR2
regulation of MAP kinase activity (GO:0043405) -3.950.039SMAD3, TGFBR1, TGFB3, TGFBR2
embryo development ending in birth or egg hatching (GO:0009792) -4.350.023SMAD3, TGFBR1, TGFB3, TGFBR2
negative regulation of cell communication (GO:0010648) -2.660.027SMAD3, TGFBR1, TGFB3, TGFBR2
cellular response to chemical stimulus (GO:0070887) NEW2.570.012SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of signaling (GO:0023051) -1.720.037SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of protein import into nucleus (GO:0042306) -4.540.004SMAD3, TGFBR1, TGFB3
anatomical structure morphogenesis (GO:0009653) -2.530.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to organic cyclic compound (GO:0014070) -3.070.009TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of protein localization (GO:0032880) -2.880.026SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to endogenous stimulus (GO:0009719) -2.790.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cellular response to growth factor stimulus (GO:0090287) -4.290.0SMAD3, TGFBR1, TGFB3, TGFBR2
in utero embryonic development (GO:0001701) -4.40.019SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of protein metabolic process (GO:0051247) -2.430.043TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of system process (GO:0044057) NEW3.530.002SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of multicellular organismal process (GO:0051240) -2.490.026SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of multicellular organismal process (GO:0051241) -2.840.004SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of protein metabolic process (GO:0051246) -1.930.012SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of cellular response to growth factor stimulus (GO:0090288) -4.920.0SMAD3, TGFBR1, TGFB3, TGFBR2
regulation of cell morphogenesis involved in differentiation (GO:0010769) -3.910.02SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of cellular protein metabolic process (GO:0032270) -2.490.03TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of protein modification process (GO:0031399) -2.320.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
gland morphogenesis (GO:0022612) -6.360.0TGFB3, TGFB2, TGFBR2
chordate embryonic development (GO:0043009) -4.380.02SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241) NEW7.090.0TGFBR1, SMAD3, TGFB2
cellular response to endogenous stimulus (GO:0071495) NEW3.330.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
negative regulation of cell proliferation (GO:0008285) -3.260.036SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
striated muscle cell development (GO:0055002) NEW5.420.025TGFBR1, SMAD3, TGFBR2
regulation of cytokine production (GO:0001817) -3.40.009SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cytokine production involved in immune response (GO:0002718) -5.690.008TGFBR1, TGFB3, TGFB2
positive regulation of molecular function (GO:0044093) -2.230.004SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of body fluid levels (GO:0050878) NEW3.760.015SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
heart development (GO:0007507) -4.240.006TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of stress-activated protein kinase signaling cascade (GO:0070302) NEW4.440.005TGFBR1, SMAD3, TGFB2, TGFBR2
establishment of protein localization to organelle (GO:0072594) -3.920.011SMAD3, TGFB3, TGFB2, TGFBR2
regulation of macrophage cytokine production (GO:0010935) -7.240.003TGFB3, TGFB2
regulation of actin filament-based process (GO:0032970) -3.970.041SMAD3, TGFBR1, TGFB3, TGFBR2
regulation of stress-activated MAPK cascade (GO:0032872) NEW4.450.005TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of striated muscle cell differentiation (GO:0051153) NEW5.260.04TGFBR1, SMAD3, TGFBR2
regulation of cell differentiation (GO:0045595) -2.420.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of cell growth (GO:0001558) -3.750.042TGFBR1, SMAD3, TGFB2
regulation of striated muscle contraction (GO:0006942) NEW5.380.01TGFBR1, SMAD3, TGFBR2
cell-cell junction organization (GO:0045216) -4.660.005SMAD3, TGFB3, TGFB2, TGFBR2
regulation of localization (GO:0032879) -1.940.009SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cytoplasmic transport (GO:0016482) NEW4.980.01SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of sarcomere organization (GO:0060298) NEW8.120.005TGFBR1, TGFBR2
negative regulation of cytokine production involved in immune response (GO:0002719) -6.640.027TGFB3, TGFB2
regulation of immune response (GO:0050776) -2.980.046SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of epithelial cell proliferation (GO:0050678) -4.060.022TGFBR1, SMAD3, TGFB2
positive regulation of locomotion (GO:0040017) -3.710.035SMAD3, TGFB2, TGFBR2
positive regulation of developmental process (GO:0051094) -2.770.017SMAD3, TGFB3, TGFB2, TGFBR2
positive regulation of cell-matrix adhesion (GO:0001954) NEW6.020.003TGFBR1, SMAD3, TGFBR2
secretion by cell (GO:0032940) -3.590.005SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of sarcomere organization (GO:0060297) NEW7.650.023TGFBR1, TGFBR2
cellular response to transforming growth factor beta stimulus (GO:0071560) NEW5.740.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to progesterone (GO:0032570) -5.840.027TGFB3, TGFB2, TGFBR2
activin receptor signaling pathway (GO:0032924) -6.640.047TGFBR1, SMAD3
positive regulation of cell morphogenesis involved in differentiation (GO:0010770) -4.650.0SMAD3, TGFBR1, TGFB3, TGFB2
gland development (GO:0048732) -4.150.013SMAD3, TGFBR1, TGFB3, TGFBR2
positive regulation of protein kinase activity (GO:0045860) -3.610.002SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to steroid hormone (GO:0048545) -4.240.003SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of cytokine production (GO:0001819) NEW3.820.047SMAD3, TGFBR1, TGFB3, TGFBR2
peptidyl-threonine phosphorylation (GO:0018107) -6.020.048TGFBR1, TGFBR2
regulation of multicellular organismal metabolic process (GO:0044246) NEW6.090.007SMAD3, TGFBR1, TGFB3
peptidyl-serine phosphorylation (GO:0018105) -4.820.024TGFBR1, SMAD3, TGFBR2
negative regulation of growth (GO:0045926) -4.240.035TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of growth (GO:0045927) -4.250.006TGFBR1, TGFB2, TGFBR2
regulation of cellular localization (GO:0060341) -3.030.024SMAD3, TGFBR1, TGFB3, TGFB2
regulation of transforming growth factor beta2 production (GO:0032909) -7.650.001SMAD3, TGFB2, TGFBR2
positive regulation of cellular metabolic process (GO:0031325) -1.810.026SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cell junction organization (GO:0034330) -4.510.009SMAD3, TGFB3, TGFB2, TGFBR2
extrinsic apoptotic signaling pathway (GO:0097191) -5.160.0TGFBR1, SMAD3, TGFB2, TGFBR2
palate development (GO:0060021) -5.380.0SMAD3, TGFBR1, TGFB3, TGFBR2
cell cycle phase transition (GO:0044770) NEW4.240.008TGFBR1, SMAD3, TGFB2, TGFBR2
lens development in camera-type eye (GO:0002088) -6.090.02TGFBR1, TGFBR2
molting cycle process (GO:0022404) NEW5.540.0TGFBR1, SMAD3, TGFB2, TGFBR2
hair cycle process (GO:0022405) NEW5.540.0TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of cell death (GO:0010942) -3.320.005SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of epidermis development (GO:0045682) NEW5.570.011SMAD3, TGFB2, TGFBR2
angiogenesis (GO:0001525) -4.150.04TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of cell division (GO:0051302) -4.880.023SMAD3, TGFBR1, TGFB3, TGFB2
cell division (GO:0051301) NEW3.680.001TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of cardioblast differentiation (GO:0051890) NEW7.780.018TGFB2, TGFBR2
response to follicle-stimulating hormone (GO:0032354) NEW7.330.027TGFBR1, SMAD3
growth (GO:0040007) -3.80.003SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to transforming growth factor beta (GO:0071559) NEW5.620.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of growth (GO:0040008) -3.260.003TGFBR1, SMAD3, TGFB2, TGFBR2
single-organism nuclear import (GO:1902593) -5.240.0SMAD3, TGFB3, TGFB2, TGFBR2
regulation of angiogenesis (GO:0045765) NEW4.360.015TGFBR1, SMAD3, TGFB2, TGFBR2
muscle cell development (GO:0055001) NEW5.290.043TGFBR1, SMAD3, TGFBR2
positive regulation of endothelial cell differentiation (GO:0045603) NEW7.020.015SMAD3, TGFBR2
muscle system process (GO:0003012) NEW4.180.024TGFBR1, SMAD3, TGFB2, TGFBR2
negative regulation of apoptotic process (GO:0043066) -3.040.044SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
extracellular structure organization (GO:0043062) -4.00.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
hematopoietic or lymphoid organ development (GO:0048534) -4.490.01TGFBR1, SMAD3, TGFB2, TGFBR2
negative regulation of programmed cell death (GO:0043069) -3.020.045SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of programmed cell death (GO:0043068) -3.380.003SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to organic substance (GO:0010033) -2.20.024SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
embryonic morphogenesis (GO:0048598) -3.720.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) -4.390.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
protein import (GO:0017038) -4.850.0SMAD3, TGFB3, TGFB2, TGFBR2
neuron fate commitment (GO:0048663) -6.120.027TGFBR1, SMAD3, TGFB2
positive regulation of phosphate metabolic process (GO:0045937) -2.780.02TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of phosphorus metabolic process (GO:0010562) -2.780.02TGFBR1, TGFB3, TGFB2, TGFBR2
cardiocyte differentiation (GO:0035051) NEW6.020.005TGFBR1, SMAD3, TGFB2
nucleocytoplasmic transport (GO:0006913) -4.230.006SMAD3, TGFB3, TGFB2, TGFBR2
regulation of hormone levels (GO:0010817) NEW3.560.029SMAD3, TGFBR1, TGFB3, TGFBR2
regulation of phosphorus metabolic process (GO:0051174) -2.350.009SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to fibroblast growth factor (GO:0071774) NEW6.170.004TGFBR1, SMAD3, TGFB2, TGFBR2
biological phase (GO:0044848) NEW4.370.016SMAD3, TGFB3, TGFB2
salivary gland morphogenesis (GO:0007435) -7.430.001TGFB3, TGFB2
nuclear import (GO:0051170) -5.060.0SMAD3, TGFB3, TGFB2, TGFBR2
response to estrogen (GO:0043627) -5.250.007SMAD3, TGFB3, TGFB2, TGFBR2
cell growth (GO:0016049) -4.830.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
tube development (GO:0035295) -4.410.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to sterol (GO:0036314) -6.550.012TGFBR1, TGFBR2
cellular protein complex assembly (GO:0043623) NEW3.90.025TGFBR1, SMAD3, TGFB2, TGFBR2
response to oxygen levels (GO:0070482) -4.020.022SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of filopodium assembly (GO:0051489) -6.040.004SMAD3, TGFBR1, TGFB3
regulation of cellular component movement (GO:0051270) -3.080.004TGFBR1, SMAD3, TGFB2, TGFBR2
positive regulation of cellular component movement (GO:0051272) -3.710.0TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of catalytic activity (GO:0050790) -1.970.018SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of ossification (GO:0045778) -5.270.0SMAD3, TGFBR1, TGFB3, TGFB2
epithelial to mesenchymal transition (GO:0001837) -5.760.0TGFBR1, SMAD3, TGFB2, TGFBR2
regulation of cellular component biogenesis (GO:0044087) -3.080.011SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to ketone (GO:1901654) -4.530.001TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of multicellular organismal development (GO:2000026) -2.310.002SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
response to lipid (GO:0033993) -3.110.046SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
regulation of alkaline phosphatase activity (GO:0010692) -7.530.004TGFBR1, SMAD3, TGFB2
regulation of protein phosphorylation (GO:0001932) -2.570.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of protein phosphorylation (GO:0001934) -2.950.039SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
positive regulation of transforming growth factor beta production (GO:0071636) NEW6.960.05SMAD3, TGFB3
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.285SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cytoplasmic part (GO:0044444) 0.825SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cell part (GO:0044464) 0.115SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
intracellular membrane-bounded organelle (GO:0043231) 0.64SMAD3, TGFBR1, TGFB3, TGFB2
membrane (GO:0016020) 0.684SMAD3, TGFBR1, TGFB3, TGFBR2
intracellular organelle (GO:0043229) 0.514SMAD3, TGFBR1, TGFB3, TGFB2
plasma membrane (GO:0005886) 1.394SMAD3, TGFBR1, TGFB3, TGFBR2
membrane-bounded organelle (GO:0043227) 0.474SMAD3, TGFBR1, TGFB3, TGFB2
organelle (GO:0043226) 0.44SMAD3, TGFBR1, TGFB3, TGFB2
protein complex (GO:0043234) 1.513TGFBR1, SMAD3, TGFBR2
receptor complex (GO:0043235) 4.013TGFBR1, SMAD3, TGFBR2
macromolecular complex (GO:0032991) 1.353TGFBR1, SMAD3, TGFBR2
cell surface (GO:0009986) 3.443TGFBR1, TGFB3, TGFBR2
cytoplasm (GO:0005737) 1.013SMAD3, TGFB3, TGFBR2
intracellular organelle part (GO:0044446) 0.813SMAD3, TGFB3, TGFB2
membrane part (GO:0044425) 0.953TGFBR1, TGFB3, TGFBR2
plasma membrane part (GO:0044459) 1.953TGFBR1, TGFB3, TGFBR2
organelle part (GO:0044422) 0.793SMAD3, TGFB3, TGFB2
membrane-enclosed lumen (GO:0031974) 3.052TGFB3, TGFB2
extracellular matrix (GO:0031012) 3.812TGFB3, TGFB2
cytoplasmic membrane-bounded vesicle lumen (GO:0060205) 5.192TGFB3, TGFB2
intracellular (GO:0005622) 2.372TGFBR1, SMAD3
intrinsic component of membrane (GO:0031224) 1.132TGFBR1, TGFBR2
vesicle lumen (GO:0031983) 5.172TGFB3, TGFB2
extracellular space (GO:0005615) 2.632TGFB3, TGFB2
platelet alpha granule lumen (GO:0031093) 5.812TGFB3, TGFB2
membrane protein complex (GO:0098796) 2.842TGFBR1, TGFBR2
vacuole (GO:0005773) 2.922TGFBR1, TGFB2
protein kinase complex (GO:1902911) 5.312TGFBR1, TGFBR2
nucleus (GO:0005634) 1.072SMAD3, TGFB3
plasma membrane receptor complex (GO:0098802) 4.632TGFBR1, TGFBR2
cytoplasmic vesicle part (GO:0044433) 3.412TGFB3, TGFB2
neuron part (GO:0097458) 2.642TGFB3, TGFB2
neuronal cell body (GO:0043025) 3.92TGFB3, TGFB2
catalytic complex (GO:1902494) 2.92TGFBR1, TGFBR2
transferase complex, transferring phosphorus-containing groups (GO:0061695) 4.612TGFBR1, TGFBR2
serine/threonine protein kinase complex (GO:1902554) 5.452TGFBR1, TGFBR2
membrane region (GO:0098589) 3.952TGFBR1, TGFBR2
cell body (GO:0044297) 3.742TGFB3, TGFB2
transferase complex (GO:1990234) 3.322TGFBR1, TGFBR2
secretory granule lumen (GO:0034774) 5.382TGFB3, TGFB2
organelle lumen (GO:0043233) 3.052TGFB3, TGFB2
cytosol (GO:0005829) 1.682SMAD3, TGFBR2
membrane raft (GO:0045121) 4.182TGFBR1, TGFBR2
extracellular region part (GO:0044421) 1.572TGFB3, TGFB2
plasma membrane protein complex (GO:0098797) 3.552TGFBR1, TGFBR2
intracellular organelle lumen (GO:0070013) 3.052TGFB3, TGFB2
extracellular region (GO:0005576) 2.182TGFB3, TGFB2
transforming growth factor beta receptor homodimeric complex (GO:0070022) 8.422TGFBR1, TGFBR2
membrane microdomain (GO:0098857) 4.172TGFBR1, TGFBR2
endosome (GO:0005768) 3.252TGFBR1, TGFB2
integral component of membrane (GO:0016021) 1.142TGFBR1, TGFBR2

NET-GE enrichment

Term New enriched termICP valueGenes
integral component of plasma membrane (GO:0005887) NEW2.570.027SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
membrane-enclosed lumen (GO:0031974) -3.050.004SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
extracellular matrix (GO:0031012) -3.810.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cytoplasmic membrane-bounded vesicle lumen (GO:0060205) -5.190.011TGFBR1, TGFB3, TGFB2
tight junction (GO:0005923) NEW5.090.006TGFBR1, SMAD3, TGFBR2
vesicle lumen (GO:0031983) -5.170.011TGFBR1, TGFB3, TGFB2
extracellular space (GO:0005615) -2.630.047SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
platelet alpha granule lumen (GO:0031093) -5.810.023TGFB3, TGFB2
transforming growth factor beta receptor homodimeric complex (GO:0070022) -8.420.0TGFBR1, TGFBR2
neuron part (GO:0097458) -2.640.024SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
neuronal cell body (GO:0043025) -3.90.007SMAD3, TGFBR1, TGFB3, TGFB2
occluding junction (GO:0070160) NEW5.070.006TGFBR1, SMAD3, TGFBR2
serine/threonine protein kinase complex (GO:1902554) -5.450.005TGFBR1, TGFBR2
cell surface (GO:0009986) -3.440.001SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
cell body (GO:0044297) -3.740.0SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
transferase complex (GO:1990234) -3.320.022TGFBR1, SMAD3, TGFB2, TGFBR2
secretory granule lumen (GO:0034774) -5.380.007TGFB3, TGFB2
receptor complex (GO:0043235) -4.010.003TGFBR1, SMAD3, TGFB2, TGFBR2
organelle lumen (GO:0043233) -3.050.003SMAD3, TGFBR1, TGFB3, TGFB2, TGFBR2
protein kinase complex (GO:1902911) -5.310.009TGFBR1, TGFB2, TGFBR2
endosome (GO:0005768) -3.250.025TGFBR1, SMAD3, TGFB2, TGFBR2
proteinaceous extracellular matrix (GO:0005578) NEW4.010.002TGFBR1, SMAD3, TGFB2, TGFBR2
contractile fiber part (GO:0044449) NEW4.530.001TGFBR1, SMAD3, TGFB2, TGFBR2